Author | Lightnews

Luca Caputo

Luca Caputo

@capluca.bsky.social

500 followers 930 following 51 posts

🌈🔬 Biology, Politics, LGBTQ+ and Juventus in random order #lgbtSTEM #loveislove #finoallafine Opinions are mine own He/They

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Luca Caputo @capluca.bsky.social · Oct 18

First post = short introduction: postdoc studying chromatin biology in skeletal and cardiac muscle (mostly), MDA funded, interested in DEI initiatives, co-founder of QueerScienceSociety of San Diego and former Board Member of @outtoinnovate.bsky.social
500queerscientists.com/luca-caputo/

Luca Caputo | 500 Queer Scientists

I work to understand how the three-dimensional folding of the genome impacts cell-fate decision, and how during development and in diseases alteration of the 3D genome impact on cell-fate decisions.

500queerscientists.com

Reposted by Luca Caputo

American Society for Cell Biology @ascbiology.bsky.social · 3d

Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.

Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”

doi.org/10.1038/s415...

Reposted by Luca Caputo

Genes & Development @genesdev.bsky.social · 1d

RESEARCH PAPER: MYOD represses gene expression from non-E-box motifs
By Nicoletti, Massenet et al., Luca Caputo and Pier Lorenzo Puri
➡️ https://genesdev.cshlp.org/content/39/21-22/1299.abstract

#transcription #trancriptionfactor #epigenetics #muscle #stemcells

Reposted by Luca Caputo

God @thegodpodcast.com · 2d

All the people “afraid” of Zohran Mamdani are racist as hell.

Reposted by Luca Caputo

Zohran Kwame Mamdani @zohrankmamdani.bsky.social · 1d

Reposted by Luca Caputo

Genes & Development @genesdev.bsky.social · 3d

🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research articles online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/21-22.toc

Luca Caputo @capluca.bsky.social · 7d

Thanks to all co-authors at @sbpdiscovery.bsky.social and our collaborators from UT Southwestern and Università di Ferrara

Luca Caputo @capluca.bsky.social · 7d

Functionally treated CD54+ cells are able to engraft and contribute to muscle regeneration with a better efficiency compared to untreated cells.

Luca Caputo @capluca.bsky.social · 7d

We were able to purify SMPCs using a single surface marker (CD54/ICAM1) and analyze the cells transcriptionally and functionally.
At transcription level treated cells resemble late fetal stage SMPCs rather than embryonal SMPCs that are usually obtained in vitro

Luca Caputo @capluca.bsky.social · 7d

We started the project wondering if modulation of the jak2/stat3 pathway would be efficient in increasing the yield. When we inhibited the pathway after the appearance of PAX3+ cells (D12) we managed to double the amount of PAX7+ cells at D30, both in H9 and hiPSCs derived cultures

Luca Caputo @capluca.bsky.social · 7d

📣 The paper is out!!

In this paper we tackled 2 major bottlenecks of cell therapy, namely how to increase the yield of progenitors in vitro and, by serendipity, how to mature them to an higher developmental stage.

#muscle #stemcelltherapy #muscleregeneration

www.cell.com/stem-cell-re...

Luca Caputo @capluca.bsky.social · 7d

Adda passà a nuttata

Luca Caputo @capluca.bsky.social · 14d

If you introduce a trainee saying "I asked chatGPT..." I agree with the eel.

And ask the pronunciation of their surname, that is basic etiquette for fuck sake.

Christophe 🔬 L @christlet.bsky.social · 15d

@mads100tist.bsky.social

Luca Caputo @capluca.bsky.social · 20d

Galley proofs! 🥳💪🔬🧫

Reposted by Luca Caputo

ISSCR @isscr.org · 28d

The ISSCR joins the global scientific community in mourning the loss of Nobel Laureate Sir John Gurdon whose enduring influence is woven into the very fabric of stem cell science.

https://ow.ly/BjHT50X8T6q

ISSCR Remembers Sir John Gurdon — International Society for Stem Cell Research

The International Society for Stem Cell Research (ISSCR) joins the global scientific community in mourning the loss of Nobel Laureate Professor Sir John Gurdon, whose visionary discoveries forever changed our understanding of biology and inspired generations of scientists around the world. Professo

Luca Caputo @capluca.bsky.social · Oct 3

The email you wish to get before heading out to a conference "I am pleased to say that the reviewers have commented enthusiastically on your revised manuscript"
Stay tuned 🥳😉

Reposted by Luca Caputo

Science News @scinews.bsky.social · Sep 26

Vaccination: Risks and Benefits

Driving is important for our jobs and lifestyles, and the risk is quite low. So is vaccination.

www.nejm.org/doi/full/10....

Reposted by Luca Caputo

Jeremy Berg @jeremymberg.bsky.social · Sep 16

My quote of the day

The sole and basic source of our strength is the solidarity of workers, peasants and the intelligentsia, the solidarity of the nation, the solidarity of people who seek to live in dignity, truth, and in harmony with their conscience.

Lech Walesa

Luca Caputo @capluca.bsky.social · Sep 8

According to a grant reviewer I have no proven experience on iPSCs 🤷

Luca Caputo @capluca.bsky.social · Aug 21

Resubmission button clicked.
Now some time off. See you all in ~10 days

Reposted by Luca Caputo

Ani Deshpande Lab @anideshpande.bsky.social · Aug 18

Really excited that our manuscript on Synovial Sarcoma is now online. Link to Open Access PDF: tinyurl.com/55bnssws

A summary🧵 :

Reposted by Luca Caputo

Sanford Burnham Prebys @sbpdiscovery.bsky.social · Aug 14

For decades, scientists thought MYOD was just a muscle-builder. But new research from Sanford Burnham Prebys shows this gene has a Jekyll-and-Hyde side—able to switch from activating muscle genes to silencing them.
sbpdiscovery.org/press/muscle...

Myogenic determination gene number 1 (MYOD) protein immunofluorescence in myofibers.

Luca Caputo @capluca.bsky.social · Aug 8

Thank you @dadapisconti.bsky.social

First co-corresponding in such a prestigious journal as @genesdev.bsky.social is amazing 🤩

Luca Caputo @capluca.bsky.social · Aug 8

We identified a novel role of MYOD as repressor of gene expression during somatic cell trans-differentiation by interaction at non-E-box motifs and a novel role of H4acme as a dynamic enhancer marker.

#MyoBlue #Epigenetics #Transcription #GeneRegulation

genesdev.cshlp.org/content/earl...

MYOD represses gene expression from non-E-box motifs

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

Luca Caputo @capluca.bsky.social · Jul 21

San Diego Pride 2025 is in the books.

We run, we march, we serve, but we don't hide

Happy Pride

Luca Caputo @capluca.bsky.social · Jul 18

Coming out is not a one-time event

Nature Cell Biology - June is the month celebrating Pride in the USA and other countries around the world to honour the Stonewall Uprising of 1969, as well as all progress and current strives...