Junhong Choi
@choijunhong.bsky.social
PI at MSKCC. Synthetic (Developmental) Biology + Molecular Recording + Genomics Tech Dev. Words like physicality of information make my heart go a little faster.
Reposted by Junhong Choi
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
November 4, 2025 at 3:10 PM
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
Reposted by Junhong Choi
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Junhong Choi
🎉 Congrats to MSK postdoc research scholar Dr. Brendan Camellato for being named a 2025 @jcchildsfund.bsky.social Research Fellow! His work will focus on how cell signaling drives #stemcell differentiation with single-cell resolution. #JCCFellow
We're thrilled to announce the 2025 class of Jane Coffin Childs Fellows!
See our latest blog post and "look book" to learn more about our newest Fellows and their exciting research!
www.jccfund.org/blog/the-jan...
www.jccfund.org/wp-content/u...
See our latest blog post and "look book" to learn more about our newest Fellows and their exciting research!
www.jccfund.org/blog/the-jan...
www.jccfund.org/wp-content/u...
www.jccfund.org
June 24, 2025 at 5:13 PM
🎉 Congrats to MSK postdoc research scholar Dr. Brendan Camellato for being named a 2025 @jcchildsfund.bsky.social Research Fellow! His work will focus on how cell signaling drives #stemcell differentiation with single-cell resolution. #JCCFellow
Congrats Brendan Camellato for his Jane Coffin Childs Fellowship!! 🎉🎉
We're thrilled to announce the 2025 class of Jane Coffin Childs Fellows!
See our latest blog post and "look book" to learn more about our newest Fellows and their exciting research!
www.jccfund.org/blog/the-jan...
www.jccfund.org/wp-content/u...
See our latest blog post and "look book" to learn more about our newest Fellows and their exciting research!
www.jccfund.org/blog/the-jan...
www.jccfund.org/wp-content/u...
www.jccfund.org
June 24, 2025 at 10:05 PM
Congrats Brendan Camellato for his Jane Coffin Childs Fellowship!! 🎉🎉
Reposted by Junhong Choi
We're thrilled to share the published version of our DRT9 story, online today @nature.com! Congratulations to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...
Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase
Bacteria defend themselves from viral predation using diverse immune systems, many of which sense and target foreign DNA for degradation. Defense-associated reverse transcriptase (DRT) systems provide...
www.biorxiv.org
May 28, 2025 at 9:06 PM
We're thrilled to share the published version of our DRT9 story, online today @nature.com! Congratulations to all authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Lineage recording in monoclonal gastruloids reveals heritable modes of early development
Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...
www.biorxiv.org
May 27, 2025 at 2:57 PM
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Very grateful to receive the Searle Scholars Award, especially during this challenging time! This support will help our lab realize our vision of genomic recording for reconstructing the mammalian cell fate decision. searlescholars.org/2025/04/14/s...
SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025
Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or …
searlescholars.org
May 6, 2025 at 2:46 PM
Very grateful to receive the Searle Scholars Award, especially during this challenging time! This support will help our lab realize our vision of genomic recording for reconstructing the mammalian cell fate decision. searlescholars.org/2025/04/14/s...
Happy to share our new review on molecular circuits for genomic recording with @chenomics.bsky.social! Here, we present our views on the remaining challenges in the field of genomic recording for reconstructing cell-fate decisions. (1/2)
Online now -- a new Review:
"Molecular circuits for genomic recording of cellular events"
by Wei Chen & Junhong Choi (@choijunhong.bsky.social)
FREE to read till June 25th using this link:
authors.elsevier.com/a/1l2gMcQbJF...
"Molecular circuits for genomic recording of cellular events"
by Wei Chen & Junhong Choi (@choijunhong.bsky.social)
FREE to read till June 25th using this link:
authors.elsevier.com/a/1l2gMcQbJF...
May 6, 2025 at 2:39 PM
Happy to share our new review on molecular circuits for genomic recording with @chenomics.bsky.social! Here, we present our views on the remaining challenges in the field of genomic recording for reconstructing cell-fate decisions. (1/2)
Reposted by Junhong Choi
Trying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1
a baby is eating a piece of food while sitting on the ground .
ALT: a baby is eating a piece of food while sitting on the ground .
media.tenor.com
March 14, 2025 at 1:29 PM
Trying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1
Reposted by Junhong Choi
New year, new beginnings! 🎉
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
January 2, 2025 at 4:01 PM
New year, new beginnings! 🎉
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
Reposted by Junhong Choi
Our latest: how to generate the notochord
"Timely TGFβ signalling inhibition induces notochord"
A thread:
www.nature.com/articles/s41...
"Timely TGFβ signalling inhibition induces notochord"
A thread:
www.nature.com/articles/s41...
Timely TGFβ signalling inhibition induces notochord - Nature
Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.
www.nature.com
December 19, 2024 at 8:52 AM
Our latest: how to generate the notochord
"Timely TGFβ signalling inhibition induces notochord"
A thread:
www.nature.com/articles/s41...
"Timely TGFβ signalling inhibition induces notochord"
A thread:
www.nature.com/articles/s41...
Reposted by Junhong Choi
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Junhong Choi
Imagine a mouse in which all 10 billion cells keep a diary from fertilization. Imagine sentinel cells recording your experiences and sending out dispatches in the form of DNA. Here's a story I wrote about cell recorders 🧪 Gift link: nyti.ms/3Z3Mqza
‘DNA Typewriters’ Can Record a Cell’s History
Labs around the world are trying to turn cells into autobiographers, tracking their own development from embryos to adults.
nyti.ms
November 25, 2024 at 4:19 PM
Imagine a mouse in which all 10 billion cells keep a diary from fertilization. Imagine sentinel cells recording your experiences and sending out dispatches in the form of DNA. Here's a story I wrote about cell recorders 🧪 Gift link: nyti.ms/3Z3Mqza
Pretty excited to see our review & DNA Typewriter covered by NY Times! Perhaps too much excitement for one Monday 🥲 www.nytimes.com/2024/11/25/s...
‘DNA Typewriters’ Can Record a Cell’s History
Labs around the world are trying to turn cells into autobiographers, tracking their own development from embryos to adults.
www.nytimes.com
November 25, 2024 at 10:47 PM
Pretty excited to see our review & DNA Typewriter covered by NY Times! Perhaps too much excitement for one Monday 🥲 www.nytimes.com/2024/11/25/s...
Reposted by Junhong Choi
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The lives of cells, recorded - Nature Reviews Genetics
Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...
www.nature.com
November 25, 2024 at 5:29 PM
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Junhong Choi
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status
and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated
chromatin is enriched for unw...
www.cell.com
November 15, 2024 at 3:35 PM
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
New synthetic biology / genomic recording lab opening in the New York city! Please reach out via choij10 _at_ mskcc.org if you are interested in joining / collaborating! Mskcc.org/research/ski/labs/junhong-choi
The Junhong Choi Lab
The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.
Mskcc.org
November 14, 2024 at 3:10 PM
New synthetic biology / genomic recording lab opening in the New York city! Please reach out via choij10 _at_ mskcc.org if you are interested in joining / collaborating! Mskcc.org/research/ski/labs/junhong-choi