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Hubrecht Institute @hubrechtinstitute.bsky.social · 15d

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

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Jeroen van den Berg @jervdberg.bsky.social · 16d

New method 🚀: scEpi2-seq lets us read DNA methylation+histone marks in the same single cell. Found that methylation “memory” after replication depends on chromatin+histones, and TF promoters repressed by H3K27me3 carry distinct methylation. So stoked to share this as first+co-corresponding author 🎉

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Cansu Koyunlar @ckoyunlar.bsky.social · 17d

Come visit my poster #3195 tomorrow, so I can tell you about the method we recently developed to study DNA replication dynamics and replication stress in hematopoietic tissues!

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Cansu Koyunlar @ckoyunlar.bsky.social · 17d

Extremely excited to be in Kumamoto for #ISEH2025 and to share our work! We had a great start today with the new investigators workshop, and I cannot wait for the coming days! @isehsociety.bsky.social 🍡

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Cansu Koyunlar @ckoyunlar.bsky.social · 21d

💯💯💯💯💯💯💯

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Cansu Koyunlar @ckoyunlar.bsky.social · 21d

Enjoy Dorien! 😊 Also, v cool bike! 🌟

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Björn Schumacher @bjornschumacher.bsky.social · 21d

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Ina Sonnen @sonnenlab.bsky.social · Sep 9

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

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Marloes Blotenburg @marloes3105.bsky.social · Aug 30

We've updated our biorxiv! Check it out if you're interested in a new technique co-profiling RNA and epigenetics in single cells, extended gastruloid culture, and our proposed model for an epigenetic timer determining sequential perceptiveness to different lineages! ➡️ www.biorxiv.org/content/10.1...

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STEMCELL Technologies @stemcell.com · Aug 8

Finally, media you can *actually* eat! 😉🍪

A collection of cookies shaped like media bottles, each decorated with icing to resemble various STEMCELL media such as "TeSR-AOF, TeSR-E8, mTeSR Plus, and eTeSR".

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Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · Jul 11

If you want to know about Blood Stem Cell Aging, then THIS is the meeting to go to.
I will be presenting the latest results of the Fraticelli Lab regarding HSC memories and clonal dynamics.

JOIN US !!!!!

ehaweb.org/connect-netw...

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Cansu Koyunlar @ckoyunlar.bsky.social · Jul 11

SO COOL!! 👀

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Hubrecht Institute @hubrechtinstitute.bsky.social · Jul 2

What if science is like solving puzzles?

We spoke with @sonnenlab.bsky.social, a group leader who recently received tenure. She tells us about her journey, her research on signaling dynamics, and the challenges of leading a lab.

Read her inspiring story here 👇 www.hubrecht.eu/ina-sonnen-t...

Ina Sonnen earned tenure: 'science is like a puzzle' - Hubrecht Institute

www.hubrecht.eu

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Grant Rowe @bloodandtime.bsky.social · Jun 30

Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...

Remembering James Till, 1931-2025

It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...

www.exphem.org

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BrunetLab @brunetlab.bsky.social · Jun 25

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Hallmarks of stem cell aging

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

www.sciencedirect.com

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Blood Journals' Portfolio @bloodjournals.hematology.org · Jun 19

In a mouse model for GATA2 deficiency, leukemia emerges from BMF. buff.ly/WPLVTrt #hemesky

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puckknipscheer.bsky.social @puckknipscheer.bsky.social · Jun 13

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

www.science.org

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Cansu Koyunlar @ckoyunlar.bsky.social · Jun 8

Congrats Dorien, big milestone! 😊

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Blake Hernandez @loxstoplox.bsky.social · May 23

I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)

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Caroline Bartman @cbartman.bsky.social · May 20

title of assistant professor's talk: amino acid metabolism of effector T cells in LCMV infection

title of senior full professor's talk: Why do cells eat?

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Jeroen van den Berg @jervdberg.bsky.social · May 16

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute

About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...

shorturl.at

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Iana V. Kim @ianakim.bsky.social · May 7

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

www.nature.com

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Rebecca Ann Jones @rebannjones.bsky.social · May 6

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...

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Shane Herbert @shaneherbert.bsky.social · May 6

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

www.science.org

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Francesca Mattiroli @fmattiroli.bsky.social · May 4

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes

Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

doi.org

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