Csaba Pal Laboratory
@csabapallab.bsky.social
Csaba Pal Lab's interest includes antibiotic resistance research, systems biology, and microbial experimental evolution. Account run by lab members.
Szeged, Hungary
http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html
Szeged, Hungary
http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html
Excited to share our collaborative work led by the Szilvia Juhasz and Mate Manczinger @matemanc.bsky.social labs: #cancer mutations converge into five protein-level “fingerprints” that shape tumor immune visibility. Mutation burden alone fails to predict #immunotherapy response! @molsystbiol.org
Our new paper is out:
Five dominant amino acid substitution signatures shape tumour immunity
link.springer.com/article/10.1...
Thread 🧵⬇
#cancer #tumor #immunity #immunotherapy #oncology
Five dominant amino acid substitution signatures shape tumour immunity
link.springer.com/article/10.1...
Thread 🧵⬇
#cancer #tumor #immunity #immunotherapy #oncology
Five dominant amino acid substitution signatures shape tumour immunity - Molecular Systems Biology
Although numerous mutational processes operate in cancer, their functional impacts are unclear. We hypothesised that certain mutation sources preferentially generate amino acid substitutions that evad...
link.springer.com
February 5, 2026 at 2:30 PM
Excited to share our collaborative work led by the Szilvia Juhasz and Mate Manczinger @matemanc.bsky.social labs: #cancer mutations converge into five protein-level “fingerprints” that shape tumor immune visibility. Mutation burden alone fails to predict #immunotherapy response! @molsystbiol.org
Reposted by Csaba Pal Laboratory
C > U mutations generate immunogenic peptides in SARS-CoV-2 @natcomms.nature.com @matemanc.bsky.social
@csabapallab.bsky.social
www.nature.com/articles/s41...
@csabapallab.bsky.social
www.nature.com/articles/s41...
November 19, 2025 at 4:23 PM
C > U mutations generate immunogenic peptides in SARS-CoV-2 @natcomms.nature.com @matemanc.bsky.social
@csabapallab.bsky.social
www.nature.com/articles/s41...
@csabapallab.bsky.social
www.nature.com/articles/s41...
Reposted by Csaba Pal Laboratory
C > U mutations generate immunogenic peptides in SARS-CoV-2
APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition.
nature.com/articles/s41...
#COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics
APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition.
nature.com/articles/s41...
#COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics
C > U mutations generate immunogenic peptides in SARS-CoV-2 - Nature Communications
The effect of new viral mutations on T cell responses remains unclear. Here, Balogh et al. show that most new mutations in SARS-CoV-2 are C > U, a bias that leads to an enhanced T cell re...
nature.com
December 1, 2025 at 5:48 PM
C > U mutations generate immunogenic peptides in SARS-CoV-2
APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition.
nature.com/articles/s41...
#COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics
APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition.
nature.com/articles/s41...
#COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics
Reposted by Csaba Pal Laboratory
A dual-target antibiotic strategy, combining membrane disruption with another cellular pathway, shows promise in reducing bacterial resistance, offering a new direction in combating antimicrobial resistance. doi.org/g855sh
Study uncovers the core principles of low-resistance antibiotics
A study published in Nature Communications has revealed novel insights into bacterial resistance and offers a promising strategy for developing antibiotics that minimize the evolution of resistance.
phys.org
March 3, 2025 at 10:02 PM
A dual-target antibiotic strategy, combining membrane disruption with another cellular pathway, shows promise in reducing bacterial resistance, offering a new direction in combating antimicrobial resistance. doi.org/g855sh
Reposted by Csaba Pal Laboratory
We are looking for a postdoc in #EvolutionarySystemsBiology.
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Research opportunities | Landry Lab
landrylab.ibis.ulaval.ca
February 23, 2025 at 4:46 PM
We are looking for a postdoc in #EvolutionarySystemsBiology.
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
www.nature.com
February 24, 2025 at 11:09 AM
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...
Reposted by Csaba Pal Laboratory
Two recent studies led by 🇭🇺 @csabapallab.bsky.social find that resistance can develop against new 💊 antibiotics even before they are widely used, compromising their effectiveness from the start. #antibioticresistance #AMR
New antibiotics can develop resistance before even hitting the market
Researchers from the HUN-REN Biological Research Centre, Szeged (Hungary), have made a concerning discovery about the future of antibiotics.
dlvr.it
February 3, 2025 at 11:30 AM
Two recent studies led by 🇭🇺 @csabapallab.bsky.social find that resistance can develop against new 💊 antibiotics even before they are widely used, compromising their effectiveness from the start. #antibioticresistance #AMR
Reposted by Csaba Pal Laboratory
Alternative drug modalities/approaches are desperately needed to supplement the pipeline of antibiotics.
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
www.nature.com
January 27, 2025 at 9:00 PM
Alternative drug modalities/approaches are desperately needed to supplement the pipeline of antibiotics.
Reposted by Csaba Pal Laboratory
ESKAPE pathogens are outsmarting us. Our latest paper in @naturemicrobiol.bsky.social reveals alarming ease of resistance evolution to antibiotics in development. Collaborative work with @csabapallab.bsky.social
and Kintses Lab
and Kintses Lab
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
www.nature.com
January 14, 2025 at 1:58 PM
ESKAPE pathogens are outsmarting us. Our latest paper in @naturemicrobiol.bsky.social reveals alarming ease of resistance evolution to antibiotics in development. Collaborative work with @csabapallab.bsky.social
and Kintses Lab
and Kintses Lab
Reposted by Csaba Pal Laboratory
💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
www.nature.com
January 13, 2025 at 1:57 PM
💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
www.nature.com
January 13, 2025 at 4:30 PM
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...
Awesome! Many thanks @thealexknapp.bsky.social for spotlighting our recent work!
Easily one of the more depressing scientific papers I've read this week - researchers found that Staph bacteria readily developed resistance to antibiotics in the development pipeline thanks to mutations already present in the population.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
www.science.org
January 13, 2025 at 12:35 PM
Awesome! Many thanks @thealexknapp.bsky.social for spotlighting our recent work!
Reposted by Csaba Pal Laboratory
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
www.science.org
January 13, 2025 at 11:52 AM
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
www.science.org
January 13, 2025 at 11:52 AM
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
Reposted by Csaba Pal Laboratory
While writing papers and grants, we received many comments on the role of CNVs in antifungal resistance. We thought we should formally assess how important they are. Here is what we found. #AMR #fungi #evolution rdcu.be/d5rbN
The role of gene copy number variation in antimicrobial resistance in human fungal pathogens
npj Antimicrobials and Resistance - The role of gene copy number variation in antimicrobial resistance in human fungal pathogens
www.nature.com
January 9, 2025 at 12:58 PM
While writing papers and grants, we received many comments on the role of CNVs in antifungal resistance. We thought we should formally assess how important they are. Here is what we found. #AMR #fungi #evolution rdcu.be/d5rbN