Daniel L. Barber, PhD
@danbarberphd.bsky.social
Immunologist. Major focus is on T cell responses to Mycobacterium tuberculosis infection.
Important paper by Björn
Corleis. For decades a central tenet of #tuberculosis immunology has that IFNγ-driven iNOS expression in macrophages is the primary mechanism of bacterial control. Turns out this is really only in mice and maybe cattle. It’s not true in most species including humans an NHP.
Corleis. For decades a central tenet of #tuberculosis immunology has that IFNγ-driven iNOS expression in macrophages is the primary mechanism of bacterial control. Turns out this is really only in mice and maybe cattle. It’s not true in most species including humans an NHP.
Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis https://www.biorxiv.org/content/10.64898/2026.01.11.697682v1
January 16, 2026 at 12:52 AM
Important paper by Björn
Corleis. For decades a central tenet of #tuberculosis immunology has that IFNγ-driven iNOS expression in macrophages is the primary mechanism of bacterial control. Turns out this is really only in mice and maybe cattle. It’s not true in most species including humans an NHP.
Corleis. For decades a central tenet of #tuberculosis immunology has that IFNγ-driven iNOS expression in macrophages is the primary mechanism of bacterial control. Turns out this is really only in mice and maybe cattle. It’s not true in most species including humans an NHP.
The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!
January 15, 2026 at 12:15 PM
The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!
What we’ve got here is failure to communicate - some macrophages you just can’t reach!
Multiple features of granulomas limit effective T cell:MΦ interactions, posing a major barrier for vaccine-mediated protection.
Check out our new review!
onlinelibrary.wiley.com/doi/10.1111/...
Multiple features of granulomas limit effective T cell:MΦ interactions, posing a major barrier for vaccine-mediated protection.
Check out our new review!
onlinelibrary.wiley.com/doi/10.1111/...
<em>Journal of Internal Medicine</em> | Wiley Online Library
Tuberculosis (TB) remains a leading infectious cause of morbidity and mortality, and the development of a new, highly effective vaccine would have a tremendous beneficial impact on global health. Alt....
onlinelibrary.wiley.com
December 5, 2025 at 8:19 PM
What we’ve got here is failure to communicate - some macrophages you just can’t reach!
Multiple features of granulomas limit effective T cell:MΦ interactions, posing a major barrier for vaccine-mediated protection.
Check out our new review!
onlinelibrary.wiley.com/doi/10.1111/...
Multiple features of granulomas limit effective T cell:MΦ interactions, posing a major barrier for vaccine-mediated protection.
Check out our new review!
onlinelibrary.wiley.com/doi/10.1111/...
Check out our new paper with @nelson-lab.bsky.social. We used scRNAseq to profile the function of Mtb peptide-specific T cells from NHP and human lung granulomas. Beyond IFNγ, Mtb-specific T cells make a bunch of unexpected stuff, and human and NHP cell are really similar.
December 4, 2025 at 10:15 PM
Check out our new paper with @nelson-lab.bsky.social. We used scRNAseq to profile the function of Mtb peptide-specific T cells from NHP and human lung granulomas. Beyond IFNγ, Mtb-specific T cells make a bunch of unexpected stuff, and human and NHP cell are really similar.
We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top global infectious killer check us out. BSL3 experience not required. The NIH intramural program in Bethesda MD is an amazing place!
September 17, 2025 at 5:50 PM
We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top global infectious killer check us out. BSL3 experience not required. The NIH intramural program in Bethesda MD is an amazing place!
We are looking for post-docs interested in studying T cell responses to M. tuberculosis infection…especially basic T cell immunologists who are interested in learning to work with BSL3 pathogens. The NIH intramural program is an amazing place to train!
May 30, 2025 at 8:47 PM
We are looking for post-docs interested in studying T cell responses to M. tuberculosis infection…especially basic T cell immunologists who are interested in learning to work with BSL3 pathogens. The NIH intramural program is an amazing place to train!
Reposted by Daniel L. Barber, PhD
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
March 13, 2025 at 6:43 AM
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
What an incredible analysis!!!
Happy to share a preprint from the Angelo lab many years in the making. Read on for a saga of multiplexed imaging, immunometabolism, and TB granulomas with some fun side quests into the realms of geographical information sciences and transcriptomics… (1/20) doi.org/10.1101/2025...
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. We prev...
doi.org
February 24, 2025 at 10:29 PM
What an incredible analysis!!!
Reposted by Daniel L. Barber, PhD
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Daniel L. Barber, PhD
Thanks to all of our amazing coauthors including @kerryhilligan.bsky.social, @danbarberphd.bsky.social for spending many, many hours tolerating me in the BSL3 lab, helping with experiments and data analysis, and providing valuable advice and moral support!
December 7, 2024 at 11:47 PM
Thanks to all of our amazing coauthors including @kerryhilligan.bsky.social, @danbarberphd.bsky.social for spending many, many hours tolerating me in the BSL3 lab, helping with experiments and data analysis, and providing valuable advice and moral support!
Reposted by Daniel L. Barber, PhD
More details in this 🧵 from my powerhouse PI @mayerbarber.bsky.social whose foresight and guidance got us to this fantastic manuscript!
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
December 7, 2024 at 11:47 PM
More details in this 🧵 from my powerhouse PI @mayerbarber.bsky.social whose foresight and guidance got us to this fantastic manuscript!
Reposted by Daniel L. Barber, PhD
Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
www.science.org
December 7, 2024 at 11:47 PM
Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.
Reposted by Daniel L. Barber, PhD
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
December 6, 2024 at 10:38 PM
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
Reposted by Daniel L. Barber, PhD
🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
www.science.org
December 6, 2024 at 10:38 PM
🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Daniel L. Barber, PhD
Candida auris Infectious by Lionakis & Chowdhary in NEJM
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Candida auris Infections | NEJM
C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health c...
www.nejm.org
November 21, 2024 at 4:12 AM
Candida auris Infectious by Lionakis & Chowdhary in NEJM
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Daniel L. Barber, PhD
As community here grows, need for starter packs will rapidly be replaced by need to curate timelines.
Enter Bluesky's custom feeds! I have made one for tuberculosis / TB posts, though it may lack specificity.
Feel free to pin & use it. Feedback welcome #IDSky #MedSky
Link👉 bsky.app/profile/did:...
Enter Bluesky's custom feeds! I have made one for tuberculosis / TB posts, though it may lack specificity.
Feel free to pin & use it. Feedback welcome #IDSky #MedSky
Link👉 bsky.app/profile/did:...
November 11, 2024 at 9:48 AM
As community here grows, need for starter packs will rapidly be replaced by need to curate timelines.
Enter Bluesky's custom feeds! I have made one for tuberculosis / TB posts, though it may lack specificity.
Feel free to pin & use it. Feedback welcome #IDSky #MedSky
Link👉 bsky.app/profile/did:...
Enter Bluesky's custom feeds! I have made one for tuberculosis / TB posts, though it may lack specificity.
Feel free to pin & use it. Feedback welcome #IDSky #MedSky
Link👉 bsky.app/profile/did:...
Reposted by Daniel L. Barber, PhD
Excited for my first post here to be our new #preprint.
👇🏻check it out below …
the recent pulmonary exposure history matters for limiting SARS-CoV-2 viral titers in the 🫁”tweetorial” to follow later
👇🏻check it out below …
the recent pulmonary exposure history matters for limiting SARS-CoV-2 viral titers in the 🫁”tweetorial” to follow later
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication https://www.biorxiv.org/content/10.1101/2024.03.27.586885v1
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication https://www.biorxiv.org/content/10.1101/2024.03.27.586885v1
SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic infection
www.biorxiv.org
March 28, 2024 at 11:24 AM
Excited for my first post here to be our new #preprint.
👇🏻check it out below …
the recent pulmonary exposure history matters for limiting SARS-CoV-2 viral titers in the 🫁”tweetorial” to follow later
👇🏻check it out below …
the recent pulmonary exposure history matters for limiting SARS-CoV-2 viral titers in the 🫁”tweetorial” to follow later