Darshak Bhatt
@darshakbhatt.com
Postdoc @ UMCG.nl. Board member @ SynBioNL.com Interested in Synthetic Biology and Tumor Viro/Immunotherapy. DarshakBhatt.com
Very glad to share my first last-author paper, now published in iScience! 🎉In this study, we addressed a key challenge in virus-based cancer therapy: macrophage-mediated suppression, which limits viral infection and restricts T cell activation in tumors.
Link: www.sciencedirect.com/science/arti...
Link: www.sciencedirect.com/science/arti...
Alphavirus replicons encoding IFN-γ enhance cancer virotherapy by overcoming macrophage-mediated suppression
Interference by tumor-associated macrophages may significantly reduce the efficacy of therapeutic viruses designed to infect cancer cells and activate…
www.sciencedirect.com
September 12, 2025 at 1:24 PM
Very glad to share my first last-author paper, now published in iScience! 🎉In this study, we addressed a key challenge in virus-based cancer therapy: macrophage-mediated suppression, which limits viral infection and restricts T cell activation in tumors.
Link: www.sciencedirect.com/science/arti...
Link: www.sciencedirect.com/science/arti...
This was a meaningful moment of introspection, looking back on 10 years of scientific mobility since I left India. Also fun to share my experience working across labs in France, Netherlands, and Brazil. Read here for the full story: www.sciencedirect.com/science/arti...
Scientific mobility in microbiology – 10
www.sciencedirect.com
September 10, 2025 at 9:34 AM
This was a meaningful moment of introspection, looking back on 10 years of scientific mobility since I left India. Also fun to share my experience working across labs in France, Netherlands, and Brazil. Read here for the full story: www.sciencedirect.com/science/arti...
Reposted by Darshak Bhatt
A tricky thing about modern society is that no one has any idea when they don’t die.
Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.
Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.
April 7, 2025 at 4:13 AM
A tricky thing about modern society is that no one has any idea when they don’t die.
Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.
Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.
Reposted by Darshak Bhatt
When you grow yeast on yeast extract medium
March 21, 2025 at 2:30 PM
When you grow yeast on yeast extract medium
Reposted by Darshak Bhatt
Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW!
woodstock.img.cas.cz
woodstock.img.cas.cz
March 1, 2025 at 5:44 PM
Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW!
woodstock.img.cas.cz
woodstock.img.cas.cz
Reposted by Darshak Bhatt
The embryologist Ernst Haeckel is famous for his maxim that “ontogeny recapitulates phylogeny” and for sketchy imaging. While Haeckel figures prominently in #DevBiol, the Fifth Dalai Lama doesn’t. Perhaps he should, though. He scooped Haeckel by about 200 years.
#LongBibliography 🧵 1/14
#LongBibliography 🧵 1/14
February 19, 2025 at 2:42 PM
The embryologist Ernst Haeckel is famous for his maxim that “ontogeny recapitulates phylogeny” and for sketchy imaging. While Haeckel figures prominently in #DevBiol, the Fifth Dalai Lama doesn’t. Perhaps he should, though. He scooped Haeckel by about 200 years.
#LongBibliography 🧵 1/14
#LongBibliography 🧵 1/14
Reposted by Darshak Bhatt
Programming alphavirus with IFN-γ overrides the adverse effects of macrophages on oncolytic virotherapy https://www.biorxiv.org/content/10.1101/2025.02.12.637841v1
February 17, 2025 at 3:17 AM
Programming alphavirus with IFN-γ overrides the adverse effects of macrophages on oncolytic virotherapy https://www.biorxiv.org/content/10.1101/2025.02.12.637841v1
Reposted by Darshak Bhatt
Another great preprint out together with @darshakbhatt.com using OVRI!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Programming alphavirus with IFN-γ overrides the adverse effects of macrophages on oncolytic virotherapy
Virus uptake by tumor-associated macrophages may significantly reduce the availability of oncolytic viruses for cancer cell infection and limit therapeutic efficacy. Through a computational model, we ...
www.biorxiv.org
February 17, 2025 at 5:44 PM
Another great preprint out together with @darshakbhatt.com using OVRI!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
📣🎓Fun time talking to #C2PO about my PhD experience between @uspoficial.bsky.social & @umcgroningen.bsky.social. It was great reflecting on how working in different places shapes one's approach to research, collaboration, & problem-solving. Check the full interview here: c2po.usp.br/c2po-intervi...
C2PO interviews Dr. Darshak Bhatt – C2PO – Comprehensive Center for Precision Oncology
c2po.usp.br
February 16, 2025 at 12:46 PM
📣🎓Fun time talking to #C2PO about my PhD experience between @uspoficial.bsky.social & @umcgroningen.bsky.social. It was great reflecting on how working in different places shapes one's approach to research, collaboration, & problem-solving. Check the full interview here: c2po.usp.br/c2po-intervi...
1/3 Happy to share one of the final chapters of my PhD on oncolytic virotherapy! This study explores how oncolytic virotherapy can impact the content and function of extracellular vesicles (EVs) from melanoma cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles - Scientific Reports
Scientific Reports - Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles
www.nature.com
January 6, 2025 at 2:48 PM
1/3 Happy to share one of the final chapters of my PhD on oncolytic virotherapy! This study explores how oncolytic virotherapy can impact the content and function of extracellular vesicles (EVs) from melanoma cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Darshak Bhatt
Reposted by Darshak Bhatt
"Researchers are rewarded if their papers are highly cited or published in prestigious journals (...)
Conversely, developing and maintaining software, even if it supports a wide body of research or meets the needs of broad scientific communities, rarely results in similar opportunities."
Conversely, developing and maintaining software, even if it supports a wide body of research or meets the needs of broad scientific communities, rarely results in similar opportunities."
'Yet despite their near-universal contributions to research and medicine, open source tools are often underfunded and difficult to support through mechanisms that support research, limiting their true potential'
www.statnews.com/sponsor/2024...
www.statnews.com/sponsor/2024...
New report highlights the scientific impact of open source software
Two of the scientists who won this year’s Nobel Prize for cracking the code of proteins’ intricate structures relied, in part, on a series of computing
www.statnews.com
December 4, 2024 at 1:41 PM
"Researchers are rewarded if their papers are highly cited or published in prestigious journals (...)
Conversely, developing and maintaining software, even if it supports a wide body of research or meets the needs of broad scientific communities, rarely results in similar opportunities."
Conversely, developing and maintaining software, even if it supports a wide body of research or meets the needs of broad scientific communities, rarely results in similar opportunities."
Reposted by Darshak Bhatt
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
A dust bunny 👇 from Studio Ghibli
November 25, 2024 at 10:18 PM
A dust bunny 👇 from Studio Ghibli
🥳Happy to share our article on oncolytic virotherapy and T-cell responses influencing outcomes. Key insights: timing of therapy, anticancer T-cell activity, and the diffusion of immune signals all play complex roles, sometimes reducing effectiveness. #Spatialmodel #oncolyticvirus #Stochasticity 💻🎉
Effects of virus-induced immunogenic cues on oncolytic virotherapy - Scientific Reports
Scientific Reports - Effects of virus-induced immunogenic cues on oncolytic virotherapy
www.nature.com
November 23, 2024 at 9:50 PM
🥳Happy to share our article on oncolytic virotherapy and T-cell responses influencing outcomes. Key insights: timing of therapy, anticancer T-cell activity, and the diffusion of immune signals all play complex roles, sometimes reducing effectiveness. #Spatialmodel #oncolyticvirus #Stochasticity 💻🎉
Reposted by Darshak Bhatt
🚨 Paper Alert!
"Six Personas to Adopt When Framing Theoretical Research Questions in Biology" guides research framing and debunks common misconceptions about theory.
royalsocietypublishing.org/doi/10.1098/...
#ProcB #Biology #Ecology #Evolution
"Six Personas to Adopt When Framing Theoretical Research Questions in Biology" guides research framing and debunks common misconceptions about theory.
royalsocietypublishing.org/doi/10.1098/...
#ProcB #Biology #Ecology #Evolution
October 31, 2024 at 9:05 AM
🚨 Paper Alert!
"Six Personas to Adopt When Framing Theoretical Research Questions in Biology" guides research framing and debunks common misconceptions about theory.
royalsocietypublishing.org/doi/10.1098/...
#ProcB #Biology #Ecology #Evolution
"Six Personas to Adopt When Framing Theoretical Research Questions in Biology" guides research framing and debunks common misconceptions about theory.
royalsocietypublishing.org/doi/10.1098/...
#ProcB #Biology #Ecology #Evolution
Reposted by Darshak Bhatt
Reposted by Darshak Bhatt
So. Incredibly. Cool.
Super cool research from @wildcru.bsky.social - Ethiopian wolves doing pollination work. Wolfination work.
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
🧪 🦊 🐝 🌸
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
🧪 🦊 🐝 🌸
November 22, 2024 at 10:06 PM
So. Incredibly. Cool.
Reposted by Darshak Bhatt
Our latest discovery of “lowest recorded temperature for eukaryotic cell motility” going all the way down to -15deg C. Come for the crazy cold Arctic & stay for diatoms. Will write longer thread - but enjoy video below of diatoms gliding on frozen ice surfaces. Congrats @zqing.bsky.social & team.
November 21, 2024 at 10:36 AM
Our latest discovery of “lowest recorded temperature for eukaryotic cell motility” going all the way down to -15deg C. Come for the crazy cold Arctic & stay for diatoms. Will write longer thread - but enjoy video below of diatoms gliding on frozen ice surfaces. Congrats @zqing.bsky.social & team.
Reposted by Darshak Bhatt
This is actually the best way to look at fossils. Why would I zoom in on a pdf and protect my posture when I can just place my face mere inches from the computer screen???
November 20, 2024 at 1:00 AM
This is actually the best way to look at fossils. Why would I zoom in on a pdf and protect my posture when I can just place my face mere inches from the computer screen???
Reposted by Darshak Bhatt
In today's Nature: A ‘Wikipedia for cells’
www.nature.com/articles/d41...
www.nature.com/immersive/d4...
www.nature.com/articles/d41...
www.nature.com/immersive/d4...
November 20, 2024 at 4:57 PM
In today's Nature: A ‘Wikipedia for cells’
www.nature.com/articles/d41...
www.nature.com/immersive/d4...
www.nature.com/articles/d41...
www.nature.com/immersive/d4...