David Harrison
@davidaharrison.bsky.social
Co-Director of ICNARC. Honorary Professor of medical statistics at LSHTM.
Reposted by David Harrison
Delighted to share details of @nihr.bsky.social James Lind Alliance research priority setting survey for delirium. For completion by UK health/social professionals and those with personal experience of delirium.
Complete the survey and have your say. More details 👇
www.qmul.ac.uk/wiph/centres...
Complete the survey and have your say. More details 👇
www.qmul.ac.uk/wiph/centres...
A Delirium (UK) James Lind Alliance Priority Setting Partnership - Wolfson Institute of Population Health
www.qmul.ac.uk
November 11, 2025 at 11:32 PM
Delighted to share details of @nihr.bsky.social James Lind Alliance research priority setting survey for delirium. For completion by UK health/social professionals and those with personal experience of delirium.
Complete the survey and have your say. More details 👇
www.qmul.ac.uk/wiph/centres...
Complete the survey and have your say. More details 👇
www.qmul.ac.uk/wiph/centres...
Reposted by David Harrison
16,500 patients randomised to #UKROXTrial presented just now at #CCR25 and simultaneously published in @jama.com
No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care
jamanetwork.com/journals/jam...
No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care
jamanetwork.com/journals/jam...
Conservative Oxygen Therapy With Mechanical Ventilation
This randomized clinical trial assesses whether reducing supplemental oxygen to a peripheral oxygen saturation target of 90% would reduce mortality among critically ill adults receiving mechanical ven...
jamanetwork.com
June 12, 2025 at 8:48 AM
16,500 patients randomised to #UKROXTrial presented just now at #CCR25 and simultaneously published in @jama.com
No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care
jamanetwork.com/journals/jam...
No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care
jamanetwork.com/journals/jam...
Reposted by David Harrison
Reposted by David Harrison
Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients.
#CCR25 @criticalcarereviews.com
https://ja.ma/4kG5gWK
#CCR25 @criticalcarereviews.com
https://ja.ma/4kG5gWK
June 12, 2025 at 8:15 AM
Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients.
#CCR25 @criticalcarereviews.com
https://ja.ma/4kG5gWK
#CCR25 @criticalcarereviews.com
https://ja.ma/4kG5gWK
Reposted by David Harrison
Calling all UK-based healthcare professionals who have undertaken a quality improvement project! Share your experiences with us and help us to develop new approaches. Certificates of participation offered. Find out more and fill out the short survey ths.im/3SUUwHG
June 3, 2025 at 8:03 AM
Calling all UK-based healthcare professionals who have undertaken a quality improvement project! Share your experiences with us and help us to develop new approaches. Certificates of participation offered. Find out more and fill out the short survey ths.im/3SUUwHG
Reposted by David Harrison
🚨UK-ROX TRIAL Results at #CCR25🚨
📍 ~100 🇬🇧 ICUs
👥 ~16,500 pts
🎯 Conservative vs usual oxygen therapy in invasively ventilated adults
🩺 Outcome: Mortality day 90
🤔 Will less oxygen save lives?
📺 Free livestream — but it's better in person!
🔗 criticalcarereviews.com/ccr25
📍 ~100 🇬🇧 ICUs
👥 ~16,500 pts
🎯 Conservative vs usual oxygen therapy in invasively ventilated adults
🩺 Outcome: Mortality day 90
🤔 Will less oxygen save lives?
📺 Free livestream — but it's better in person!
🔗 criticalcarereviews.com/ccr25
May 31, 2025 at 3:58 PM
🚨UK-ROX TRIAL Results at #CCR25🚨
📍 ~100 🇬🇧 ICUs
👥 ~16,500 pts
🎯 Conservative vs usual oxygen therapy in invasively ventilated adults
🩺 Outcome: Mortality day 90
🤔 Will less oxygen save lives?
📺 Free livestream — but it's better in person!
🔗 criticalcarereviews.com/ccr25
📍 ~100 🇬🇧 ICUs
👥 ~16,500 pts
🎯 Conservative vs usual oxygen therapy in invasively ventilated adults
🩺 Outcome: Mortality day 90
🤔 Will less oxygen save lives?
📺 Free livestream — but it's better in person!
🔗 criticalcarereviews.com/ccr25
Reposted by David Harrison
The Society and the Faculty of Intensive Care Medicine (FICM) are updating the Guidelines for the Provision of Intensive Care Services (GPICS).
The consultation period for Version 3 is now open and we would value your feedback on the proposed changes.
Read more and take part below👇
bit.ly/GPICSv3
The consultation period for Version 3 is now open and we would value your feedback on the proposed changes.
Read more and take part below👇
bit.ly/GPICSv3
May 14, 2025 at 1:11 PM
The Society and the Faculty of Intensive Care Medicine (FICM) are updating the Guidelines for the Provision of Intensive Care Services (GPICS).
The consultation period for Version 3 is now open and we would value your feedback on the proposed changes.
Read more and take part below👇
bit.ly/GPICSv3
The consultation period for Version 3 is now open and we would value your feedback on the proposed changes.
Read more and take part below👇
bit.ly/GPICSv3
Shocked to wake up to this news. Condolences to Rinaldo’s family and friends, and all our friends and colleagues in the ANZICS community. Vale Rinaldo.
May 7, 2025 at 6:50 AM
Shocked to wake up to this news. Condolences to Rinaldo’s family and friends, and all our friends and colleagues in the ANZICS community. Vale Rinaldo.
Reposted by David Harrison
It’s #WorldImmunizationWeek
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
April 24, 2025 at 5:50 AM
It’s #WorldImmunizationWeek
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.
A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
Reposted by David Harrison
People who take part in #ClinicalTrials and other research have a right to know the results of these studies.
Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders.
More details👉 buff.ly/SGrmL7o
Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders.
More details👉 buff.ly/SGrmL7o
April 17, 2025 at 11:31 AM
People who take part in #ClinicalTrials and other research have a right to know the results of these studies.
Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders.
More details👉 buff.ly/SGrmL7o
Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders.
More details👉 buff.ly/SGrmL7o
Reposted by David Harrison
Invitation to a Two-Round Delphi Study on Sample Size Reporting in Trial Grant Applications and Protocols for Adaptive Designs!
Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...
Or directly contact: [email protected].
Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...
Or directly contact: [email protected].
February 17, 2025 at 1:55 PM
Invitation to a Two-Round Delphi Study on Sample Size Reporting in Trial Grant Applications and Protocols for Adaptive Designs!
Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...
Or directly contact: [email protected].
Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...
Or directly contact: [email protected].
Reposted by David Harrison
I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...
Hype, hallucination, hope – what might AI mean for our health?
In our fifth REAL Challenge annual lecture, Hetan Shah will warn of the risk of rushing breathlessly to unleash technology. He will explore how policymakers can navigate the hype and critically assess...
www.health.org.uk
January 6, 2025 at 8:43 AM
I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...
Reposted by David Harrison
The College is seeking applications for the position of Director of our Centre for Research and Improvement, which oversees delivery of all College research projects.
An exciting opportunity to play a vital role in our research and improvement work.
ow.ly/A47350UQfxx @rcoa-cri.bsky.social
An exciting opportunity to play a vital role in our research and improvement work.
ow.ly/A47350UQfxx @rcoa-cri.bsky.social
January 30, 2025 at 2:26 PM
The College is seeking applications for the position of Director of our Centre for Research and Improvement, which oversees delivery of all College research projects.
An exciting opportunity to play a vital role in our research and improvement work.
ow.ly/A47350UQfxx @rcoa-cri.bsky.social
An exciting opportunity to play a vital role in our research and improvement work.
ow.ly/A47350UQfxx @rcoa-cri.bsky.social
Reposted by David Harrison
Post-hoc analysis of Oxy-PICU by baseline severity of gas exchange - no detectable heterogeneity of treatment effect.
journals.lww.com/pccmjournal/...
journals.lww.com/pccmjournal/...
Severity of Impaired Oxygenation and Conservative... : Pediatric Critical Care Medicine
2% was associated with a shorter duration of organ support and greater survival, compared with Spo2 greater than 94%, in mechanically ventilated children following unplanned admission to PICU. We inve...
journals.lww.com
January 13, 2025 at 3:01 PM
Post-hoc analysis of Oxy-PICU by baseline severity of gas exchange - no detectable heterogeneity of treatment effect.
journals.lww.com/pccmjournal/...
journals.lww.com/pccmjournal/...
Reposted by David Harrison
1 year follow-up and health economics of Oxy-PICU.
All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.
www.sciencedirect.com/science/arti...
All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.
www.sciencedirect.com/science/arti...
Longer-term survival, quality of life, and cost-effectiveness of conservative versus liberal oxygenation targets in critically ill children: a pre-specified analysis from Oxy-PICU, a multicentre, open...
Peripheral oxygen saturation (SpO2) above 94% is typical in children in paediatric intensive critical care units (PICUs) who are receiving invasive ve…
www.sciencedirect.com
December 18, 2024 at 7:05 AM
1 year follow-up and health economics of Oxy-PICU.
All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.
www.sciencedirect.com/science/arti...
All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.
www.sciencedirect.com/science/arti...
Reposted by David Harrison
The third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial
Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU
Register via the QR code or on the CCR website
criticalcarereviews.com/meetings/ccr25
Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU
Register via the QR code or on the CCR website
criticalcarereviews.com/meetings/ccr25
January 10, 2025 at 6:21 PM
The third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial
Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU
Register via the QR code or on the CCR website
criticalcarereviews.com/meetings/ccr25
Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU
Register via the QR code or on the CCR website
criticalcarereviews.com/meetings/ccr25
Reposted by David Harrison
The second trial result for #CCR25 in Titanic Belfast
in June is GASTROSAM
Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition
Join us in June for the best critical care trials in the world
Register at criticalcarereviews.com/meetings/ccr25
in June is GASTROSAM
Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition
Join us in June for the best critical care trials in the world
Register at criticalcarereviews.com/meetings/ccr25
January 9, 2025 at 9:50 PM
The second trial result for #CCR25 in Titanic Belfast
in June is GASTROSAM
Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition
Join us in June for the best critical care trials in the world
Register at criticalcarereviews.com/meetings/ccr25
in June is GASTROSAM
Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition
Join us in June for the best critical care trials in the world
Register at criticalcarereviews.com/meetings/ccr25
Reposted by David Harrison
Designing an adaptive platform trial with parents, young people and PICU staff in a NIHR accelerator grant. Here’s how we did it and what the platform should look like: bmjopen.bmj.com/content/15/1... @nihr.bsky.social @trakmitch.bsky.social @lyvonnetume.bsky.social @liverpooluni.bsky.social
Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study
Objectives Platform trials were used successfully in adult populations during the COVID-19 pandemic. By testing multiple treatments within a single trial, platform trials can help identify the most ef...
bmjopen.bmj.com
January 8, 2025 at 7:16 PM
Designing an adaptive platform trial with parents, young people and PICU staff in a NIHR accelerator grant. Here’s how we did it and what the platform should look like: bmjopen.bmj.com/content/15/1... @nihr.bsky.social @trakmitch.bsky.social @lyvonnetume.bsky.social @liverpooluni.bsky.social
Reposted by David Harrison
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
www.nature.com
December 19, 2024 at 9:50 PM
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by David Harrison
Want to advance as a leader in 2025?
Apply for #LeaP4 before 10 January to explore your leadership potential and explore modules on authentic leadership, managing work and emotional intelligence.
Learn more below and join our transformative programme👇
bit.ly/leaP4
Apply for #LeaP4 before 10 January to explore your leadership potential and explore modules on authentic leadership, managing work and emotional intelligence.
Learn more below and join our transformative programme👇
bit.ly/leaP4
December 12, 2024 at 8:23 AM
Want to advance as a leader in 2025?
Apply for #LeaP4 before 10 January to explore your leadership potential and explore modules on authentic leadership, managing work and emotional intelligence.
Learn more below and join our transformative programme👇
bit.ly/leaP4
Apply for #LeaP4 before 10 January to explore your leadership potential and explore modules on authentic leadership, managing work and emotional intelligence.
Learn more below and join our transformative programme👇
bit.ly/leaP4
Congratulations Rob! @criticalcarereviews.com
@criticalcarereviews.com
Congratulations to the newly announced PROFESSOR Rob MacSweeney. Richly deserved for a modest person who works tirelessly in support of improving care of the critically ill through world leadership and creativity for clinical research dissemination with real impact. 👏 Prof.
Congratulations to the newly announced PROFESSOR Rob MacSweeney. Richly deserved for a modest person who works tirelessly in support of improving care of the critically ill through world leadership and creativity for clinical research dissemination with real impact. 👏 Prof.
December 12, 2024 at 7:04 AM
Congratulations Rob! @criticalcarereviews.com
Reposted by David Harrison
Published in JAMA with #CCRdownunder:
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @criticalcarereviews.com
ja.ma/3BovM5v
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @criticalcarereviews.com
ja.ma/3BovM5v
December 9, 2024 at 10:20 PM
Published in JAMA with #CCRdownunder:
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @criticalcarereviews.com
ja.ma/3BovM5v
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @criticalcarereviews.com
ja.ma/3BovM5v
Reposted by David Harrison
A design that came up in discussion at the #ACTA clinical trials conference last week was the”effectiveness-implementation hybrid design” 1/8
#MethodologyMonday #108
#MethodologyMonday #108
December 9, 2024 at 5:31 AM
A design that came up in discussion at the #ACTA clinical trials conference last week was the”effectiveness-implementation hybrid design” 1/8
#MethodologyMonday #108
#MethodologyMonday #108
Reposted by David Harrison
It's 9am in Melbourne
Just 24 hours to CCR Down Under
8 major trial results
Full, free livestream
https://criticalcarereviews.com
Just 24 hours to CCR Down Under
8 major trial results
Full, free livestream
https://criticalcarereviews.com
December 8, 2024 at 10:00 PM
It's 9am in Melbourne
Just 24 hours to CCR Down Under
8 major trial results
Full, free livestream
https://criticalcarereviews.com
Just 24 hours to CCR Down Under
8 major trial results
Full, free livestream
https://criticalcarereviews.com