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David Jones

@davidjonesbrain.bsky.social

320 followers 140 following 82 posts

Behavioral neurologist and AI director working to end degeneration of mental function and use technology to transform the practice of neurology. Neuro AI Program (NAIP) https://naip.mayo.edu https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg

naip.mayo.edu

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David Jones @davidjonesbrain.bsky.social · Nov 20

So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨

#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz

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David Jones @davidjonesbrain.bsky.social · 28d

NPH is real, it’s common, and it’s treatable! #NPH #endalz

www.nejm.org/doi/full/10....

David Jones @davidjonesbrain.bsky.social · Sep 9

NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....

Idiopathic Normal Pressure Hydrocephalus | Neurology Open Access

Background and ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is an underdiagnosed but potentially treatable condition in older adults. Population-based data on incidence and progression re...

doi.org

David Jones @davidjonesbrain.bsky.social · Aug 22

This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM

FDG-PET-Based Machine Learning Framework to Support Neurologic Decision-Making

YouTube video by Neurology Journal

youtu.be

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Reposted by David Jones

Earl K. Miller @earlkmiller.bsky.social · Aug 13

Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too.

Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience

Programmable wave-based analog computing machine: a metastructure that designs metastructures - Nature Communications

This study introduces and validates a reconfigurable metastructure that uses electromagnetic waves to perform analog complex-valued mathematical computations. This device executes both stationary and ...

www.nature.com

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David Jones @davidjonesbrain.bsky.social · Aug 8

www.govtech.com/artificial-i...

Mayo Clinic Pushing to Become AI Health-Care Leader

With hospitals and researchers around the globe racing to use AI tools as part of a technological gold rush poised to redefine medicine, the Mayo Clinic is seeking to become a leader.

www.govtech.com

Reposted by David Jones

Guido Meijer @guidomeijer.com · Aug 5

🚨Pre-print alert🚨

We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭

How is this possible? Strap in! (1/9) 👇🧵

doi.org/10.1101/2025...

Serotonin drives choice-independent reconfiguration of distributed neural activity

Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...

doi.org

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David Jones @davidjonesbrain.bsky.social · Aug 6

www.statnews.com/2025/08/05/m...

An AI tool to help diagnose dementia leverages the Mayo Clinic’s expertise — and its data

A new Mayo Clinic tool that uses AI to diagnose dementia leverages the institution's expertise — and its data.

www.statnews.com

David Jones @davidjonesbrain.bsky.social · Jul 10

newsnetwork.mayoclinic.org/discussion/h...

newsnetwork.mayoclinic.org

David Jones @davidjonesbrain.bsky.social · Jul 10

www.aarp.org/health/condi...

AI Tool Can Distinguish Dementia Types and Point to Reversible Causes of Thinking Problems

It helps identify reversible causes of dementia symptoms more easily and accurately than humans alone

www.aarp.org

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David Jones @davidjonesbrain.bsky.social · Jul 3

Focusing on AD only, out of context of all degenerative disease of intelligence is one of the major errors IMO. Intelligence is energetically expensive and FDG-PET provides a landscape for all dementias, and connects to the clinic to computational neuroscience: bsky.app/profile/davi...

David Jones @davidjonesbrain.bsky.social · Jun 29

1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz

David Jones @davidjonesbrain.bsky.social · Jul 1

newsnetwork.mayoclinic.org/discussion/h...

David Jones @davidjonesbrain.bsky.social · Jun 29

19/end

www.neurology.org/doi/10.1212/...

An FDG-PET–Based Machine Learning Framework to Support Neurologic Decision-Making in Alzheimer Disease and Related Disorders | Neurology

Background and ObjectivesDistinguishing neurodegenerative diseases is a challenging task requiring neurologic expertise. Clinical decision support systems (CDSSs) powered by machine learning (ML) and ...

www.neurology.org

David Jones @davidjonesbrain.bsky.social · Jun 29

18/
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org

David Jones @davidjonesbrain.bsky.social · Jun 29

17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...

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David Jones @davidjonesbrain.bsky.social · Jun 29

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StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech

David Jones @davidjonesbrain.bsky.social · Jun 29

15/
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI

David Jones @davidjonesbrain.bsky.social · Jun 29

14/
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials

David Jones @davidjonesbrain.bsky.social · Jun 29

13/
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI

David Jones @davidjonesbrain.bsky.social · Jun 29

12/
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare

David Jones @davidjonesbrain.bsky.social · Jun 29

11/
Here’s what makes StateViewer different:
✅ Needs only 1 input: a brain FDG-PET scan
✅Returns multiple diagnoses with statistics
✅Visual maps to explain “why”
✅Supports (not replaces) the physician
It’s made for real-world use and it’s already used in the real-world.

David Jones @davidjonesbrain.bsky.social · Jun 29

10/
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech

David Jones @davidjonesbrain.bsky.social · Jun 29

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That’s why we’re building scalable solutions.
So that even where no specialist is present, expertise is.
Inside Mayo Clinic, we built a platform to bring precision diagnosis anywhere.
👉 siliconangle.com/2025/04/16/i...
#AI

AI diagnostics improve neurological care - SiliconANGLE

AI diagnostics accelerate brain scan analysis, helping clinicians close the expertise gap and deliver faster, accurate neurological care.

siliconangle.com

David Jones @davidjonesbrain.bsky.social · Jun 29

8/
But here’s the problem:

There are too many people with dementia symptoms...
And not enough specialists.

🧑‍⚕️ Cognitive neurology is scarce
🌎 Rural access is limited
📈 Dementia is rising fast

We need to scale expert-level decision-making.
#healthequity

David Jones @davidjonesbrain.bsky.social · Jun 29

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There’s also a human cost.
🧭 There is peace in knowing.

Once a diagnosis is clear, people can focus on what comes next — not more tests, second opinions, or doubt.

That peace matters.
#NeuroEthics #PatientCare

a picture of a beach at sunset with the word peace written on it

ALT: a picture of a beach at sunset with the word peace written on it

media.tenor.com

David Jones @davidjonesbrain.bsky.social · Jun 29

6/
Misdiagnosis doesn’t just cause harm.
It wastes years.

⏳ Endless referrals
💰Financial cost
😔Uncertainty and grief

Families deserve clarity.

Trials need precision.

Without a clear diagnosis, progress stalls.
#Alzheimers #DementiaDiagnosis

a man with a mustache says barbecue sauce in white

ALT: a man with a mustache says barbecue sauce in white

media.tenor.com