“Streets of Minneapolis” names Renée Good and Alex Pretti, and excoriates “King Trump.”

In the nucleus accumbens, acetylcholine boosts dopamine release to promote effortful behaviour.

Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

Biological Brains Inspire a New Building Block for Artificial Neural Networks on Simons Foundation

NotebookLM explains StateViewer, FDG-PET, and SLOD

ALT: a man in a suit is making a funny face and says `` mind blown '' while standing in a bar .

npj Dementia - Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Background and ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is an underdiagnosed but potentially treatable condition in older adults. Population-based data on incidence and progression re...

YouTube video by Neurology Journal

This study introduces and validates a reconfigurable metastructure that uses electromagnetic waves to perform analog complex-valued mathematical computations. This device executes both stationary and ...

With hospitals and researchers around the globe racing to use AI tools as part of a technological gold rush poised to redefine medicine, the Mayo Clinic is seeking to become a leader.

Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...

A new Mayo Clinic tool that uses AI to diagnose dementia leverages the institution's expertise — and its data.

It helps identify reversible causes of dementia symptoms more easily and accurately than humans alone