David W. Sanders!
@davidwsanders.bsky.social
Assistant Professor of Molecular Biology, Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern. My lab studies damaged things. Sometimes we fix them. Hiring! Write if interested in postdoc or tech position. https://www.davidwsanders.com
Pinned
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
No shit, Sherlock. Its speed! Did Nico get free drugs again at least?
December 25, 2025 at 1:46 AM
No shit, Sherlock. Its speed! Did Nico get free drugs again at least?
Reposted by David W. Sanders!
The Senate version of the NIH appropriations bill has language that limits the use of multiyear/upfront funding. Please call your Senators and Representatives to make sure it is in the final bill.
We must stop the brain drain in our research workforce before it's too late.
We must stop the brain drain in our research workforce before it's too late.
December 23, 2025 at 4:08 PM
The Senate version of the NIH appropriations bill has language that limits the use of multiyear/upfront funding. Please call your Senators and Representatives to make sure it is in the final bill.
We must stop the brain drain in our research workforce before it's too late.
We must stop the brain drain in our research workforce before it's too late.
Thanks for the clarification and keep posting your critiques. Disagreement and debate make science stronger! It’s why I love academic science!
December 2, 2025 at 9:25 PM
Thanks for the clarification and keep posting your critiques. Disagreement and debate make science stronger! It’s why I love academic science!
I do not personally enjoy arguments about jargon. Clusters, phases, networks, percolated fluids, granules, bodies. Whatever. I’m not a physicist. I just want to understand what these cool multicomponent droplet thingies do in living systems. Deciding who “owns” the “discovery” is a distraction.
November 28, 2025 at 10:23 PM
I do not personally enjoy arguments about jargon. Clusters, phases, networks, percolated fluids, granules, bodies. Whatever. I’m not a physicist. I just want to understand what these cool multicomponent droplet thingies do in living systems. Deciding who “owns” the “discovery” is a distraction.
Fine. True “Llps” is not a thing in biology. Pure physics don’t apply. You can quote me on this. Biology is complex. But biological liquids are real. The polyphasic linkage of these co-existing phases requires decades of study to understand fully. Whether awards are deserved is above my pay grade.
November 28, 2025 at 4:41 AM
Fine. True “Llps” is not a thing in biology. Pure physics don’t apply. You can quote me on this. Biology is complex. But biological liquids are real. The polyphasic linkage of these co-existing phases requires decades of study to understand fully. Whether awards are deserved is above my pay grade.
I dunno why this is a bridge to die on. I like you a lot. I like Cliff a lot. I am amenable to your criticisms of “the field”. I certainly think an opportunity for productive debate about terms/complexities was missed circa 2020. But your tone reads as personal. Cliff eg is not a snakeoil salesman.
November 28, 2025 at 4:37 AM
I dunno why this is a bridge to die on. I like you a lot. I like Cliff a lot. I am amenable to your criticisms of “the field”. I certainly think an opportunity for productive debate about terms/complexities was missed circa 2020. But your tone reads as personal. Cliff eg is not a snakeoil salesman.
Your thoughtful opinions have provided a useful counterpoint to “rah-rah dogma” in the phase separation field. My opinion: such discourse has inspired greater rigor and skepticism, which was urgently needed when you started your righteous debate. This post is beneath that. It reads as personal.
November 28, 2025 at 12:53 AM
Your thoughtful opinions have provided a useful counterpoint to “rah-rah dogma” in the phase separation field. My opinion: such discourse has inspired greater rigor and skepticism, which was urgently needed when you started your righteous debate. This post is beneath that. It reads as personal.
We regularly get three agricultural ms applicants from Bangladesh (eg) for open positions that require a PhD. The issue is that everyone wants to be in three or four geographic locales. If applicants are more flexible, they can find positions.
November 7, 2025 at 5:14 AM
We regularly get three agricultural ms applicants from Bangladesh (eg) for open positions that require a PhD. The issue is that everyone wants to be in three or four geographic locales. If applicants are more flexible, they can find positions.
DPRIT passes! $3-billion Texas investment in dementia research: www.alz.org/news/2025/te...
Texans Make History with Passage of Proposition 14, Launching Nation’s Largest State-Funded Dementia Research Initiative
Texas voters approved funding the Dementia Prevention and Research Institute of Texas (DPRIT), the nation's largest state-funded dementia research initiative. OG image: press release
www.alz.org
November 5, 2025 at 5:14 PM
DPRIT passes! $3-billion Texas investment in dementia research: www.alz.org/news/2025/te...
Reposted by David W. Sanders!
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
Reposted by David W. Sanders!
mStayRose is published in JBC 🥳🎉
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric green fluorescent protein recently
monomerised through sequence engi...
www.jbc.org
October 22, 2025 at 4:58 PM
mStayRose is published in JBC 🥳🎉
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Ut southwestern is recruiting! 3-milly start-up for tenure-track or tenured PI positions in O’Donnell Brain institute. Basic and translational neuroscientists both. If I can call myself a neuroscientist, so can you! Please consider reposting :) #DPRITisComing apply.interfolio.com/174927
Apply - Interfolio
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apply.interfolio.com
October 17, 2025 at 9:54 PM
Ut southwestern is recruiting! 3-milly start-up for tenure-track or tenured PI positions in O’Donnell Brain institute. Basic and translational neuroscientists both. If I can call myself a neuroscientist, so can you! Please consider reposting :) #DPRITisComing apply.interfolio.com/174927
Reposted by David W. Sanders!
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
It’s a good inducing system for gene expression? Don’t throw the baby out with the bathwater man. Tet off vectors rule!
October 14, 2025 at 2:40 AM
It’s a good inducing system for gene expression? Don’t throw the baby out with the bathwater man. Tet off vectors rule!
haven't been to the theaters in 12 years. no thanks.
October 12, 2025 at 3:19 AM
haven't been to the theaters in 12 years. no thanks.
Haven’t seen it yet. But will because it’s fucking pta. There will be blood remains my favorite by him. I assume it remains only in theaters? I don’t go there. Movies are meant to be watched from a laptop. In bed. In underwear. With beer. I think Scorsese said this?
October 12, 2025 at 2:54 AM
Haven’t seen it yet. But will because it’s fucking pta. There will be blood remains my favorite by him. I assume it remains only in theaters? I don’t go there. Movies are meant to be watched from a laptop. In bed. In underwear. With beer. I think Scorsese said this?
Be nice to greenwood. He has tinnitus.
October 12, 2025 at 2:50 AM
Be nice to greenwood. He has tinnitus.
Reposted by David W. Sanders!
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Aaron is coming in a couple months. Hope to hear—not in talk form—about your work. Let’s catch up soon! Hope you are enjoying the non-Texas weather.
October 9, 2025 at 4:47 AM
Aaron is coming in a couple months. Hope to hear—not in talk form—about your work. Let’s catch up soon! Hope you are enjoying the non-Texas weather.
It is very familiar. I have dealt with this nonsense for 15 years. Please don’t sully the reputation of my Alma mater with bullshit. Thanks.
October 9, 2025 at 4:43 AM
It is very familiar. I have dealt with this nonsense for 15 years. Please don’t sully the reputation of my Alma mater with bullshit. Thanks.
I’m glad I didn’t follow your faculty market proposal/chalk talk advice. I would have received more offers. And I might not be at UTSW. And this would suck. Oh. And my dp2 ordered my projects as you recommended for job pitch. Wash-out of good/bad advice I think. So. Don’t owe you anything.
October 9, 2025 at 4:36 AM
I’m glad I didn’t follow your faculty market proposal/chalk talk advice. I would have received more offers. And I might not be at UTSW. And this would suck. Oh. And my dp2 ordered my projects as you recommended for job pitch. Wash-out of good/bad advice I think. So. Don’t owe you anything.
This is great. Glad you joined us yeehaws in the beautiful state of Texas! And glad we can enjoy this lucky moment in the sun together. —apologies for the informality. I know we haven’t met. But @boeynaemssteven.bsky.social vouches for you. That is all I need to know to call you a friend.
October 9, 2025 at 3:24 AM
This is great. Glad you joined us yeehaws in the beautiful state of Texas! And glad we can enjoy this lucky moment in the sun together. —apologies for the informality. I know we haven’t met. But @boeynaemssteven.bsky.social vouches for you. That is all I need to know to call you a friend.
Reposted by David W. Sanders!
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
Dr. Graham Erwin @grahamerwin.bsky.social receives NIH New Innovator Award! www.bcm.edu/news/dr-grah... @bcmhouston.bsky.social @bcmgenetics.bsky.social #BCMCancerCenter
October 8, 2025 at 8:05 PM
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
My proposal, like most DP2s, was pie in the sky stuff that I thought we would disprove quickly. Yet, we have not. This is thanks to our incredible postdoc, Shefali Banerjee, who is moving toward mic drop/textbook territory. We are in replication and red team/blue team territory now. Stay tuned.
October 9, 2025 at 3:18 AM
My proposal, like most DP2s, was pie in the sky stuff that I thought we would disprove quickly. Yet, we have not. This is thanks to our incredible postdoc, Shefali Banerjee, who is moving toward mic drop/textbook territory. We are in replication and red team/blue team territory now. Stay tuned.