Débora Y C Brandt
@deboraycb.bsky.social
240 followers 260 following 28 posts
Bióloga do IB-USP 07 🇧🇷 PhD UCBerkeley 🇺🇸 now postdoc at GEE-UCL 🇬🇧 Evolutionary genomics 🧬 🌳 popgen, ARGs, balancing selection. Interested in teaching, conservation. https://profiles.ucl.ac.uk/92078-debora-yoshihara-caldeira-brandt/
Posts Media Videos Starter Packs
Reposted by Débora Y C Brandt
avesbrasil.bsky.social
🇧🇷Saí-de-perna-amarela
🌎Cyanerpes caeruleus
Conservação:Pouco Preocupante

A saí-de-perna-amarela é um Passeriforme da família Thraupidae.

📷 Ester Ramirez
Um pequeno pássaro azul brilhante com pernas e pés amarelos brilhantes está empoleirado em um galho. Ele tem uma mancha preta no peito e no abdômen. O fundo é verde borrado.
Atenção: O alt da imagem foi gerado automaticamente.
deboraycb.bsky.social
Important heads up! This is crazy
jbonfield.bsky.social
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned
Reposted by Débora Y C Brandt
Reposted by Débora Y C Brandt
aidaandres.bsky.social
Jasmin Rees PhD chapter as a paper just out at the AJHG @ajhgnews.bsky.social, with Sergi Castellano, who first envisioned the study. Jas investigated signatures of human local genetic adaptation in hundreds of micronutrient-associated genes.
Reposted by Débora Y C Brandt
yun-s-song.bsky.social
SINGER, our ARG inference method, is finally published and freely available online:

doi.org/10.1038/s415...

It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics
SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.
doi.org
Reposted by Débora Y C Brandt
official-smbe.bsky.social
📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.

🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3

More information: smbe2026.org/symposia
SMBE2026 - Call for Symposia Proposals
Reposted by Débora Y C Brandt
lvilavalls.bsky.social
Excited to share our new preprint🙌
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
medrxivpreprint.bsky.social
Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts https://www.medrxiv.org/content/10.1101/2025.09.01.25334828v1
deboraycb.bsky.social
Ah I see… I’m joining the “it’s all epistasis” team. Thanks!
deboraycb.bsky.social
Yes, I prefer locus=SNP (or indel etc) and so defining this as epistasis. I think there’s always more information if you deal with the “smaller” loci and know the haplotypes. But I guess if you don’t have that level of detail the locus=gene works, no? And I wouldn’t say it’s wrong to treat it as dom
deboraycb.bsky.social
Ah then I think I would be fine with WT dominant to m2, m2 dominant to m1. And I agree it comes down to how you define what is the locus. But also agree with others that if a 4th double mutant allele exists, locus=whole gene doesn’t work well
deboraycb.bsky.social
But with two mutations wouldn’t you have 3 alleles (with locus=whole gene)? So if I understood the example wt=AA, and the double mutant BC would be same as AA. I wouldn’t call it dominance either…
deboraycb.bsky.social
SMBE2023 vs #ESEB2025
#momademia
Reposted by Débora Y C Brandt
flodebarre.bsky.social
... and here's a second #ESEB2025 starter pack!

go.bsky.app/DnUAnt5
Reposted by Débora Y C Brandt
Reposted by Débora Y C Brandt
atila.bsky.social
Quem tá no lockdown agora, né
Reposted by Débora Y C Brandt
birdhistory.bsky.social
When she was just 26 Florence Merriam wrote the first guide to birding with binoculars in 1889. And she slipped in this incredible feminist gem:
Reposted by Débora Y C Brandt
aidaandres.bsky.social
Outstanding work by @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social (and other collaborators) that massively advances identification of human gene duplicates, with links to important traits and our evolution. So happy to have contributed a bit to this fantastic paper.
mydennis.bsky.social
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
Reposted by Débora Y C Brandt
evoldir.bsky.social
The University of São Paulo seeks a Professor Doutor in Zoology, specializing in Bioinformatics and Phylogenomics. Applicants should promote research, teaching, and outreach. Details: https://academica.ib.usp.br/concursos/zoologia/edital-19-2025 #job
Instituto de Biociências - Edital 19-2025
EDITAL IB/AAcad/19/2025 (Português)
academica.ib.usp.br
deboraycb.bsky.social
And today I learned this

data <- c()

for (d in 1:200){
for (n in 1:d){
data <- c(data, n/d)
}}

tabd <- table(data)
plot(as.numeric(names(tabd)), tabd, type='l')
deboraycb.bsky.social
Yes, there are theorems and proofs about this, which "every computer scientist should know about". Luckily (?), I'm not a computer scientist :)
docs.oracle.com/cd/E19957-01...
What Every Computer Scientist Should Know About Floating-Point Arithmetic
docs.oracle.com
deboraycb.bsky.social
I learned this today

>>> round(0.5)
0
>>> round(1.5)
2
>>> round(2.5)
2
>>> round(3.5)
4