Danielle
@dmackowsky.bsky.social
Hail to Pitt with some Mass Spec on the side
Reposted by Danielle
A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules #ChemMedChem chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules
This study uses six small-molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96-well format with high performance liquid chromatography with tandem mass spectrometry ...
chemistry-europe.onlinelibrary.wiley.com
December 9, 2025 at 7:38 PM
A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules #ChemMedChem chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Danielle
Multistage Tandem Mass Spectrometry Using an Electron-Activated Dissociation Device with a Linear Ion Trap and Structural Identification of Cardiolipins #AC pubs.acs.org/doi/10.1021/...
pubs.acs.org
November 19, 2025 at 8:24 PM
Multistage Tandem Mass Spectrometry Using an Electron-Activated Dissociation Device with a Linear Ion Trap and Structural Identification of Cardiolipins #AC pubs.acs.org/doi/10.1021/...
Reposted by Danielle
Characterization and Elucidation of the Fragmentation Pathway of 17 Nitazenes by Liquid Chromatography High-Resolution Mass Spectrometry Using Collision-Induced Dissociation and Electron-Activated Dissociation #JASMS pubs.acs.org/doi/10.1021/...
Characterization and Elucidation of the Fragmentation Pathway of 17 Nitazenes by Liquid Chromatography High-Resolution Mass Spectrometry Using Collision-Induced Dissociation and Electron-Activated Dis...
Nitazenes, a class of new psychoactive substances, have emerged as a significant public health and safety concern due to their widespread abuse. While various detection methods, particularly mass spec...
pubs.acs.org
October 24, 2025 at 10:38 AM
Characterization and Elucidation of the Fragmentation Pathway of 17 Nitazenes by Liquid Chromatography High-Resolution Mass Spectrometry Using Collision-Induced Dissociation and Electron-Activated Dissociation #JASMS pubs.acs.org/doi/10.1021/...
Reposted by Danielle
Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood #JAT academic.oup.com/jat/article/...
Validate User
academic.oup.com
October 22, 2025 at 6:15 PM
Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood #JAT academic.oup.com/jat/article/...
Reposted by Danielle
Heard a bunch of old guys singing in an Irish pub in Cooperstown. Turns out they were members of the Pitt glee club in the 70’s.
Here is ‘Hail to Pitt’ courtesy of them:
Here is ‘Hail to Pitt’ courtesy of them:
October 17, 2025 at 9:03 PM
Heard a bunch of old guys singing in an Irish pub in Cooperstown. Turns out they were members of the Pitt glee club in the 70’s.
Here is ‘Hail to Pitt’ courtesy of them:
Here is ‘Hail to Pitt’ courtesy of them:
Reposted by Danielle
We made a Pitt Version of this too.
Fat Roc as Big Pun.
Fat Roc as Big Pun.
October 16, 2025 at 5:40 PM
We made a Pitt Version of this too.
Fat Roc as Big Pun.
Fat Roc as Big Pun.
Reposted by Danielle
Enhancing glycopeptide annotation and glycan localization using electron activated dissociation through a multiplexed parallel reaction monitoring design of experiments #JProteomics #MassSpec www.sciencedirect.com/science/arti...
Enhancing glycopeptide annotation and glycan localization using electron activated dissociation through a multiplexed parallel reaction monitoring design of experiments
We present an optimized electron activated dissociation (EAD) methodology, based on hot electron capture dissociation, for liquid chromatography-tande…
www.sciencedirect.com
October 16, 2025 at 8:34 AM
Enhancing glycopeptide annotation and glycan localization using electron activated dissociation through a multiplexed parallel reaction monitoring design of experiments #JProteomics #MassSpec www.sciencedirect.com/science/arti...
Reposted by Danielle
Join us Oct. 16 for the VENDOR SHOWCASE at Proteoform Thursday. Great lineup of speakers presenting the latest tech and apps for top-down proteomics. us06web.zoom.us/meeting/regi... #proteomics #massspec #proteoforms #Thermo #Bruker #Sciex #Agilent #NewObjective #ImmPro
October 1, 2025 at 8:07 PM
Join us Oct. 16 for the VENDOR SHOWCASE at Proteoform Thursday. Great lineup of speakers presenting the latest tech and apps for top-down proteomics. us06web.zoom.us/meeting/regi... #proteomics #massspec #proteoforms #Thermo #Bruker #Sciex #Agilent #NewObjective #ImmPro
Reposted by Danielle
We want it this way.
September 18, 2025 at 8:24 PM
We want it this way.
I am hiring! Do you have #massspec experience and are looking to get out of the lab and into sales? #chemjobs jobs.danaher.com/global/en/jo...
Territory Manager, Mass Spectrometry - New Jersey job in Newark, New Jersey, United States of America | Sales jobs at Danaher
Apply for Territory Manager, Mass Spectrometry - New Jersey job with Danaher in Newark, New Jersey, United States of America. Sales at Danaher
jobs.danaher.com
August 6, 2025 at 11:48 AM
I am hiring! Do you have #massspec experience and are looking to get out of the lab and into sales? #chemjobs jobs.danaher.com/global/en/jo...
Reposted by Danielle
Endocannabinoid and steroid hormone levels during and after pregnancy in fingernail samples from mothers and their infants #Steroids #MassSpec www.sciencedirect.com/science/arti...
Endocannabinoid and steroid hormone levels during and after pregnancy in fingernail samples from mothers and their infants
Stress exposure and protective biological factors such as steroid hormones and endocannabinoids (eCBs) play a crucial role in pregnancy and birth outc…
www.sciencedirect.com
July 30, 2025 at 5:54 AM
Endocannabinoid and steroid hormone levels during and after pregnancy in fingernail samples from mothers and their infants #Steroids #MassSpec www.sciencedirect.com/science/arti...
Reposted by Danielle
Accelerating Characterization of Therapeutic Antibodies: A Comparative Assessment of icIEF-UV/MS and the Traditional Fractionation Workflow #JASMS pubs.acs.org/doi/10.1021/...
Accelerating Characterization of Therapeutic Antibodies: A Comparative Assessment of icIEF-UV/MS and the Traditional Fractionation Workflow
Accurate characterization of charge variants in biologics is crucial to uphold stringent quality standards ensuring the safety and efficacy of biotherapeutic products and regulatory requirements for t...
pubs.acs.org
July 29, 2025 at 11:01 AM
Accelerating Characterization of Therapeutic Antibodies: A Comparative Assessment of icIEF-UV/MS and the Traditional Fractionation Workflow #JASMS pubs.acs.org/doi/10.1021/...
Reposted by Danielle
Even now, almost 30 years later, you drive down this street and feel like you're driving toward Something. Whatever it is, Something is happening and you're driving toward it.
July 27, 2025 at 9:07 PM
Even now, almost 30 years later, you drive down this street and feel like you're driving toward Something. Whatever it is, Something is happening and you're driving toward it.
Reposted by Danielle
High-Throughput Detection and Quantitation of Metal Contamination with Acoustic Ejection Mass Spectrometry #JASMS pubs.acs.org/doi/10.1021/...
pubs.acs.org
July 22, 2025 at 4:45 AM
High-Throughput Detection and Quantitation of Metal Contamination with Acoustic Ejection Mass Spectrometry #JASMS pubs.acs.org/doi/10.1021/...
Reposted by Danielle
If you know, you know.
Happy Bobby Bonilla Day to all who observe.
Happy Bobby Bonilla Day to all who observe.
July 1, 2025 at 12:20 PM
If you know, you know.
Happy Bobby Bonilla Day to all who observe.
Happy Bobby Bonilla Day to all who observe.
Reposted by Danielle
Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors #SLASTechnol www.slas-technology.org/article/S247...
Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors
Covalent drug discovery has garnered renewed interest due to its potential to target
proteins previously considered
www.slas-technology.org
June 13, 2025 at 9:34 AM
Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors #SLASTechnol www.slas-technology.org/article/S247...
Reposted by Danielle
Sciex/Evosep | Selecting optimal ZT Scan DIA acquisition methods on the ZenoTOF 7600+ system for quantitative proteomics sciex.com/tech-notes...
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#proteomics #prot-other
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#proteomics #prot-other
June 2, 2025 at 12:00 PM
Sciex/Evosep | Selecting optimal ZT Scan DIA acquisition methods on the ZenoTOF 7600+ system for quantitative proteomics sciex.com/tech-notes...
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#proteomics #prot-other
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#proteomics #prot-other
Reposted by Danielle
ZenoTOF 8600 #ASMS2025 summary:
- Up to 10x more sensitive than 7600+ (Hardware improvements DJet/QJet ion guides, OptiFlow Pro source and TOF optics)
- Up to 858 Hz MS2 (ZT Scan DIA 2.0)
- Lower contamination with 7500+ mass guard tech (so maybe no 8600+ is needed)
- EAD negative mode up to 50 KE
- Up to 10x more sensitive than 7600+ (Hardware improvements DJet/QJet ion guides, OptiFlow Pro source and TOF optics)
- Up to 858 Hz MS2 (ZT Scan DIA 2.0)
- Lower contamination with 7500+ mass guard tech (so maybe no 8600+ is needed)
- EAD negative mode up to 50 KE
June 2, 2025 at 1:15 PM
ZenoTOF 8600 #ASMS2025 summary:
- Up to 10x more sensitive than 7600+ (Hardware improvements DJet/QJet ion guides, OptiFlow Pro source and TOF optics)
- Up to 858 Hz MS2 (ZT Scan DIA 2.0)
- Lower contamination with 7500+ mass guard tech (so maybe no 8600+ is needed)
- EAD negative mode up to 50 KE
- Up to 10x more sensitive than 7600+ (Hardware improvements DJet/QJet ion guides, OptiFlow Pro source and TOF optics)
- Up to 858 Hz MS2 (ZT Scan DIA 2.0)
- Lower contamination with 7500+ mass guard tech (so maybe no 8600+ is needed)
- EAD negative mode up to 50 KE
Reposted by Danielle
The Hispanic and LatinX in MS Group will attend the SCIEX Inclusion and Belonging Networking Event! Join us for an evening of connection and community. We’ll be giving away prizes to our followers. You’ll recognize the HLXMS members by the badges featuring our logo!
#ASMS2025
#ASMS2025
May 21, 2025 at 3:53 PM
The Hispanic and LatinX in MS Group will attend the SCIEX Inclusion and Belonging Networking Event! Join us for an evening of connection and community. We’ll be giving away prizes to our followers. You’ll recognize the HLXMS members by the badges featuring our logo!
#ASMS2025
#ASMS2025
Reposted by Danielle
Absolute Quantitation of Neopterin as an Endogenous Pharmacodynamic Biomarker: The Successful Method Development, Validation, and Use of a Surrogate Matrix for Clinical Sample Analysis #AnBiochem #MassSpec www.sciencedirect.com/science/arti...
Absolute Quantitation of Neopterin as an Endogenous Pharmacodynamic Biomarker: The Successful Method Development, Validation, and Use of a Surrogate Matrix for Clinical Sample Analysis.
Biomarkers are playing an increasing role in the drug discovery and drug development process. Molecular biomarkers pose a bioanalytical challenge due …
www.sciencedirect.com
May 8, 2025 at 12:01 PM
Absolute Quantitation of Neopterin as an Endogenous Pharmacodynamic Biomarker: The Successful Method Development, Validation, and Use of a Surrogate Matrix for Clinical Sample Analysis #AnBiochem #MassSpec www.sciencedirect.com/science/arti...
Reposted by Danielle
A Validated Screening and Confirmation Method for 946 Drugs and Metabolites Using LC-QTOF-MS with SWATH Acquisition #JAT academic.oup.com/jat/advance-...
A Validated Screening and Confirmation Method for 946 Drugs and Metabolites Using LC-QTOF-MS with SWATH Acquisition
Abstract. A streamlined liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) method utilizing protein precipitation and filtratio
academic.oup.com
May 6, 2025 at 7:54 AM
A Validated Screening and Confirmation Method for 946 Drugs and Metabolites Using LC-QTOF-MS with SWATH Acquisition #JAT academic.oup.com/jat/advance-...
In honor of the draft, what team would your dog play for? This guy would be a Raider: kinda a jerk, rocks the color black, would thrive as a Vegas bro.
April 24, 2025 at 10:20 PM
In honor of the draft, what team would your dog play for? This guy would be a Raider: kinda a jerk, rocks the color black, would thrive as a Vegas bro.
Reposted by Danielle
Quantification of total sBCMA in human plasma by peptide-level immunocapture LC-MS/MS #JMSACL www.sciencedirect.com/science/arti...
Quantification of total sBCMA in human plasma by peptide-level immunocapture LC-MS/MS
B-cell maturation antigen (BCMA) is a membrane protein that is overexpressed in multiple myeloma cells and can be targeted with biotherapeutic agents.…
www.sciencedirect.com
April 18, 2025 at 11:24 AM
Quantification of total sBCMA in human plasma by peptide-level immunocapture LC-MS/MS #JMSACL www.sciencedirect.com/science/arti...
Reposted by Danielle
Optimization of Parallel Artificial Liquid Membrane Extraction for the Determination of Over 50 Psychoactive Substances in Oral Fluid Through UHPLC–MS/MS #DTA analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10....
Optimization of Parallel Artificial Liquid Membrane Extraction for the Determination of Over 50 Psychoactive Substances in Oral Fluid Through UHPLC–MS/MS
This study is related to the development of a microextraction method for the determination of 56 psychoactive substances in oral fluid. Sample clean-up is obtained by parallel artificial liquid membr...
analyticalsciencejournals.onlinelibrary.wiley.com
April 12, 2025 at 7:31 AM
Optimization of Parallel Artificial Liquid Membrane Extraction for the Determination of Over 50 Psychoactive Substances in Oral Fluid Through UHPLC–MS/MS #DTA analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10....