Adam J Rose
@drajrose.bsky.social
Scientist studying signalling pathways & processes in metabolism and vice versa. Thoughts are my own.
Reposted by Adam J Rose
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
October 29, 2025 at 12:11 PM
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
Reposted by Adam J Rose
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics
Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by
low sensitivity for small molecules, limited scalability, and the lack of standardized
frameworks for data analysis....
www.cell.com
October 16, 2025 at 4:28 PM
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...
Reposted by Adam J Rose
A famous graphic, now updated, compares locomotion in the animal kingdom
The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike
A famous graphic, now updated, compares locomotion in the animal kingdom
www.scientificamerican.com
October 14, 2025 at 1:52 PM
A famous graphic, now updated, compares locomotion in the animal kingdom
Reposted by Adam J Rose
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 3, 2025 at 11:02 AM
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
Reposted by Adam J Rose
Reposted by Adam J Rose
Nominations are now open for the AuPS Publication Prizes — and they close on 15 October 2025.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
a gold trophy with a laurel wreath around it and the words well done on a gold ribbon
ALT: a gold trophy with a laurel wreath around it and the words well done on a gold ribbon
media.tenor.com
September 23, 2025 at 6:46 AM
Nominations are now open for the AuPS Publication Prizes — and they close on 15 October 2025.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.
Reposted by Adam J Rose
RACMEM 2025
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Home | RACMEM
Recent Advances and Controversies in the Measurement of Energy Metabolism
www.racmem.com
September 23, 2025 at 8:20 AM
RACMEM 2025
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.
Reposted by Adam J Rose
Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/
Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This
study indicates that semaglutide has unexpected effects on skeletal muscle mass and
strength in mice, demonstrating a...
www.cell.com
August 6, 2025 at 5:29 AM
Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/
Reposted by Adam J Rose
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 17, 2025 at 3:45 PM
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adam J Rose
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 7:24 PM
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adam J Rose
Based on studies of mice with increased energy expenditure the authors propose myeloid CAMKK2 as a key regulator of macrophage function and a potential therapeutic target for treating #obesity and related metabolic disorders www.sciencedirect.com/science/arti...
September 13, 2025 at 10:48 PM
Based on studies of mice with increased energy expenditure the authors propose myeloid CAMKK2 as a key regulator of macrophage function and a potential therapeutic target for treating #obesity and related metabolic disorders www.sciencedirect.com/science/arti...
Reposted by Adam J Rose
This is a friendly reminder that early-bird registration and abstract submission for the 2025 AuPS annual meeting hosted by the University of Western Sydney in Paramatta is open until Friday 12/09/2025. Nominations for our prizes, grants and awards are also due tomorrow- exception Publication prize
September 11, 2025 at 4:53 AM
This is a friendly reminder that early-bird registration and abstract submission for the 2025 AuPS annual meeting hosted by the University of Western Sydney in Paramatta is open until Friday 12/09/2025. Nominations for our prizes, grants and awards are also due tomorrow- exception Publication prize
Reposted by Adam J Rose
An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social.
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
Our Preoccupation With Protein Intake
The data on high protein diets, bars, supplements, and powders will surprise you
open.substack.com
September 5, 2025 at 5:42 PM
An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social.
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.
open.substack.com/pub/erictopo...
Reposted by Adam J Rose
An amygdala–liver axis that regulates rapid glycaemic adaptations to stress and links recurrent stress to metabolic dysfunction www.nature.com/articles/s41...
Amygdala–liver signalling orchestrates glycaemic responses to stress - Nature
Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independen...
www.nature.com
September 3, 2025 at 3:18 PM
An amygdala–liver axis that regulates rapid glycaemic adaptations to stress and links recurrent stress to metabolic dysfunction www.nature.com/articles/s41...
Reposted by Adam J Rose
Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids
go.nature.com/3V8r3Lw
go.nature.com/3V8r3Lw
Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature
Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.
go.nature.com
August 24, 2025 at 3:00 PM
Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids
go.nature.com/3V8r3Lw
go.nature.com/3V8r3Lw
Reposted by Adam J Rose
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications
Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...
www.nature.com
August 4, 2025 at 7:27 PM
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
Reposted by Adam J Rose
The 2025 AuPS Annual Meeting is open for registration and abstract submissions!
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
July 30, 2025 at 1:02 AM
The 2025 AuPS Annual Meeting is open for registration and abstract submissions!
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au
Reposted by Adam J Rose
🌟 Early Career Physiologists – This is your moment!
The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪
🏅 $1000 + medal
🎤 Invited talk in Queenstown 2026
🗓️ Apply by Sept 12
www.aups.org.au/Prizes/ for more information
#ECR #ScienceAwards #Physiology #McIntyrePrize
The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪
🏅 $1000 + medal
🎤 Invited talk in Queenstown 2026
🗓️ Apply by Sept 12
www.aups.org.au/Prizes/ for more information
#ECR #ScienceAwards #Physiology #McIntyrePrize
AuPS Prizes
www.aups.org.au
July 17, 2025 at 5:16 AM
🌟 Early Career Physiologists – This is your moment!
The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪
🏅 $1000 + medal
🎤 Invited talk in Queenstown 2026
🗓️ Apply by Sept 12
www.aups.org.au/Prizes/ for more information
#ECR #ScienceAwards #Physiology #McIntyrePrize
The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪
🏅 $1000 + medal
🎤 Invited talk in Queenstown 2026
🗓️ Apply by Sept 12
www.aups.org.au/Prizes/ for more information
#ECR #ScienceAwards #Physiology #McIntyrePrize
Reposted by Adam J Rose
www.nature.com/articles/s41...
Imidazole propionate is a driver and therapeutic target in atherosclerosis
Congrats to @sancholab.bsky.social and his team!
Imidazole propionate is a driver and therapeutic target in atherosclerosis
Congrats to @sancholab.bsky.social and his team!
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
www.nature.com
July 16, 2025 at 4:01 PM
www.nature.com/articles/s41...
Imidazole propionate is a driver and therapeutic target in atherosclerosis
Congrats to @sancholab.bsky.social and his team!
Imidazole propionate is a driver and therapeutic target in atherosclerosis
Congrats to @sancholab.bsky.social and his team!
The role of metabolism in shaping enzyme structures over 400 million years | Nature share.google/7QQrLX8knlgD...
The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
share.google
July 10, 2025 at 9:04 AM
The role of metabolism in shaping enzyme structures over 400 million years | Nature share.google/7QQrLX8knlgD...
Reposted by Adam J Rose
This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...
A simple action reduces high-fat diet intake and obesity in mice
Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…
www.sciencedirect.com
June 19, 2025 at 3:05 PM
This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...
Reposted by Adam J Rose
Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...
Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials
A robust dose–response relationship between bodyweight loss and diabetes remission
was observed, independent of age, diabetes duration, HbA1c, BMI, and type of intervention.
These findings highlight t...
www.thelancet.com
June 15, 2025 at 6:53 AM
Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...
Reposted by Adam J Rose
🎉 AuPS turns 65!
Join us at the 2025 Annual Meeting at Western Sydney Uni (Parramatta) — 23–26 Nov Save the date
Celebrate physiology, share your research, and connect with colleagues.
Details soon! #AuPS2025 #Physiology #STEM
Join us at the 2025 Annual Meeting at Western Sydney Uni (Parramatta) — 23–26 Nov Save the date
Celebrate physiology, share your research, and connect with colleagues.
Details soon! #AuPS2025 #Physiology #STEM
May 2, 2025 at 12:31 AM
🎉 AuPS turns 65!
Join us at the 2025 Annual Meeting at Western Sydney Uni (Parramatta) — 23–26 Nov Save the date
Celebrate physiology, share your research, and connect with colleagues.
Details soon! #AuPS2025 #Physiology #STEM
Join us at the 2025 Annual Meeting at Western Sydney Uni (Parramatta) — 23–26 Nov Save the date
Celebrate physiology, share your research, and connect with colleagues.
Details soon! #AuPS2025 #Physiology #STEM
Reposted by Adam J Rose
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology
imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial
cell lines grown in their respective standard conditions reveals common and distinctive
metabolic signatur...
www.embopress.org
June 6, 2025 at 1:23 AM
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.