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William Hill @drwilliamhill.bsky.social · 9d

6 incredible years. So grateful for the opportunity to work with such brilliant people. What an adventure. Goodbye @crick.ac.uk

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Reposted by William Hill

Mark Peifer (He, him) @peiferlabunc.bsky.social · Jul 26

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Diagram illustrating the two-hit model of retinoblastoma

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William Hill @drwilliamhill.bsky.social · Jun 7

Thank you!!

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William Hill @drwilliamhill.bsky.social · Jun 7

Thanks Helen! Definitely!

William Hill @drwilliamhill.bsky.social · Jun 7

Thank you! Hopefully cross paths soon!

William Hill @drwilliamhill.bsky.social · Jun 6

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

Cancer Research UK Manchester Institute @cruk-mi.bsky.social · Jun 6

We are recruiting two exciting #Postdoctoral roles:

🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer

🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer

Full details of both positions at:
www.cruk.manchester.ac.uk/careers/

Photo shows three glowing green bottles of chemicals, with a space where a fourth bottle can be placed

Text says "New job openings" and "See all recruitment opportunities by visiting cruk.manchester.ac.uk/careers/"

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Reposted by William Hill

Cancer Research UK @cancerresearchuk.org · Apr 27

William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer.

#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk

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William Hill @drwilliamhill.bsky.social · Feb 26

Very interesting, I hadn't seen this. I know p53 mutations occur in normal lung tissue. Will be interesting to test the association of presence/absence of p53 mutations and expansion/selection of those mutations in people who smoke and those who don't.

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William Hill @drwilliamhill.bsky.social · Feb 26

Fantastic insight into NSCLC, going from biology to interception

Translating premalignant biology to accelerate non-small-cell lung cancer interception - Nature Reviews Cancer

While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively i...

www.nature.com

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William Hill @drwilliamhill.bsky.social · Feb 25

Imaging mass cytometry of 122 early stage lung adeno patients explores the balance of of the tumour microenvironment and changes in malignant cell fate.

Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression

Lung cancer remains the deadliest cancer in the United States, with lung adenocarcinoma (LUAD) as its most prevalent subtype. While computed tomography (CT)-based screening has improved early detectio...

www.biorxiv.org

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Reposted by William Hill

Surya Nagaraja @snaga13.bsky.social · Feb 18

New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)

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Reposted by William Hill

Adam Rutherford @adamrutherford.bsky.social · Feb 12

It is with great sadness to hear that the great Tim Radford has died. He was, unequivocally, the best science journalist, and a kind and generous man. I used his Manifesto for the Simple Scribe in lectures for student this very week. It’s faultless.

www.theguardian.com/science/blog...

A manifesto for the simple scribe – my 25 commandments for journalists | Tim Radford

Former Guardian science editor, letters editor, arts editor and literary editor Tim Radford has condensed his journalistic experience into a handy set of rules for aspiring hacks

www.theguardian.com

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William Hill @drwilliamhill.bsky.social · Feb 4

I had a fantastic day at the CRUK workshop last week at the intersection between aging and cancer.

British Society for Research on Ageing @bsrageing.bsky.social · Feb 4

Can ageing research be used to prevent cancer? BSRA Chair @dweinkove.bsky.social shares his thoughts after an excellent @cancerresearchuk.org “From Biology of Ageing to Cancer Prevention”.

bsra.org.uk/preventing-c...

#WorldCancerDay #UnitedByUnique #Ageing #Aging

Preventing Cancer by Understanding Ageing - BSRA

David Weinkove, 4 February 2025 – World Cancer Day Age is the biggest risk factor for cancer – higher even than smoking. So can we use findings from ageing research to prevent people getting cancer? T...

bsra.org.uk

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William Hill @drwilliamhill.bsky.social · Jan 31

That's cool

Eric Topol @erictopol.bsky.social · Jan 31

How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...

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Reposted by William Hill

Hazel Cheeseman @hazelcheeseman.bsky.social · Jan 31

At individual level those who vape more likely to go on to smoke (but causality not proven) but at population level higher levels of youth vaping could mean lower levels of youth smoking - really important work from @jhb19.bsky.social showing how carefully we need to keep the evidence under review

Lion Shahab @lionshahab.bsky.social · Jan 31

New expansive CRUK-funded systematic review led by the brilliant @jhb19.bsky.social on youth transitions between vaping & smoking doi.org/10.1111/add..... It’s complex: there’s potential inverse associations between vaping & smoking at population level but positive association at individual level.

Electronic cigarettes and subsequent cigarette smoking in young people: A systematic review

Aims To assess the evidence for a relationship between the use of e-cigarettes and subsequent smoking in young people (≤29 years), and whether this differs by demographic characteristics. Methods ...

doi.org

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Reposted by William Hill

Kit Curtius @yosoykit.bsky.social · Jan 30

Today our study using copy number alterations (CNAs) from low-coverage WGS to predict FUTURE colorectal cancer in patients with IBD is published, details in thread! 1/5
gut.bmj.com/content/earl...

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis

Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

gut.bmj.com

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Reposted by William Hill

Amy C. Moore, PhD @acmoorephd.bsky.social · Jan 23

One of my frustrations with our work to understand the causes of #cancer #cachexia as part of Cancer Grand Challenges Team #CANCAN is the limitation of animal models that don't reflect the realities of the patient population. This development helps. #LCSM #lungcancer

www.biorxiv.org/content/10.1...

Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer

PIK3CA mutation is frequently concurrent with known oncogenic drivers such as EGFR mutation in lung cancer, raising an interesting question about its real function. Cachexia is a systemic disease invo...

www.biorxiv.org

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Reposted by William Hill

The OncoAlert Network 🚨 @oncoalert.bsky.social · Jan 15

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma

https://buff.ly/4akMe3C

While further prospective validation is required, this approach could significantly enhance risk stratification and treatment planning in early-stage LUAD.

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Reposted by William Hill

J Magarian Blander @magarianblander.bsky.social · Jan 6

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.

Happy to share here: www.nature.com/articles/s41...

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology

Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

www.nature.com

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Reposted by William Hill

Chris Whelan @chrisdwhelan.bsky.social · Jan 10

I'm delighted to announce that the Pharma Proteomics Project will commence full-scale proteomic profiling of the UK Biobank in 2025. We have selected the Olink Proteomics Explore HT platform and Ultima Genomics UG 100 sequencers for this unprecedented study.

www.ukbiobank.ac.uk/learn-more-a...

Launch of world’s most significant protein study set to usher in new understanding for medicine

www.ukbiobank.ac.uk

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Reposted by William Hill

Rod Rahimi @rodrahimi.bsky.social · Jan 9

"unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression." #ImmunoSky

Reinventing type 2 immunity in cancer - Nature

This Review addresses the roles of type 2 immunity in cancer and the potential for cancer immunotherapies targeting this pathway.

www.nature.com

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William Hill @drwilliamhill.bsky.social · Jan 9

Metabolic changes at the interface between mutant and normal skin epidermis www.nature.com/articles/s41...

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations - Nature Cell Biology

Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaini...

www.nature.com

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William Hill @drwilliamhill.bsky.social · Jan 8

But also who will I listen to the Rest is politics with in ex3?!

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William Hill @drwilliamhill.bsky.social · Jan 8

Congratulations!

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Reposted by William Hill

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · Jan 1

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer. https://www.biorxiv.org/content/10.1101/2024.12.31.630523v1

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