David Shaywitz
@dshaywitz.bsky.social
Biology-grounded MD/PhD exec | Healthy aging & flourishing at scale | Evidence-based medicine x lifestyle × tech | Agency as engine of change | Strategic Advisor | Writer | kindwellhealth.com
On left: dimensions of health that McKinsey apparently sees; in my view, they (like many) are essentially stuck on biometrics (not a big surprise), and miss critically important, evidence-based but more difficult to quantify measures, as outlined in my diagram of flourishing health, right.
November 25, 2025 at 8:03 PM
On left: dimensions of health that McKinsey apparently sees; in my view, they (like many) are essentially stuck on biometrics (not a big surprise), and miss critically important, evidence-based but more difficult to quantify measures, as outlined in my diagram of flourishing health, right.
Reposted by David Shaywitz
"The growing popularity of these drugs [peptides]
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
The Internet Loves Peptide Therapy. Is It Really a Miracle Cure?
www.nytimes.com
November 25, 2025 at 3:10 PM
"The growing popularity of these drugs [peptides]
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
Fun feature on musicals in today's NYT, asking, "If you had to convince a nonbeliever, in just a few minutes, why they should make musical theater their religion, what evidence would you offer?" & offering response: www.nytimes.com/2025/11/24/t.... Would **love** @jackviertel.bsky.social POV here...
5 Minutes That Will Make You Love Musicals
www.nytimes.com
November 25, 2025 at 9:54 AM
Fun feature on musicals in today's NYT, asking, "If you had to convince a nonbeliever, in just a few minutes, why they should make musical theater their religion, what evidence would you offer?" & offering response: www.nytimes.com/2025/11/24/t.... Would **love** @jackviertel.bsky.social POV here...
Now out in & just in time for your long Thanksgiving drive: my annual podcast recs, from Acquired & Ground Truths @erictopol.bsky.social to Not Otherwise Specified @lisarosenbaum.bsky.social & Grand Rounds @ai.nejm.org to The Rest is History & excellence actually timmermanreport.com/2025/11/reco...
Recommended Podcasts (and A Few Books), 2025 Year-End Edition - TimmermanReport.com
It’s time for my annual feature: recommended podcasts (and a few books) for TR readers to consider. As usual, these suggestions generally steer clear of politics; they also aren’t the only podcasts I ...
timmermanreport.com
November 24, 2025 at 6:33 PM
Now out in & just in time for your long Thanksgiving drive: my annual podcast recs, from Acquired & Ground Truths @erictopol.bsky.social to Not Otherwise Specified @lisarosenbaum.bsky.social & Grand Rounds @ai.nejm.org to The Rest is History & excellence actually timmermanreport.com/2025/11/reco...
1/Enjoyed this @statnews.com piece by @mgurven.bsky.social offering sensible perspective on improving life expectancy of populations, incl increasing physical activity, "the best anti-aging remedy we have, an all-purpose longevity extender." www.statnews.com/2025/11/20/l...
The anti-aging gold rush should focus on quality of life, not just quantity
“If Moore’s law applies to life expectancy the way it does to electronics, then we’ll have to spend and innovate exponentially more to keep pace,” writes Michael D. Gurven.
www.statnews.com
November 24, 2025 at 1:03 PM
1/Enjoyed this @statnews.com piece by @mgurven.bsky.social offering sensible perspective on improving life expectancy of populations, incl increasing physical activity, "the best anti-aging remedy we have, an all-purpose longevity extender." www.statnews.com/2025/11/20/l...
Reposted by David Shaywitz
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
Why Patients – And Many Innovative Doctors – Are Pursuing Health Outside the System - TimmermanReport.com
Our current system of delivering care is awful from the perspective of seemingly every stakeholder. It frustrates, enrages, saddens, and depletes patients and physicians alike. No one designed it this...
timmermanreport.com
November 23, 2025 at 10:59 AM
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
Reposted by David Shaywitz
Hudson River Run.
November 23, 2025 at 2:43 PM
Hudson River Run.
Good piece describing current comprehensive testing efforts so popular in consumer hlth, despised by med establishment b/c of v real concerns abt false +s: nytimes.com/2025/11/22/b.... Today: reasonable worry; in future, w more/richer/longitudinal data-likely less true
@danielsodickson.bsky.social
@danielsodickson.bsky.social
The Rise of the ‘Just in Case’ M.R.I.
nytimes.com
November 23, 2025 at 12:48 PM
Good piece describing current comprehensive testing efforts so popular in consumer hlth, despised by med establishment b/c of v real concerns abt false +s: nytimes.com/2025/11/22/b.... Today: reasonable worry; in future, w more/richer/longitudinal data-likely less true
@danielsodickson.bsky.social
@danielsodickson.bsky.social
Strongly endorse what @halle.blue calling for here, in this concise piece published by @chrissyfarr.bsky.social Second Opinion: secondopinion.media/p/should-pat.... OF COURSE pts should have access to med grade AI!! Access to AI can't be what makes docs special or valuable. @bijans.bsky.social
Should patients have access to medical-grade AI?
secondopinion.media
November 23, 2025 at 12:28 PM
Strongly endorse what @halle.blue calling for here, in this concise piece published by @chrissyfarr.bsky.social Second Opinion: secondopinion.media/p/should-pat.... OF COURSE pts should have access to med grade AI!! Access to AI can't be what makes docs special or valuable. @bijans.bsky.social
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
Why Patients – And Many Innovative Doctors – Are Pursuing Health Outside the System - TimmermanReport.com
Our current system of delivering care is awful from the perspective of seemingly every stakeholder. It frustrates, enrages, saddens, and depletes patients and physicians alike. No one designed it this...
timmermanreport.com
November 23, 2025 at 10:59 AM
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
New TR -why patients-and many innovative doctors-are building health outside what feels like our impossibly broken system. Starting point=preemption, secret sauce=talent, & focus on agency & meaning, as well as relevant biometrics. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social
Why Patients – And Many Innovative Doctors – Are Pursuing Health Outside the System - TimmermanReport.com
Our current system of delivering care is awful from the perspective of seemingly every stakeholder. It frustrates, enrages, saddens, and depletes patients and physicians alike. No one designed it this...
timmermanreport.com
November 22, 2025 at 7:12 PM
New TR -why patients-and many innovative doctors-are building health outside what feels like our impossibly broken system. Starting point=preemption, secret sauce=talent, & focus on agency & meaning, as well as relevant biometrics. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social
Tx for flagging, @thgoetz.bsky.social -what a well-done visual feature, kudos @alicecallahan.bsky.social & team. The impact of a changing food environment is also key theme of important book by nutrition scientist @kevinh-phd.bsky.social & @juliabelluz.bsky.social timmermanreport.com/2025/10/food...
November 21, 2025 at 5:32 PM
Tx for flagging, @thgoetz.bsky.social -what a well-done visual feature, kudos @alicecallahan.bsky.social & team. The impact of a changing food environment is also key theme of important book by nutrition scientist @kevinh-phd.bsky.social & @juliabelluz.bsky.social timmermanreport.com/2025/10/food...
Reposted by David Shaywitz
It's sad that AI conference reviewers use "incremental" as reason to reject a paper -- e.g., "the contribution of this paper is incremental; reject". Where do they think most progress in science comes from, and what eventually fuels big discoveries?
November 19, 2025 at 9:54 PM
It's sad that AI conference reviewers use "incremental" as reason to reject a paper -- e.g., "the contribution of this paper is incremental; reject". Where do they think most progress in science comes from, and what eventually fuels big discoveries?
Reposted by David Shaywitz
Pretty New York City.
November 19, 2025 at 11:49 PM
Pretty New York City.
Wow: powerful & impt Timmerman Report piece by Dr. Amanda Banks abt the (v real) dark side of GLP-1s: exacerbation of eating disorders, as she poignantly discusses (telling us at end about her personal interest in this "as mom of a daughter in recovery"): timmermanreport.com/2025/11/the-...
The Dark Side of the GLP-1 Weight Loss Drugs: Eating Disorders - TimmermanReport.com
There has been much fanfare about the acquisition by Pfizer of Metsera, the developer of injectable and oral GLP-1 agonists and other peptides for the treatment of obesity. The $10 billion price tag, ...
timmermanreport.com
November 18, 2025 at 12:35 PM
Wow: powerful & impt Timmerman Report piece by Dr. Amanda Banks abt the (v real) dark side of GLP-1s: exacerbation of eating disorders, as she poignantly discusses (telling us at end about her personal interest in this "as mom of a daughter in recovery"): timmermanreport.com/2025/11/the-...
I assumed this was a pitch-perfect parody; apparently, it’s real…
Sensors and wearables for animals ...
Garmin straps one on the horse's tail and a business model is born
www.garmin.com/en-CA/p/1277...
Garmin straps one on the horse's tail and a business model is born
www.garmin.com/en-CA/p/1277...
November 18, 2025 at 3:16 AM
I assumed this was a pitch-perfect parody; apparently, it’s real…
Reposted by David Shaywitz
In 1582, a papal bull introduced the Gregorian calendar, still used today by most of the world. Because it’s 11 days ahead of the Julian calendar, countries introducing it simply skipped a third of October, and if you scroll back far enough in the iPhone calendar app you can see it change
December 31, 2024 at 2:41 PM
In 1582, a papal bull introduced the Gregorian calendar, still used today by most of the world. Because it’s 11 days ahead of the Julian calendar, countries introducing it simply skipped a third of October, and if you scroll back far enough in the iPhone calendar app you can see it change
Important NYT piece www.nytimes.com/2025/11/16/w... on use of chatbots for health h/t @ruthcoxeter.bsky.social. tl;dr: pts turning to chatbots bc basically they’re available, empathetic-sounding, and often correct or useful-all as foretold by Carey Goldberg (especially) & colleagues in 2023 AI book
www.nytimes.com
November 16, 2025 at 5:34 PM
Important NYT piece www.nytimes.com/2025/11/16/w... on use of chatbots for health h/t @ruthcoxeter.bsky.social. tl;dr: pts turning to chatbots bc basically they’re available, empathetic-sounding, and often correct or useful-all as foretold by Carey Goldberg (especially) & colleagues in 2023 AI book
My biggest recent surprise was learning how many people were getting GLP-1s from semi-official compounders, apparently some even on Amazon (?!). I don't mean for microdosing (also a thing); this is to obtain affordable, regular doses of GLP-1s; not sure anyone is or can track volume but likely huge.
I’m seeing more patients recently taking peptides off label. This is an exceptionally well written review, I found it very helpful in understanding the trend and the (lack of) data around these new and unproven meds
Influencers and celebrities
apnews.com/article/pept...
My recent review of the field
erictopol.substack.com/p/the-peptid...
apnews.com/article/pept...
My recent review of the field
erictopol.substack.com/p/the-peptid...
November 14, 2025 at 8:16 PM
My biggest recent surprise was learning how many people were getting GLP-1s from semi-official compounders, apparently some even on Amazon (?!). I don't mean for microdosing (also a thing); this is to obtain affordable, regular doses of GLP-1s; not sure anyone is or can track volume but likely huge.
ICYMI yesterday & looking4 w/e reading-my new @statnews.com on oppy assoc w expanded GLP1 access-influx of newly-hopeful pts re-engaging w/their health. Huge oppy too for hlth platforms-but only if they embrace hlth vision broader than performance metric optimization www.statnews.com/2025/11/13/w...
This era of weight loss drugs requires a new kind of health platform
How the tech world can support the weight-loss drug revolution.
www.statnews.com
November 14, 2025 at 5:03 PM
ICYMI yesterday & looking4 w/e reading-my new @statnews.com on oppy assoc w expanded GLP1 access-influx of newly-hopeful pts re-engaging w/their health. Huge oppy too for hlth platforms-but only if they embrace hlth vision broader than performance metric optimization www.statnews.com/2025/11/13/w...