Dvir Schirman
@dvirschirman.bsky.social
@EMBOFellows postdoc in @johan_elf_ lab, @UU_University.
Chromosome organization in bacteria. Combining microscopy and large synthetic libraries to study genotype-to-phenotype.
alumnus of @TPilpel lab
Chromosome organization in bacteria. Combining microscopy and large synthetic libraries to study genotype-to-phenotype.
alumnus of @TPilpel lab
Reposted by Dvir Schirman
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Wow! Very impressive work 🤯
October 23, 2025 at 7:21 AM
Wow! Very impressive work 🤯
I tried the previous version on my preprint, and the feedback was pretty impressive and useful 🧐🔬
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 11:08 PM
I tried the previous version on my preprint, and the feedback was pretty impressive and useful 🧐🔬
Reposted by Dvir Schirman
The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment:
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Bioinformatician - Uppsala University
Bioinformatician, Department of Organismal Biology, Uppsala University
www.uu.se
August 12, 2025 at 7:10 AM
The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment:
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Reposted by Dvir Schirman
📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
July 30, 2025 at 10:20 AM
📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Reposted by Dvir Schirman
Just few days left to register for this chromosome biology fête! 🧬🧬🧬
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
July 14, 2025 at 12:47 PM
Just few days left to register for this chromosome biology fête! 🧬🧬🧬
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
"A missile attack is not going to hold back science, science is held back by itself" 🤣
youtube.com/shorts/FMOi-...
youtube.com/shorts/FMOi-...
couldn't complete the assignment, my lab was destroyed | אין מעבדה, תרקדו עכשיו עם כתוביות
YouTube video by Shahar Halevi | שחר הלוי
youtube.com
June 19, 2025 at 1:55 PM
"A missile attack is not going to hold back science, science is held back by itself" 🤣
youtube.com/shorts/FMOi-...
youtube.com/shorts/FMOi-...
I can add my n=2 anecdotal experience.
I suffered a lot from allergies back in Israel, and since moving to Sweden, I'm completely allergy-free 🙌 (but every home visit, they come back with a vengeance!).
My partner had no allergies back home, and here she does 🤧
I suffered a lot from allergies back in Israel, and since moving to Sweden, I'm completely allergy-free 🙌 (but every home visit, they come back with a vengeance!).
My partner had no allergies back home, and here she does 🤧
June 18, 2025 at 11:33 AM
I can add my n=2 anecdotal experience.
I suffered a lot from allergies back in Israel, and since moving to Sweden, I'm completely allergy-free 🙌 (but every home visit, they come back with a vengeance!).
My partner had no allergies back home, and here she does 🤧
I suffered a lot from allergies back in Israel, and since moving to Sweden, I'm completely allergy-free 🙌 (but every home visit, they come back with a vengeance!).
My partner had no allergies back home, and here she does 🤧
This is how you revolutionize science 🕺
#TCTeAC
#TCTeAC
@odedrechavi.bsky.social says he wants to change science for the better.
How? I’m still not quite sure. But 1.5 days into #TCTeAC, the plan seems to involve, among other things, walk-up songs, jumping, dancing, and a hefty serving of joy.
How? I’m still not quite sure. But 1.5 days into #TCTeAC, the plan seems to involve, among other things, walk-up songs, jumping, dancing, and a hefty serving of joy.
June 11, 2025 at 1:46 PM
This is how you revolutionize science 🕺
#TCTeAC
#TCTeAC
🔬
#TCTeAC brought more stickers for day2, find the girl with the lipstick 💄 to get yours! 😉
June 11, 2025 at 8:07 AM
🔬
I used Memrise when I started to learn Swedish (they also have Polish). I don't know if they use AI nowadays, but anyway, they rely a lot on short clips of a variety of native speakers.
www.memrise.com
www.memrise.com
Learn a language. Memrise is authentic, useful & personalised.
Learn a language as it's used now. Immerse yourself in lessons that feature videos of native speakers, so you start speaking real life language, fast.
www.memrise.com
May 12, 2025 at 5:45 AM
I used Memrise when I started to learn Swedish (they also have Polish). I don't know if they use AI nowadays, but anyway, they rely a lot on short clips of a variety of native speakers.
www.memrise.com
www.memrise.com
We got today samples of iSpacer from SunJinLab.
www.sunjinlab.com/ispacer-sele...
It seems promising, although might be a bit too thin on the short side of the rectangle.
I'll update once we've tested it properly.
www.sunjinlab.com/ispacer-sele...
It seems promising, although might be a bit too thin on the short side of the rectangle.
I'll update once we've tested it properly.
iSpacer selection guide – SUNJIN LAB
www.sunjinlab.com
May 7, 2025 at 2:53 PM
We got today samples of iSpacer from SunJinLab.
www.sunjinlab.com/ispacer-sele...
It seems promising, although might be a bit too thin on the short side of the rectangle.
I'll update once we've tested it properly.
www.sunjinlab.com/ispacer-sele...
It seems promising, although might be a bit too thin on the short side of the rectangle.
I'll update once we've tested it properly.
Reposted by Dvir Schirman
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 7:45 AM
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Reposted by Dvir Schirman
There's a lot of joy in doing science and Woodstock Night Science (June 10-13 in Prague) will be a celebration of the science that we know and love. Many exciting talks & innovations that will push the boundaries of what a scientific conference can really do.
woodstock.img.cas.cz Only 40 spots left!
woodstock.img.cas.cz Only 40 spots left!
April 10, 2025 at 1:20 AM
There's a lot of joy in doing science and Woodstock Night Science (June 10-13 in Prague) will be a celebration of the science that we know and love. Many exciting talks & innovations that will push the boundaries of what a scientific conference can really do.
woodstock.img.cas.cz Only 40 spots left!
woodstock.img.cas.cz Only 40 spots left!
We are using them, and also our neighboring lab.
Johan Elf & Magnus Johansson labs, Uppsala University, Sweden
Johan Elf & Magnus Johansson labs, Uppsala University, Sweden
April 9, 2025 at 3:57 PM
We are using them, and also our neighboring lab.
Johan Elf & Magnus Johansson labs, Uppsala University, Sweden
Johan Elf & Magnus Johansson labs, Uppsala University, Sweden
Reposted by Dvir Schirman
Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy!
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Live Cell Imaging of Bacillus subtilis and Streptococcus pneumoniae using Automated Time-lapse Microscopy
42.1K Views. University of Groningen. This protocol provides a step-by-step procedure to monitor single cell behavior of different bacteria in time using automated fluorescence time-lapse microscopy....
www.jove.com
April 8, 2025 at 1:26 PM
Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy!
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Good chance you already listen to it, but if not @dancarlin.bsky.social Hardcore History is the best recommendation. Very long series each of them basically an audio book. Wrath of the Khans on the mongol empire would be a great start
April 3, 2025 at 9:29 AM
Good chance you already listen to it, but if not @dancarlin.bsky.social Hardcore History is the best recommendation. Very long series each of them basically an audio book. Wrath of the Khans on the mongol empire would be a great start
Reposted by Dvir Schirman
We are looking for a postdoc with microbiology background for #superresolution #singlemolecule #ERC tracking project. Apply by 27.4.2025. 🦠🔬🧫
Pls share!
www.aalto.fi/en/open-posi...
Pls share!
www.aalto.fi/en/open-posi...
April 1, 2025 at 7:30 AM
We are looking for a postdoc with microbiology background for #superresolution #singlemolecule #ERC tracking project. Apply by 27.4.2025. 🦠🔬🧫
Pls share!
www.aalto.fi/en/open-posi...
Pls share!
www.aalto.fi/en/open-posi...
Reposted by Dvir Schirman
New on #biorXiv: 'Inferring single-cell heterogeneity of bacteriophage life-history traits from population-scale dynamics'. A theory-experiment collaboration, led by @mariandm.bsky.social + Ran Tahan w/the Lindell group at Technion (and yes, I am excited).
a 🧵
www.biorxiv.org/contenat/10....
a 🧵
www.biorxiv.org/contenat/10....
March 26, 2025 at 2:29 PM
New on #biorXiv: 'Inferring single-cell heterogeneity of bacteriophage life-history traits from population-scale dynamics'. A theory-experiment collaboration, led by @mariandm.bsky.social + Ran Tahan w/the Lindell group at Technion (and yes, I am excited).
a 🧵
www.biorxiv.org/contenat/10....
a 🧵
www.biorxiv.org/contenat/10....
Reposted by Dvir Schirman
1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome duplication in a long-term multicellularity evolution experiment - Nature
In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...
www.nature.com
March 5, 2025 at 11:00 PM
1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dvir Schirman
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Dvir Schirman
Hi folks, I'm excited to share a whale of a tale (sorry, bad pun), where we engineer snowflake yeast to express sperm whale myoglobin, and explore how oxygen-binding proteins may have helped overcome anatomical limitations to early multicellularity. 🧪 #MEvoSky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
January 30, 2025 at 8:42 PM
Hi folks, I'm excited to share a whale of a tale (sorry, bad pun), where we engineer snowflake yeast to express sperm whale myoglobin, and explore how oxygen-binding proteins may have helped overcome anatomical limitations to early multicellularity. 🧪 #MEvoSky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Dvir Schirman
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 4:30 AM
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫