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Reposted by Emilie Wigdor

Nik Baya @nbaya.bsky.social · Sep 4

Read about our recent paper here: www.bdi.ox.ac.uk/news/first-d...

First direct evidence links gene to fat storage, hinting at new obesity therapies

A new study, involving researchers at the Big Data Institute, has shown for the first time that a little-known gene, SLTM, plays a direct role in how fat is stored inside human cells. While large popu...

www.bdi.ox.ac.uk

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Reposted by Emilie Wigdor

Nik Baya @nbaya.bsky.social · Sep 4

✨ NEW PUBLICATION ✨

We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.

Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

Overall and tissue-specific fat accumulation are associated with altered risk of cardiometabolic disease and mortality. By combining exome-wide association analysis of traits related to obesity and fa...

www.cell.com

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Emilie Wigdor @emiliewigdor.bsky.social · Jul 21

New app deadline August 1st 📣

If you're interested in human genetics, stats, big data, and/or ML, this is in an incredible opportunity 🧬💻

✨Fully funded ✨ PhD at Oxford with @astheeggeggs.bsky.social, available to international students 🌎🌍🌏, embedded in the new and exciting SMARTBiomed Centre 🤩

Duncan Palmer @astheeggeggs.bsky.social · Jun 9

Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford.
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!

Research Studentships | statistics

bit.ly

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Emilie Wigdor @emiliewigdor.bsky.social · Jun 11

Incredible opportunity for international and domestic students to do a PhD in stat gen at Oxford in a dynamic, engaging, fun and supportive environment! 🤩🧬🎓

Apply by June 30th for an October 2025 start!

Duncan Palmer @astheeggeggs.bsky.social · Jun 9

Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford.
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!

Research Studentships | statistics

bit.ly

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Reposted by Emilie Wigdor

Nicky Whiffin @nickywhiffin.bsky.social · May 24

It's #eshg2025 #eshg25 time 🥳

Here is where you can catch the team over the next few days.

Please go and say hi!

A flyer advertising four talks and one poster:
Yuyang Chen - 11:30am Saturday 24th; talk (C01) - De novo variants in small open reading frames harbour new rare disease diagnoses
Anthony McGuigan - 6:45pm Saturday 24th; talk (C09) - Gene knockouts across 120,404 individuals for novel rare disease gene discovery
François Lecoquierre - 7:15pm Saturday 24th; talk (C09) - A map of predicted pseudoexons in human genes
Hyung Chul Kim - 1pm Sunday 25th; poster (P18.006.A) - Rare variant association study reveals small open reading frames (smORFs) as novel regulators of cardiometabolic diseases
Nicky Whiffin - 10:30am Monday 26th; talk (C29) - Saturation genome editing of RNU4-2 reveals distinct dominant and recessive neurodevelopmental disorders

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Reposted by Emilie Wigdor

Angelica Ronald @angelicaronald.bsky.social · May 7

Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...

www.nature.com

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King's Perinatal Functional Imaging Group, Tomoki Arichi @kingspfig.bsky.social · May 8

Very excited about this important piece of work with @angelicaronald.bsky.social characterising gene associations with age of walking onset. We also show using dHCP data that these are related to volume in key brain motor regions (like the deep grey nuclei and cerebellum) even as a newborn infant

Angelica Ronald @angelicaronald.bsky.social · May 7

Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...

www.nature.com

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Reposted by Emilie Wigdor

Centre for Personalised Medicine @cpmoxford.bsky.social · Apr 30

We have two vacancies for Junior Research Fellows to join the CPM team next academic year. Please repost and send to anyone who might be interested. shorturl.at/DOV5s

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Samvida Venkatesh @samvidav.bsky.social · Apr 14

Delighted to share that the revised version of this work on the genetic basis of infertility is now out in @naturegenet.bsky.social ! Give it a read and let us know what you think - rdcu.be/ehEgG 🧬💻

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Sarah Briggs @sarahbriggs.bsky.social · Feb 13

This is going to be a great lecture, do come along to the Sheldonian this afternoon to hear @philipcball.bsky.social

Centre for Personalised Medicine @cpmoxford.bsky.social · Feb 6

There's just 1 week to go until our Annual Lecture from @philipcball.bsky.social at the Sheldonian Theatre, 'How life works: Dealing with biology’s changing narrative'.
All welcome! You can register here: cpm.ox.ac.uk/event/cpm-an...

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Reposted by Emilie Wigdor

Sophie Belman @sophiebelman.bsky.social · Feb 9

I’m racing a Half Ironman triathlon this June. 2km swim, 90km cycle, 20km run and raising money for the Meningitis Research Foundation.
Meningitis has ~2.5 million cases and 250,000 deaths annually predominantly among children. Any donation would be great!

gofund.me/a958252f

Donate to Half Iron(wo)man for Meningitis Research, organized by Sophie Belman

I will be racing my first Half Ironman triathlon in Zurich this June. It includ… Sophie Belman needs your support for Half Iron(wo)man for Meningitis Research

gofund.me

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Reposted by Emilie Wigdor

Coleman Research Group (KCL) @coleman-group-kcl.bsky.social · Jan 14

V. pleased to see this work out — huge effort from 10s of analysts, 100s of scientists, 1000000s of participants. 🤞 a key resource in future MDD research.

🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.

Read all about it below.

Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · Jan 14

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.

www.cell.com/cell/fulltex...

A thread 🧵:

Article screenshot of a genome-wide association study of major depression published in the journal Cell

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Reposted by Emilie Wigdor

Barney Hill @barneyhill.bsky.social · Dec 18

Ever get lost searching through genetic literature? We've built a new interface for bioRxiv+medRxiv to directly browse preprint findings on the genome! (1/N)

Try genorxiv: sitlabs.org/genorxiv

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Reposted by Emilie Wigdor

Institute of Developmental & Regenerative Medicine @idrm.ox.ac.uk · Nov 25

Meet Michael Griffiths, our most recent featured member.
Currently a Data Manager in the Sanders Group, Michael's varied career includes writing code on research vessels around the world to help understand the effects of oceans on the climate.
Find out more here: lnkd.in/erJXmd6k

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Reposted by Emilie Wigdor

Institute of Developmental & Regenerative Medicine @idrm.ox.ac.uk · Dec 11

📢 Huge News! 📢

The MRC has launched two centres of research excellence to transform gene therapies: IDRM’s Paul Riley will co-direct the MRC/BHF CoRE in Advanced Cardiac Therapies & Stephan Sanders will direct the MRC CoRE in Therapeutic Genomics.
Read more: lnkd.in/g-3CmAsP
#GeneTherapies

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Emilie Wigdor @emiliewigdor.bsky.social · Nov 27

Thanks, Sarah!!

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Centre for Personalised Medicine @cpmoxford.bsky.social · Nov 26

A mere starting point, we're sure. Please use, and add to.

go.bsky.app/KuUsm35

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Genetics Society UK @gensocuk.bsky.social · Nov 22

Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...

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Emilie Wigdor @emiliewigdor.bsky.social · Nov 25

Congratulations, Nicky!!! So well deserved - thrilled to bits for you! 🍾🎉

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Nicky Whiffin @nickywhiffin.bsky.social · Nov 22

Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬

But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
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Genetics Society UK @gensocuk.bsky.social · Nov 22

Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...

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Reposted by Emilie Wigdor

Carl Anderson @carlanderson.bsky.social · Nov 22

Common variants don’t contribute to rare diseases, right? Wrong! Wonderful work published in Nature by @hilarycmartin.bsky.social, Qinqin Huang, @emiliewigdor.bsky.social and others in the Human Genetics Programme at Sanger showing that common vars contribute to rare neurodevelopmental diseases.

Hilary Martin @hilarycmartin.bsky.social · Nov 20

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.

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Emilie Wigdor @emiliewigdor.bsky.social · Nov 21

Thanks, Kartik!! 😊 Still remember us debugging code for this over Zoom in the lockdown days. Thank god for post-docs like you and @qinqinhuang.bsky.social ♥️

Emilie Wigdor @emiliewigdor.bsky.social · Nov 21

Thanks, Leo!

Emilie Wigdor @emiliewigdor.bsky.social · Nov 21

Thanks, Varun! It was great working together on this—your contributions were really appreciated, and they made a big difference!

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Emilie Wigdor @emiliewigdor.bsky.social · Nov 21

Thanks so much, Joanna! Great to hear that the FAQ and lay summary are useful, too—starting to untangle this has definitely been a team effort!

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