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Manuel Collado @manuel-collado.bsky.social · 5d

Sad to hear about the passing of John Gurdon, a titan and pioneer of developmental biology and much more. Winner of the Nobel Prize in Medicine or Physiology, shared with Shinya Yamanaka, who actually was inspired by his work
www.cam.ac.uk/research/new...

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

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Waggoner Lab @labwaggoner.bsky.social · 9d

Review @sciimmunology.bsky.social @platten-lab.bsky.social
@dkfz.bsky.social
The immunology of brain tumors
www.science.org/doi/10.1126/...

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Nature Communications @natcomms.nature.com · 10d

Diabetes-induced senescence of endothelial cells shown to promote pancreatic cancer progression doi.org/10.1038/s414...

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Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · 13d

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Johan Duchêne @johanduchene.bsky.social · 13d

PARKIN labels damaged mitochondria for recycling
No PARKIN → no cleanup → neurodegeneration
Mutations in PARK2 are common in Parkinson’s disease

Accurate detection of PARKIN is crucial

Problem:
The most used antibodies are not selective
In contrast, some very specific antibodies are not used

Parkin antibody screening by immunoblot.
Lysates of SH-SY5Y (WT and PRKN KO) were prepared and 50 μg of protein were processed for immunoblot with the indicated Parkin antibodies. The Ponceau stained transfers of each blot are shown. Antibody dilution used: 702785 at 1/200; 711820 at 1/200; 39-0900 at 1/500; ab77924 at 1/200; ab15954 at 1/500; 14060-1-AP at 1/1000; MAB1438 at 1/250; MAB14381 at 1/500; GTX39745 at 1/1000; GTX65811 at 1/1000. Predicted band size: 52 kDa.

Which antibody should you choose then?

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Centro de Biología Molecular Severo Ochoa @cbm-csic-uam.bsky.social · 13d

🎥🔬 50 años descodificando la vida.
Descubre en este video cómo el CBM ha marcado la biomedicina en España y el mundo, formando talento y generando ciencia de impacto.
#CincuentenarioCBM #DecodingLife youtu.be/7bzJOIW5kyM

Cincuentenario del Centro Biología Molecular Severo Ochoa - Decoding life

YouTube video by Centro de Biología Molecular Severo Ochoa

youtu.be

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Nature @nature.com · Sep 4

Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth

go.nature.com/4lZtawb

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

go.nature.com

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Javier DN @javierdn.bsky.social · Aug 30

José Antonio Marina (86 años), catedrático de filosofía: “Un amigo de verdad es el que te hace mejor. Y si no te hace mejor, no es un amigo, es otra cosa”

www.cuerpomente.com/psicologia/j...

José Antonio Marina (86 años), catedrático de filosofía: “Un amigo de verdad es el que te hace mejor. Y si no te hace mejor, no es un amigo, es otra cosa”

¿Qué significa tener un buen amigo? ¿Cuál es el verdadero valor de la amistad? ¿Y cómo deberíamos cultivar nuestras relaciones de amistad para hacerlas verdaderamente significativas? El filósofo José ...

www.cuerpomente.com

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Waggoner Lab @labwaggoner.bsky.social · Aug 6

Hematopoietic loss of Y chromosome leads to immune inhibitory receptor up-regulation, impairing senescent cell clearance
www.science.org/doi/10.1126/...

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CSIC @csic.es · Aug 4

🔬Un estudio del CSIC demuestra que el deterioro asociado a la edad de los linfocitos T CD4 debilita la barrera intestinal y favorece la inflamación crónica y el envejecimiento celular

💉 El trabajo también presenta una posible terapia

➡️ https://tinyurl.com/97ssrv74

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Enrique Gabandé Rodríguez @enriquegab.bsky.social · Aug 2

@cbm-csic-uam.bsky.social

Reposted by Enrique Gabandé Rodríguez

Jorge Oller Pedrosa PhD. 🫀🪸🐭🔬🧫🧑‍🧑‍🧒‍🧒🏳️‍🌈 @jorgeoller.bsky.social · Jul 30

Our paper is here online! EHJ . Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response url: academic.oup.com/eurheartj/ar...

Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response

AbstractBackground and Aims. Thoracic aortic aneurysms and dissections (TAADs) are depicted by aortic medial degeneration characterized by glycan-rich matr

academic.oup.com

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Enrique Gabandé Rodríguez @enriquegab.bsky.social · Aug 2

Manu got the cover on our lab latest publication. Congratulations @mmgomezheras.bsky.social . So much deserved!

Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

www.science.org

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Elisa Carrasco @ecarrascouam.bsky.social · Aug 1

Especially excited to share this research led by @mmgomezheras.bsky.social ! 🤩 We show that a competent CD4+ T cell compartment is key to fostering host-microbiota mutualism and maintaining intestinal barrier integrity, becoming crucial to prevent inflammaging www.science.org/doi/10.1126/...

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

www.science.org

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Jose M. Adrover @adrover.bsky.social · Jul 17

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Centro de Biología Molecular Severo Ochoa @cbm-csic-uam.bsky.social · May 9

Hoy nos ha visitado Nina Cabezas-Wallscheid (ETH Zurich) para dar un seminario organizado por nuestro comité de Predocs & Postdocs. Nos ha hablado de cómo los componentes de la dieta influyen en la regulación metabólica y epigenética de las células madre hematopoyéticas en estado latente.

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Centro de Biología Molecular Severo Ochoa @cbm-csic-uam.bsky.social · May 7

Investigadores del Hospital 12 de Octubre y del CBM, junto a otros colaboradores, descubren porqué aumenta el riesgo de padecer un grupo de enfermedades hematológicas crónicas como las leucemias. www.cbm.uam.es/index.php/20...

Descubren porqué aumenta el riesgo de padecer un grupo de enfermedades hematológicas crónicas. - Centro de Biología Molecular Severo Ochoa

Una investigación liderada por el Hospital público 12 de Octubre de la Comunidad de Madrid en colaboración con el Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM), ha descubierto el motivo […]

www.cbm.uam.es

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Elisa Carrasco @ecarrascouam.bsky.social · May 3

Check out the most recent publication of our team at @cbm-csic-uam.bsky.social. Thanks to #GonzaloSoto-Heredero @enriquegab.bsky.social and all the team! www.nature.com/articles/s43...

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging - Nature Aging

T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate with age in both ...

www.nature.com

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Centro de Biología Molecular Severo Ochoa @cbm-csic-uam.bsky.social · Apr 25

Investigadores del grupo de Felipe X. Pimentel han identificado un mecanismo que podría potenciar la inmunoterapia frente al cáncer. Han hallado conexiones inesperadas entre la muerte celular programada y la autofagia o ‘autocanibalismo’ celular.
www.cbm.uam.es/index.php/20...
@csic.es @uam.es

Identificado un mecanismo que podría potenciar la inmunoterapia frente al cáncer - Centro de Biología Molecular Severo Ochoa

Un equipo del Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) ha hallado un mecanismo celular que podría potenciar la respuesta inmune del organismo frente al cáncer. La investigación, que ap...

www.cbm.uam.es

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María A. Moro @mariangelesmoro.bsky.social · Apr 21

Amazing talk on “New insights into the anatomy of ‘brainwashing’” by Jonathan Kipnis @jonykipnis.bsky.social from @washumedicinebsky.social at #CNIC today 🙇🏼‍♀️🙇🏼‍♀️👏🏻👏🏻👏🏻👏🏻

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Jason Moore @moorejh.bsky.social · Apr 20

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines www.nature.com/articles/s41... #vaccines #immunology #virology

Combating vaccine revisionism - Nature Medicine

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.

www.nature.com

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Waggoner Lab @labwaggoner.bsky.social · Mar 28

NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma @bloodjournal.bsky.social
doi.org/10.1182/bloo...

NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma

Key Points. CD4 CTLs are significantly increased and clonally expanded in the bone marrow of patients with multiple myeloma.CD4 CTLs directly kill myeloma

doi.org

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