Fabrizio Musacchio
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fabmusacchio.bsky.social
Fabrizio Musacchio
@fabmusacchio.bsky.social
Hi 👋 I'm a postdoc in the #Neuroimmunology and #Imaging group at the @dzne.science Bonn 🧪🔬 Passionate about #ComputationalNeuroscience 🧠💻 and #NeuralModeling 🧮

🌍 fabriziomusacchio.com
👨‍💻 github.com/FabrizioMusacchio
🐘 sigmoid.social/@pixeltracker
Reposted by Fabrizio Musacchio
Excited to see the paper fully published. It's an important milestone for training SNNs with exact gradients, replacing our earlier tricks of a "delay line augmentation" to capture temporal relationships. Delays can now be learnt alongside weights naturally. Amazing work @mbalazs98.bsky.social !
November 25, 2025 at 6:24 PM
Reposted by Fabrizio Musacchio
🚀 Introducing TMLR Beyond PDF!

🎬 This is a new, HTML-based submission format for TMLR, that supports interactive figures and videos, along with the usual LaTeX and images.

🎉 Thanks to TMLR Editors in Chief: Hugo Larochelle, @gautamkamath.com, Naila Murray, Nihar B. Shah, and Laurent Charlin!
November 25, 2025 at 4:12 PM
Reposted by Fabrizio Musacchio
(recycled form X @ 2021)

Are you interested in the dimensionality of neural data, but missed our #BernsteinConference workshop?

Worry not!

Instead, join me in this long thread (1/37) attempting to summarise it and (my view of) the field more broadly.
an aerial view of a large body of water surrounded by rocky shoreline
ALT: an aerial view of a large body of water surrounded by rocky shoreline
media.tenor.com
December 11, 2024 at 3:00 PM
Reposted by Fabrizio Musacchio
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
www.biorxiv.org
November 23, 2025 at 1:38 PM
Reposted by Fabrizio Musacchio
Dysfunctional oscillatory bursting patterns linked to working memory in adolescents with attention deficit hyperactivity disorder
link.springer.com/article/10.3...
#neuroscience
Dysfunctional oscillatory bursting patterns linked to working memory in adolescents with attention deficit hyperactivity disorder - Cognitive, Affective, & Behavioral Neuroscience
Background Identifying neural markers of clinical symptom fluctuations is prerequisite to developing more precise brain-targeted treatments in psychiatry. We have recently shown that working memory (W...
link.springer.com
November 22, 2025 at 7:44 PM
Reposted by Fabrizio Musacchio
Elevated DNA damage without signs of ageing in the short-sleeping Mexican cavefish offers a unique model to study sleep, DNA repair, and ageing.
buff.ly/6VrO19l
November 21, 2025 at 9:01 PM
Reposted by Fabrizio Musacchio
Happy #FluorescenceFriday. This beautiful video shows slice by slice section of a zebrafish embryo's head. The embryo is almost completely transparent, proving that zebrafish is an amazing model system for microscopy.
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
November 21, 2025 at 5:34 PM
Reposted by Fabrizio Musacchio
Looking for a postdoc to understand dynamic vision in action in freely moving mice? Get in touch!

This is a @erc.europa.eu postdoc in a project between us and @sinzlab.bsky.social: miniature 2-photon, rich behavior tracking, and deep learning models linking natural behavior to cortical activity|RT
🔬 Exciting PostDoc Opportunity! 🐁🧠

We - the @sinzlab.bsky.social (sinzlab.org) and @trose-neuro.bsky.social (troselab.de) Labs - are seeking an experimental postdoc to work at @unibonn.bsky.social with cutting-edge miniature 2-photon microscopy and gaze tracking in freely behaving mice.
November 21, 2025 at 5:49 PM
Reposted by Fabrizio Musacchio
𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗶𝗺𝗽𝗹𝗲𝗺𝗲𝗻𝘁 𝗱𝗲𝗰𝗶𝘀𝗶𝗼𝗻𝘀 𝗶𝗳 𝘁𝗵𝗲𝗿𝗲 𝗶𝘀 𝗻𝗼 "𝗰𝗲𝗻𝘁𝗿𝗮𝗹 𝗲𝘅𝗲𝗰𝘂𝘁𝗶𝘃𝗲" (𝗮𝗸𝗮 𝗵𝗼𝗺𝘂𝗻𝗰𝘂𝗹𝘂𝘀)?
Via Decision Formation Through Multi-Area Population Dynamics
Excellent short review.
doi.org/10.1523/JNEU...
#neuroskyence
November 20, 2025 at 8:37 PM
Reposted by Fabrizio Musacchio
🔔 NEW PREPRINT FROM THE LAB ‼️
We introduce a new ML model, LoRAX, for predicting olfactory responses from chemical features, a tricky problem that benefits from progress in ML for biochem. We combine LoRA fine-tuning with protein and chemical foundation models, www.biorxiv.org/content/10.1...
Low rank adaptation of chemical foundation models generate effective odorant representations
Featurizing odorants to enable robust prediction of their properties is difficult due to the complex activation patterns that odorants evoke in the olfactory system. Structurally similar odorants can ...
www.biorxiv.org
November 20, 2025 at 1:38 PM
Reposted by Fabrizio Musacchio
Are you interested in visuo-motor mismatch and serotonin? Come see @norambr.bsky.social featuring mice spinning in VR at R16!

#SfN2025 #vestibulo-VR #serotonin #predictive_processing
November 19, 2025 at 9:04 PM
Reposted by Fabrizio Musacchio
"A unifying conclusion from both studies is that behaviour emerges from rapid consensus across different brain regions... No single individual is responsible for a group decision, and correlates of upcoming decisions are detectable throughout populations."

Great review by @timothyoleary.bsky.social
my little take on whole-brain neurophysiology and what it tells us about global coordination of neural activity on behavioural timescales

(I steered clear of tasteless analogies for this one...)

authors.elsevier.com/a/1m7H5_LsQS...
authors.elsevier.com
November 19, 2025 at 2:19 PM
Reposted by Fabrizio Musacchio
We're presenting Miniscope Zero, the first fully-wireless Miniscope, at #SfN25! Wireless power + data enable long-term neural recordings from multiple freely behaving animals. @MiniscopeTeam

Poster: Nov. 17, 1–5 pm, ZZ7
Info: tinyurl.com/mhdfb67u
Full video: youtu.be/mIt15LA-rZI?...
November 16, 2025 at 5:57 PM
Reposted by Fabrizio Musacchio
🛑 Researchers often use a personal email for submissions so they can stay contactable.

✅ What's best is to add an institutional email your ORCID record so publications + funders collecting authenticated iDs in their processes can use the #TrustMarker assoc. w/ the institutional domain

More👇
Add a verified institutional email domain to your record
Introduction We believe ORCID records have an important role to play in helping uphold the integrity of research since the data in them can be shared widely and re-used within a growing number of s...
support.orcid.org
November 18, 2025 at 3:01 PM
Reposted by Fabrizio Musacchio
🧠DENDRITES 2026 is OPEN for registration & abstracts!

Join us in Heraklion, Crete (May 19-22, 2026) for the 6th EMBO Workshop on Dendrites & Network Processing.

🗓️ Abstract Deadline: Feb 1, 2026 🔗 Register & Submit: meetings.embo.org/event/26-den...

#Dendrites2026 #Neuroscience #EMBO #Crete
Dendrites and beyond: properties, function and contributions to network processing
Understanding how the brain generates perception and behavior remains a major challenge in neuroscience. Neurons communicate through synaptic inputs located on dendrites, complex, highly branched str…
meetings.embo.org
November 17, 2025 at 9:18 AM
Reposted by Fabrizio Musacchio
6. The AI scientist took 45 minutes and $8.25 in LLM tokens to find a new tuning equation that fits the data better, and predicts the population code’s high-dimensional structure – even though we had only tasked it to model single-cell tuning.
November 14, 2025 at 6:07 PM
Reposted by Fabrizio Musacchio
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
November 14, 2025 at 5:45 PM
Reposted by Fabrizio Musacchio
Ending my #FluorescenceFriday with this beautiful avian retina image depicting the beautiful stratification in the avian eyes.
This is where complexity meets art.
#retina #avian #bird #plexiformlayer
November 14, 2025 at 4:18 PM
Reposted by Fabrizio Musacchio
New paper out: Heterogeneous plasticity of amygdala interneurons in associative learning and extinction: Favila, Natalia; Capece Marsico, Jessica; Pacheco, Catarina M.; et al.
Nature Communications Vol. 16, no. 1, p. 9926
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
Favila, Natalia; Capece Marsico, Jessica; Pacheco, Catarina M.; et al. Nature Communications Vol. 16, no. 1, p. 9926
pub.dzne.de
November 14, 2025 at 12:32 PM
Reposted by Fabrizio Musacchio
I have updated my "Optimal Transport for Machine Learners" repository with a Pytorch illustration of Wasserstein gradient flows on pairwise interaction functionals (MMD distances) github.com/gpeyre/ot4ml
November 14, 2025 at 10:56 AM
Reposted by Fabrizio Musacchio
Migration of cell populations is a fundamental process in morphogenesis and disease. Researchers have identified a novel form of collective mesenchymal cell migration during chick gastrulation, where cells self-organise into a dynamic meshwork structure.
buff.ly/JDp0rUo
November 14, 2025 at 9:21 AM
Reposted by Fabrizio Musacchio
Driving science, sharing and technology --- a review of the impact of a cortical microcircuit model on the fields of computational neuroscience and neuromorphic computing, a decade after its publication:
doi.org/10.1093/cerc...
November 14, 2025 at 7:28 AM
Reposted by Fabrizio Musacchio
🗓️ Mark your calendars: the next #BernsteinConference will take place September 28 to October 1, 2026, in Frankfurt am Main!

Follow the link below to meet the first confirmed speakers. More to come!

👉 bernstein-network.de/bernstein-co...

#BernsteinNetwork #CompNeuro
November 13, 2025 at 8:00 AM
Reposted by Fabrizio Musacchio
How “intelligent” is a slime mold? When it solves mazes, it might not be thinking:it’s obeying physics. Our new paper with
@jordiplam.bsky.social shows how it follows a least action principle,letting physics do the job arxiv.org/pdf/2511.08531
@drmichaellevin.bsky.social @docteur-drey.bsky.social
November 12, 2025 at 4:17 AM