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Reposted by Frank

Bas Heijne @basheijne.bsky.social · 47m

29 oktober: stem vóór de democratie.

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Frank @frankdejong.bsky.social · 3h

You seem surprised? They are republicans.

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Frans Timmermans @franstimmermans.groenlinkspvda.nl · 3h

Trump eist schreeuwend dat Poetin van Oekraïne moet krijgen wat hij wil: controle over bijna de gehele Donbas. En anders volgt ‘vernietiging’. Compleet ontoelaatbare taal en even onaanvaardbare eisen. Wij moeten pal naast president Zelensky gaan staan.

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Chise @sailorrooscout.bsky.social · 7d

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

HIGHLIGHTS
•Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons
• NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells
• NPs improve tumor-free outcomes with memory against multiple aggressive tumor models
SUMMARY
We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines.
Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other
proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages.
Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells.

Graphical Abstract

The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.

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Casper Albers 🟥 @casperalbers.nl · 5h

Misschien, heel misschien, vonden we zorg al die tijd al wel gewoon superbelangrijk en hadden de journalisten dat niet goed door omdat ze als een kip zonder kop achter Geert aan holden

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Frank @frankdejong.bsky.social · 3h

These farmers didn't just vote against their interests—they voted for their own extinction, and now they're living with the consequences.
Sometimes the cruelest teacher is experience itself.

Frank @frankdejong.bsky.social · 3h

Perhaps this is democracy's harshest lesson: you can vote your way into oblivion. The question is whether the electorate learns from this cautionary tale, or whether we simply wait for economic Darwinism to run its course.

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Frank @frankdejong.bsky.social · 3h

in a perverse echo of the immigrant labor force they once employed.
And now, facing ruin, where do they turn? To the government subsidies they've long derided as socialism. To the safety net they voted to dismantle for others.

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Frank @frankdejong.bsky.social · 3h

The bitter irony deepens when we see wealthy investors—including political figures and their associates—positioning themselves to acquire foreclosed farmland at bargain prices. The very people who worked the soil for generations may soon find themselves as employees on land they once owned,

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Frank @frankdejong.bsky.social · 3h

The Harvest of Their Own Votes

These farmers were not blind to what they were choosing. The ballot boxes told the story, and they cast their votes accordingly. Now they're confronting the stark reality of a Republican agenda they helped empower.

Mark Bauer @thepurplebauer.bsky.social · 8h

Good job Trump, try some more tariffs!

Kansas, Missouri farmers went big for Trump. His tariffs are gutting them | Opinion — The Kansas City Star

China was Kansas and Missouri farmers’ biggest buyer of soybeans and milo or sorghum. Donald Trump’s tariffs destroyed that market and Brazil is stepping in.

apple.news

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Frank @frankdejong.bsky.social · 18h

Helemaal mee eens.

Frank @frankdejong.bsky.social · 18h

Dat is toch wel een terugkerende factor, de Telegraaf, al 132 jaar bruin.

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Straight w/o Hate @dellrecycles.bsky.social · 20h

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Levi @levi98k.bsky.social · 19h

En dit soort dingen normaliseren het.
bsky.app/profile/myrt...

Myrthe Hilkens @myrthehilkens.bsky.social · 20h

Zeg NOS; waarom leek het jullie een goed idee om een promotiefilm voor Forum voor Democratie te maken zonder ENIGE factcheck? Luchtiges het principe van remigratie toelichten. Echt man… anders doe er meteen een rode loper bij. Volledig van de pot gerukt.

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Levi @levi98k.bsky.social · 21h

Een compilatie van wat er zoal rondgaat in de groepen waarvan leden aanwezig zijn bij de "anti-immigratieprotesten".

We hebben een naziprobleem in Nederland.

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Frank @frankdejong.bsky.social · 19h

Vergeet de LPF niet.

Reposted by Frank

reijer hendrikse @reijer.bsky.social · 1d

Again, where the US pushes private crypto schemes and prohibits digitization of dollar, China pushes its digital yuan by prohibiting private crypto.

Seems pretty obvious who is going to win this battle.

"Chinese tech giants pause stablecoin plans after Beijing steps in" - on.ft.com/46YTWR5 via @FT

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Frank @frankdejong.bsky.social · 2d

Hegseth's "highest male standard"

Paulley Ticks @tomadelsbach.bsky.social · 2d

One thing's for certain, if there ever really was such a thing as a "Master Race" - these human bloatation devices would've finished last in it.

#YoungRepublicans

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Frank @frankdejong.bsky.social · 2d

Beautiful kids 🤭

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Frank @frankdejong.bsky.social · 2d

Verstandige vent die Hoebink.

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Frank @frankdejong.bsky.social · 2d

😂👍

Frank @frankdejong.bsky.social · 2d

Mooi artikel, dank.

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Kai Arzheimer @kai-arzheimer.com · 2d

The latest @wired.com cover is a work of art

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Chris Klomp @chrisklomp.nl · 3d

Nieuw verhaal. 'Als ergens in Nederland de onvrede opborrelt, steekt Wierd Duk er wellustig zijn toetsenbord in. Hoe onwelriekend die ophef ook is: chrisklomp.nl/de-hypocrisi...

De hypocrisie van Wierd Duk - Chris Klomp

Propagandist van de Telegraaf Wierd Duk staat op verschillende manieren in de belangstelling. Zo werd onlangs duidelijk dat hij veel minder als journalist gaat werken en meer als opiniemaker. Een vers...

chrisklomp.nl

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Frank @frankdejong.bsky.social · 2d

Het is werkelijk onbestaanbaar, wat maakt nou dat die @vvdonline.bsky.social, van een beetje rechtse maar verder ongevaarlijke en toch verantwoordelijke sukkelaars, verworden is tot zo'n afbraakclub met klaarblijkelijk geen enkel greintje verantwoordelijkheidsgevoel. I'm lost.

Sander Schimmelpenninck @schimmelpenninck.bsky.social · 2d

Eerst de deur open naar de PVV, nu de deur dicht naar wat Wiegel ooit een ‘Nationaal Kabinet’ noemde. Wat een miserabele kleuters bij de VVD.

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