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Gregor Hagelueken

@gha14.bsky.social

92 followers 120 following 8 posts

Structural Biologist. Likes Proteins - most of the time.

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Gregor Hagelueken @gha14.bsky.social · Nov 15

Yesterday my student Niels Schneberger successfully defended his PhD thesis! Congratulations Niels and thanks for everything. What a journey!

Reposted by Gregor Hagelueken

Cluster of Excellence ImmunoSensation @immunosens.bsky.social · May 22

Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉

www.immunosensation.de/news/immunos...

Excellence Strategy Funds Bonn Cluster for Immune Research

The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…

www.immunosensation.de

Reposted by Gregor Hagelueken

Universität Bonn @unibonn.bsky.social · May 22

A landmark success! The University of Bonn secured funding for all six existing Clusters of Excellence and both new initiatives – more than any other German university. More: www.uni-bonn.de/en/news/095-...

© G. Hübl, V. Lannert, M. Thürbach/ECONtribute, J. F. Saba/UKB, S. Wegener/ML4Q; N. Wietrich

A collage with symbolic images of all eight clusters of excellence. A man working on a machine, an observatory, two people in a field, a woman writing something on a piece of paper, a woman in front of a device, a man writing something on a blackboard, an exhibition, a woman looking through a telescope.

Gregor Hagelueken @gha14.bsky.social · May 18

Thanks to @biancabroske.bsky.social , @scbinder.bsky.social , @tim-kempchen.bsky.social and all the other authors for a fantastic collaboration. A big thank you goes to the developers of #RFdiffusion, #Chroma, #Bindcraft and others to make these amazing algorithms available.

Gregor Hagelueken @gha14.bsky.social · May 18

We created a number of high affinitiy and highly specific #AI-Binders against several cancer surface proteins and converted them into easy to use #FACS reagents that we termed #Quattrobinders.

Gregor Hagelueken @gha14.bsky.social · May 18

In close collaboration with the @mholzel-lab.bsky.social and @jsb-lab.bsky.social labs, we setup a scaleable AI-Binder design and validation pipeline.

Gregor Hagelueken @gha14.bsky.social · May 18

When we saw the first tweats about #RFdiffusion and #Chroma, we wanted to try if we can apply these tools to our own research.
Have a look at our preprint and learn what worked out of the box and what didn't.

Gregor Hagelueken @gha14.bsky.social · May 18

Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

www.biorxiv.org

Reposted by Gregor Hagelueken

jsb-lab.bsky.social @jsb-lab.bsky.social · May 16

Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...

Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells

Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...

www.biorxiv.org

Reposted by Gregor Hagelueken

jsb-lab.bsky.social @jsb-lab.bsky.social · May 16

Please also check out another exciting work on AI-based protein design, which was a fantastic team effort with Michael Hölzel, @gha14.bsky.social, Tobias Bald and many colleagues at @unibonn.bsky.social
www.biorxiv.org/content/10.1...

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

www.biorxiv.org

Reposted by Gregor Hagelueken

Sorek Lab @soreklab.bsky.social · Jan 30

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria

We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase

Congrats Francois Rousset, Ilya Osterman and coauthors!

www.science.org/doi/10.1126/...

Reposted by Gregor Hagelueken

Emmanuele Severi @emmseveri.bsky.social · Dec 2

www.nature.com/articles/s41...

A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections - Nature Communications

The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...

Reposted by Gregor Hagelueken

Randall Munroe @xkcd.com · Nov 28

Neutrino Modem xkcd.com/3017

Gregor Hagelueken @gha14.bsky.social · Nov 27

Well done, Philipp!

Niels Schneberger @nschneberger.bsky.social · Nov 27

Congratulations to @philipphendricks.bsky.social for winning the #PosterPrize at this year's #ClusterScienceDays.
Way to go Jimbo!

Reposted by Gregor Hagelueken

Niels Schneberger @nschneberger.bsky.social · Nov 27

Congratulations to @philipphendricks.bsky.social for winning the #PosterPrize at this year's #ClusterScienceDays.
Way to go Jimbo!

Reposted by Gregor Hagelueken

Niels Schneberger @nschneberger.bsky.social · Nov 25

We identified a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP.
Thanks to the team including: @philipphendricks.bsky.social @scbinder.bsky.social @gavinhthomas.bsky.social @gha14.bsky.social
Read the full story here:

doi.org/10.1038/s420...

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein - Communications Biology

Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

Gregor Hagelueken @gha14.bsky.social · Nov 24

Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP.
Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort!
rdcu.be/d1foN

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein

Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

Reposted by Gregor Hagelueken

Sergey Ovchinnikov @sokrypton.org · Nov 22

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀

@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...

Reposted by Gregor Hagelueken

Chris Mulligan @chrismulligan.bsky.social · Nov 19

Really happy to share our latest work in its final form in @jgenphysiol.bsky.social on the characterisation of a TAXI TRAP binding protein from V. cholerae.
shorturl.at/88tdH

This work was led by SoCoBio DTP student Joe Davies (not on Bluesky yet) and was really fun to work on.

Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae | Journal of General Physiology | Rockefeller University Press

Bacterial TAXI-TRAP transporters are widespread but poorly understood. Davies et al. characterize a TAXI from Vibrio cholerae, revealing its glutamate spec

Reposted by Gregor Hagelueken

Gavin Thomas (he/him) @gavinhthomas.bsky.social · Nov 18

Newest paper from the Reyme Herman on a Staphylococcal peptidase which we found is involved in the production of thioalcohol-based body odour in human. Continuing our long collaboration with Unilever www.jbc.org/article/S002...

Identification of a staphylococcal dipeptidase involved in the production of human body odor

The production of human body odor is the result of the action of commensal skin bacteria, including Staphylococcus hominis, acting to biotransform odorless apocrine gland secretions into volatile chem...

Reposted by Gregor Hagelueken

Malcolm White @mfwhite2.bsky.social · Nov 18

If you work on bacterial immune systems, this founding paper by Burroughs and Aravind is a must-read (and must-cite). pubmed.ncbi.nlm.nih.gov/32868406/

Reposted by Gregor Hagelueken

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Nov 17

This is the first fully open source release of a AF3 like model. Awesome! Congratulations to the team.

Gabriele Corso @gcorso.bsky.social · Nov 17

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

Reposted by Gregor Hagelueken

Malcolm White @mfwhite2.bsky.social · Nov 16

Important paper - just imagining the possibilities if bacteria sense phage infection in neighbours

Cameron Thrash @jcamthrash.bsky.social · Nov 15

Metabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria www.nature.com/articles/s41... #jcampubs

Metabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria - Nature Microbiology

The authors use time-resolved metabolomics and microfluidics to characterize enhanced heterotroph chemoattraction to metabolites released from cyanobacteria during early stages of phage infection.

Reposted by Gregor Hagelueken

Gavin Thomas (he/him) @gavinhthomas.bsky.social · Nov 11

New paper from the lab, expanding our work on bacterial AT3's using DALI/FoldSeek to provide the first solid structural evidence to support a Transmembrane Acyl Transferase (TmAT) superfamily of membrane-bound enzymes in all three domains of life.
www.biorxiv.org/content/10.1...

Structural unification of diverse membrane-bound acyltransferases reveals a conserved fold that defines the Transmembrane Acyl Transferase (TmAT) superfamily

The movement of acyl groups across biological membranes is essential for many cellular processes. One major family of proteins catalysing this reaction are the acyl transferase family 3 (AT3) proteins...

www.biorxiv.org

Gregor Hagelueken @gha14.bsky.social · Nov 15

Yesterday my student Niels Schneberger successfully defended his PhD thesis! Congratulations Niels and thanks for everything. What a journey!