GuccioneLab
@guccionelab.bsky.social
62 followers 69 following 7 posts
We work to identify and validate new targets in oncology. Our objective is to discover innovative and personalized cancer therapies.
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davidlabmsk.bsky.social
Excited for this summer’s NYC Chromatin Club!

Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!

#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
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davidlabmsk.bsky.social
🚨 New meeting this fall in Brussels! 🚨
Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩
#epigenetics2025

Registration is open!!

@epicypher.bsky.social
xcellsconferences.com/epigenetics2025
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carolynbertozzi.bskyverified.social
Very sad to see that #RareDiseaseDay event at FDA-NIH has been cancelled. Cuts that limit rare disease research and cures (1) leave patients behind, and (2) forfeit precious opportunity to learn more about common human diseases.

udnf.org/udnf-stateme...
Statement on Rare Disease Day, Research and Funding - UDNF
UDNF Statement on Rare Disease Day 2025 Cancellation, Research Funding, and Policy Impacts on the Ultra-Rare and Undiagnosed Community
udnf.org
guccionelab.bsky.social
Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition!
On to the next!

Congrats to Daniel Messerschmidt the true mastermind behind this work and the whole team!
www.nature.com/articles/s41...
Maternal PRDM10 activates essential genes for oocyte-to-embryo transition - Nature Communications
The oocyte-to-embryo transition marks the beginning of development but the mechanisms underlying this process are incompletely described. Here they show that PRDM10 activates Septin11 and is required ...
www.nature.com
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standupforscience.bsky.social
Another article detailing anxiety among young researchers. Future careers are at stake with the US funding cuts, and talented young researchers are already being driven to pursue opportunities abroad.

www.nature.com/articles/d41...
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
www.nature.com
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nature.com
Nature @nature.com · Feb 24
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.

https://go.nature.com/43ao2zq
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
go.nature.com
guccionelab.bsky.social
Celebrating the Nature Genetics manuscript on CRC OncoFetal reprogramming. Good to smile together and be reminded that what makes our jobs rewarding is being surrounded by talented smart people who are very committed to what they do! Especially in the current climate!
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epigenometech.bsky.social
Epigenetics Update - Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer go.nature.com/40W2vry

Slim Mzoughi and Ernesto Guccione reporting in Nature Genetics

#Epigenetics #Cancer #Reprogramming

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Discover the Paired-tag breakthrough at epigenome.us
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warren.senate.gov
Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.
Reposted by GuccioneLab
sleemmz.bsky.social
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
guccionelab.bsky.social
Thanks! Hope it will be helpful!
guccionelab.bsky.social
First post on Bluesky: Finally out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered!
The NATURA system is available (Addgene or reach out). Congrats to Tommaso Tabaglio for leading this incredible effort! www.sciencedirect.com/science/arti...
Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform
Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of the…
www.sciencedirect.com