GuccioneLab
@guccionelab.bsky.social
62 followers
69 following
7 posts
We work to identify and validate new targets in oncology.
Our objective is to discover innovative and personalized cancer therapies.
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Reposted by GuccioneLab
Reposted by GuccioneLab
Reposted by GuccioneLab
The Onion
@theonion.com
· Feb 28
NOAA Cuts Leave Wind Chimes As Sole Predictor Of Approaching Hurricanes
SILVER SPRING, MD—As mass firings of career experts and scientists continued to roil the federal government, officials confirmed Friday that cuts to the National Oceanic and Atmospheric Administration...
theonion.com
GuccioneLab
@guccionelab.bsky.social
· Feb 28
Maternal PRDM10 activates essential genes for oocyte-to-embryo transition - Nature Communications
The oocyte-to-embryo transition marks the beginning of development but the mechanisms underlying this process are incompletely described. Here they show that PRDM10 activates Septin11 and is required ...
www.nature.com
GuccioneLab
@guccionelab.bsky.social
· Feb 25
Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform
Citrin deficiency (CD) is an autosomal recessive urea cycle disorder caused by biallelic
loss-of-function variants in the SLC25A13 gene, leading to life-threatening hyperammonemia
and hypoglycemia. Va...
www.journal-of-hepatology.eu
Reposted by GuccioneLab
Reposted by GuccioneLab
Reposted by GuccioneLab
Nature Genetics
@natgenet.nature.com
· Feb 11
Oncofetal reprogramming induces phenotypic heterogeneity in colorectal cancer - Nature Genetics
Phenotypic plasticity of cancer cells is increasingly recognized as a mechanism of tumor escape from targeted therapies. Yet, the phenotypic heterogeneity of colorectal cancer remains poorly explored....
www.nature.com
Reposted by GuccioneLab
Nature Genetics
@natgenet.nature.com
· Feb 11
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
Reposted by GuccioneLab
Slim Mzoughi
@sleemmz.bsky.social
· Feb 10
GuccioneLab
@guccionelab.bsky.social
· Feb 10
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
GuccioneLab
@guccionelab.bsky.social
· Feb 6
GuccioneLab
@guccionelab.bsky.social
· Feb 5
Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform
Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of the…
www.sciencedirect.com