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W1-TT-W2 Artificial Intelligence - Georg-August-University Göttingen

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Hauke Hillen @haukehillen.bsky.social · Sep 4

Congrats Martin!

Reposted by Hauke Hillen

Constantin Pape @cppape.bsky.social · Aug 15

Join us as a colleague in Göttingen!

Alexander Ecker @aecker.bsky.social · Aug 15

📢 We have an opening for a tenure track assistant professor position (W1 t.t. W2) in AI in our CS dept @uni-goettingen.de, Germany.
⏰ Application deadline: Sept 19
🗣️ Please share!
uni-goettingen.de/en/697924.html

Website of the Georg-August-University Göttingen

uni-goettingen.de

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Hauke Hillen @haukehillen.bsky.social · Jul 25

Congrats Martin and best of luck!

Reposted by Hauke Hillen

Christian Frezza @frezzalab.bsky.social · Jul 16

www.nature.com/articles/s41...

anything that mitochondria are not involved?

Mitochondrial origins of the pressure to sleep - Nature

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites

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Reposted by Hauke Hillen

Hana Antonicka @hantonicka.bsky.social · Jul 11

Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.

doi.org/10.1093/nar/...

FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites

Abstract. The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mito

doi.org

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Hauke Hillen @haukehillen.bsky.social · Jun 18

Join us for the 1st Symposium on Interconnections and Cross-Regulation of Gene Expression Processes this September in Göttingen! Great Lineup of international speakers and plenty of opportunities for early career researchers to present & discuss their work!
Link: sfb1565.uni-goettingen.de/symposion/

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Hauke Hillen @haukehillen.bsky.social · Jun 3

We are looking for new colleagues! UMG has an open call for five (!!) new junior group leaders with the broad topic of "metabolic plasticity" - generous startup package, great infrastructure and a thriving research community in Göttingen. Click here to apply by June 30th: tinyurl.com/4hud95rn

Vorstand Forschung und Lehre -- Early Career Researchers (f/m/d) to establish and lead a Junior Research Group in the field of Metabolic Plasticity

Early Career Researchers (f/m/d) to establish and lead a Junior Research Group in the field of Metabolic Plasticity

https://umg.recruiting-portal.com/r/z123rkiwf7v6qrq/Early+Career+Researchers+fmd+to+establish+and+lead+a+Junior+Research+Group+in+the+field+of+Metabolic+Plasticity/37075/Göttingen

Reposted by Hauke Hillen

Nils-Göran Larsson @nils-goranlarsson.bsky.social · May 29

Join us at the EMBO/FEBS lecture course:
The evolving role of mitochondria in metabolism
14 – 18 September 2025 | Belgrade, Serbia:
meetings.embo.org/event/25-mit...

The evolving role of mitochondria in metabolism

The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…

meetings.embo.org

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Hauke Hillen @haukehillen.bsky.social · May 27

Congrats Sveta and the team!!

Hauke Hillen @haukehillen.bsky.social · May 21

Congratulations!

Hauke Hillen @haukehillen.bsky.social · Apr 23

Looks familiar - also from a FLAG IP in HEK cells.

Coupling of ribosome biogenesis and translation initiation in human mitochondria - Nature Communications

Reposted by Hauke Hillen

Michal Minczuk @mitogene.bsky.social · Apr 12

🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

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Hauke Hillen @haukehillen.bsky.social · Apr 19

Very nice work, congratulations Sam and the team!

Hauke Hillen @haukehillen.bsky.social · Apr 17

Our data suggest that mitochondrial ribosome biogenesis and translation initiation are not strictly sequential, but can occur simulatenously with MTG3 acting as a quality control factor.

Hauke Hillen @haukehillen.bsky.social · Apr 17

Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...

Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis an...

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature

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Reposted by Hauke Hillen

Mito@GU @mito-at-gu.bsky.social · Apr 9

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

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Hauke Hillen @haukehillen.bsky.social · Mar 22

This is really mindblowing stuff, congrats again Florent, Ben and the team!

Reposted by Hauke Hillen

Florent Waltz @florentwaltz.bsky.social · Mar 20

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

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Hauke Hillen @haukehillen.bsky.social · Mar 10

Please see the paper for more details! Please also see the great complementary work by Rachel Fearns & Jonathan Abrahams: www.cell.com/cell/fulltex...
and the several other complementary papers published recently describing the apo structure of the NiV polymerase complex.

www.cell.com

Hauke Hillen @haukehillen.bsky.social · Mar 10

Comparisons between the two structures show how rearrangements of key elements in the RdRp upon RNA binding lead to large-scale reorganisation of the complex and ordering of the C-terminal domains required for RNA capping.

Hauke Hillen @haukehillen.bsky.social · Mar 10

The structure reveals how NiV RdRp interacts with template and product RNA and with the incoming substrate nucleoside triphosphate during RNA synthesis. To our knowledge, this represents the first structure of a non-segmented negative-strand RNA virus RdRp in this state.

Hauke Hillen @haukehillen.bsky.social · Mar 10

By using a non-hydrolyzable GTP-analog, we were additionally able to visualise the RdRp after de novo synthesis of 9 nt of product RNA. In this early replicating state, the C-terminal domains of L become stabilised and visible in the cryo-EM reconstruction.

Hauke Hillen @haukehillen.bsky.social · Mar 10

The NiV RNA-dependent RNAP (RdRp) adopts an architecture similar to that of other negative strand RNA viruses such as Ebola or RSV, in which four copies of P protein protrude from the core formed by L. In the apo state, the C-terminal domains of L are mobile and hence invisible.

Molekulare 3D-Struktur viraler „Kopiermaschine“ entschlüsselt

Hauke Hillen @haukehillen.bsky.social · Mar 10

Press release in German by UMG:
www.umg.eu/news-detail/...

and in English by MPI-NAT:
www.mpinat.mpg.de/4947945/pr_2...

Short thread below.

Forschende der Universitätsmedizin Göttingen (UMG) und des Max-Planck-Instituts (MPI) für Multidisziplinäre Naturwissenschaften konnten erstmals zeigen, wie sich das Erbgut des Nipah-Virus in infizier...

www.umg.eu

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Hauke Hillen @haukehillen.bsky.social · Mar 10

The peer-revied version of our paper on the structure of the Nipah virus RNA polymerase in complex with RNA is out in @naturecomms.bsky.social. Congratulations to first-author @salafernanda.bsky.social and many thanks to the reviewers for their constructive comments!

www.nature.com/articles/s41...

Structural basis of Nipah virus RNA synthesis - Nature Communications

Sala et al. report the first structural snapshot of the Nipah virus RNA-dependent RNA polymerase in the actively elongating state, uncovering key mechanisms of RNA synthesis by non-segmented negative ...