Hiten Madhani
@hitenmadhani.bsky.social
Gene regulation in health and disease | Professor/Vice-Chair @UCSF Dept. of Biochemistry and Biophysic | via Stanford, UCSF and MIT | https://madhanilab.ucsf.edu
Reposted by Hiten Madhani
Appreciate @nationalacademies.org speaking up about the RFK jr directed changes to CDC website and pointing out that the science cited did not include the greater context or full body of research. Where is the “radical transparency”?
National Academies - Statement on CDC’s Updated Vaccine Guidance
National Academies respond to CDC’s updated vaccine guidance, offering scientific context and clarity on vaccine safety.
www.nationalacademies.org
November 25, 2025 at 2:14 AM
Appreciate @nationalacademies.org speaking up about the RFK jr directed changes to CDC website and pointing out that the science cited did not include the greater context or full body of research. Where is the “radical transparency”?
Unfortunately I am…
November 22, 2025 at 2:40 AM
Unfortunately I am…
Reposted by Hiten Madhani
Establishment of a Congenic Strain for the Oyster mushroom reveals the Structure and Evolution of Mating-Type Loci https://www.biorxiv.org/content/10.1101/2025.11.21.689727v1
November 22, 2025 at 2:32 AM
Establishment of a Congenic Strain for the Oyster mushroom reveals the Structure and Evolution of Mating-Type Loci https://www.biorxiv.org/content/10.1101/2025.11.21.689727v1
Reposted by Hiten Madhani
Fantastic seminar on 'chromatin regulation and evolution' by @hitenmadhani.bsky.social at @ucriverside.bsky.social
Loved how he started with the classic Linaria vulgaris epigenetics example 🌱
Loved how he started with the classic Linaria vulgaris epigenetics example 🌱
November 18, 2025 at 10:35 PM
Fantastic seminar on 'chromatin regulation and evolution' by @hitenmadhani.bsky.social at @ucriverside.bsky.social
Loved how he started with the classic Linaria vulgaris epigenetics example 🌱
Loved how he started with the classic Linaria vulgaris epigenetics example 🌱
Cloudy (but nice) day for a ride!
November 16, 2025 at 10:21 PM
Cloudy (but nice) day for a ride!
Reposted by Hiten Madhani
Reposted by Hiten Madhani
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Hiten Madhani
Michael is my neighbor and a wonderful, courageous person. When Nazis left anti-Semitic leaflets on people’s cars, he organized a neighborhood sign-making session and led people in posting the signs communicating our solidarity against hate.
Oh wow @reuters.com got the photo here:
November 14, 2025 at 9:33 PM
Michael is my neighbor and a wonderful, courageous person. When Nazis left anti-Semitic leaflets on people’s cars, he organized a neighborhood sign-making session and led people in posting the signs communicating our solidarity against hate.
Reposted by Hiten Madhani
I realize that these timelines are absurd and wanting to take on one of these important positions under the present circumstances is problematic, but NIH needs qualified applicants to apply.
Please consider applying, even if you are not sure you would accept the position if offered.
3/3
Please consider applying, even if you are not sure you would accept the position if offered.
3/3
a man wearing a red shirt with the letter w on it says " who are we if we don 't even try "
ALT: a man wearing a red shirt with the letter w on it says " who are we if we don 't even try "
media.tenor.com
November 12, 2025 at 4:18 PM
I realize that these timelines are absurd and wanting to take on one of these important positions under the present circumstances is problematic, but NIH needs qualified applicants to apply.
Please consider applying, even if you are not sure you would accept the position if offered.
3/3
Please consider applying, even if you are not sure you would accept the position if offered.
3/3
Reposted by Hiten Madhani
Alert for scientists: NIH institute director vacancies are posted! Please apply so we get actual scientists in these positions instead of just political appointees!!!!
More new NIH institute and center director positions posted
with a closing date of 11/26/25.
hr.nih.gov/careers/open...
These include the Center for Scientific Review (CSR), National Institute of Nursing Research (NINR), National Institute of Allergy and Infectious Diseases (NIAID), ...
1/3
with a closing date of 11/26/25.
hr.nih.gov/careers/open...
These include the Center for Scientific Review (CSR), National Institute of Nursing Research (NINR), National Institute of Allergy and Infectious Diseases (NIAID), ...
1/3
hr.nih.gov
November 13, 2025 at 3:06 PM
Alert for scientists: NIH institute director vacancies are posted! Please apply so we get actual scientists in these positions instead of just political appointees!!!!
Nice day for a ride!
November 9, 2025 at 10:53 PM
Nice day for a ride!
Nice day for a stroll! 70 and clear. Not bad for November.
November 8, 2025 at 11:28 PM
Nice day for a stroll! 70 and clear. Not bad for November.
Nucleosome socks from the 5th biannual @epicypher.bsky.social meeting!
I have had the (perhaps dubious) honor of giving the final talk at last four. Great meeting as usual. Thanks to Michael and the gang for putting it together.
I have had the (perhaps dubious) honor of giving the final talk at last four. Great meeting as usual. Thanks to Michael and the gang for putting it together.
November 8, 2025 at 5:46 PM
Nucleosome socks from the 5th biannual @epicypher.bsky.social meeting!
I have had the (perhaps dubious) honor of giving the final talk at last four. Great meeting as usual. Thanks to Michael and the gang for putting it together.
I have had the (perhaps dubious) honor of giving the final talk at last four. Great meeting as usual. Thanks to Michael and the gang for putting it together.
Reposted by Hiten Madhani
Raise a glass for Rosalind Franklin tonight and honor her memory and scientific contributions
NYT obituary of Jim Watson.
A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology.
[Gift Link]
www.nytimes.com/2025/11/07/s...
A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology.
[Gift Link]
www.nytimes.com/2025/11/07/s...
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 9:12 PM
Raise a glass for Rosalind Franklin tonight and honor her memory and scientific contributions
Reposted by Hiten Madhani
8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM).
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
hr.nih.gov
November 7, 2025 at 10:20 PM
8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM).
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
Reposted by Hiten Madhani
In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
November 7, 2025 at 10:18 PM
In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
Vivid reminder that HHS sec is not an MD.
RFK Jr's response to someone collapsing nearby him was to haul ass out of the room as quickly as possible
November 6, 2025 at 8:13 PM
Vivid reminder that HHS sec is not an MD.
Reposted by Hiten Madhani
Absolutely, this.
I did not intend to bury the lede in my data nerdiness.
I did not intend to bury the lede in my data nerdiness.
and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.
2025
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
November 5, 2025 at 4:56 PM
Absolutely, this.
I did not intend to bury the lede in my data nerdiness.
I did not intend to bury the lede in my data nerdiness.
Sad news indeed. I only knew Zara at ‘smile, wave and say hi’ level, but she always smiled, waved and said hi and always I did the same.
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
November 1, 2025 at 1:23 AM
Sad news indeed. I only knew Zara at ‘smile, wave and say hi’ level, but she always smiled, waved and said hi and always I did the same.
Reposted by Hiten Madhani
Pitt faculty taking a stand against the higher education "compact"
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
University of Pittsburgh professors push back against Trump 'compact' for higher education
University of Pittsburgh professors have asked their school to reject a Trump "compact" that promises more access to federal resources to schools that sign on to his agenda
www.wesa.fm
October 31, 2025 at 4:10 PM
Pitt faculty taking a stand against the higher education "compact"
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
Reposted by Hiten Madhani
Reposted by Hiten Madhani
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
www.gov.uk/government/p...
The value of public R&D
www.gov.uk
October 30, 2025 at 1:28 PM
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
www.gov.uk/government/p...
Good to see Nature recognize fundamental research. Honestly, it’s the only kind that has ever floated my boat. Everything else just seems boring to me and I would rather live an interesting life. And, of course, as argued in the piece, it has an outsized impact.
In praise of fundamental research
Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different
🧪
@nature.com
www.nature.com/articles/d41...
Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different
🧪
@nature.com
www.nature.com/articles/d41...
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
www.nature.com
October 30, 2025 at 2:30 PM
Good to see Nature recognize fundamental research. Honestly, it’s the only kind that has ever floated my boat. Everything else just seems boring to me and I would rather live an interesting life. And, of course, as argued in the piece, it has an outsized impact.
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
The Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin
Wu et al. reveal that the SFiNX complex triggers transposon silencing through the
association of Sov with two transcription termination factors, PNUTS and Senataxin,
leading to RNA Pol II stalling. Th...
www.cell.com
October 29, 2025 at 3:47 PM
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Hiten Madhani
Trouble in paradise...
NEW: Steven Hatfill, the biosecurity expert and opponent of mNRA research, tells me he was fired by RFK Jr.'s chief of staff as part of "a coup to overthrow Mr. Kennedy." HHS says he misrepresented himself & didn't play well in the sandbox.
www.nytimes.com/2025/10/28/u...
www.nytimes.com/2025/10/28/u...
Steven Hatfill, Covid Vaccine Critic, Is Ousted From HHS
www.nytimes.com
October 28, 2025 at 11:23 PM
Trouble in paradise...