Pascal Falter-Braun
@interactome.bsky.social
Head of Institute of Network Biology - INET @Helmholtz Munich. We analyse molecular interaction networks to understand infectious and genetic diseases. Opinions are my own. Believe in progress, science and humanism.
Pinned
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation - Nature Microbiology
Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathwa...
t1p.de
Very happy and proud that our paper “Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation” is out today in #NatureMicrobiology @natmicrobiol.nature.com
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Reposted by Pascal Falter-Braun
Greetings from inside the economic blockade zones of Minneapolis and St Paul! Don’t look away, please. We need you. It’s been a month and they’re trying to destroy us.
February 2, 2026 at 12:25 PM
Greetings from inside the economic blockade zones of Minneapolis and St Paul! Don’t look away, please. We need you. It’s been a month and they’re trying to destroy us.
Reposted by Pascal Falter-Braun
Happy Black History Month
We have leadership who refuses to acknowledge it, so we have to take up the torch. They can’t erase history.
“Always remember you have within you the strength, the patience, and the passion to reach for the stars
to change the world”
-HARRIET TUBMAN
❤️💛💚
#Pinks #ProudBlue
We have leadership who refuses to acknowledge it, so we have to take up the torch. They can’t erase history.
“Always remember you have within you the strength, the patience, and the passion to reach for the stars
to change the world”
-HARRIET TUBMAN
❤️💛💚
#Pinks #ProudBlue
February 2, 2026 at 1:57 PM
Happy Black History Month
We have leadership who refuses to acknowledge it, so we have to take up the torch. They can’t erase history.
“Always remember you have within you the strength, the patience, and the passion to reach for the stars
to change the world”
-HARRIET TUBMAN
❤️💛💚
#Pinks #ProudBlue
We have leadership who refuses to acknowledge it, so we have to take up the torch. They can’t erase history.
“Always remember you have within you the strength, the patience, and the passion to reach for the stars
to change the world”
-HARRIET TUBMAN
❤️💛💚
#Pinks #ProudBlue
This looks like a great opportunity. Consider applying ...
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
January 29, 2026 at 11:29 AM
This looks like a great opportunity. Consider applying ...
Reposted by Pascal Falter-Braun
Die Klimakrise gibt es immer noch, auch wenn Friedrich Merz & Co. nicht darüber reden (wollen).
January 29, 2026 at 7:48 AM
Die Klimakrise gibt es immer noch, auch wenn Friedrich Merz & Co. nicht darüber reden (wollen).
Reposted by Pascal Falter-Braun
Out Now! Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation #MicroSky
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation
Nature Microbiology, Published online: 26 January 2026; doi:10.1038/s41564-025-02241-yLarge-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathways.
go.nature.com
January 26, 2026 at 6:28 PM
Out Now! Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation #MicroSky
Reposted by Pascal Falter-Braun
"Our findings indicate that T3SS contribute to microorganism–host cohabitation and that effector–host protein interactions may represent an underappreciated route by which commensal gut microbiota influences health." www.nature.com/articles/s41...
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation - Nature Microbiology
Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathwa...
www.nature.com
January 27, 2026 at 5:28 PM
"Our findings indicate that T3SS contribute to microorganism–host cohabitation and that effector–host protein interactions may represent an underappreciated route by which commensal gut microbiota influences health." www.nature.com/articles/s41...
Reposted by Pascal Falter-Braun
My second dissertation paper is now out in @natcomms.nature.com! Here we introduce the co-expression-wide association study (COWAS) method for identifying pairs of genes or proteins whose genetically regulated co-expression is associated with complex traits. 🧵⬇️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Co-expression-wide association studies link genetically regulated interactions with complex traits - Nature Communications
Proteins can affect traits through their interactions with one another. Here, the authors propose the COWAS method to identify pairs of interacting genes or proteins whose genetically regulated co-exp...
www.nature.com
December 20, 2025 at 1:52 AM
My second dissertation paper is now out in @natcomms.nature.com! Here we introduce the co-expression-wide association study (COWAS) method for identifying pairs of genes or proteins whose genetically regulated co-expression is associated with complex traits. 🧵⬇️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
What's the science behind our paper? A thread 🧵 1/10
The human gut microbiome plays a major role in immunity, metabolism, and disease risk—but we still don’t fully understand how gut bacteria communicate with our cells.
The human gut microbiome plays a major role in immunity, metabolism, and disease risk—but we still don’t fully understand how gut bacteria communicate with our cells.
Very happy and proud that our paper “Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation” is out today in #NatureMicrobiology @natmicrobiol.nature.com
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation - Nature Microbiology
Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathwa...
t1p.de
January 26, 2026 at 7:40 PM
What's the science behind our paper? A thread 🧵 1/10
The human gut microbiome plays a major role in immunity, metabolism, and disease risk—but we still don’t fully understand how gut bacteria communicate with our cells.
The human gut microbiome plays a major role in immunity, metabolism, and disease risk—but we still don’t fully understand how gut bacteria communicate with our cells.
Reposted by Pascal Falter-Braun
Happy and proud as well to see the paper out in @natmicrobiol.nature.com! Thanks to Pascal @interactome.bsky.social and all collaborators for this fantastic work. A special thank to the people in our team at @tagc-u1090.bsky.social, @netbiotagc.bsky.social and Renaud at @afmblab.bsky.social
Very happy and proud that our paper “Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation” is out today in #NatureMicrobiology @natmicrobiol.nature.com
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation - Nature Microbiology
Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathwa...
t1p.de
January 26, 2026 at 5:42 PM
Happy and proud as well to see the paper out in @natmicrobiol.nature.com! Thanks to Pascal @interactome.bsky.social and all collaborators for this fantastic work. A special thank to the people in our team at @tagc-u1090.bsky.social, @netbiotagc.bsky.social and Renaud at @afmblab.bsky.social
Very happy and proud that our paper “Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation” is out today in #NatureMicrobiology @natmicrobiol.nature.com
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation - Nature Microbiology
Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathwa...
t1p.de
January 26, 2026 at 5:07 PM
Very happy and proud that our paper “Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation” is out today in #NatureMicrobiology @natmicrobiol.nature.com
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Paper 👉 t1p.de/v42xb
#microbiome #commensal #pathomechanism #T3SS #immune #health #IBD
Reposted by Pascal Falter-Braun
My friend Sara posted this about the superb care her father received from with Alex Pretti
Absolutely heartbreaking
Absolutely heartbreaking
January 25, 2026 at 4:19 PM
My friend Sara posted this about the superb care her father received from with Alex Pretti
Absolutely heartbreaking
Absolutely heartbreaking
Reposted by Pascal Falter-Braun
Thanks for including me Sassy. We must get stronger no matter what. We must stand together.
@filosia.bsky.social 🫂👊
go.bsky.app/DMPHjDE
@filosia.bsky.social 🫂👊
go.bsky.app/DMPHjDE
January 26, 2026 at 8:30 AM
Thanks for including me Sassy. We must get stronger no matter what. We must stand together.
@filosia.bsky.social 🫂👊
go.bsky.app/DMPHjDE
@filosia.bsky.social 🫂👊
go.bsky.app/DMPHjDE
Reposted by Pascal Falter-Braun
I am in Minneapolis now and I wanted to share my latest piece on Substack:
substack.com/@katiephang/...
substack.com/@katiephang/...
“Do not stand idly by while your neighbor’s blood is shed.”
Some painfully key words from Leviticus 19:16
substack.com
January 26, 2026 at 1:33 PM
I am in Minneapolis now and I wanted to share my latest piece on Substack:
substack.com/@katiephang/...
substack.com/@katiephang/...
Reposted by Pascal Falter-Braun
More Than Just Gut Cohabitants: How Gut Bacteria Control Immune Responses
New research led by #HelmholtzMunich shows that common gut bacteria can actively shape our immune system by injecting proteins directly into human cells.
👉 t1p.de/g2b98
🔗 Original publication: t1p.de/v42xb
#Microbiome
New research led by #HelmholtzMunich shows that common gut bacteria can actively shape our immune system by injecting proteins directly into human cells.
👉 t1p.de/g2b98
🔗 Original publication: t1p.de/v42xb
#Microbiome
January 26, 2026 at 10:08 AM
More Than Just Gut Cohabitants: How Gut Bacteria Control Immune Responses
New research led by #HelmholtzMunich shows that common gut bacteria can actively shape our immune system by injecting proteins directly into human cells.
👉 t1p.de/g2b98
🔗 Original publication: t1p.de/v42xb
#Microbiome
New research led by #HelmholtzMunich shows that common gut bacteria can actively shape our immune system by injecting proteins directly into human cells.
👉 t1p.de/g2b98
🔗 Original publication: t1p.de/v42xb
#Microbiome
Reposted by Pascal Falter-Braun
In solidarity with today's ICE OUT OF MINNESOTA blackout, MinnMax is donating $1 to the Immigrant Law Center of Minnesota for every share of this Bluesky post for the next hour.
January 23, 2026 at 4:01 PM
In solidarity with today's ICE OUT OF MINNESOTA blackout, MinnMax is donating $1 to the Immigrant Law Center of Minnesota for every share of this Bluesky post for the next hour.
Reposted by Pascal Falter-Braun
Trump’s stream-of-consciousness brain droppings ought to be called what they are: the bitter and bigoted ramblings of a seemingly mentally deteriorating, elderly narcissist.
Opinion | Stop sanewashing Donald Trump’s incoherent ramblings
It's well past time to call Trump’s stream-of-consciousness monologues exactly what they are.
www.ms.now
January 22, 2026 at 9:48 PM
Trump’s stream-of-consciousness brain droppings ought to be called what they are: the bitter and bigoted ramblings of a seemingly mentally deteriorating, elderly narcissist.
@gruene.de ich hab euch seit Jahrzehnten immer gewählt und bin heute entsetzt, dass ihr mit den Rechtsextremen zusammen das #mercursor Abkommen verzögert und möglicherweise stoppt. Das ist absolut das falsche Zeichen. In welcher Welt lebt ihr? Was soll das??
January 21, 2026 at 7:09 PM
@gruene.de ich hab euch seit Jahrzehnten immer gewählt und bin heute entsetzt, dass ihr mit den Rechtsextremen zusammen das #mercursor Abkommen verzögert und möglicherweise stoppt. Das ist absolut das falsche Zeichen. In welcher Welt lebt ihr? Was soll das??
Reposted by Pascal Falter-Braun
Eine Freundin von mir stand heute vor Gericht. Weil sie für die Letzte Generation friedliche Blockaden durchführte.
Ich bin mir sicher: KEIN Bauer wird diese konsequenzen fürchten müssen. Und DA beginnt das Problem.
www.ndr.de/nachrichten/...
Ich bin mir sicher: KEIN Bauer wird diese konsequenzen fürchten müssen. Und DA beginnt das Problem.
www.ndr.de/nachrichten/...
Bauernprotest an Autobahnen: Diese Auffahrten in MV sind betroffen
Aus Protest gegen das Mercosur-Freihandelsabkommen zwischen der EU und vier südamerikanischen Staaten wollen Landwirte am Donnerstag an Autobahnauffahrten protestieren. Aufgerufen dazu hat der Verein ...
www.ndr.de
January 7, 2026 at 7:29 PM
Eine Freundin von mir stand heute vor Gericht. Weil sie für die Letzte Generation friedliche Blockaden durchführte.
Ich bin mir sicher: KEIN Bauer wird diese konsequenzen fürchten müssen. Und DA beginnt das Problem.
www.ndr.de/nachrichten/...
Ich bin mir sicher: KEIN Bauer wird diese konsequenzen fürchten müssen. Und DA beginnt das Problem.
www.ndr.de/nachrichten/...
Reposted by Pascal Falter-Braun
Wusstet ihr, dass die Antidiskriminierungsstelle des Bundes eine Umfrage zur Diskriminierung in Deutschland durchführt?
=> bis 28.02.26 könnt ihr anonym teilnehmen. Nutzt es bitte reichlich! 🫶🏻
(Wofür so ein Arbeitnehmer manchmal gut ist)
diskriminierung-umfrage.de
=> bis 28.02.26 könnt ihr anonym teilnehmen. Nutzt es bitte reichlich! 🫶🏻
(Wofür so ein Arbeitnehmer manchmal gut ist)
diskriminierung-umfrage.de
Die Umfrage zu Diskriminierung in Deutschland. Mach mit.
Drei gute Gründe, bei der großen Umfrage zu Diskriminierung mitzumachen: 1. Deine Stimme hilft, Diskriminierung sichtbar zu machen.
diskriminierung-umfrage.de
January 9, 2026 at 12:52 PM
Wusstet ihr, dass die Antidiskriminierungsstelle des Bundes eine Umfrage zur Diskriminierung in Deutschland durchführt?
=> bis 28.02.26 könnt ihr anonym teilnehmen. Nutzt es bitte reichlich! 🫶🏻
(Wofür so ein Arbeitnehmer manchmal gut ist)
diskriminierung-umfrage.de
=> bis 28.02.26 könnt ihr anonym teilnehmen. Nutzt es bitte reichlich! 🫶🏻
(Wofür so ein Arbeitnehmer manchmal gut ist)
diskriminierung-umfrage.de
This is horrifying. Gestapo sounds about right ...
What in the Gestapo is going on in Grand Rapids?
Watch this activist get arrested *mid-interview* for speaking out against U.S. action in Venezuela.
Watch this activist get arrested *mid-interview* for speaking out against U.S. action in Venezuela.
January 5, 2026 at 11:13 PM
This is horrifying. Gestapo sounds about right ...
Reposted by Pascal Falter-Braun
New preprint: Cross-View Latent Integration via Nonparametric Gamma Shrinkage Factor Analysis.
We introduce a fully Bayesian, unsupervised multi-view factor model that automatically learns the number of factors, handles heterogeneous noise, and yields sparse, interpretable loadings.
We introduce a fully Bayesian, unsupervised multi-view factor model that automatically learns the number of factors, handles heterogeneous noise, and yields sparse, interpretable loadings.
January 3, 2026 at 9:53 AM
New preprint: Cross-View Latent Integration via Nonparametric Gamma Shrinkage Factor Analysis.
We introduce a fully Bayesian, unsupervised multi-view factor model that automatically learns the number of factors, handles heterogeneous noise, and yields sparse, interpretable loadings.
We introduce a fully Bayesian, unsupervised multi-view factor model that automatically learns the number of factors, handles heterogeneous noise, and yields sparse, interpretable loadings.
Reposted by Pascal Falter-Braun
The destruction doesn't make for a photo-op like tearing down the East Wing of the White House or bulldozing the Rose Garden, but it's every bit as bad. Generations of American children learned to spell and count, learned the Preamble to the Constitution, from watching shows produced by the CPB.
The Corporation for Public Broadcasting has been dissolved, ending its 58 years as the primary funder for PBS, NPR and local TV and radio stations
Corporation For Public Broadcasting Is Dissolved After 58 Years Of Service
www.huffpost.com
January 5, 2026 at 8:04 PM
The destruction doesn't make for a photo-op like tearing down the East Wing of the White House or bulldozing the Rose Garden, but it's every bit as bad. Generations of American children learned to spell and count, learned the Preamble to the Constitution, from watching shows produced by the CPB.
Reposted by Pascal Falter-Braun
Great work led by @marcostock.bsky.social and Florin Ratajczak , thanks to all coauthors Paul Bertin
@evahoermanseder.bsky.social @yoshuabengio.bsky.social Jason Hartford @interactome.bsky.social Matthias Heinig @alextong.bsky.social
@evahoermanseder.bsky.social @yoshuabengio.bsky.social Jason Hartford @interactome.bsky.social Matthias Heinig @alextong.bsky.social
December 23, 2025 at 8:04 PM
Great work led by @marcostock.bsky.social and Florin Ratajczak , thanks to all coauthors Paul Bertin
@evahoermanseder.bsky.social @yoshuabengio.bsky.social Jason Hartford @interactome.bsky.social Matthias Heinig @alextong.bsky.social
@evahoermanseder.bsky.social @yoshuabengio.bsky.social Jason Hartford @interactome.bsky.social Matthias Heinig @alextong.bsky.social
Reposted by Pascal Falter-Braun
Are you a bachelor or master student anywhere in the world, and would like to come to us to work full-time on a supervised research project? Applications for the 2026 MPIA Summer Internship are open now!
Summer internships
www.mpia.de
December 17, 2025 at 9:13 PM
Are you a bachelor or master student anywhere in the world, and would like to come to us to work full-time on a supervised research project? Applications for the 2026 MPIA Summer Internship are open now!
Reposted by Pascal Falter-Braun
Breaking news: U.S. Senator Rand Paul (R–KY) has asked Science to divulge a range of confidential information about its scholarly articles and external private communications on that family of viruses.
U.S. senator asks Science to provide its coronavirus manuscripts, emails
Rand Paul has blasted government science officials and scientists over COVID-19’s origin
www.science.org
December 19, 2025 at 8:37 PM
Breaking news: U.S. Senator Rand Paul (R–KY) has asked Science to divulge a range of confidential information about its scholarly articles and external private communications on that family of viruses.