Ioannis Tsirkas
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ioannistsirkas.bsky.social
Ioannis Tsirkas
@ioannistsirkas.bsky.social
100 followers 310 following 66 posts
Post doc and manga lover, I will be sharing science-related stuff and manga reads.
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Reposted by Ioannis Tsirkas
smitslab.bsky.social
Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · Aug 4
DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology journals.asm.org/doi/10.1128/...
DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology
The regulation of DNA replication is fundamental to cell growth and cell cycle control. In eukaryotes, under-initiation or over-initiation leads to genome instability. In bacteria, it is unclear how c...
journals.asm.org
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Reposted by Ioannis Tsirkas
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Aug 4
Such a nice review for one of our latest research works!
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ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · Aug 4
We look forward to the community's feedback!
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Reposted by Ioannis Tsirkas
motherjones.com
Mother Jones @motherjones.com · Aug 2
The BLS did exactly what it's supposed to do: provide accurate, nonpartisan data. When the numbers showed Trump's "economic boom" was actually a bust (33k jobs vs claimed 291k), he fired the messenger. After all, when it rains too much, true leaders fire the meteorologists.
We’re officially in Donald Trump’s mad king era
All the books that are fit to cook.
www.motherjones.com
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Reposted by Ioannis Tsirkas
mads100tist.bsky.social
MwahahahahahadScientist @mads100tist.bsky.social · Jul 19
I don't like the person I become when designing primers
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Reposted by Ioannis Tsirkas
jopkind.bsky.social
Jop Kind @jopkind.bsky.social · Jul 10
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
www.nature.com
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Reposted by Ioannis Tsirkas
biorxiv-cellbio.bsky.social
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jul 15
RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3 https://www.biorxiv.org/content/10.1101/2025.07.14.664777v1
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Reposted by Ioannis Tsirkas
metorrespadilla.bsky.social
ME Torres-Padilla @metorrespadilla.bsky.social · Jul 15
🎤 Apply to speak @our TALENT FORUM by July 31!
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists

🧳Travel+accommodation covered if selected!
📝 Info+how to apply: lnkd.in/drkRvz7N

#postdoc #career #groupleader #HelmholtzMunich #research
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ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · Jun 19
Great week for #manga readers!

#WildStrawberry ch45
#Yattara ch18
#DramaQueen ch23
#Centuria ch56
#Dandadan ch198
#Chainsawman ch206
#Bugego ch10
#MärchenCrown ch11
#TheGodofTime ch5
#AsurasVerdict ch14

Especially the last one was so good! Here are a few artworks.
Reposted by Ioannis Tsirkas
biorxiv-cellbio.bsky.social
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jun 16
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms https://www.biorxiv.org/content/10.1101/2025.06.02.657494v1
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ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · Jun 13
#spoileralert

#WildStrawberrt #Manga with itdld best double spread. Too sad this is getting axed ;(
Reposted by Ioannis Tsirkas
puckknipscheer.bsky.social
puckknipscheer.bsky.social @puckknipscheer.bsky.social · Jun 13
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
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ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · Jun 9
#spoileralert

#dandadan #manga nailed it this time, one of its coolest #artworks! Remember, this is a weekly #manga!
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ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · Jun 9
www.nature.com/articles/s41...

POPtag is officially my new favourite named tag! BTW, nice work!
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems - Nature Communications
“Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. Here the authors show that PopZ condensate dynamics support cell division a...
www.nature.com
ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · Jun 8
This was a gift from a colleague, and it looks breathtaking. Done within one day (1000 pieces, around 12-15 hours)
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Reposted by Ioannis Tsirkas
spottingthespot.bsky.social
spottingthespot.bsky.social @spottingthespot.bsky.social · May 27
A rather remarkable retraction for a paper where apparently no authors contributed! I guess these #papermill authors were a bit too honest... #fraud
@elsevierconnect.bsky.social

doi.org/10.1016/j.ij...
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Reposted by Ioannis Tsirkas
genomestability.bsky.social
Andrew Deans @genomestability.bsky.social · May 26
CST complex blocks end resection by BLM-DNA2 or EXO1, therefore promoting non-homologous endjoining and inhibiting repair templated DNA repair.
www.science.org/doi/10.1126/...
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
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Reposted by Ioannis Tsirkas
apanagopoulos.bsky.social
Andreas Panagopoulos @apanagopoulos.bsky.social · May 21
Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
doi.org
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Reposted by Ioannis Tsirkas
helmholtzmunich.bsky.social
Helmholtz Munich @helmholtzmunich.bsky.social · May 14
Grab a pint & dive into science! 🍻

Pint of Science is back in Munich:
🗓️ May 19–21, 2025
🕢 19:30–22:00

#HelmholtzMunich researchers share big ideas – from AI to antibodies.

🎟️ Info & tickets: t1p.de/lvpuv

#pint25 #pint25de
Pint of Science Munich
Explore Pint of Science Deutschland events in Munich
pintofscience.de
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ioannistsirkas.bsky.social
Ioannis Tsirkas @ioannistsirkas.bsky.social · May 12
Spoiler alert!

#Dandadan #manga #194 does not disappoint this Monday too! Back2back peak chapters!
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Reposted by Ioannis Tsirkas
alebrambati.bsky.social
Alessandra Brambati @alebrambati.bsky.social · May 12
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
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Reposted by Ioannis Tsirkas
katmabu.bsky.social
Kat Abughazaleh @katmabu.bsky.social · May 7
I used to have nightmares about getting a pet and forgetting to feed it.

I have not had a single one of those dreams since getting Heater because there is not a chance in Hell she will let me forget breakfast.
Heater, laying in bed, patiently waiting for breakfast.
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Reposted by Ioannis Tsirkas
rogerslabucd.bsky.social
Crystal Rogers, PhD @rogerslabucd.bsky.social · May 7
I just woke up from a nightmare where I was giving a guest lecture to an undergrad cell biology class and none of them knew the central dogma or what DNA or RNA were. I spent an hour teaching that instead. They didn’t understand why they needed to know about DNA for cell biology. 🫠😫😱
homer simpson is laying in bed under a blue blanket .
Alt: homer simpson is laying in bed under a blue blanket waking up from a nightmare
media.tenor.com
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Reposted by Ioannis Tsirkas
rebannjones.bsky.social
Rebecca Ann Jones @rebannjones.bsky.social · May 6
What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...
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Reposted by Ioannis Tsirkas
biorxiv-cellbio.bsky.social
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · May 7
Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 foci https://www.biorxiv.org/content/10.1101/2025.05.07.652606v1
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