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Reposted by Josh Osowicki

Fabian Kong @fabysk.bsky.social · 7d

I am exciting to publish our validated, lab-based model of oral gonorrhoea infection! With this model we can begin to understand how gonorrhoea behaves in the mouth (which is lacking) and screen for new compounds for interventions such as a gum to prevent infections. sti.bmj.com/content/earl...

sti.bmj.com

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Josh Osowicki @joshosowicki.bsky.social · 22d

Melbourne 𝘚𝘵𝘳𝘦𝘱𝘵𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘱𝘺𝘰𝘨𝘦𝘯𝘦𝘴 researchers have been dealing with a similar challenge too…

www.theguardian.com/australia-ne...

Buruli ulcer: flesh-eating bacteria spreads in Melbourne suburb amid warning about rise in cases

Increase in cases ‘linked to Ascot Vale’ leads health officials to warn the disease is ‘spreading geographically’

www.theguardian.com

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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Aug 23

Our new review “𝘛𝘩𝘦 𝘊𝘦𝘯𝘵𝘳𝘢𝘭 𝘐𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘤𝘦 𝘰𝘧 𝘝𝘢𝘤𝘤𝘪𝘯𝘦𝘴 𝘵𝘰 𝘔𝘪𝘵𝘪𝘨𝘢𝘵𝘦 𝘵𝘩𝘦 𝘛𝘩𝘳𝘦𝘢𝘵 𝘰𝘧 𝘈𝘯𝘵𝘪𝘣𝘪𝘰𝘵𝘪𝘤-𝘙𝘦𝘴𝘪𝘴𝘵𝘢𝘯𝘵 𝘉𝘢𝘤𝘵𝘦𝘳𝘪𝘢𝘭 𝘗𝘢𝘵𝘩𝘰𝘨𝘦𝘯𝘴” is out

Compared to antibiotics, vaccines:

✓ Act prophylactically at low pathogen burden

✓ Less prone to inducing resistance due to multifactorial nature of immune pressure

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Josh Osowicki @joshosowicki.bsky.social · Aug 22

Some NICUs don’t specifically cover anaerobes for NEC, although more to do with understanding of the developing GI microbiome. Your Q isn’t whether anaerobes are there, more what happens if we don’t go out of our way to treat them? There are some cholangitis & asp pneumonia studies 🤷‍♂️

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Josh Osowicki @joshosowicki.bsky.social · Aug 22

🤔 could consider when clindamycin was abandoned for IAI (because rising Bacteroides-R). If this was preceded by ⬆️ refractory cases that would be convincing-ish. And how about before any of these drugs were available? Anaerobic culture standards probably haven’t been consistent enough to be useful.

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Reposted by Josh Osowicki

Michael Marks @drmichaelmarks.bsky.social · Aug 21

Exited to announce 2 EDCTP consortiums led @lshtm.bsky.social w partners in Europe & West, East & Southern Africa

MAMS4CL will deliver seamless Phase 2-3 trial of treatments for Cutaneous Leishmaniasis.

IVMKIDS will provide data on paediatric dosing ivermectin down to 5kg/weight for STH & Scabies.

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Josh Osowicki @joshosowicki.bsky.social · Aug 13

pubmed.ncbi.nlm.nih.gov/10443871/

Case report of osteomyelitis relapse after 50 years

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Reposted by Josh Osowicki

Michael Marks @drmichaelmarks.bsky.social · Aug 8

Phenomenal piece of work by a great team across @mrcunitgambia.bsky.social @lshtm.bsky.social @sheffielduni.bsky.social - Delighted to have played a small part in combining epidemiology & immunology to shed light on what protection for #StrepA might look like & help advance vaccine development.

Alex Keeley @alexjkeeley.bsky.social · Aug 8

🧵 Our paper out today in @naturemedicine.bsky.social

www.nature.com/articles/s41...

On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon

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#Immunosky #IDsky #MicroSky #globalhealth.

www.nature.com

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Reposted by Josh Osowicki

Claire Turner @claireyt.bsky.social · Aug 8

Fantastic to see this immense body of excellent work published! Well done @alexjkeeley.bsky.social and everyone involved 👏

#StrepA
@floreyinstitute.bsky.social
@molmicrosheffield.bsky.social

Alex Keeley @alexjkeeley.bsky.social · Aug 8

🧵 Our paper out today in @naturemedicine.bsky.social

www.nature.com/articles/s41...

On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon

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#Immunosky #IDsky #MicroSky #globalhealth.

www.nature.com

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Reposted by Josh Osowicki

Thushan de Silva @thushan-desilva.bsky.social · Aug 8

VERY excited by our latest work on StrepA below, but also rhe multiple collaborations and work to come off the back of this at MRCG

Alex Keeley @alexjkeeley.bsky.social · Aug 8

🧵 Our paper out today in @naturemedicine.bsky.social

www.nature.com/articles/s41...

On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon

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#Immunosky #IDsky #MicroSky #globalhealth.

www.nature.com

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Reposted by Josh Osowicki

Alex Keeley @alexjkeeley.bsky.social · Aug 8

🧵 Our paper out today in @naturemedicine.bsky.social

www.nature.com/articles/s41...

On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon

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#Immunosky #IDsky #MicroSky #globalhealth.

www.nature.com

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Reposted by Josh Osowicki

Andrew S. MacDonald @profandrewmac.bsky.social · Jul 28

A real pleasure to be a part of this beautiful new study on T cell responses in repeat controlled human infection vs natural infection with #schistosomes, spearheaded by @emmahoulder.bsky.social with many wonderful colleagues #helminths #ImmunoSky #IDSky 🪱 🧪 www.nature.com/articles/s41...

T cell responses in repeated controlled human schistosome infection compared to natural exposure - Nature Communications

In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma mansoni infection, designed...

www.nature.com

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Reposted by Josh Osowicki

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Jul 26

Congratulations to 𝐃𝐎𝐂𝐓𝐎𝐑 𝐃𝐀𝐍𝐈𝐄𝐋 𝐒𝐔𝐍 on the successful defense of his PhD "𝘊𝘰𝘯𝘴𝘪𝘥𝘦𝘳𝘪𝘯𝘨 𝘵𝘩𝘦 𝘏𝘰𝘴𝘵-𝘗𝘢𝘵𝘩𝘰𝘨𝘦𝘯 𝘐𝘯𝘵𝘦𝘳𝘧𝘢𝘤𝘦 𝘧𝘰𝘳 𝘕𝘰𝘷𝘦𝘭 𝘈𝘱𝘱𝘳𝘰𝘢𝘤𝘩𝘦𝘴 𝘵𝘰 𝘛𝘳𝘦𝘢𝘵 𝘋𝘳𝘶𝘨 𝘙𝘦𝘴𝘪𝘴𝘵𝘢𝘯𝘵 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴" in the Biomedical Sciences Graduate Program as part of his dual degree training in the UCSD SSPPS PharmD/PhD Program

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Reposted by Josh Osowicki

Paul Sax @paulsaxmd.bsky.social · Jul 18

Thanks for the reference! And of course there's this classic from @tonybreu.bsky.social x.com/tony_breu/st...

Tony Breu on X: "1/ Why hasn't syphilis developed resistance to penicillin (PCN)? It took staph aureus about a year to demonstrate resistance. After 75 years, there has never been a reported case of treponema pallidum resistant to PCN. Let’s have a look at why this might be..." / X

1/ Why hasn't syphilis developed resistance to penicillin (PCN)? It took staph aureus about a year to demonstrate resistance. After 75 years, there has never been a reported case of treponema pallidum resistant to PCN. Let’s have a look at why this might be...

x.com

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Josh Osowicki @joshosowicki.bsky.social · Jul 18

Apropos of #7…

pubmed.ncbi.nlm.nih.gov/9636860/

Why have group A streptococci remained susceptible to penicillin? Report on a symposium - PubMed

In spite of 50 years of extensive use of penicillin, group A streptococci remain exquisitely susceptible to this antibiotic. This observation that continuing susceptibility has occurred despite the de...

pubmed.ncbi.nlm.nih.gov

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Josh Osowicki @joshosowicki.bsky.social · Jul 13

Many, perhaps most, of the deaths from ‘nephropathies’ (8%) and heart disease (12%) would have been infection-related so >2/3 deaths likely infection-related. Many, probably most, due to APSGN & RHD (i.e. #StrepA). Guess what? 🇺🇸 made a vaccine (it worked). 🌏 needs to do it again.

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Reposted by Josh Osowicki

Michael Marks @drmichaelmarks.bsky.social · Jul 6

Latest from @mrcunitgambia.bsky.social #StrepA group. Show clinical decision rules developed elsewhere (mostly HIC) have poor performance in Gambia & molecular tests detect far more #StrepA than culture. Given burden of RhD in Africa we urgently need better & affordable tests for #StrepA diagnosis

Evaluating clinical decision rules and rapid diagnostic tests for the diagnosis of Streptococcus pyogenes pharyngitis in Gambian children: a diagnostic accuracy study

Accurate diagnosis of Streptococcus pyogenes (S. pyogenes) pharyngitis is imperative in high rheumatic heart disease-burden countries. We aimed to assess the diagnostic accuracy of two rapid diagnosti...

www.journalofinfection.com

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Reposted by Josh Osowicki

Ben Morton @benmorton.bsky.social · Jul 2

RSV and pneumococcus demonstrate close interaction in epidemiological studies but which is 🐥 and which is 🥚. This study by our group is designed to find out...

#idsky #medsky

journals.plos.org/plosone/arti...

Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled stu...

Background Streptococcus pneumoniae (pneumococcus) and respiratory syncytial virus (RSV) are major causes of respiratory infections globally. Viral and bacterial co-infections are commonly observed in...

journals.plos.org

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Reposted by Josh Osowicki

Alexander V. Veselov 😷🎮 @alexxxmd.bsky.social · Jul 2

A Phase II, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of HEX17, a Novel Broad-Spectrum Antiviral Drug, in a Controlled Human Infection Model of Influenza Challenge.
Kitson, G., Byford, M., Cass, L. et al.
Infect Dis Ther (2025).
doi.org/10.1007/s401...

A Phase II, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of HEX17, a Novel Broad-Spectrum Antiviral Drug, in a Controlled Human Infection Model of Influenza Challenge - ...

Introduction Viral respiratory tract infections are of global concern, with an unmet need for a broad-spectrum antiviral prophylactic. HEX17, a multivalent carbohydrate-binding module, binds to sialic...

doi.org

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Michael Marks @drmichaelmarks.bsky.social · Jun 24

Come & work with me @benvyle.bsky.social @lshtm.bsky.social & @thelovetankcic.bsky.social Research Assistant with funded PhD within multidisciplinary project on Syphilis & STI control in the UK. Working with us to understand stakeholder & community perspectives on novel STI control strategies

Job Opportunity at LSHTM: Research Assistant

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...

jobs.lshtm.ac.uk

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Josh Osowicki @joshosowicki.bsky.social · Jun 24

It becomes the Thesis of Theseus.

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British Infection Association @biainfection.bsky.social · Jun 22

Read the latest Journal of #Infection for the Phase-IIa trial and how it evaluates the safety and pharmacokinetics of high-dose, 10 weekly subcutaneous injections of penicillin (#SCIP) in young people with a history of acute rheumatic fever (#ARF) 👉 www.journalofinfecti...

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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Jun 14

🄰🅆🄴🅂🄾🄼🄴
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌

Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:

Nutrient-rich environments ➜ kill competitors

Under starvation ➜ lyse neighbors to scavenge their nutrients

Even “non-pathogens” shift from competition to predation as a survival strategy

Antagonism as a foraging strategy in microbial communities

In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...

www.science.org

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Josh Osowicki @joshosowicki.bsky.social · Jun 11

en.m.wikipedia.org/wiki/Victore...

Victorella - Wikipedia

en.m.wikipedia.org

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Reposted by Josh Osowicki

Stuart Campbell @sc345.bsky.social · Jun 5

Dr O Xie has an entertaining talk on S. dys subsp eq [SDSE]

🐴 iSDSE has similar incidence and mortality v iGAS
🐎 Less genomic clustering in SDSE
🫏 Global dissemination iSDSE driven by stG62647-lineage

#LISSSD25 #clinmicro #idsky

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