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Andrew S. MacDonald

@profandrewmac.bsky.social

3K followers 680 following 130 posts

Prof at Edinburgh University. #Immunologist. #Inflammation, #infection, #helminths, #allergy, #metabolism and the #microbiome. https://scholar.google.com/citations?user=gcuDni4AAAAJ&hl=en&oi=ao Not interested in pitchfork politics of any flavour…

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Andrew S. MacDonald @profandrewmac.bsky.social · Jun 16

Delighted to share our paper on the role of SOX9 in liver #fibrosis and #granuloma formation during #schistosome infection - a really great collaboration over the past few years with the Piper Hanley lab! #ImmunSky 🪱🧪

dx.plos.org/10.1371/jour...

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage

Author summary Mammalian infection with schistosome worms results in the deposition of parasite eggs in the liver, where they secrete organ damaging toxins. In response, the liver generates a cellular...

dx.plos.org

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Reposted by Andrew S. MacDonald

Emma Houlder @emmahoulder.bsky.social · Jul 31

In schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles.

In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58

T cell responses in repeated controlled human schistosome infection compared to natural exposure

Nature Communications - In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma...

rdcu.be

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Reposted by Andrew S. MacDonald

David E Sanin @davidesanin.bsky.social · Aug 22

🚨 Want to find interesting cells in single-cell RNAseq data independently of clusters? Try our method to identify transcriptional shifts using OAR scores!
Pre-print: doi.org/10.1101/2025...
R tool and tutorials: sanin-lab.github.io/OARscRNA/
@biorxiv-bioinfo.bsky.social
1/n

Missing data in single-cell transcriptomes reveals transcriptional shifts

Profiling thousands of single cell transcriptomes is routine, yet cell prioritization based on response to biological perturbations is challenging and confounded by clustering, normalization and dimen...

doi.org

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Reposted by Andrew S. MacDonald

Tara Sutherland @drtesutherland.bsky.social · 20d

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

Lecturer in Neuroimmunology, Medicine, Medical Sciences & Nutrition (MED243A) | The University of Aberdeen

Browse and apply for current job openings at the University of Aberdeen across various schools, departments and roles, including admin and academic.

www.abdn.ac.uk

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Reposted by Andrew S. MacDonald

Denise Fitzgerald @deefitzgerald.bsky.social · 19d

Fantastic thread on budgeting from @labliston.bsky.social . Great advice for new (and not so new!) PIs. I would add awareness of how psychology impacts spending based on moving from low budget to high budget setting and vice versa....

Adrian Liston @labliston.bsky.social · Sep 3

🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

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Reposted by Andrew S. MacDonald

Adrian Liston @labliston.bsky.social · 20d

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Reposted by Andrew S. MacDonald

emds2025.bsky.social @emds2025.bsky.social · 20d

A massive thanks to all the #EMDS2025 speakers, delegates, sponsors & @edinburgh-uni.bsky.social staff for making @emds2025.bsky.social such a success.

We had a great time, we hope you did too and your travel home was smooth.

Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social

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Andrew S. MacDonald @profandrewmac.bsky.social · 21d

The end of #EMDS2025 - so much amazing science, and great to meet up in person with so many friends and colleagues (and make some new ones!). Very proud of @vshek.bsky.social and @nwasowska.bsky.social winning poster prizes for the team - well done both!

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Andrew S. MacDonald @profandrewmac.bsky.social · 21d

A fantastic talk from David Russell to end #EMDS2025 - about #macrophage subset responses to #Mycobaterium tuberculosis, and their re-programming to improve drug efficacy in vitro and in vivo

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Reposted by Andrew S. MacDonald

Elaine Emmerson @doctoremmerson.bsky.social · 21d

A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh

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Reposted by Andrew S. MacDonald

Lucy Jackson-Jones @lucyhjackson-j.bsky.social · 21d

Heading home after a fabulous few days in Edinburgh @emds2025.bsky.social Excellent venue, amazing programme, thanks @bainlab.bsky.social @profandrewmac.bsky.social and Samanta Mariani #EMDS2025 #Macrophage #DCs ♥️

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Andrew S. MacDonald @profandrewmac.bsky.social · 21d

Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 21d

Another great talk from @immunobladder.bsky.social about #macrophage subsets in the #bladder, including in memory response to bacterial infection and key differences in males vs females #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 21d

Final day of #EMDS2025 opens with a fantastic talk from Will Wood - beautiful imaging of #macrophage migration following wounding, using the tractability of #Drosophila in ingenious ways to identify key chemoattractants in this process

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Reposted by Andrew S. MacDonald

martinguilliams.bsky.social @martinguilliams.bsky.social · 22d

When the PhD student gives a better talk than his promotors! 👏🏻👏🏻👏🏻 Spectacular talk from @StijnVerwaerde #EMDS2025 🤩🤩. Very cool collaboration with @bart_lambrecht team. Identification of regulatory circuits switching homeostatic regulons to type 2 inflammatory regulons in AMs

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Fantastic talk and new data from @lukeanthonyoneill.bsky.social about #mitochondrial control of #inflammation by #itaconate and derivatives in multiple settings #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Really interesting talk from @chrysothemisbrown.bsky.social about ontogeny, transcriptional regulation and function of subsets of #ThetisCells, including their role in #Treg induction and oral #tolerance #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Beautiful and energetic talk from @drpetercook.bsky.social about #DendriticCell uptake of and activation by #fungal spores in #allergic airway #inflammation, and metabolic requirements for this #EMDS2025

Reposted by Andrew S. MacDonald

Barbara Schraml @barbaraschraml.bsky.social · 22d

Thank you. Very happy to discuss pur work at this amazing meeting! Great times: #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Final talk pre-lunch from @mariolaks.bsky.social defining some of the key #DendriticCell subsets involved in shaping joint #inflammation vs remission, in both human and mouse #EMDS2025

Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Interesting short talk from Anita Qualls about RORgt+ #APCs in oral tolerance and #Treg induction #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Another lovely talk, this time from David Munro, about the context dependent roles for #HIF1a in #microglia, including in stroke #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

First talk so far about #immunometabolism at #EMDS2025 - really interesting murine and human data about mitochondrial (dys)function in #macrophages as a regulator of #inflammation, from @immunometlab.bsky.social

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Lovely talk from Samanta Mariani about embryonic #macrophages in hematopoiesis, in health and in malignancy #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Really interesting talk by Barbara Schraml, showing how dietary cues at weaning can activate splenic #cDC1 to induce CTL-like effector CD8+ T cells #EMDS2025

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Andrew S. MacDonald @profandrewmac.bsky.social · 22d

Day 2 of #EMDS2025 starts with a beautiful talk about lung tissue resident #alveolar #macrophage identity and the influence of #IL-33 on this, by Stijn Verwaerde from BART Lambrecht’s lab.

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