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Reposted by Jure Majnik

Janet Hill @saskajanet.bsky.social · 1d

Look at her go!
#invertebrates 🌿

Screen shot of Project Monarch app map of progress of a monarch butterfly from southern Ontario to Oklahoma.

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Greg Jefferis @jefferis.bsky.social · 4d

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Male CNS Connectome

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

www.janelia.org

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Max Fürst @maxfus.bsky.social · 4d

Un-frigging-believable. I have waited for something like this for so long!

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Adam Glaser @adamkglaser.bsky.social · 10d

Latest imaging data from our completely re-designed ExA-SPIM system.

Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.

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kuba sędziński @kuba-sedzinski.bsky.social · 17d

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

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Anna Foix @afoix.bsky.social · 16d

Happy to share that ShapeEmbed has been accepted at @neuripsconf.bsky.social 🎉 SE is self-supervised framework to encode 2D contours from microscopy & natural images into a latent representation invariant to translation, scaling, rotation, reflection & point indexing
📄 arxiv.org/pdf/2507.01009 (1/N)

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Misha Ahrens @mishaahrens.bsky.social · Sep 8

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

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Dan Goodman @neural-reckoning.org · Sep 4

So how did it work out? Well, some things went well and others not so well. We published a paper with our results and reflections on the process. If you're interested in spiking neural networks, sound localisation, or anarchist science, check it out: www.eneuro.org/content/12/7...

Spiking Neural Network Models of Interaural Time Difference Extraction via a Massively Collaborative Process

Neuroscientists are increasingly initiating large-scale collaborations which bring together tens to hundreds of researchers. At this scale, such projects can tackle big challenges and engage diverse p...

www.eneuro.org

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Ardem Patapoutian @ardemp.bskyverified.social · Sep 1

I rarely dive into circuit-mapping papers, but this blockbuster from @ribeirocarlitos.bsky.social lab is a doozy! Check it out.

www.biorxiv.org/content/10.1...

From Sensory Detection to Motor Action: The Comprehensive Drosophila Taste-Feeding Connectome

In Drosophila , the gustatory system is distributed across multiple body parts and tightly couples sensory input to value-based behaviors such as feeding, foraging, and social interactions. Despite th...

www.biorxiv.org

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Alexander Shakeel Bates @asbates.bsky.social · Aug 2

Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc

Different from prior connectomes - it is brain + cord (think spinal cord)

We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...

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Pau Formosa-Jordan @pauformosa.bsky.social · Aug 4

Introducing five concepts from dynamical systems to decode developmental regulatory mechanisms, have a read! @perez-carrasco.bsky.social‬ @roederlab.bsky.social @mpipz.bsky.social This effort started in a morphogenesis meeting @kitp-ucsb.bsky.social‬ in 2023. journals.biologists.com/dev/article/...

Adapted from Fig. 1 from Kadiyala et al 2025.

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Mattia Chini @mattiachini.bsky.social · Aug 1

"people use it very differently".. this applies to so many concepts in neuroscience!
We (@irinapochinok.bsky.social and Simon Musall) put together a #BernsteinConference Workshop on exactly this and @juangallego.bsky.social will be one of our speakers!
@bernsteinneuro.bsky.social
shorturl.at/4kV00

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Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · Jul 31

Beautiful and inspiring work from Gero Miesenböck and colleagues www.nature.com/articles/s41...

Mitochondrial origins of the pressure to sleep - Nature

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

www.nature.com

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Ben Gallusser @bengallusser.bsky.social · Jul 30

Cell tracking is never perfect, and it's important to understand the types of errors your solution contains.

Here is my stab at this: Divisualisations in @napari.org. github.com/bentaculum/d...

You spin tracks out upwards from the playing video. Green edges are correct, FP in magenta, FN in cyan.

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Matt Perich @mattperich.bsky.social · Jul 29

Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!

🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW

A neural manifold view of the brain - Nature Neuroscience

Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

www.nature.com

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carolinehaimerl.bsky.social @carolinehaimerl.bsky.social · Jul 29

When neurons change, but behavior doesn’t: Excitability changes driving representational drift

New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...

Representational drift without synaptic plasticity

Neural computations support stable behavior despite relying on many dynamically changing biological processes. One such process is representational drift (RD), in which neurons' responses change over ...

www.biorxiv.org

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Tanner Fadero @tanner-fadero.bsky.social · Jul 26

If you've ever wanted to know what the actin filaments on the scales in a developing moth wing look like in 3D, here you go!

Kyle DeMarr from @mullinslab.bsky.social acquired these beautiful data on the single objective light sheet at the UCSF Center for Advanced Light Microscopy.

#snouty

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katja heuer @k4tj4.bsky.social · Jul 27

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

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Petr Znamenskiy @petrznam.bsky.social · Jul 21

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵

www.biorxiv.org/content/10.1...

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits

Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...

www.biorxiv.org

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Axel Visel @axelvisel.bsky.social · Jul 16

No new genes needed to fly - just rewire what you have! 🦇🧬

Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social

doi.org/10.1038/s415...

#EvoDevo #SingleCell #BatWings

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Kevin Mitchell @wiringthebrain.bsky.social · Jul 16

This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)

W. Brent Derry @wbderry.bsky.social · Jul 16

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

Giant study finds a research field that’s mostly reproducible

Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

www.nature.com

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Chaitanya Chintaluri @chaichinta.bsky.social · Jul 10

Meme of an astronaut looking at Earth and exclaiming 'wait, is it metabolism?', behind them is another astronaut about to shoot them, saying 'it has always been'

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Jure Majnik @juremaj.bsky.social · Jul 10

Our preprint on tracking cells in 2p calcium imaging during development is now online at @elife.bsky.social !

Its cool that the reviews are open - now its revision time 🫡🫡🫡

doi.org/10.7554/eLif...

Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p

doi.org

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Sofia Zangila @sofiazang.bsky.social · Jun 8

Hi! How is the rate of change of behavior represented in mouse V1?

If intrigued by how we approach this question with a group of NeuroMatch fellows, take a look at our micropublication zenodo.org/records/1539...

Thanks a lot to Impact Scholars program & @neuromatch.bsky.social :) !

V1 Neurons Track the Rate-of-Change of Behavioral Variables

Population-level neuronal dynamics across the brain are shaped by behavioral state variables, such as running speed or pupil area. Given this real-time integration of state variables within sensory ne...

zenodo.org

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Evelina Tutucci @anilevetu.bsky.social · Jul 8

Optogenetic storage and release of protein and mRNA in live cells and animals | Nature Communications share.google/gz8nYXZ3hUVh...

#spatialbiology #imagingtools #fluorescencemicroscopy

Optogenetic storage and release of protein and mRNA in live cells and animals - Nature Communications

Spatiotemporal control of biomolecules is a key challenge in cell biology. Here, authors introduce RELISR, an optogenetic condensate system enabling reversible, light-dependent sequestration and relea...

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