Lightnews — Scholar-powered news

Celeste Karch @karchlab.bsky.social · Jun 18

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Celeste Karch @karchlab.bsky.social · Jun 18

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Celeste Karch @karchlab.bsky.social · Jun 12

🎉🎉🎉🎉🎉🎉🎉

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Celeste Karch @karchlab.bsky.social · Jun 6

Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?

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Reposted by Celeste Karch

Martin Kampmann @kampmann.bsky.social · May 20

www.alz.org/news/2025/ke...

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research

The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

www.alz.org

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Reposted by Celeste Karch

Soyon Hong @soyonhonglab.bsky.social · May 9

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

https://ucl.ac.uk/work-at-ucl/se…

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Celeste Karch @karchlab.bsky.social · May 5

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Reposted by Celeste Karch

Shannon Macauley @macauleylab.bsky.social · May 1

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data

bioRxivpreprint @biorxivpreprint.bsky.social · May 1

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data https://www.biorxiv.org/content/10.1101/2025.04.28.650893v1

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Celeste Karch @karchlab.bsky.social · May 1

Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...

URGENT ACTION ALERT: Historic Threat to SNAP – Keep The Pressure On

secure.everyaction.com

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Reposted by Celeste Karch

Young-Pearse Lab @typlab.bsky.social · Apr 30

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

www.cell.com

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Celeste Karch @karchlab.bsky.social · Apr 18

Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social

Could blocking ‘jumping genes’ help fight disease and aging?

The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

www.science.org

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Reposted by Celeste Karch

Charleston Conference on Alzheimer's Disease (CCAD) @the-ccad.bsky.social · Apr 17

Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!

Registration 🔗 us02web.zoom.us/meeting/regi...

#NewVisionResearch #ProfessionalDevelopment

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Reposted by Celeste Karch

Prof Malú Gámez Tansey @malutansey.bsky.social · Apr 10

Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration

Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.

us02web.zoom.us

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Reposted by Celeste Karch

Kepecs Lab @ WashU @kepecslab.bsky.social · Apr 11

1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...

A neuroimmune circuit mediates cancer cachexia-associated apathy

Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...

doi.org

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Celeste Karch @karchlab.bsky.social · Mar 31

Celeste Karch @karchlab.bsky.social · Mar 27

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Reposted by Celeste Karch

Na Zhao @zhaonaa.bsky.social · Mar 20

Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social

Neuron @cp-neuron.bsky.social · Mar 19

APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease

Using single-nucleus RNA sequencing on post-mortem brains from control subjects and Alzheimer’s disease patients, Li et al. revealed APOE-genotype-specific molecular alterations across distinct brain cell types associated with AD. This study offers a…

dlvr.it

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Celeste Karch @karchlab.bsky.social · Mar 19

When educators, students, families, and community members come together, there is nothing we cannot achieve. Join us to protect students and families on March 19 by attending or hosting a “walk-in” at your local school: nea.org/March19

March 19 Participant Toolkit | NEA

On Wednesday, March 19, our communities will walk into our schools together to show elected leaders that we are united in support for the programs and protections our communities need to thrive.

nea.org

Reposted by Celeste Karch

Maya Voichek @mayavoichek.bsky.social · Mar 17

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

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Reposted by Celeste Karch

Frank Shewmaker @frank-shewmaker.bsky.social · Mar 17

NfL beats GFAP in a head-to-head FTD biomarker competition. Gendron et al. show plasma GFAP and NfL correlate with FTD disorder severity; however, NfL outperforms GFAP as a prognostic biomarker and potential susceptibility marker.

molecularneurodegeneration.biomedcentral.com/articles/10....

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders - Molecular Neurodegeneration

Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and the underlying causative pathology. Blood gli...

molecularneurodegeneration.biomedcentral.com

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Reposted by Celeste Karch

John Lukens @lukensjohnr.bsky.social · Mar 14

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration
www.nature.com/articles/s41...

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Reposted by Celeste Karch

John Lukens @lukensjohnr.bsky.social · Mar 14

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum: Neuron www.cell.com/neuron/fullt...

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Reposted by Celeste Karch

Wilfried Rossoll @rossolllab.bsky.social · Mar 13

Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies - Molecular Neurodegeneration

Background Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite extensive research, the mec...

molecularneurodegeneration.biomedcentral.com

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Reposted by Celeste Karch

Melissa E. Murray @drneurochic.bsky.social · Mar 13

🤩Preprint alert👇 Excited to introduce the concept of transformative neuropathology, a term we use to describe the integration of foundational descriptive pathology with advanced technologies and methodologies 🔬🏛️🧬🧪🖥️🔬 🧠📊🤖
@cshlnews.bsky.social

www.preprints.org/manuscript/2...

www.preprints.org

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Reposted by Celeste Karch

Bess Frost @bessfrost.bsky.social · Mar 12

Results from our AntiRetroviral Therapy for Alzheimer's Disease (ART-AD) clinical trial are available online today and will be included in the inaugural issue of npj Dementia.

rdcu.be/edfwq

A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)

npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)

rdcu.be

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