Nice paper on the temporal dynamics of early infancy. Once again, it was shown that Escherichia & Klebsiella correlate with higher ARG load, and their abundance is in turn negatively associated with Bifidos. Kudos to the authors for the excellent paper!
rdcu.be/eDRPa

Proud of our group's newest publication!

Great thread from @antagomir.bsky.social about our latest collaborative study led by the brilliant @katammp.bsky.social on the antibiotic resistome in a representative Finnish population of n>6,500 individuals and factors associated with carriage.

Link to study: doi.org/10.1038/s414...

Read the study: doi.org/10.1038/s414... - /w @katammp.bsky.social @begia.bsky.social Guilhem Sommeria-Klein, Ville Laitinen, Pyry Kantanen, @gmeric.bsky.social @gazollavolpiano.bsky.social Michael Inouye, Rob Knight, Veikko Salomaa, Aki S. Havulinna, Teemu Niiranen, @antagomir.bsky.social

Variation and prognostic potential of the gut antibiotic resistome in a population-based cohort www.nature.com/articles/s41...

We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.

Thank you #ASMicrobe 2025 for an excellent conference in Los Angeles! It was great to meet new people and present our team's recent work with #AMR

International comparison reveals gender differences in antimicrobial resistance - an analysis of more than 14,000 open gut metagenomes indicates that in high-income countries women had more antibiotic resistance than men www.utu.fi/en/news/pres... /w @katammp.bsky.social @mahkamehsalehi.bsky.social

Hi! One of the lead authors here. We think it is mostly because women have more antibiotics than men on average, but also other things like profession (nursing, teaching small children), as well as behaviours, are likely to contribute. We're planning to do more research on this later.

🦠🌍 Antibiotic resistance differs by gender

A global study of 14,000+ gut samples found women in high-income countries have 9% more antibiotic resistance genes than men.

In lower-income countries, patterns flip – but context matters.

🔗 www.nature.com/articles/s41...

#SciComm #AMR 🧪

Kansainvälinen vertailu paljasti antibiooteille vastustuskykyisten bakteerien erot sukupuolten välillä www.utu.fi/fi/ajankohta...

Take home message! Recognizing gender and age-specific differences in AMR is essential for research and for creating fair healthcare strategies. For more details, data, and code, read the full study with @katammp.bsky.social et al. here: www.nature.com/articles/s41...

Age and geography were significant factors associated with resistome composition, with infants and the elderly showing higher ARG loads and diversity. This pattern underscores the impact of life stages on AMR.

Genders share similar ARGs despite the difference in their abundance. Region and age explained far more variation in ARG composition than gender.

Gender differences in ARG abundance emerged in adulthood, indicating that gender-associated lifestyle, biological, or healthcare-related factors in adulthood may be linked to antibiotic resistance.

In LMICs, limited data indicated that when accounting for confounding factors such as age and socio-economics, the difference between men and women was not significant.

Women in HICs also showed slightly higher ARG diversity than men, suggesting a broader range of resistance genes present in their gut microbiomes.

In high-income countries (HICs), women had 9% higher ARG abundance compared to men. This suggests that women in HICs may be more exposed to or carry more antibiotic-resistant bacteria. In low-income countries (LMICs), the trend was reversed. www.nature.com/articles/s41...

Antimicrobial resistance #AMR is a major #globalhealth threat. How does it vary between genders? We analyzed 14,641 open human gut #metagenomes from 32 countries to investigate gender differences in #antibioticResistance genes (ARGs). www.nature.com/articles/s41...

Did you know that the female #microbiome is unique in many ways, and antibiotic resistance in the gut microbiome varies between genders? See npj Biofilms and Microbiomes special issue, Women and their microbes, to learn more! www.nature.com/collections/...