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Reposted by Lukas Groschner

MPI for Biological Intelligence @mpiforbi.bsky.social · 10d

We are recruiting PhD students! Join us in exploring the multiple dimensions of biological intelligence at our international and fully funded graduate program IMPRS-BI in the Munich area, Germany!

🔔 Application period: 1 October to 10 November
🧪 Apply here: imprs-bi.mpg.de

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Reposted by Lukas Groschner

Ana Marija Jakšić @merianelion.bsky.social · 11d

🚨Preprint🚨
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images

www.biorxiv.org/content/10.1...

Figure showing 3 panels. Panel A: workflow of a classical deep learning model vs TopoTome workflow, with marked differences between the methods, including manual segmentation of images, design and optimization of neural network and data post processing that is needed in deep learning workflow but not in TopoTome. Panel B: core concepts behind TopoTome shown connected by arrows. From left to right, there is a microCT scan of a fly brain (3D reconstruction), a persistence barcode of H2 homologies, an image of how persistent barcodes map to the original CT brain scan, and a segmentation of a CT scan. Panel C shows the concept of cubical complex filtration of 2D and 3D image data.

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Katrin Vogt @katrinvogt.bsky.social · 14d

How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading!
www.biorxiv.org/content/10.1...

A multisensory, bidirectional, valence encoder guides behavioral decisions

A key function of the brain is to categorize sensory cues as repulsive or attractive and respond accordingly. While we have some understanding of how sensory information is processed in the sensory pe...

www.biorxiv.org

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Max-Planck-Gesellschaft @maxplanck.de · 24d

Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors

Directors

The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.

www.mpg.de

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Daniel Kronauer @danielkronauer.bsky.social · 22d

The final version of our paper on how ants and possibly other insects use a crazy mechanism involving extensive transcriptional interference to regulate odorant receptor expression is now open access in my favorite journal, @currentbiology.bsky.social

authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Thomas Luo @thomas-zhihao-luo.bsky.social · 23d

How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv

Transitions in dynamical regime and neural mode during perceptual decisions - Nature

Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...

www.nature.com

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Reposted by Lukas Groschner

MPI for Biological Intelligence @mpiforbi.bsky.social · 22d

Apply now to become a speaker at our Institute! We invite excellent postdocs in neuroscience, ecology and other fields related to our research to apply for our Emerging Scientist Talk Series. Apply by October 24: www.bi.mpg.de/ess

@chr-mayer.bsky.social @fleyes.bsky.social @michaelahau.bsky.social

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Andrew Lin @andrewclin.bsky.social · Sep 1

Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx doi.org/10.1113/JP28...

Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells

Abstract figure legend: We tested the effects of expressing the bacterial voltage-gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expressi...

doi.org

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FlyBase @flybase.bsky.social · Aug 15

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase:Contribute to FlyBase - FlyBase Wiki

wiki.flybase.org

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Lucia Prieto Godino @neuroluci.bsky.social · Jun 12

How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇

bit.ly/44aVm9E

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The Transmitter @thetransmitter.bsky.social · Aug 13

FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research.

By @claudia-lopez.bsky.social

www.thetransmitter.org/community/ha...

Harvard University lays off fly database team

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

www.thetransmitter.org

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Katrin Vogt @katrinvogt.bsky.social · Aug 12

Exciting new paper from the Bahl lab @bahllab.bsky.social @zwitscherarmin.bsky.social and Katja Slangewal about parallel and convergent processing pathways of different visual features in the larval zebrafish brain🐟
www.biorxiv.org/content/10.1...

Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making

Animals continuously extract and evaluate diverse sensory information from the environment to guide behavior. Yet, how neural circuits integrate multiple, potentially conflicting, inputs during decisi...

www.biorxiv.org

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Matt Collie @mottcallie.bsky.social · Aug 4

We need more papers that start with Steve Urkel quotes. Thank you @kylethieringer.com and @tuthill.bsky.social for this wonderful and fun review of our recent paper describing limb feedback in the visual system!

doi.org/10.1016/j.cu...

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Annalisa Bucci @anbucci.bsky.social · Jul 24

Excited to share our Nature Neuroscience paper!
We explored how the human #retina keeps signals in sync despite big differences in axon length.
Great collaboration with @iobswiss.bsky.social + @bel-bsse.bsky.social — special thanks to @ffranke.bsky.social
#neuroskyence

🧠👁️⏱️
bsky.app/profile/natn...

Nature Neuroscience @natneuro.nature.com · Jul 18

The human brain synchronizes visual signals by adjusting axonal conduction speed in the retina—revealing a previously
unknown mechanism for precise perceptual timing

@anbucci.bsky.social @ffranke.bsky.social @iobswiss.bsky.social

www.nature.com/articles/s41...

Synchronization of visual perception within the human fovea - Nature Neuroscience

Combining behavioral data, electrophysiology and modeling, the authors show that the human brain synchronizes visual signals by adjusting axonal conduction speed in the retina, revealing a previously ...

www.nature.com

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Flor Iacaruso @flor-iacaruso.bsky.social · Aug 1

1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & ‪@bturner-bridger.bsky.social‬ in collab w/ ‪@petrznam.bsky.social‬ @crick.ac.uk
www.biorxiv.org/content/10.1...

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Petr Znamenskiy @petrznam.bsky.social · Jul 21

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵

www.biorxiv.org/content/10.1...

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits

Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...

www.biorxiv.org

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Matt Collie @mottcallie.bsky.social · Jul 17

New paper from our lab! This was such a fun project to be a part of - proof that sometimes following a spurious observations down the rabbit hole leads to awesome findings.

www.cell.com/current-biol...

A cell type in the visual system that receives feedback about limb movement

Hartman et al. describe a cell type in the Drosophila visual system that is activated during head grooming through visual and non-visual signals arising from foreleg movements. These neurons inhibit a...

www.cell.com

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Reposted by Lukas Groschner

Alice Mosberger @alicemosberger.bsky.social · Jun 25

🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab!

Are you interested in understanding how the brain moves our arms?

Reach to your computer and apply!

www.mosbergerlab.com/open-positions

Open Positions — Mosberger Lab

www.mosbergerlab.com

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Christian Mayer @chr-mayer.bsky.social · Jul 8

Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

www.nature.com

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Jeremiah Cohen @jeremiahycohen.bsky.social · Jul 7

We have an open position for a Scientist I at the Allen Institute for Neural Dynamics. Come join our exciting research environment @alleninstitute.org. Please share!

alleninstitute.org/careers/jobs...

Jobs

We are working to solve the biggest mysteries in bioscience.

alleninstitute.org

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Rui Ponte Costa @somnirons.bsky.social · Jul 4

Pleased to say that our story of how a theory of self-supervised learning in cortical layers accounts for several experimental observations is now out 🎉
www.nature.com/articles/s41...

Self-supervised predictive learning accounts for cortical layer-specificity - Nature Communications

How the cortex learns an internal representation of the world and why the cortex relies on a layered structure remain poorly understood. Here, the authors propose a computational theory in which the n...

www.nature.com

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Edvard I Moser @edvardmoser.bsky.social · Jun 26

Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)

👉 www.science.org/doi/10.1126/...

Event structure sculpts neural population dynamics in the lateral entorhinal cortex

Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

www.science.org

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Thiago Carvalho @cyrilpedia.bsky.social · Jun 24

'(...) there is no established resource for group leaders to improve their lab culture with concrete action points for implementation. Here, we introduce the SAFE Labs Handbook: a collection of thirty “commitments” which can be verifiably actioned without requiring institutional support.'
#Preprint

www.biorxiv.org

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Bahl Lab @bahllab.bsky.social · Jun 23

We are proud to have @maxcapelle.bsky.social's paper out on bioRxiv! He found that phototactic behavior in #zebrafish switches during #ontogeny🐟🔆 Through elegant behavioral dissections, he identifies the navigational strategies related to this transition. www.biorxiv.org/content/10.1... Thread 👇

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Samuel Liebana @samuel-liebana.bsky.social · Jun 15

Does the brain learn by gradient descent?

It's a pleasure to share our paper at @cp-cell.bsky.social, showing how mice learning over long timescales display key hallmarks of gradient descent (GD).

The culmination of my PhD supervised by @laklab.bsky.social, @saxelab.bsky.social and Rafal Bogacz!

Dopamine encodes deep network teaching signals for individual learning trajectories

Longitudinal tracking of long-term learning behavior and striatal dopamine reveals that dopamine teaching signals shape individually diverse yet systematic learning trajectories, captured mathematical...

www.cell.com

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