Luke Allsopp
@lukeallsopp.bsky.social
Senior Lecturer Imperial College London
Microbiology Bacteriology Scientist Biofilm Bacteria Nature T6SS and bacterial competition
Microbiology Bacteriology Scientist Biofilm Bacteria Nature T6SS and bacterial competition
Reposted by Luke Allsopp
Reposted by Luke Allsopp
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications
Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...
www.nature.com
November 25, 2025 at 10:40 AM
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
Reposted by Luke Allsopp
Happy to share our latest T6SS review:
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
The type VI secretion system and associated effector proteins - Nature Reviews Microbiology
In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...
nature.com
November 17, 2025 at 10:08 AM
Happy to share our latest T6SS review:
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
Reposted by Luke Allsopp
It was powerful to see the many stories of how antibiotics have changed people's lives as part of the Fleming Initiative's takeover of the Piccadilly Lights in London last night. #WAAW2025
November 19, 2025 at 9:21 AM
It was powerful to see the many stories of how antibiotics have changed people's lives as part of the Fleming Initiative's takeover of the Piccadilly Lights in London last night. #WAAW2025
Reposted by Luke Allsopp
This week is World Antimicrobial Resistance Awareness Week and this #ResearchWednesday we wanted to explain why preventing and tackling antimicrobial resistance is so important to people with #cysticfibrosis.
➡️ www.cysticfibrosis.org.uk/news/improvi...
➡️ www.cysticfibrosis.org.uk/news/improvi...
November 19, 2025 at 10:27 AM
This week is World Antimicrobial Resistance Awareness Week and this #ResearchWednesday we wanted to explain why preventing and tackling antimicrobial resistance is so important to people with #cysticfibrosis.
➡️ www.cysticfibrosis.org.uk/news/improvi...
➡️ www.cysticfibrosis.org.uk/news/improvi...
Reposted by Luke Allsopp
This week is World #AntimicrobialResistance Awareness week
To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
World AMR Awareness Week call to action: Patient and public involvement and engagement to improve impact on antimicrobial resistance – the time to act is now
A step change is required in citizen awareness of the global AMR health crisis and, crucially, public involvement in tackling it. The global context presents new challenges but real-world examples show what is possible and an historic moment approaches, that we can leverage for positive action.
bit.ly
November 19, 2025 at 9:39 AM
This week is World #AntimicrobialResistance Awareness week
To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
To mark the occasion, Dr Scott-Dearing reflects on her @natcomms.nature.com paper published in January, noting the setbacks and progress made in tackling #AMR since
Reposted by Luke Allsopp
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
buff.ly/JST7ZR1
October 4, 2025 at 10:01 AM
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
buff.ly/JST7ZR1
Reposted by Luke Allsopp
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
www.nature.com
November 5, 2025 at 7:32 AM
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Luke Allsopp
Rare disease research needs a more integrated and collaborative approach.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
November 4, 2025 at 9:15 AM
Rare disease research needs a more integrated and collaborative approach.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
Great kick off meeting for the Precision CF Innovation Hub @imperialnhli.bsky.social @janedaviescf.bsky.social. Awesome talks and a real energy. Thanks to funders @lifearc.bsky.social and @cysticfibrosis.org.uk
October 22, 2025 at 8:51 AM
Great kick off meeting for the Precision CF Innovation Hub @imperialnhli.bsky.social @janedaviescf.bsky.social. Awesome talks and a real energy. Thanks to funders @lifearc.bsky.social and @cysticfibrosis.org.uk
Reposted by Luke Allsopp
New in JB: Bhattacharya, Zhang, & Yu review the current state of knowledge around protein trafficking across the membrane by gram-positive bacteria with a focus on the model organisms Bacillus subtilis and Staphylococcus aureus.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
October 21, 2025 at 12:44 PM
New in JB: Bhattacharya, Zhang, & Yu review the current state of knowledge around protein trafficking across the membrane by gram-positive bacteria with a focus on the model organisms Bacillus subtilis and Staphylococcus aureus.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
Reposted by Luke Allsopp
Today is #WorldPhageDay! One of our key aims is to advance #phagetherapy, which uses natural viruses called #phage to target bacteria instead of antibiotics. We are working to develop new phage combinations, test the best way of giving them, and ensure the UK can produce phage at medical standards.
October 22, 2025 at 8:16 AM
Today is #WorldPhageDay! One of our key aims is to advance #phagetherapy, which uses natural viruses called #phage to target bacteria instead of antibiotics. We are working to develop new phage combinations, test the best way of giving them, and ensure the UK can produce phage at medical standards.
Reposted by Luke Allsopp
Thrilled to share that two of our papers with @jrpenades.bsky.social & GoogleDeepMind
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
September 9, 2025 at 3:06 PM
Thrilled to share that two of our papers with @jrpenades.bsky.social & GoogleDeepMind
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
Reposted by Luke Allsopp
Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏
www.imperial.ac.uk/media/imperi...
www.imperial.ac.uk/media/imperi...
www.imperial.ac.uk
July 28, 2025 at 4:13 PM
Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏
www.imperial.ac.uk/media/imperi...
www.imperial.ac.uk/media/imperi...
Reposted by Luke Allsopp
Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Systematic discovery of antibacterial and antifungal bacterial toxins - Nature Microbiology
Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.
www.nature.com
October 22, 2024 at 5:37 PM
Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Luke Allsopp
Preparing for ETOX meeting in Bilbao with Yaara, Tracy, and Luke @lukeallsopp.bsky.social @proftracypalmer.bsky.social
June 29, 2025 at 12:15 PM
Preparing for ETOX meeting in Bilbao with Yaara, Tracy, and Luke @lukeallsopp.bsky.social @proftracypalmer.bsky.social
Reposted by Luke Allsopp
This week I celebrate 10 years at FILM, the Facility for Imaging by Light Microscopy @imperialcollegeldn.bsky.social @imperialnhli.bsky.social
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
June 20, 2025 at 7:36 AM
This week I celebrate 10 years at FILM, the Facility for Imaging by Light Microscopy @imperialcollegeldn.bsky.social @imperialnhli.bsky.social
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
Reposted by Luke Allsopp
Today is Wear Yellow Day to raise awareness of and fundraise for Cystic Fibrosis. Teams of @janedaviescf.bsky.social, @lukeallsopp.bsky.social and Hughes in yellow. Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk
www.cysticfibrosis.org.uk/get-involved...
www.cysticfibrosis.org.uk/get-involved...
June 13, 2025 at 1:09 PM
Today is Wear Yellow Day to raise awareness of and fundraise for Cystic Fibrosis. Teams of @janedaviescf.bsky.social, @lukeallsopp.bsky.social and Hughes in yellow. Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk
www.cysticfibrosis.org.uk/get-involved...
www.cysticfibrosis.org.uk/get-involved...
Reposted by Luke Allsopp
Harriet Ellis, a postdoc in @lukeallsopp.bsky.social's Group, is uncovering how Pseudomonas aeruginosa – a key bacterial threat in cystic fibrosis – adapts & causes infection. 💛🦠 #CFweek
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
June 11, 2025 at 8:51 AM
Harriet Ellis, a postdoc in @lukeallsopp.bsky.social's Group, is uncovering how Pseudomonas aeruginosa – a key bacterial threat in cystic fibrosis – adapts & causes infection. 💛🦠 #CFweek
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
#Myth busting #immunology, promoting #critical thinking and the awe of #science !!!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
June 9, 2025 at 10:00 AM
#Myth busting #immunology, promoting #critical thinking and the awe of #science !!!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
Enjoyed @dandavis101.bsky.social lecture at @ri-science.bsky.social on Saturday night. Myth busting and promoting critical thinking with a clear passion for scientific discovery!!
June 9, 2025 at 9:56 AM
Enjoyed @dandavis101.bsky.social lecture at @ri-science.bsky.social on Saturday night. Myth busting and promoting critical thinking with a clear passion for scientific discovery!!
Reposted by Luke Allsopp
White-nose disease in bats:
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
Two distinct host-specialized fungal species cause white-nose disease in bats - Nature
The identification of two cryptic species of the fungal pathogen that causes white-nose disease in bats highlights the need to integrate studies of genetic variability in pathogens into disease survei...
www.nature.com
June 3, 2025 at 8:44 AM
White-nose disease in bats:
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
Reposted by Luke Allsopp
“I was confident that macrophages would digest the microplastics and everything would be fine. I was truly surprised by what we found,” explained Adam Soloff, PhD, to Futura on his latest study on microplastics, which he presented at #ATS2025.
Read more: www.futura-sciences.com/en/i-was-rea...
Read more: www.futura-sciences.com/en/i-was-rea...
June 2, 2025 at 8:16 PM
“I was confident that macrophages would digest the microplastics and everything would be fine. I was truly surprised by what we found,” explained Adam Soloff, PhD, to Futura on his latest study on microplastics, which he presented at #ATS2025.
Read more: www.futura-sciences.com/en/i-was-rea...
Read more: www.futura-sciences.com/en/i-was-rea...
Reposted by Luke Allsopp
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
elifesciences.org/articles/101...
elifesciences.org/articles/101...
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
An upstream open-reading frame in Escherichia coli regulates expression of the downstream genes in response to diverse translation stresses.
elifesciences.org
June 3, 2025 at 7:05 AM
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
elifesciences.org/articles/101...
elifesciences.org/articles/101...
Reposted by Luke Allsopp
I talked to 15 teachers/professors about how AI and ChatGPT is ruining their lives:
www.404media.co/teachers-are...
www.404media.co/teachers-are...
Teachers Are Not OK
AI, ChatGPT, and LLMs "have absolutely blown up what I try to accomplish with my teaching."
www.404media.co
June 2, 2025 at 2:13 PM
I talked to 15 teachers/professors about how AI and ChatGPT is ruining their lives:
www.404media.co/teachers-are...
www.404media.co/teachers-are...