Andrew Maclean
@macleanlab.bsky.social
MRC research fellow at the University of Edinburgh working on parasite metabolism.
Reposted by Andrew Maclean
FYI were starting weird structure/evolution/biology stuff at Glasgow University!
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
January 18, 2026 at 2:42 PM
FYI were starting weird structure/evolution/biology stuff at Glasgow University!
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
Reposted by Andrew Maclean
We are actively recruiting a Post doc to work on the regulation of Toxoplasma différenciation. Please send a CV and cover letter if interested.
ciil.fr/teams/apicompl…
ciil.fr/teams/apicompl…
Accueil - Université de LilleAccueil - Université de Lille
L’Université de Lille a obtenu la labellisation DD&RS – Développement durable et Responsabilité sociétale pour une durée de quatre ans.
https://ciil.fr/teams/apicompl…
January 15, 2026 at 8:06 AM
We are actively recruiting a Post doc to work on the regulation of Toxoplasma différenciation. Please send a CV and cover letter if interested.
ciil.fr/teams/apicompl…
ciil.fr/teams/apicompl…
Reposted by Andrew Maclean
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Double stranded RNA sensing is silenced during early embryonic development
Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...
rdcu.be
January 7, 2026 at 3:28 PM
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Reposted by Andrew Maclean
I am pleased to share our latest preprint, detailing the characterisation of BDF7 in Leishmania. This non-canonical bromodomain factor is essential for the parasite to live inside the host macrophage and has a parasite specific function compared to the host ortholog , ATAD2. Details in the link:
A non-canonical role for the ATAD2 ortholog BDF7 in nucleolar ribosome maturation and amastigote survival in Leishmania mexicana. https://www.biorxiv.org/content/10.64898/2025.12.23.692120v1
January 5, 2026 at 3:32 PM
I am pleased to share our latest preprint, detailing the characterisation of BDF7 in Leishmania. This non-canonical bromodomain factor is essential for the parasite to live inside the host macrophage and has a parasite specific function compared to the host ortholog , ATAD2. Details in the link:
Reposted by Andrew Maclean
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
www.biorxiv.org
December 26, 2025 at 4:37 PM
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Was a lot of fun working with @sheinerlab.bsky.social and Julius Lukes and his lab to explore the weird mitochondria of these under explored parasites. Thanks to all the authors.
Perkinsus marinus is an important marine pathogen yet we know little about its biology.
@macleanlab.bsky.social reports here complexome work of whole parasite and mitochondria mapping the essential mitochondrial enzymes and kickstarting future functional studies.
www.biorxiv.org/content/10.6...
@macleanlab.bsky.social reports here complexome work of whole parasite and mitochondria mapping the essential mitochondrial enzymes and kickstarting future functional studies.
www.biorxiv.org/content/10.6...
Complexome profile of mitochondrial complexes in the myzozoan parasite of oysters, Perkinsus marinus
Mitochondrial complexes, such as the mitochondrial electron transport chain (mETC), the F1Fo-ATP synthase and the mitochondrial ribosome, are centrally important for mitochondrial function. Recently, ...
www.biorxiv.org
December 23, 2025 at 9:09 AM
Was a lot of fun working with @sheinerlab.bsky.social and Julius Lukes and his lab to explore the weird mitochondria of these under explored parasites. Thanks to all the authors.
Reposted by Andrew Maclean
In the early 1980ies the labs of Cordingley, Boothroyd and Borst
discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events. academic.oup.com/nar/article/...
discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events. academic.oup.com/nar/article/...
A trypanosome-specific complex mediates late-stage processing of cytosolic LSU rRNA
Abstract. Unlike most eukaryotes, Trypanosoma brucei processes its cytosolic large subunit (LSU) RNA into six fragments. The factors responsible for these
academic.oup.com
December 15, 2025 at 12:30 PM
In the early 1980ies the labs of Cordingley, Boothroyd and Borst
discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events. academic.oup.com/nar/article/...
discovered that the LSU rRNA of T. brucei is processed into 6 fragment. Now more than 30 years later Simona Amodeo at al. found the factors that mediate these trypanosomatid-specific processing events. academic.oup.com/nar/article/...
Reposted by Andrew Maclean
Save the date! The next instalment of Comparative Genomics of Unicellular Eukaryotes is a GO! Join us next year for a programme of talks, posters, ECR/networking activities.
Website and registration details to follow in the coming weeks.
See you October 5-10 2026 in beautiful San Feliu!!
Website and registration details to follow in the coming weeks.
See you October 5-10 2026 in beautiful San Feliu!!
December 13, 2025 at 10:56 AM
Save the date! The next instalment of Comparative Genomics of Unicellular Eukaryotes is a GO! Join us next year for a programme of talks, posters, ECR/networking activities.
Website and registration details to follow in the coming weeks.
See you October 5-10 2026 in beautiful San Feliu!!
Website and registration details to follow in the coming weeks.
See you October 5-10 2026 in beautiful San Feliu!!
Interested in parasitology? Looking to do a PhD? Cone join me and @geordieparasit.bsky.social in Edinburgh as we try and work out how human parasites get their vitamins.
🎓 Funded #PhD studentships in pathogen biology and parasitology
*Cell and Molecular Biology*; *Host-pathogen interactions*
Part of the EastBio Doctoral Landscape Award
Based in the Edinburgh area of Scotland
PhD 1:
bit.ly/Host-pathoge...
PhD 2:
bit.ly/Parasite-sca...
@uoe-eid.bsky.social
*Cell and Molecular Biology*; *Host-pathogen interactions*
Part of the EastBio Doctoral Landscape Award
Based in the Edinburgh area of Scotland
PhD 1:
bit.ly/Host-pathoge...
PhD 2:
bit.ly/Parasite-sca...
@uoe-eid.bsky.social
EastBio: A host-directed approach to identify novel therapeutic targets of infectious reproductive diseases at Moredun Research Institute on FindAPhD.com
PhD Project - EastBio: A host-directed approach to identify novel therapeutic targets of infectious reproductive diseases at Moredun Research Institute, listed on FindAPhD.com
www.findaphd.com
December 2, 2025 at 9:52 AM
Interested in parasitology? Looking to do a PhD? Cone join me and @geordieparasit.bsky.social in Edinburgh as we try and work out how human parasites get their vitamins.
Reposted by Andrew Maclean
Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
November 28, 2025 at 11:41 AM
Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Andrew Maclean
Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 28, 2025 at 8:30 AM
Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrew Maclean
There's still time to register for CoccidiaUK in London - it's going to be a jam-packed two days of talks by early-career parasitologists, a knowledge transfer session, plus trivia and prizes! It's @crick.ac.uk (very central) & we're cooking up some fun swag :) www.eventbrite.co.uk/e/coccidiauk...
CoccidiaUK 2025
A biannual gathering of parasitologists from across the UK to discuss all things coccidian!
www.eventbrite.co.uk
November 26, 2025 at 5:15 PM
There's still time to register for CoccidiaUK in London - it's going to be a jam-packed two days of talks by early-career parasitologists, a knowledge transfer session, plus trivia and prizes! It's @crick.ac.uk (very central) & we're cooking up some fun swag :) www.eventbrite.co.uk/e/coccidiauk...
Reposted by Andrew Maclean
Looking to start a PhD in October 2026 and learn about bioinformatics and the regulation of TGF-beta signalling in macrophages?
Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh: www.findaphd.com/phds/project...
Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh: www.findaphd.com/phds/project...
Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh on FindAPhD.com
PhD Project - Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh, listed on ...
www.findaphd.com
November 24, 2025 at 12:15 PM
Looking to start a PhD in October 2026 and learn about bioinformatics and the regulation of TGF-beta signalling in macrophages?
Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh: www.findaphd.com/phds/project...
Check out this PhD opportunity with a multidisciplinary team at the University of Edinburgh: www.findaphd.com/phds/project...
Reposted by Andrew Maclean
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Andrew Maclean
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
November 4, 2025 at 11:45 AM
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
Reposted by Andrew Maclean
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com
PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 2, 2025 at 6:07 PM
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Andrew Maclean
Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in
@PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student
@BacchettiRoss
and carried on by current PhD student, Sarah Stevens.
@PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student
@BacchettiRoss
and carried on by current PhD student, Sarah Stevens.
Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission
Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available t...
journals.plos.org
October 23, 2025 at 6:40 PM
Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in
@PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student
@BacchettiRoss
and carried on by current PhD student, Sarah Stevens.
@PLOSPathogens
journals.plos.org/plospathogen...
Led by previous PhD student
@BacchettiRoss
and carried on by current PhD student, Sarah Stevens.
Reposted by Andrew Maclean
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator
Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...
rdcu.be
October 20, 2025 at 12:55 PM
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
Reposted by Andrew Maclean
Excited to share our new paper!
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.
A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.
A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites
Tepsin and AP4 mediate transport from the trans-#Golgi to the plant-like vacuole in #toxoplasma, say Janessa Grech, Elena Jiménez-Ruiz @jimenezruizlab.bsky.social, Markus Meissner @meissnerlab.bsky.social & colleagues @lmumuenchen.bsky.social: rupress.org/jcb/article/...
#Microbiology #Cytoskeleton
#Microbiology #Cytoskeleton
October 20, 2025 at 1:36 PM
Excited to share our new paper!
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.
A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.
A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites
Reposted by Andrew Maclean
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
The Matthews Lab | Biology
The Matthews Lab
biology.ed.ac.uk
October 17, 2025 at 12:06 PM
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
Reposted by Andrew Maclean
Delighted to share this story from my PhD! 🎉 🪱
Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
September 29, 2025 at 7:36 AM
Delighted to share this story from my PhD! 🎉 🪱
Reposted by Andrew Maclean
From nutrient acquisition to drug resistance, membrane transport is especially important for intracellular parasites! This review will help you stay up-to-date on the latest transport research for crypto/malaria/toxo: www.sciencedirect.com/science/arti...
September 26, 2025 at 9:34 AM
From nutrient acquisition to drug resistance, membrane transport is especially important for intracellular parasites! This review will help you stay up-to-date on the latest transport research for crypto/malaria/toxo: www.sciencedirect.com/science/arti...
Reposted by Andrew Maclean
Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
September 25, 2025 at 7:28 AM
Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
Reposted by Andrew Maclean
[We are Hiring!]
The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM.
This project aims to unlock new strategies for treating toxoplasmosis.
DM for more info!
The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM.
This project aims to unlock new strategies for treating toxoplasmosis.
DM for more info!
September 19, 2025 at 4:28 PM
[We are Hiring!]
The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM.
This project aims to unlock new strategies for treating toxoplasmosis.
DM for more info!
The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM.
This project aims to unlock new strategies for treating toxoplasmosis.
DM for more info!