MaRtiNA Hallegger
@martinahallegger.bsky.social
RNA biochemist, RNA-network enthusiast and IMCM fellow @NDMOxford at the @UniofOxford, former @UKDRI at King’s and @TheCrick. Condenses RNA to study ALS and Dementia. High 5 4 RNA
Reposted by MaRtiNA Hallegger
I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture.
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
November 25, 2025 at 9:26 AM
I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture.
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
Reposted by MaRtiNA Hallegger
Exciting Symposium on Biopolymers coming up in Mainz in March 2026!
Great lineup of speakers from both the polymer and life sciences 👇
Great lineup of speakers from both the polymer and life sciences 👇
Registrations are now open for the 1st International Symposium on Polymer Concepts in Cellular Function
📍Venue: Gonsberg Lounge, Mainz
📅 Dates: 4–6 Mar. 2026
🗓️ Registration & Abstract Submission Deadline: 15 Jan. 2026
Register: crc1551.com/sfb1551-inte...
We look forward to welcoming you in Mainz!
📍Venue: Gonsberg Lounge, Mainz
📅 Dates: 4–6 Mar. 2026
🗓️ Registration & Abstract Submission Deadline: 15 Jan. 2026
Register: crc1551.com/sfb1551-inte...
We look forward to welcoming you in Mainz!
November 25, 2025 at 5:54 PM
Exciting Symposium on Biopolymers coming up in Mainz in March 2026!
Great lineup of speakers from both the polymer and life sciences 👇
Great lineup of speakers from both the polymer and life sciences 👇
Which TDP-43 regulated events go first? Very exciting to read this! No need for Angst on here!
Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential
Cryptic splicing caused by TDP-43 proteinopathy is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, which cryptic splicing e...
www.biorxiv.org
November 24, 2025 at 12:09 PM
Which TDP-43 regulated events go first? Very exciting to read this! No need for Angst on here!
Reposted by MaRtiNA Hallegger
Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential
Cryptic splicing caused by TDP-43 proteinopathy is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, which cryptic splicing e...
www.biorxiv.org
November 24, 2025 at 11:28 AM
Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...
One week left to apply! Great Opportunity! Make sure to check out the joint project in the Hallegger and Fowler lab! Please, share and repost!
A new round of Oxford-GSK Clinical DPhil applications are open, deadline Dec 2nd. If you are ST4 and above, check out the projects in neurodegeneration, liver, respiratory and fibrotic pathology. www.ox.ac.uk/admissions/g...
DPhil in Biomedical and Clinical Sciences (Oxford-GSK) | University
About the courseThe DPhil in Biomedical and Clinical Sciences (Oxford-GSK) aims to address an unmet need among clinicians for training in data science and translational medicine.
www.ox.ac.uk
November 24, 2025 at 12:06 PM
One week left to apply! Great Opportunity! Make sure to check out the joint project in the Hallegger and Fowler lab! Please, share and repost!
Reposted by MaRtiNA Hallegger
(Part 2/2) The model uncovers how homotypic and heterotypic interactions shape condensate architecture and reveals how protein dynamics differ depending on whether they are DNA-bound, in the dense phase, or freely diffusing.
November 18, 2025 at 8:03 PM
(Part 2/2) The model uncovers how homotypic and heterotypic interactions shape condensate architecture and reveals how protein dynamics differ depending on whether they are DNA-bound, in the dense phase, or freely diffusing.
Reposted by MaRtiNA Hallegger
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
November 15, 2025 at 9:51 AM
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
Reposted by MaRtiNA Hallegger
Developing new treatments is essential for MND, but the process is lengthy and people with MND don’t have time to wait.
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Drug development is a complex and costly process.
By using medicines approved for other conditions, we can overcome barriers in drug development.
Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS.
ukmndri.org/2025/11/13/r...
By using medicines approved for other conditions, we can overcome barriers in drug development.
Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS.
ukmndri.org/2025/11/13/r...
Repurposed Drugs: Accelerating MND Treatment Discovery
Discover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research.
ukmndri.org
November 14, 2025 at 12:28 PM
Developing new treatments is essential for MND, but the process is lengthy and people with MND don’t have time to wait.
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible.
Read more👇
Reposted by MaRtiNA Hallegger
Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome - Nature Communications
The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...
www.nature.com
November 14, 2025 at 1:49 PM
Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by MaRtiNA Hallegger
It's coming again!! Can't wait...
How to tackle emerging questions in cellular organisation, adaptation, and robustness? Join #EESPhaseSeparation! 🧬🦠
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
November 13, 2025 at 6:58 PM
It's coming again!! Can't wait...
Reposted by MaRtiNA Hallegger
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
November 13, 2025 at 7:16 PM
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Reposted by MaRtiNA Hallegger
Check out our work on RNA structure in introns! Testing >100k base pairing patterns, we found that RNA structure can predictably tune gene expression. Just by changing intron sequence, we see a dynamic range of regulation comparable to messing e.g. with promoters. @karlaneugebauer.bsky.social
Control of gene output by intron RNA structure https://www.biorxiv.org/content/10.1101/2025.11.08.687378v1
November 10, 2025 at 5:32 PM
Check out our work on RNA structure in introns! Testing >100k base pairing patterns, we found that RNA structure can predictably tune gene expression. Just by changing intron sequence, we see a dynamic range of regulation comparable to messing e.g. with promoters. @karlaneugebauer.bsky.social
Reposted by MaRtiNA Hallegger
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
bit.ly
October 4, 2025 at 2:40 PM
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Reposted by MaRtiNA Hallegger
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:32 AM
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
Reposted by MaRtiNA Hallegger
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
wi.mit.edu
November 7, 2025 at 4:14 PM
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Reposted by MaRtiNA Hallegger
As Scottish Rugby celebrates 100 years of Murrayfield, they’re asking fans to choose the defining moment in the stadium’s history!
For us, there’s only one 💙💛 Doddie’s unforgettable match ball delivery in 2017 - a moment that inspired the nation.
Vote here 👉 scottishrugby.org/murrayfieldm...
For us, there’s only one 💙💛 Doddie’s unforgettable match ball delivery in 2017 - a moment that inspired the nation.
Vote here 👉 scottishrugby.org/murrayfieldm...
November 6, 2025 at 4:35 PM
As Scottish Rugby celebrates 100 years of Murrayfield, they’re asking fans to choose the defining moment in the stadium’s history!
For us, there’s only one 💙💛 Doddie’s unforgettable match ball delivery in 2017 - a moment that inspired the nation.
Vote here 👉 scottishrugby.org/murrayfieldm...
For us, there’s only one 💙💛 Doddie’s unforgettable match ball delivery in 2017 - a moment that inspired the nation.
Vote here 👉 scottishrugby.org/murrayfieldm...
Reposted by MaRtiNA Hallegger
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted by MaRtiNA Hallegger
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by MaRtiNA Hallegger
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
November 4, 2025 at 5:33 PM
@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
Reposted by MaRtiNA Hallegger
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
October 15, 2025 at 4:02 PM
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Reposted by MaRtiNA Hallegger
Hot off the press from the RTI: TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
buff.ly/X23QYQI #RNA #RNATherapeutics
buff.ly/X23QYQI #RNA #RNATherapeutics
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - PubMed
Motor neuron hyperexcitability is a broadly observed yet poorly understood feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Nuclear depletion and cytoplasmic aggregation...
buff.ly
November 2, 2025 at 6:02 PM
Hot off the press from the RTI: TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
buff.ly/X23QYQI #RNA #RNATherapeutics
buff.ly/X23QYQI #RNA #RNATherapeutics
Reposted by MaRtiNA Hallegger
New preprint from Tongyin Zheng in the lab about how FUS condensates can unfold RNA G-quadruplex structure www.biorxiv.org/content/10.1...
Visualizing TERRA RNA G-quadruplex unfolding in FUS biomolecular condensates
RNA G-quadruplexes (rG4s) are remarkably stable secondary structures with critical regulatory roles in gene expression, RNA metabolism, and telomere maintenance. However, their behavior within cells r...
www.biorxiv.org
October 30, 2025 at 7:35 PM
New preprint from Tongyin Zheng in the lab about how FUS condensates can unfold RNA G-quadruplex structure www.biorxiv.org/content/10.1...
Reposted by MaRtiNA Hallegger
Come join us for the next monthly on-line seminar (7th November, 1 pm GMT) aimed to connect the UK Biomolecular Condensate community (All are welcome to come and listen) @g-heller.bsky.social @dimitrislagos.bsky.social @physicsoflifeuk.bsky.social
October 29, 2025 at 10:44 AM
Come join us for the next monthly on-line seminar (7th November, 1 pm GMT) aimed to connect the UK Biomolecular Condensate community (All are welcome to come and listen) @g-heller.bsky.social @dimitrislagos.bsky.social @physicsoflifeuk.bsky.social
Reposted by MaRtiNA Hallegger
Thrilled that our PAR-labeling tech supported new Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui Liu & Raymond Cai!
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 29, 2025 at 7:42 PM
Thrilled that our PAR-labeling tech supported new Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui Liu & Raymond Cai!
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...