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Dr. Lucky Tran @luckytran.com · 19h

🎵 They did the Monster Slash 😭 @ellecordova.bsky.social

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James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Ammar Al-Chalabi @ammaralchalabi.bsky.social · 3d

We must find an effective treatment for #ALS #MND

@ukmndri.bsky.social

BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...

Lewis Moody: Former England captain reveals motor neurone disease diagnosis

Former England captain Lewis Moody reveals he has been diagnosed with motor neurone disease in an exclusive BBC interview.

www.bbc.com

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My Name'5 Doddie Foundation @mndoddie5.bsky.social · 3d

We are shocked and saddened to learn of Lewis Moody’s diagnosis with motor neuron disease (MND). Everyone at My Name’5 Doddie Foundation sends their full support to Lewis.

Full statement: www.myname5doddie.co.uk/whats-on/art...

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MaRtiNA Hallegger @martinahallegger.bsky.social · 4d

Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation

David Kuster @rnadavid.bsky.social · 4d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Simon Fisher @profsimonfisher.bsky.social · 4d

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪

Image shows the first two printed pages of the paper “A forkhead-domain gene is mutated in a severe speech and language disorder” by Cecilia Lai and colleagues, published in Nature in 2001 (volume 413, pages 519-523). The abstract reads as follows:
Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. Although studies of twins consistently indicate that a significant genetic component is involved, most families segregating speech and language deficits show complex patterns of inheritance, and a gene that predisposes individuals to such disorders has not been identified. We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait. Our previous work mapped the locus responsible, SPCH1, to a 5.6-cM interval of region 7q31 on chromosome 7. We also identified an unrelated individual, CS, in whom speech and language impairment is associated with a chromosomal translocation involving the SPCH1 interval. Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS. In addition, we identify a point mutation in affected members of the KE family that alters an invariant amino-acid residue in the forkhead domain. Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language.

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idpgrc.bsky.social @idpgrc.bsky.social · 6d

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...

2026 Intrinsically Disordered Proteins Conference GRC

The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

grc.org

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Mireya Plass @mireyaplass.bsky.social · 6d

🚨New preprint from the lab! This work led by @akshayjg.bsky.social & @smfernandezmoya.bsky.social shows how the RNA binding protein STAU2 regulates the timing of neurogenesis in iPSC-derived human cells
www.biorxiv.org/content/10.1...

Staufen2 modulates the temporal dynamics of human neurogenesis in vitro

RNA-binding proteins (RBPs) play a central role in post-transcriptional regulation during brain development, yet their specific functions in coordinating human neural lineage decisions remain poorly u...

www.biorxiv.org

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Mireya Plass @mireyaplass.bsky.social · 6d

Upon deletion of STAU2, we observe metabolic changes and accelerated differentiation of iPSCs

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Janet Kumita @jrkumita.bsky.social · 8d

Join us THIS Friday (3rd October 2025).

Janet Kumita @jrkumita.bsky.social · 16d

Come join us for the next monthly on-line seminar (3rd October, 1 pm BST) aimed to connect the UK Biomolecular Condensate community (All are welcome to come and listen). @danbose.bsky.social @physicsoflifeuk.bsky.social

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The Francis Crick Institute @crick.ac.uk · 7d

Researchers from the Crick, @ucl.ac.uk, @cam.ac.uk and @polymtl.bsky.social have directly observed the protein clusters believed to trigger Parkinson’s disease in human brain tissue, developing a new technique that could support future diagnostics and treatments.

www.crick.ac.uk/news/2025-10...

Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time

A team of scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease. Their new technique, published today in Nature Biomedica...

www.crick.ac.uk

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Sarah Shammas @sarahshammas.bsky.social · 7d

Please share with anyone you think may be interested

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UK Dementia Research Institute @ukdri.ac.uk · 9d

Researchers led by Prof Jernej Ule (@ulelab.bsky.social)
have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡

The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...

Better together: researchers discover how cells keep groups of proteins in check

Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

www.crick.ac.uk

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Yiliang Ding @yiliangding.bsky.social · 10d

Our annual event at Norwich RNA Club: AI in RNA Biology. Great speakers! Please join us this Thursday at 2pm @norwichrnaclub.bsky.social @johninnescentre.bsky.social @earlhaminst.bsky.social @uniofeastanglia.bsky.social @alperakay.bsky.social

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Lori Passmore @lapassmore.bsky.social · 12d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

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Ule Lab @ulelab.bsky.social · 14d

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

This link will take you to a page that’s not on LinkedIn

lnkd.in

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UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 14d

🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social
www.bbc.co.uk/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.co.uk

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MaRtiNA Hallegger @martinahallegger.bsky.social · 14d

Rupert Faraway and Neve Costello-Heaven lead this fantastic study on protein-RNA interstasis in Nature.

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The Francis Crick Institute @crick.ac.uk · 14d

Researchers have discovered a new biological process they've called 'interstasis', which keeps groups of proteins in check, preventing excessive build up and protecting the cell from potential harm.
www.crick.ac.uk/news/2025-09...

Better together: researchers discover how cells keep groups of proteins in check

Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

www.crick.ac.uk

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 18d

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com

GPU-accelerated homology search with MMseqs2 - Nature Methods

Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

www.nature.com

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Led By Donkeys @ledbydonkeys.org · 20d

Windsor Castle Tuesday night. Four of us arrested for 'malicious communications'. Now released.
www.youtube.com/watch?v=K8V4...

Hey Donald, welcome to Windsor Castle

YouTube video by Led By Donkeys

www.youtube.com

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Melvin Noe Gonzalez @melv-noe-gonzalez.bsky.social · 20d

Check out the work here!

www.biorxiv.org/content/10.1...

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...

www.biorxiv.org

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annstapleton8.bsky.social @annstapleton8.bsky.social · 24d

bsky.app/profile/tesl...

Tesla Takedown UK @teslatakedownuk.bsky.social · Aug 19

act.38degrees.org.uk/act/no-to-el...

I thought this headline was a joke when I first read it, but no…it's real.

I've signed a petition telling Ofgem to reject Musk's application to supply electricity to British households. Will you join me and add your name?

act.38degrees.org.uk

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MaRtiNA Hallegger @martinahallegger.bsky.social · 26d

They fill the evidence gap which top 14 polluter’s emissions are accountable for historical climate extremes.

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Markus Landthaler @landthalerm.bsky.social · 27d

Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome

UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...

www.cell.com

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