Lightnews — Scholar-powered news

Reposted by Matteo Guardamagna

Ann Kennedy @antihebbiann.bsky.social · 8h

Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.

A brief rundown...

www.nature.com/articles/s41...

A parabrachial hub for need-state control of enduring pain - Nature

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

www.nature.com

7 28 68

Matteo Guardamagna @matteoguardamagna.bsky.social · 2h

How does the brain's spatial navigation system develop? I had so many fun discussions with the incredible communities at Johns Hopkins and Columbia this past week - a lot of exciting ideas for experimental and theoretical work ahead.
Grateful to be hosted by @kavlifoundation.org @lorenzoposani.com

5

Reposted by Matteo Guardamagna

Dan Levenstein @dlevenstein.bsky.social · 1d

Come do a postdoc at the Wu Tsai Institute!

WTI fellows have freedom to work with anyone at the institute, and preference is given to applicants who want to work on interdisciplinary projects with multiple faculty mentors.

If you’re interested to work with me, please reach out!

Wu Tsai Institute | Yale University @wutsaiyale.bsky.social · 3d

📣 Calling experimental, computational, or theoretical researchers!

WTI's Postdoc Fellowships application is now open, offering a competitive salary, structured mentorship, world-class facilities + more: wti.yale.edu/initiatives/...

Apply by November 10: apply.interfolio.com/174525

#KnowTogether

10 19

Reposted by Matteo Guardamagna

Stephanie L. Grella, PhD @sgrella.bsky.social · 5d

How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...

How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions

The brain constantly generates predictions based on one’s knowledge of the world, as captured in memory. When these predictions are in error, our knowledge base must be revised to remain relevant. Her...

www.cell.com

2 19 68

Matteo Guardamagna @matteoguardamagna.bsky.social · 6d

🎉🎉

1

Reposted by Matteo Guardamagna

manfredic.bsky.social @manfredic.bsky.social · 7d

I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

4 27 65

Reposted by Matteo Guardamagna

May-Britt Moser @m-bmoser.bsky.social · 7d

We have lost an eminent scientist, Jane Goodall, - do not forget her beautiful work and strong voice: - «hope and action: - value and respect animals and protect them and their habitats»

The New Yorker @newyorker.com · 7d

The naturalist Jane Goodall died today at 91. Hope, she argued, is not merely “passive wishful thinking” but a “crucial survival trait.” Revisit a conversation with Goodall, from 2021: nyer.cm/F55JtsS

An image of Jane Goodall and a chimpanzee, from 1965. Photo courtesy CBS Photo Archive / Getty.

19 110

Matteo Guardamagna @matteoguardamagna.bsky.social · 8d

😞😔 standing on the shoulders of giants

The New York Times @nytimes.com · 8d

Breaking News: Jane Goodall, one of the world’s most revered conservationists, died at 91. Her discoveries in the 1960s about how chimpanzees behaved in the wild broke new ground and represented what was called “one of the Western world’s great scientific achievements.” nyti.ms/42kpGxt

2

Reposted by Matteo Guardamagna

Matteo Carandini @carandinilab.net · 9d

Neuropixels Ultra!

By @steinmetzneuro.bsky.social, who led a big collaboration

www.sciencedirect.com/science/arti...

Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings

To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single-neuron and single-spike re…

www.sciencedirect.com

18 81

Reposted by Matteo Guardamagna

Angelo Forli @aforli89.bsky.social · 15d

Interested in the brain, circuits, and behavior?
Enjoy tinkering and asking bold questions in neuroscience?

The Forli Lab (IIT, Genova, Italy) is hiring!

🧠 🔬 🟩◻️🟥->🍕🚫🍍

Check out our website for updates:
sites.google.com/view/forli-lab

2 7 13

Matteo Guardamagna @matteoguardamagna.bsky.social · 10d

Fantastico, Angelo! 🎉🎉 Can't wait to see the breakthrough science coming out of your lab

1

Reposted by Matteo Guardamagna

Jerome Beetz @beetzjerome.bsky.social · 11d

Insect spatial memory is thought to be based on panoramic snapshots that are modelled as retinotopic images. This idea won't allow a distinction of landmarks from the scene. Unexpectedly, our data suggest that 🐝 learn 3D-objects as individual landmarks. #neuroethology
www.biorxiv.org/content/10.1...

4 20 46

Matteo Guardamagna @matteoguardamagna.bsky.social · 14d

Excited to be part of this work and amazing team. A deep dive into remapping dynamics🗺️! Thread below 👇

Edvard I Moser @edvardmoser.bsky.social · 14d

1/5 How does the brain turn the low-dimensional, universal grid cell metric into the rich, diverse codes needed for memory in hippocampal place cells? 🧵
Preprint link 👇

www.biorxiv.org/content/10.1...

Functional independence of entorhinal grid cell modules enables remapping in hippocampal place cells

A systems-level understanding of cortical computation requires insight into how neural codes are transformed across distinct brain circuits. In the mammalian cortex, one of the few systems where such ...

www.biorxiv.org

2 12

Reposted by Matteo Guardamagna

Matthias Nau @matthiasnau.bsky.social · 14d

Incredible study by Raut et al.: by tracking a single measure (pupil size), you can model slow, large-scale dynamics in neuronal calcium, metabolism, and brain blood oxygen through a shared latent space! www.nature.com/articles/s41...

1 17 66

Reposted by Matteo Guardamagna

Qingqing Zhang @qqzhang.bsky.social · 17d

Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience
www.biorxiv.org/cgi/content/...

4 24 85

Reposted by Matteo Guardamagna

Marlene Cohen @marlenecohen.bsky.social · 16d

New preprint! How can you remember an image you saw once, even after seeing thousands of them? We find a role for humble mid-level visual cortex in high-capacity, one-shot learning. doi.org/10.1101/2025.09.22.677855 🧵🧪1/

Neuronal signatures of successful one-shot memory in mid-level visual cortex

High-capacity, one-shot visual recognition memory challenges theories of learning and neural coding because it requires rapid, robust, and durable representations. Most studies have focused on the hip...

doi.org

3 28 89

Reposted by Matteo Guardamagna

Mari Sosa @marisosa.bsky.social · 16d

The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.

Sosa Lab

www.sosaneurolab.com

37 88

Reposted by Matteo Guardamagna

Adrien Peyrache @apeyrache.bsky.social · 23d

🚨New preprint alert!

The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.

Some explanation 🧵👇 1/13

www.biorxiv.org/content/10.1...

Coherent dynamics of thalamic head-direction neurons irrespective of input

While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The anterodorsal...

www.biorxiv.org

2 25 91

Reposted by Matteo Guardamagna

Denis Jabaudon @djabaudon.bsky.social · 20d

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

www.science.org

6 20 65

Reposted by Matteo Guardamagna

Butt Lab - Oxford @interneuron.bsky.social · 21d

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!

www.sciencedirect.com/science/arti...

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex

Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

www.sciencedirect.com

2 13 40

Reposted by Matteo Guardamagna

Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 22d

1/
🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

9 56 120

Reposted by Matteo Guardamagna

Nature Reviews Neuroscience @natrevneuro.nature.com · 23d

Multisensory coding of self-motion and its contribution to navigation — a Review by Dun Mao & Yong Gu

www.nature.com/articles/s41...

#neuroscience #neuroskyence

Multisensory coding of self-motion and its contribution to navigation - Nature Reviews Neuroscience

As an animal moves within its environment, self-motion signals are generated by the inner ear vestibular organs and the retina and transmitted to the CNS. In this Review, Mao and Gu describe how these...

www.nature.com

8 23

Reposted by Matteo Guardamagna

Cian O'Donnell @cianodonnell.bsky.social · 24d

excellent writeup by @thegeekygoth.bsky.social on the MICrONS project to build large-scale connectivity maps of the brain, with some small comments by me.

I have been blown away by all the connectome work and really do think it will change neuroscience forever

www.the-scientist.com/a-map-of-the...

A Map of the Impossible: MICrONS Delivers AI and Neuroscience Advances

Scientists characterized the largest sample of a neural circuit to date to improve artificial intelligence models and better understand the brain.

www.the-scientist.com

1 4

Matteo Guardamagna @matteoguardamagna.bsky.social · 27d

Noncanonical circuits, states, and computations of the hippocampus | Science www.science.org/doi/10.1126/...

Noncanonical circuits, states, and computations of the hippocampus

Traditional views of hippocampal function are largely based on the canonical flow of information from the entorhinal cortex through the trisynaptic loop—comprising the dentate gyrus and cornu ammonis ...

www.science.org

1

Reposted by Matteo Guardamagna

The Transmitter @thetransmitter.bsky.social · 28d

Oxytocin controls both sides of the mother-pup relationship in mice, influencing how pups communicate when separated from their mothers, a new study finds.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/oxytocin/oxy...

Oxytocin shapes both mouse mom and pup behavior

Distressed pups emit distinct cries for help, which depend on oxytocin neurons in their hypothalamus.

www.thetransmitter.org

1 11 46