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Reposted by Michal Galdzicki

samuel mehr @mehr.nz · 19d

this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result

www.science.org/doi/abs/10.1...

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Reposted by Michal Galdzicki

Chaitanya K. Joshi @chaitjo.bsky.social · Aug 15

RosettaFold 3 is here! 🧬🚀

AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!

Congratulations @simonmathis.bsky.social and team!!! ❤️

bioRxiv preprint: www.biorxiv.org/content/10.1...

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Michal Galdzicki @mgaldzic.bsky.social · Aug 12

I think ... I read about this years ago in a Michael Crichton book. I think it goes something like, I WANT TO TALK TO TED. Jerry? Is that you?

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Michal Galdzicki @mgaldzic.bsky.social · Apr 27

A summary of the update posted with the announcement x.com/GabriCorso/s...

Gabriele Corso @ICLR2025 on X: "🚀 Excited to release a major update to the Boltz-1 model: Boltz-1x! Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training, and more! 🔥🧵 https://t.co/Ea2eVZbwTh" / X

🚀 Excited to release a major update to the Boltz-1 model: Boltz-1x! Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training, and more! 🔥🧵 https://t.co/Ea2eVZbwTh

x.com

Michal Galdzicki @mgaldzic.bsky.social · Apr 27

Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training.
www.biorxiv.org/content/10.1...

Boltz-1: Democratizing Biomolecular Interaction Modeling

Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating...

www.biorxiv.org

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Michal Galdzicki @mgaldzic.bsky.social · Apr 13

@unroll.bsky.social unroll

Unroll Threads (@unroll.bsky.social)

Create links to threads on Bluesky. I may take up to five minutes to respond! Content is not saved. If posts are deleted on Bluesky, they will not show up in the thread unroller.

unroll.bsky.social

Michal Galdzicki @mgaldzic.bsky.social · Apr 12

I just got that ad late this week.i guess they need a challenge

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Michal Galdzicki @mgaldzic.bsky.social · Apr 12

When Traditional Methods Say No, Say Yes
No more rejected sequences with DNA Script

Our Enzymatic DNA Synthesis (EDS) technology enables direct synthesis of challenging DNA sequences, eliminating the need for time-consuming sequence redesign
console.dnascript.com/request-form

DNA Script Console

console.dnascript.com

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Reposted by Michal Galdzicki

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · Apr 7

BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design https://www.biorxiv.org/content/10.1101/2025.04.06.647261v1

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Reposted by Michal Galdzicki

Jim Haseloff @jimhaseloff.bsky.social · Apr 6

...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices.
www.instructables.com/Meshtastic-S...

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Michal Galdzicki @mgaldzic.bsky.social · Mar 25

That's an origin story opener

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Reposted by Michal Galdzicki

Guilhem Faure @guilhemfaure.bsky.social · Feb 28

🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...)

We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.

More details coming soon 👀

#TIGR #RNA #GeneEditing #CRISPR

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Reposted by Michal Galdzicki

bioRxiv Genomics @biorxiv-genomic.bsky.social · Feb 24

Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1

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Michal Galdzicki @mgaldzic.bsky.social · Feb 1

Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming?
I missed the memo.

a.co/d/4s5izkO

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Reposted by Michal Galdzicki

Phil Plait @philplait.bsky.social · Jan 25

This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy.

www.scientificamerican.com/article/why-...

Why Grapefruit Interferes with Medication, and What to Do about It

Could gene editing produce a tasty citrus fruit that doesn’t interfere with prescription drugs?

www.scientificamerican.com

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Michal Galdzicki @mgaldzic.bsky.social · Jan 25

Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign
www.prnewswire.com/news-release...

Arzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security

/PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research...

www.prnewswire.com

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Michal Galdzicki @mgaldzic.bsky.social · Jan 23

Speculative writeup and the webinar Feb 20
web.cvent.com/event/e77566...

Reposted by Michal Galdzicki

Rob Carlson @robcarlson.bsky.social · Jan 16

From the dependably insightful @aukehoekstra.bsky.social .

Auke Hoekstra @aukehoekstra.bsky.social · Jan 16

This can't be repeated often enough: batteries are getting cheaper incredibly fast.

This not only means that our cars can drive on electricity.

But also that solar and wind become "firm" sources of power, and we can use our electricity grid much better.
www.iea.org/reports/batt...

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Reposted by Michal Galdzicki

Dietram A. Scheufele @dietram.bsky.social · Dec 21

Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)

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Michal Galdzicki @mgaldzic.bsky.social · Dec 14

WSU's got you www.nwpb.org/2024/12/10/s...
Note: The new apple won’t hit stores until 2029.

Sunflare: Meet Washington’s new apple - Northwest Public Broadcasting

The sunlight glints across Sunflare apples ripening on a branch at WSU’s research orchard near Wenatchee, Washington, in late summer 2024. (Credit: Jeremy Tamsen / WSU) Listen (Runtime :45) Read […]

www.nwpb.org

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Reposted by Michal Galdzicki

Nick Tsergas @nicktsergas.ca · Nov 28

You guys remember TweetDeck?

Bluesky has it, and it's free.

Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface.

2/10

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Reposted by Michal Galdzicki

Howard Salis @hsalis.bsky.social · Dec 2

NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/
www.nature.com/articles/s41...

An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications

Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...

www.nature.com

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Michal Galdzicki @mgaldzic.bsky.social · Dec 3

This is a really cool paper. They developed a reasonably robust circuit to generate patterns.

Tom Ellis @proftomellis.bsky.social · Dec 2

SynBio Turing patterns in E.coli. I've seen this amazing project progress over the last few years at Imperial and excited that it's now published. Well done to all involved! www.cell.com/cell-systems...

A three-node Turing gene circuit forms periodic spatial patterns in bacteria

Engineering Turing patterns has been one of the most challenging problems in synthetic biology because even tiny changes in the reaction parameters destroy patterning. Here, the authors construct a mo...

www.cell.com

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Reposted by Michal Galdzicki

Jonathan Jacobs @bioinformer.bsky.social · Nov 27

🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐

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Michal Galdzicki @mgaldzic.bsky.social · Nov 23

Technically they failed to prosecute the criminal effectively in a timely manner. Perhaps it is in fact a performance issue.