New multicohort resource for researchers exploring proteomics in neurodegenerative diseases — including data from the Whitehall II study. 🧠🔬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging - Nature Medicine
The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic proteomic signatures...
www.nature.com
July 16, 2025 at 6:03 AM
New multicohort resource for researchers exploring proteomics in neurodegenerative diseases — including data from the Whitehall II study. 🧠🔬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...
May 29, 2025 at 11:06 AM
It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...
Workplaces are an important but underused channel for health promotion – a new review examines the most effective strategies.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Effectiveness of workplace interventions for health promotion
Workplaces are an important setting for health promotion, offering established infrastructure,
daily access to large populations, and opportunities to engage groups that are often
under-represented in...
www.thelancet.com
May 28, 2025 at 6:30 AM
Workplaces are an important but underused channel for health promotion – a new review examines the most effective strategies.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted
2 new studies on weight loss
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...
May 27, 2025 at 3:22 PM
2 new studies on weight loss
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...
1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam...
2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...
Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Weight Loss in Midlife, Chronic Disease Incidence, and All-Cause Mortality
This cohort study investigates the association of sustained weight loss in midlife with long-term health benefits.
jamanetwork.com
May 27, 2025 at 7:31 PM
Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted
My conversation with Sir John Bell, one of the most influential physician-scientists in the world.
(it's free, with transcript)
erictopol.substack.com/p/sir-john-b...
(it's free, with transcript)
erictopol.substack.com/p/sir-john-b...
May 26, 2025 at 6:07 PM
My conversation with Sir John Bell, one of the most influential physician-scientists in the world.
(it's free, with transcript)
erictopol.substack.com/p/sir-john-b...
(it's free, with transcript)
erictopol.substack.com/p/sir-john-b...
A state-of-the-art review with 1700+ references unpacks how systemic factors shape brain and vascular ageing—drawing on parabiosis, blood exchange and plasma transfer studies.
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
link.springer.com
May 25, 2025 at 12:13 PM
A state-of-the-art review with 1700+ references unpacks how systemic factors shape brain and vascular ageing—drawing on parabiosis, blood exchange and plasma transfer studies.
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
A 10-year gap in frailty-free life expectancy between the highest and lowest socioeconomic groups.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Frailty-free life expectancy and its association with socio-economic characteristics: an analysis of the English Longitudinal Study of Ageing cohort study - BMC Medicine
Background Frailty is more prevalent in socio-economically disadvantaged groups; however, little is known about how this translates to differences in the number of years people live with and without f...
link.springer.com
May 25, 2025 at 10:24 AM
A 10-year gap in frailty-free life expectancy between the highest and lowest socioeconomic groups.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted
Multiple recent studies, including 3 impressive natural experiments, consistently show a link between Shingles vaccines and reduced dementia. This week a nationwide S Korea study added a reduction of cardiovascular events
My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...
My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...
May 11, 2025 at 9:27 PM
Multiple recent studies, including 3 impressive natural experiments, consistently show a link between Shingles vaccines and reduced dementia. This week a nationwide S Korea study added a reduction of cardiovascular events
My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...
My summary Table. More here on dementia erictopol.substack.com/p/the-shingl...
Reposted
Things with evidence that promote healthy aging, and I've adopted
gift link
www.wsj.com/health/welln...
gift link
www.wsj.com/health/welln...
A Doctor’s Science-Backed Formula for Aging Better
Dr. Eric Topol’s research revealed it’s not so much genes that lead to long life but instead simple and practical steps to stay healthy. He’s taking his own advice.
www.wsj.com
May 8, 2025 at 4:25 PM
Things with evidence that promote healthy aging, and I've adopted
gift link
www.wsj.com/health/welln...
gift link
www.wsj.com/health/welln...
Reposted
Reducing high blood pressure substantially lowers the risk of dementia and cognitive impairment without dementia, according to the results of a clinical trial published in Nature Medicine. go.nature.com/44z6kGy #medsky 🧪
April 22, 2025 at 7:25 PM
Reducing high blood pressure substantially lowers the risk of dementia and cognitive impairment without dementia, according to the results of a clinical trial published in Nature Medicine. go.nature.com/44z6kGy #medsky 🧪
Reposted
A study in Nature Medicine shows that a meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors had superior performance in predicting the 10-year risk of coronary artery disease. go.nature.com/4igXqAJ 🔒
April 21, 2025 at 4:38 PM
A study in Nature Medicine shows that a meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors had superior performance in predicting the 10-year risk of coronary artery disease. go.nature.com/4igXqAJ 🔒
Reposted
The future burden of dementia in the US may be substantially lower than current projections.
Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...
Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...
April 17, 2025 at 1:09 PM
The future burden of dementia in the US may be substantially lower than current projections.
Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...
Watch and learn more, then read the full JAMA Viewpoint on the changing story of the dementia epidemic. jamanetwork.com/journals/jam...
Reposted
In case you follow me @X, my account was HACKED and someone is impersonating me selling bitcoin (and who knows what else to come).
Beyond that, all attempts to contact X to rectify the matter go nowhere.
If you have an account there, and get the chance, please post so people will know. Thanks!
Beyond that, all attempts to contact X to rectify the matter go nowhere.
If you have an account there, and get the chance, please post so people will know. Thanks!
April 4, 2025 at 6:07 PM
In case you follow me @X, my account was HACKED and someone is impersonating me selling bitcoin (and who knows what else to come).
Beyond that, all attempts to contact X to rectify the matter go nowhere.
If you have an account there, and get the chance, please post so people will know. Thanks!
Beyond that, all attempts to contact X to rectify the matter go nowhere.
If you have an account there, and get the chance, please post so people will know. Thanks!
Reposted
Do viruses play a role in the cause of Alzheimer's disease?
In the wake of observational studies showing some protection from the vaccines vs. shingles
www.economist.com/science-and-...
Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve
In the wake of observational studies showing some protection from the vaccines vs. shingles
www.economist.com/science-and-...
Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve
Do viruses trigger Alzheimer’s?
A growing group of scientists think so, and are asking whether antivirals could treat the disease
www.economist.com
March 18, 2025 at 11:22 AM
Do viruses play a role in the cause of Alzheimer's disease?
In the wake of observational studies showing some protection from the vaccines vs. shingles
www.economist.com/science-and-...
Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve
In the wake of observational studies showing some protection from the vaccines vs. shingles
www.economist.com/science-and-...
Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve
Reposted
We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, ⬆️ inflammation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 14, 2025 at 9:25 PM
We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, ⬆️ inflammation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism.
#Aging #SocialDeterminants #NFkB
rdcu.be/edyqo
#Aging #SocialDeterminants #NFkB
rdcu.be/edyqo
Social disadvantage accelerates aging
Nature Medicine - Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.
rdcu.be
March 14, 2025 at 1:13 PM
This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism.
#Aging #SocialDeterminants #NFkB
rdcu.be/edyqo
#Aging #SocialDeterminants #NFkB
rdcu.be/edyqo
New study on excess deaths during the COVID-19 pandemic across 18 European countries
–Countries with lower GDP saw a greater loss of years of life
–Higher vaccination coverage was linked to fewer years of life lost—independent of GDP
#PublicHealth #Vaccination
journals.plos.org/plosmedicine...
–Countries with lower GDP saw a greater loss of years of life
–Higher vaccination coverage was linked to fewer years of life lost—independent of GDP
#PublicHealth #Vaccination
journals.plos.org/plosmedicine...
Direct and indirect impacts of the COVID-19 pandemic on life expectancy and person-years of life lost with and without disability: A systematic analysis for 18 European countries, 2020–2022
Sara Ahmadi-Abhari and colleagues explore the impact that the COVID-19 pandemic might have had on life expectancy and years of life lost, with and without disability, in 18 European countries. They ho...
journals.plos.org
March 12, 2025 at 8:33 AM
New study on excess deaths during the COVID-19 pandemic across 18 European countries
–Countries with lower GDP saw a greater loss of years of life
–Higher vaccination coverage was linked to fewer years of life lost—independent of GDP
#PublicHealth #Vaccination
journals.plos.org/plosmedicine...
–Countries with lower GDP saw a greater loss of years of life
–Higher vaccination coverage was linked to fewer years of life lost—independent of GDP
#PublicHealth #Vaccination
journals.plos.org/plosmedicine...
Reposted
The person-years of life lost from the pandemic (here for Europe) with premature mortality reflects an underestimate of the toll of Covid @plos.org
journals.plos.org/plosmedicine...
journals.plos.org/plosmedicine...
March 11, 2025 at 6:51 PM
The person-years of life lost from the pandemic (here for Europe) with premature mortality reflects an underestimate of the toll of Covid @plos.org
journals.plos.org/plosmedicine...
journals.plos.org/plosmedicine...
Reposted
🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study
Advanced proteomic organ ageing is associated with the long-term risk of age-related
diseases. In most cases, faster ageing of a specific organ increases susceptibility
to morbidity affecting multiple...
www.thelancet.com
February 26, 2025 at 10:33 AM
🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted
Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
February 26, 2025 at 12:10 AM
Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted
Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment
www.nature.com/articles/s41...
open-access
www.nature.com/articles/s41...
open-access
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...
www.nature.com
February 19, 2025 at 2:37 PM
Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment
www.nature.com/articles/s41...
open-access
www.nature.com/articles/s41...
open-access
Reposted
✅
Quantitative genetics is poorly understood by many biologists, and that's surely a failure in how it is taught. But teaching biology as 'fundamentally complex' seems like one of the least promising educational ideas since those 1970s schools that made lessons optional.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Should biology put complexity first?
The dictum “Everything should be made as simple as possible, but no simpler” poses
a problem for biology. How simply can it be told without doing damage to its complex
nature? The answer might be foun...
www.cell.com
February 22, 2025 at 11:28 PM
✅
Reposted
Worth reposting!
Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...
February 21, 2025 at 3:09 AM
Worth reposting!
Engaging in leisure-time physical activity adds 1–2 extra disease-free years, with greater benefits among smokers, those with social disadvantage, and individuals with depression.
💡 Boosting physical activity may reduce health disparities.
Read more: www.thelancet.com/journals/lan...
💡 Boosting physical activity may reduce health disparities.
Read more: www.thelancet.com/journals/lan...
Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study
In addition to confirming the association between leisure-time physical activity and
increased disease-free years across population subgroups, our findings show that these
health benefits are often mo...
www.thelancet.com
February 4, 2025 at 10:28 AM
Engaging in leisure-time physical activity adds 1–2 extra disease-free years, with greater benefits among smokers, those with social disadvantage, and individuals with depression.
💡 Boosting physical activity may reduce health disparities.
Read more: www.thelancet.com/journals/lan...
💡 Boosting physical activity may reduce health disparities.
Read more: www.thelancet.com/journals/lan...