Lightnews — Scholar-powered news

Reposted by Shutt Lab

Thompson Lab @jthompsonlab.bsky.social · 21d

We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...

Hyper-proliferation of Adipose Progenitors During Developmental Adipogenesis Programs Higher Adipocyte Number and Early-onset Obesity in Offspring Born to Obese Dams

Being born to a mother who was obese during pregnancy is one of the strongest predictors of early onset obesity and metabolic syndrome. To identify the developmental mechanism linking maternal obesity...

www.biorxiv.org

2 1

Shutt Lab @mitomorph.bsky.social · Sep 3

Congrats Jonathan!

1 1

Reposted by Shutt Lab

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jun 27

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1

1 2

Shutt Lab @mitomorph.bsky.social · Jun 27

Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.

Wiseman Lab @wisemanlab.bsky.social · Jun 27

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells

Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...

www.biorxiv.org

3

Shutt Lab @mitomorph.bsky.social · Jun 3

Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa

6

Reposted by Shutt Lab

A. Phillip West @westlabmito.bsky.social · Jun 1

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications

Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...

www.nature.com

2 16 40

Reposted by Shutt Lab

Natalie Niemi @nieminm.bsky.social · May 29

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵

www.biorxiv.org/content/10.1...

Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...

www.biorxiv.org

4 27 73

Reposted by Shutt Lab

Hansi Weissensteiner @whansi.bsky.social · May 22

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell

great work by Martin Picard

www.scientificamerican.com/article/why-...

The Hidden Social Lives of Mitochondria

When these energy-giving organelles thrive, so do we

www.scientificamerican.com

6 15

Reposted by Shutt Lab

Journal of Cell Science @jcellsci.bsky.social · May 15

Our Special Issue: Cell Biology of Mitochondria is complete.

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria

Journal of Cell Science cover
Special Issue on Cell Biology of Mitochondria
Guest Editors: Ana J. Garcia-Saez and Heidi McBride
Image of mitochondria (magenta) and DNA (cyan) in glioblastoma cells

1 7 17

Shutt Lab @mitomorph.bsky.social · May 13

Happy to see this fun piece finally out. Congrats to Laurie for bringing this all together and thanks to Martin for his contributions.

Journal of Cell Science @jcellsci.bsky.social · May 9

In their Opinion article, Laurie Lee-Glover, Martin Picard and Timothy Shutt @mitomorph.bsky.social argue that mitochondria should be considered as the ‘Chief Executive Organelle’ – the CEO – of the cell. #JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...

Schematic showing that mitochondria can be understood as the ‘Chief Executive Organelle’ of the cell! Mitochondria play key roles in determining cell fate, including regulation of cell division, stem cell differentiation, senescence and cell death, akin to decisions a CEO makes about the growth, diversification or closure of a company. Mitochondria also control key cell resources, including ATP and a variety of other metabolites. Furthermore, mitochondria act as signalling hubs, mediating both intracellular and intercellular signalling, much like communication lines within and between organizations, and regulate innate immune pathways that act as the security system of the cell. Given the many instructive roles mitochondria carry out, we argue that they should be considered the CEO of the cell. This figure was partly generated using Servier Medical Art, provided by Servier, licensed under a CC-BY 3.0 Unported license.

3 11

Reposted by Shutt Lab

Danielle Grotjahn @nanigrotjahn.bsky.social · May 1

🚨New preprint!🚨 #teamtomo
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles.

Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

bioRxivpreprint @biorxivpreprint.bsky.social · May 1

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments https://www.biorxiv.org/content/10.1101/2025.04.30.651574v1

5 31 75

Reposted by Shutt Lab

A. Phillip West @westlabmito.bsky.social · Apr 27

Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover:
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social

Inter-organelle Stress Communication in Inflammation & Disease Conference | Fusion Conferences

Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

bit.ly

3 4

Reposted by Shutt Lab

Life Science Alliance @lsajournal.org · Apr 11

This work characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, and shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release and subsequent inflammation @mitomorph.bsky.social www.life-science-alliance.org/content/8/6/...

3 6

Reposted by Shutt Lab

Danielle Grotjahn @nanigrotjahn.bsky.social · Apr 9

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩

@zidlab.bsky.social @tomo.science @hamid13r.bsky.social

Journal of Cell Biology @jcb.org · Apr 7

Our April issue is here! rupress.org/jcb/issue/22...
The cover shows a segmented model of cytoplasmic #ribosomes associated with mitochondrial membrane in a Saccharomyces cerevisiae cell. From Ya-Ting Chang, @nanigrotjahn.bsky.social and colleagues (doi.org/10.1083/jcb....)

3 14 66

Reposted by Shutt Lab

Life Science Alliance @lsajournal.org · Apr 4

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...

4 6

Reposted by Shutt Lab

David Pla Martin @dplamartin.bsky.social · Apr 4

Are u tired of reading about tariffs? Then take a look to our last work! @science.org

www.science.org/doi/10.1126/...

Retromer promotes the lysosomal turnover of mtDNA

Lysosomal uptake of mtDNA controls mitochondrial quality.

www.science.org

2 8 26

Reposted by Shutt Lab

David Pla Martin @dplamartin.bsky.social · Apr 3

A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation

Pathogenic variants in the mitochondrial protein MFN2 are typically associated with a peripheral neuropathy phenotype, but can also cause a variety of additional pathologies including myopathy. Here, ...

www.life-science-alliance.org

2 7

Shutt Lab @mitomorph.bsky.social · Apr 3

The main addition since our original pre-print is new work showing that when we re-express this variant in MFN2 KO cells, we still see mtDNA release, similar to what we observed in patient cells. This new data confirms the mtDNA release is mediated by the MFN2 variant.

2

Shutt Lab @mitomorph.bsky.social · Apr 3

Our paper describing a novel MFN2 variant linked to mtDNA-mediated inflammation is now published at Life Science Alliance @lsajournal.org.

doi.org/10.26508/lsa...

1 2

Reposted by Shutt Lab

mitotalks.bsky.social @mitotalks.bsky.social · Apr 1

MITOtalks this week

8 9

Shutt Lab @mitomorph.bsky.social · Apr 1

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

DMartin @drddom.bsky.social · Apr 1

Missed the deadline for the abstract submission for the CSMB meeting on Protein Homeostasis – From Basic Science to Human Health?

Well the deadline was extended until April 15th!

event.fourwaves.com/csmb-prince-...

2025 CSMB-PRinCE Joint Conference

Fourwaves - 2025 CSMB-PRinCE Joint Conference

event.fourwaves.com

4 3

Reposted by Shutt Lab

Andrew Roger @andrewjroger.bsky.social · Mar 14

I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt

A robustly rooted tree of eukaryotes reveals their excavate ancestry - Nature

The root of the eukaryote Tree of Life is estimated from a new, larger dataset of mitochondrial proteins including all known eukaryotic supergroups, showing it lies between two multi-supergroup assemb...

doi.org

3 64 150

Reposted by Shutt Lab

Martin Ott lab @mitolab.bsky.social · Mar 3

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658

Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

www.nature.com

6 7

Reposted by Shutt Lab

Peng Huang @penghuang031.bsky.social · Feb 27

The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open. event.fourwaves.com/12cdb/pages

1 7 9

Reposted by Shutt Lab

Isi Molina-Riquelme @isimolinar.bsky.social · Feb 21

I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social
Available in @cp-trendscellbio.bsky.social

www.cell.com/trends/cell-...

#mito #mitochondria

How are mitochondrial nucleoids trafficked?

Mitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding inner mitochondrial membrane (...

www.cell.com

8 8