Shai Bel (The Mucus Man)
@mucusman.bsky.social
The Bel Lab, boldly going where no one else bothers to. @erc.europa.eu funded lab. Opinions are my microbiota's. #NewPI www.thebellab.com
Reposted by Shai Bel (The Mucus Man)
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
Reposted by Shai Bel (The Mucus Man)
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I'm happy to share a perspective that
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
www.science.org
November 20, 2025 at 8:28 PM
I'm happy to share a perspective that
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...
Reposted by Shai Bel (The Mucus Man)
Additional talks this fall include @mucusman.bsky.social, Selena Sagan (hosted by @uwmadisonmdtp.bsky.social), @teralevin.bsky.social, @csdetweiler.bsky.social, Jan Rehwinkel, Sung Chul Park, Claire O'Leary, Sean Crosson, @torreslab.bsky.social, and Patricia Champion
September 3, 2025 at 3:08 PM
Additional talks this fall include @mucusman.bsky.social, Selena Sagan (hosted by @uwmadisonmdtp.bsky.social), @teralevin.bsky.social, @csdetweiler.bsky.social, Jan Rehwinkel, Sung Chul Park, Claire O'Leary, Sean Crosson, @torreslab.bsky.social, and Patricia Champion
Highly recommend 👇🏻
Think that this is cool biology? We agree.
Love 20+ color flow?
Are you within 2-3 years of your PhD and are looking for a postdoc?
We're hiring @sinaiimmuno.bsky.social 😁 ⬇️
Love 20+ color flow?
Are you within 2-3 years of your PhD and are looking for a postdoc?
We're hiring @sinaiimmuno.bsky.social 😁 ⬇️
Post Doctoral Fellow-MSH-20093-003 in New York, NY | Mount Sinai Health Systems
Mount Sinai is hiring a Post Doctoral Fellow-MSH-20093-003 in New York, NY. Review all of the job details and apply today!
careers.mountsinai.org
August 14, 2025 at 4:36 PM
Highly recommend 👇🏻
Reposted by Shai Bel (The Mucus Man)
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…
www.sciencedirect.com
August 7, 2025 at 9:36 PM
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
🚨While the world is burning down around us, I'm happy to share that I've been promoted to Associate Professor with tenure. Though this is considered a personal achievement, it was only possible due to the wonderful trainees in the lab, who carried me here❤️.
a man is writing prof on a blackboard
ALT: a man is writing prof on a blackboard
media.tenor.com
August 14, 2025 at 3:58 PM
🚨While the world is burning down around us, I'm happy to share that I've been promoted to Associate Professor with tenure. Though this is considered a personal achievement, it was only possible due to the wonderful trainees in the lab, who carried me here❤️.
Reposted by Shai Bel (The Mucus Man)
This was not our conference, please redirect to the appropriate advisory committee. beneficialmicrobes.events/advisory-com...
The 11th Beneficial Microbes Conference
The 11th Beneficial Microbes Conference will provide an overview of the latest scientific results and future developments related to pre- and probiotics and their importance to human and animal health...
beneficialmicrobes.events
June 18, 2025 at 4:45 PM
This was not our conference, please redirect to the appropriate advisory committee. beneficialmicrobes.events/advisory-com...
Reposted by Shai Bel (The Mucus Man)
This is unacceptable. A total disgrace. Shame on the organizers. Leave science out of it! I am appalled to see this in the microbiology community 🦠
June 18, 2025 at 3:30 PM
This is unacceptable. A total disgrace. Shame on the organizers. Leave science out of it! I am appalled to see this in the microbiology community 🦠
Reposted by Shai Bel (The Mucus Man)
Total disgrace!
This is unacceptable. A total disgrace. Shame on the organizers. Leave science out of it! I am appalled to see this in the microbiology community 🦠
June 18, 2025 at 3:56 PM
Total disgrace!
Reposted by Shai Bel (The Mucus Man)
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
June 3, 2025 at 4:40 PM
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
Reposted by Shai Bel (The Mucus Man)
A coordinated cellular network regulates tolerance to food @nature.com @annarudnitsky.bsky.social @kedmiranit.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 28, 2025 at 1:43 AM
A coordinated cellular network regulates tolerance to food @nature.com @annarudnitsky.bsky.social @kedmiranit.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Shai Bel (The Mucus Man)
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
May 27, 2025 at 6:50 PM
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
Reposted by Shai Bel (The Mucus Man)
Excited to share the work of Mikayla Olson in the lab making a replication competent reporter virus for murine norovirus. journals.plos.org/plospathogen...
Development of a replication competent murine norovirus reporter system
Author summary Colloquially known as “the stomach bug,” human norovirus is a leading cause of foodborne illness worldwide. Despite its prevalence, there are no approved therapeutics or vaccines agains...
journals.plos.org
May 27, 2025 at 8:24 PM
Excited to share the work of Mikayla Olson in the lab making a replication competent reporter virus for murine norovirus. journals.plos.org/plospathogen...
Reposted by Shai Bel (The Mucus Man)
Our latest paper is now out. A long standing collaboration with the Sunyer lab where our teams show the requirement for secretory IgM in the gut mucosa to control microbiota homeostasis and metabolism. Enjoy! #sIgM #mucosalimmunology www.nature.com/articles/s41...
Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology
Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.
www.nature.com
May 27, 2025 at 3:57 AM
Our latest paper is now out. A long standing collaboration with the Sunyer lab where our teams show the requirement for secretory IgM in the gut mucosa to control microbiota homeostasis and metabolism. Enjoy! #sIgM #mucosalimmunology www.nature.com/articles/s41...
Reposted by Shai Bel (The Mucus Man)
Tomorrow I will host Will Ratcliff @wcratcliff.bsky.social in the virtual microbiology journal club.
Title: "Exploring the origin of multicellularity in real time: what we've learned from 10,000 generations of laboratory evolution"
link below -
Title: "Exploring the origin of multicellularity in real time: what we've learned from 10,000 generations of laboratory evolution"
link below -
May 25, 2025 at 7:44 PM
Tomorrow I will host Will Ratcliff @wcratcliff.bsky.social in the virtual microbiology journal club.
Title: "Exploring the origin of multicellularity in real time: what we've learned from 10,000 generations of laboratory evolution"
link below -
Title: "Exploring the origin of multicellularity in real time: what we've learned from 10,000 generations of laboratory evolution"
link below -
Secretory autophagy strikes again! 🧪
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex | PNAS
PARK7/DJ-1, a redox-sensitive protein implicated in neurodegeneration, cancer, and
inflammation, exhibits increased secretion under stress. We prev...
www.pnas.org
May 24, 2025 at 9:25 PM
Secretory autophagy strikes again! 🧪
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Shai Bel (The Mucus Man)
🧪🔬🦠🧫🌍
This is the kind of paper we should all be waiting for!
Because sadly we still don't have reliable methods to count bacterial abundance from microbiomes.
(I haven't read it yet, but I love the intention already)
www.nature.com/articles/s41...
This is the kind of paper we should all be waiting for!
Because sadly we still don't have reliable methods to count bacterial abundance from microbiomes.
(I haven't read it yet, but I love the intention already)
www.nature.com/articles/s41...
Absolute quantification of prokaryotes in the microbiome by 16S rRNA qPCR or ddPCR - Nature Protocols
This protocol enables rigorous and reproducible quantification of prokaryotic concentration in stool samples by 16S rRNA qPCR or ddPCR.
www.nature.com
May 22, 2025 at 5:08 PM
🧪🔬🦠🧫🌍
This is the kind of paper we should all be waiting for!
Because sadly we still don't have reliable methods to count bacterial abundance from microbiomes.
(I haven't read it yet, but I love the intention already)
www.nature.com/articles/s41...
This is the kind of paper we should all be waiting for!
Because sadly we still don't have reliable methods to count bacterial abundance from microbiomes.
(I haven't read it yet, but I love the intention already)
www.nature.com/articles/s41...
Reposted by Shai Bel (The Mucus Man)
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
kwnsfk27.r.eu-west-1.awstrack.me
May 17, 2025 at 10:25 PM
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
On my way to #DDW25!!
a pinkfong advertisement shows a cartoon character pushing a yellow object
ALT: a pinkfong advertisement shows a cartoon character pushing a yellow object
media.tenor.com
May 1, 2025 at 7:01 PM
On my way to #DDW25!!
Reposted by Shai Bel (The Mucus Man)
Had an amazing time at #APS2025, and so happy to have presented my poster and flash talk! First conference ✅
And that’s a wrap on #APS2025! Thanks to all our amazing @apsphysiology.bsky.social GI & Liver Section leaders + members for a fantastic meeting. One last shoutout to @ananya-p.bsky.social for excellent presentations all around 🤩 #proudPI #GIresearch @sinaiimmuno.bsky.social
April 27, 2025 at 3:37 PM
Had an amazing time at #APS2025, and so happy to have presented my poster and flash talk! First conference ✅
Reposted by Shai Bel (The Mucus Man)
✨🦟✨HOW DO MOSQUITOES HAVE SEX? ✨🦟✨
Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES!
www.biorxiv.org/content/10.1...
Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES!
www.biorxiv.org/content/10.1...
April 20, 2025 at 3:05 PM
✨🦟✨HOW DO MOSQUITOES HAVE SEX? ✨🦟✨
Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES!
www.biorxiv.org/content/10.1...
Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES!
www.biorxiv.org/content/10.1...
Reposted by Shai Bel (The Mucus Man)
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
a purple octopus with big eyes is crawling on the ground in the ocean .
ALT: a purple octopus with big eyes is crawling on the ground in the ocean .
media.tenor.com
April 21, 2025 at 6:11 PM
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
Reposted by Shai Bel (The Mucus Man)
Honored to have been invited to give a #GlobalImmunoTalk! Grateful for the opportunity to share our work with the global immunology community.
If you missed it, you can watch the full talk here 👇🏼
www.youtube.com/live/jBLDd3M...
If you missed it, you can watch the full talk here 👇🏼
www.youtube.com/live/jBLDd3M...
"The Architecture of Intestinal Inflammation and Healing" by Dr. Eduardo Villablanca
YouTube video by GLOBAL IMMUNOTALKS
www.youtube.com
April 23, 2025 at 8:18 PM
Honored to have been invited to give a #GlobalImmunoTalk! Grateful for the opportunity to share our work with the global immunology community.
If you missed it, you can watch the full talk here 👇🏼
www.youtube.com/live/jBLDd3M...
If you missed it, you can watch the full talk here 👇🏼
www.youtube.com/live/jBLDd3M...