Nate Jacobs
@nacobs.bsky.social
Biotech patent attorney (opinions not advice). Craft beer, viruses, urbanism, puns, and board games.
Reposted by Nate Jacobs
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Alas, the actual paper focuses more on viruses and bacteria than Pop-Tarts or filled pasta, but I'm still excited to see it published! www.doi.org/10.1093/jlb/...
November 3, 2025 at 9:02 PM
Alas, the actual paper focuses more on viruses and bacteria than Pop-Tarts or filled pasta, but I'm still excited to see it published! www.doi.org/10.1093/jlb/...
Reposted by Nate Jacobs
The news in the world is awful, but it's almost Halloween, so let's talk about pumpkin enrichment for big cats.
This is Jinx the black leopard (Big Cat Rescue, Florida) enjoying shredding a pumpkin.
This is Jinx the black leopard (Big Cat Rescue, Florida) enjoying shredding a pumpkin.
October 30, 2023 at 11:51 AM
The news in the world is awful, but it's almost Halloween, so let's talk about pumpkin enrichment for big cats.
This is Jinx the black leopard (Big Cat Rescue, Florida) enjoying shredding a pumpkin.
This is Jinx the black leopard (Big Cat Rescue, Florida) enjoying shredding a pumpkin.
Reposted by Nate Jacobs
A homebuilt printing press for publishing after the rapture without drawing the attention of the Antichrist.
Patent Application Publication US 2012/0279405
Patent Application Publication US 2012/0279405
September 23, 2025 at 12:25 PM
A homebuilt printing press for publishing after the rapture without drawing the attention of the Antichrist.
Patent Application Publication US 2012/0279405
Patent Application Publication US 2012/0279405
Reposted by Nate Jacobs
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025
The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...
www.biorxiv.org
September 8, 2025 at 9:48 PM
In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...
Reposted by Nate Jacobs
While riding the B or Q trains between Dekalb Ave station and the Manhattan Bridge, you may catch a glimpse of "Masstransiscope," a public art installation by Bill Brand. It was added to the #NYCsubway system in 1980.
August 22, 2025 at 2:03 PM
While riding the B or Q trains between Dekalb Ave station and the Manhattan Bridge, you may catch a glimpse of "Masstransiscope," a public art installation by Bill Brand. It was added to the #NYCsubway system in 1980.
Reposted by Nate Jacobs
“Send our friends in Washington a message — it is working,” Gov. Hochul said of the vehicle tolls.
Q Train Expansion Into Harlem Gets a Green Light, Thanks in Part to Congestion Pricing
“Send our friends in Washington a message — it is working,” Gov. Hochul said of the vehicle tolls.
buff.ly
August 20, 2025 at 12:36 PM
“Send our friends in Washington a message — it is working,” Gov. Hochul said of the vehicle tolls.
Reposted by Nate Jacobs
This is the science I want funded (alongside curing cancer etc)
A defined microbial community reproduces attributes of fine flavour chocolate fermentation
www.nature.com/articles/s41...
A defined microbial community reproduces attributes of fine flavour chocolate fermentation
www.nature.com/articles/s41...
A defined microbial community reproduces attributes of fine flavour chocolate fermentation - Nature Microbiology
An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...
www.nature.com
August 18, 2025 at 3:52 PM
This is the science I want funded (alongside curing cancer etc)
A defined microbial community reproduces attributes of fine flavour chocolate fermentation
www.nature.com/articles/s41...
A defined microbial community reproduces attributes of fine flavour chocolate fermentation
www.nature.com/articles/s41...
Reposted by Nate Jacobs
ICYMI: New online! Experimental evolution in an era of molecular manipulation
Experimental evolution in an era of molecular manipulation
Nature Reviews Genetics, Published online: 21 July 2025; doi:10.1038/s41576-025-00867-6In this Review, Ascensao and Desai discuss how methodological advances in genotype and phenotype manipulation are transforming experimental evolution approaches and providing new insights into the underlying genetics and forces that shape phenotypic evolution.
www.nature.com
July 28, 2025 at 2:46 PM
ICYMI: New online! Experimental evolution in an era of molecular manipulation
Reposted by Nate Jacobs
the singular message of this ad is "zohran loves new york city" and it is incredibly effective
Shooting our videos is a little bit different now.
July 8, 2025 at 2:33 AM
the singular message of this ad is "zohran loves new york city" and it is incredibly effective
My “Taxonomy and Phylogenetics for Patent Attorneys” presentation is coming along nicely.
May 14, 2025 at 12:41 PM
My “Taxonomy and Phylogenetics for Patent Attorneys” presentation is coming along nicely.
Wore my pinkest shirt and greenest pants today to channel this Nicole Kidman energy on my way out of my last ever law school final tonight.
May 2, 2025 at 1:12 AM
Wore my pinkest shirt and greenest pants today to channel this Nicole Kidman energy on my way out of my last ever law school final tonight.
My Pumpkins? Smashing.
April 30, 2025 at 1:53 AM
My Pumpkins? Smashing.
Reposted by Nate Jacobs
April 28, 2025 at 9:04 PM
Playing a zero-sum game of poker in the presence of multiple mirrors may not have been the wisest decision.
April 27, 2025 at 9:20 PM
Playing a zero-sum game of poker in the presence of multiple mirrors may not have been the wisest decision.
Reposted by Nate Jacobs
I come from a small town and a blue collar family. I’m a first generation college graduate. There’s dignity in all labor. There’s nothing inspiring about dreams of people placing small screws in phones for non-living wages. We should build big things in America. And it requires many hands to do it.
April 6, 2025 at 3:07 PM
I come from a small town and a blue collar family. I’m a first generation college graduate. There’s dignity in all labor. There’s nothing inspiring about dreams of people placing small screws in phones for non-living wages. We should build big things in America. And it requires many hands to do it.
Reposted by Nate Jacobs
I have a lovely colleague whose title is the "Thomas Pickles Professor of Law," and all I can think of when I see their email signature is
Rugrats Nap GIF
ALT: Rugrats Nap GIF
media.tenor.com
February 24, 2025 at 8:51 PM
I have a lovely colleague whose title is the "Thomas Pickles Professor of Law," and all I can think of when I see their email signature is
Reposted by Nate Jacobs
if you need a break from doom, please take 5 seconds to help my labmate make a family feud style game for her very cool microbes and society class she's developing and teaching this quarter: docs.google.com/forms/d/e/1F...
Survey Says....You're Helping Out Maddy! Family Feud Survey
Become a member of the audience for a Family Feud style game that I am playing with my undergrad class! This is an introduction activity where I will ask them to guess the most popular answers to the ...
docs.google.com
February 13, 2025 at 10:39 PM
if you need a break from doom, please take 5 seconds to help my labmate make a family feud style game for her very cool microbes and society class she's developing and teaching this quarter: docs.google.com/forms/d/e/1F...
Reposted by Nate Jacobs
"The value added is a feeling that you’re on the cutting edge of technology even though you’re using a product that is now actively worse."
Our Customers Demand Terrible AI Systems
We’ve been banging our heads against the wall, trying to think of the new “it” thing our customers want. At one point, somebody suggested improving...
buff.ly
January 26, 2025 at 2:30 PM
"The value added is a feeling that you’re on the cutting edge of technology even though you’re using a product that is now actively worse."
Had 40 minutes to kill between classes after one ended early. Were it not Dry January, I probably would’ve found a nearby bar and had a beer, but instead wandered over to HomeGoods, and wound up bringing a guest to Medicare Law.
January 14, 2025 at 2:23 AM
Had 40 minutes to kill between classes after one ended early. Were it not Dry January, I probably would’ve found a nearby bar and had a beer, but instead wandered over to HomeGoods, and wound up bringing a guest to Medicare Law.
Reposted by Nate Jacobs
Disease prevalence in US states before & after vaccine introduction
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
November 15, 2024 at 5:00 AM
Disease prevalence in US states before & after vaccine introduction
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
Reposted by Nate Jacobs
An interesting concept but what if instead we did cars cars cars all policy revolves around cars everyone not in a car should die cars bigger cars even bigger cars no you can't walk cars only cars parking lots cars defund public transit cars more cars obey the cars
trains are such a great example of how the future is here, if we want it and are willing to subsidize it
It’s over 1,000km from Berlin to Paris
There’s now a direct daytime train between them, that takes 8 hours and costs just €59. Leave at 10am, arrive 6pm.
And… it’s just 1% the carbon emissions of the equivalent flight
www.euronews.com/travel/2024/...
There’s now a direct daytime train between them, that takes 8 hours and costs just €59. Leave at 10am, arrive 6pm.
And… it’s just 1% the carbon emissions of the equivalent flight
www.euronews.com/travel/2024/...
January 2, 2025 at 2:57 PM
An interesting concept but what if instead we did cars cars cars all policy revolves around cars everyone not in a car should die cars bigger cars even bigger cars no you can't walk cars only cars parking lots cars defund public transit cars more cars obey the cars
Reposted by Nate Jacobs
Interviewer: Can you explain this gap in your UMAP?
No.
No.
Interviewer: Can you explain this gap in your resume?
Well I was trying to embed a diagram in Microsoft word…
Well I was trying to embed a diagram in Microsoft word…
Interviewer: Can you explain this gap in your resume?
What can I say, my toddler found the scissors.
What can I say, my toddler found the scissors.
December 21, 2024 at 11:22 PM
Interviewer: Can you explain this gap in your UMAP?
No.
No.
Reposted by Nate Jacobs
My perfect Christmas present is a map of the US color coded or broken up by circuit and district - in the style of a fantasy book map. LoTR meets lawyer, if you will.
December 13, 2024 at 3:43 PM
My perfect Christmas present is a map of the US color coded or broken up by circuit and district - in the style of a fantasy book map. LoTR meets lawyer, if you will.