Lightnews — Scholar-powered news

Reposted by Nan Zhang

Denis Wirtz @deniswirtz.bsky.social · 9d

We have developed a new workflow to map in 3D at single-cell resolution whole human organs.

Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment.

More here: www.biorxiv.org/content/10.1...

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Reposted by Nan Zhang

Payal Yokota @payalyokota.bsky.social · 20d

Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS www.pnas.org/doi/abs/10.1...

congratulations to Joe Saglimbeni and Boris Reizis lab!

Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS

Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing opposing roles during tumor progression and/or response to ...

www.pnas.org

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Reposted by Nan Zhang

Science Magazine @science.org · Jul 31

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency

Republicans on spending committee push back against proposed reorganization and overhead cuts

scim.ag

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Nan Zhang @nanzhangwistar.bsky.social · Jul 31

Here is the bill approved today by the subcommittee. Fingers crossed for next steps. www.appropriations.senate.gov/imo/media/do...

www.appropriations.senate.gov

Reposted by Nan Zhang

Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · Jul 31

This just in…

FY’26 Bill Highlights:

National Institutes of Health: $48.7 billion for biomedical investments in research.

Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.

www.statnews.com/2025/07/31/n...

Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut

Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday

www.statnews.com

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Nan Zhang @nanzhangwistar.bsky.social · Jul 31

Cautious optimistic! Was there a streamed hearing? What’s the source?

Max Kozlov @maxkozlov.bsky.social · Jul 31

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.

"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

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Reposted by Nan Zhang

Carla Nowosad PhD @carlanowosad.bsky.social · Jul 22

Nowosad Lab will be recruiting postdocs soon. Reach out if you are interested!

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Reposted by Nan Zhang

Ivan Zanoni @lozanzi.bsky.social · Jul 9

#MicrobiotaPower via #Exercise! Phelps, Meisel &co show @cp-cell.bsky.social that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against #melanoma! dlvr.it/TLqLW7

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

dlvr.it

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Nan Zhang @nanzhangwistar.bsky.social · Jul 9

We are hiring! Please help spread the words. Thank you!

Post-Doctoral Fellow - Zhang Lab - Philadelphia, Pennsylvania (US) job with The Wistar Institute | 12841397

The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Nan Zhang.

www.nature.com

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Reposted by Nan Zhang

International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Jun 25

Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.

International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · Jun 10

Don't forget 📆 Abstract deadline for poster or oral presentations is June 18. Please repost to your network to spread the word! More info or register at seattle.cytokinesociety.org

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Reposted by Nan Zhang

@KingOfPathogens @kingofpathogens.bsky.social · Jun 16

Last week was big for IL-12 engineering @cytokinesociety.bsky.social : Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control url:https://rupress.org/jem/article-abstract/222/9/e20241454/278038/Membrane-IL12-adjuvant-mRNA-vaccine-polarizes-pre

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Reposted by Nan Zhang

Hensley Lab @scottehensley.bsky.social · Jun 6

Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu

www.science.org/doi/10.1126/...

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses

IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

www.science.org

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Nan Zhang @nanzhangwistar.bsky.social · Jun 5

They might need education more than research. 🧐🤷🏻‍♂️

Reposted by Nan Zhang

Denis Wirtz @deniswirtz.bsky.social · May 9

188 PhD/graduate fellowships from private foundations, federal agencies and international organizations.

Database can be downloaded here: research.jhu.edu/rdt/funding-...

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Nan Zhang @nanzhangwistar.bsky.social · Apr 7

A few quotes I love from this article about writing: "There’s no such thing as thinking", "Writing. Is. Thinking.", "Without writing there is no thinking and no real opportunity for exchange in the marketplace of ideas."

An open letter to graduate students and other procrastinators: it's time to write - PubMed

An open letter to graduate students and other procrastinators: it's time to write

pubmed.ncbi.nlm.nih.gov

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Reposted by Nan Zhang

Ivan Zanoni @lozanzi.bsky.social · Apr 1

#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb

IL-1β+ macrophages and the control of pathogenic inflammation in cancer

While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

dlvr.it

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Reposted by Nan Zhang

Ivan Zanoni @lozanzi.bsky.social · Mar 19

#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!

Matrix-producing neutrophils populate and shield the skin - Nature

A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

www.nature.com

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Nan Zhang @nanzhangwistar.bsky.social · Mar 20

That’s a good one!

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Nan Zhang @nanzhangwistar.bsky.social · Mar 14

😱Never heard of anything like this.

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Nan Zhang @nanzhangwistar.bsky.social · Mar 13

Whenever I feel hopeless, I’d look back 100 years and then feel much more grateful and hopeful with what we have now. I hope it doesn’t get worse than that. 🤐🤐🤐

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Nan Zhang @nanzhangwistar.bsky.social · Mar 12

Beautiful work by Ed Thorp’s team. We did a journal club on this paper and learned a lot about the crosstalk between resident macrophages and cardiomyocytes through thromoxane signaling and efferocytosis.

www.cell.com/immunity/abs...

Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration

Mechanisms that differentiate the capacity of newborn immune cells to orchestrate tissue regeneration are inadequately understood. Lantz et al. discover that in response to dying cells, neonatal macro...

www.cell.com

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Reposted by Nan Zhang

Filippo Veglia Lab @filippov81.bsky.social · Mar 2

Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social

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Nan Zhang @nanzhangwistar.bsky.social · Mar 7

#StandUpForSciencePhilly

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Nan Zhang @nanzhangwistar.bsky.social · Mar 7

Congratulations, Jie, Xiaoqin, and the team! Beautiful work!

Ivan Zanoni @lozanzi.bsky.social · Mar 6

#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

www.science.org

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Nan Zhang @nanzhangwistar.bsky.social · Mar 7

Do we meet at City Hall or do we march to City Hall? I guess probably meet at City Hall since people will be from many different institutions.

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