Dr. Natalie Tatum
@nataliejtatum.bsky.social
🧬 senior postdoc with Endicott & Noble Lab [ https://t.ly/iinwc & https://t.ly/AAaA7 ]
💊 structure-based & computational drug discovery
💎 crystals, protein science
🏳️🌈 geek & mammy shark
📍Cancer Research Horizons Newcastle
📍Newcastle University
📣 Views mine
💊 structure-based & computational drug discovery
💎 crystals, protein science
🏳️🌈 geek & mammy shark
📍Cancer Research Horizons Newcastle
📍Newcastle University
📣 Views mine
Reposted by Dr. Natalie Tatum
Next up is Robbie Burton from Newcastle University
November 7, 2025 at 9:55 AM
Next up is Robbie Burton from Newcastle University
Reposted by Dr. Natalie Tatum
Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio
📖 www.sciencedirect.com/science/arti...
📖 www.sciencedirect.com/science/arti...
August 14, 2025 at 3:33 PM
Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio
📖 www.sciencedirect.com/science/arti...
📖 www.sciencedirect.com/science/arti...
Reposted by Dr. Natalie Tatum
Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants - Nature Communications
Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recog...
www.nature.com
August 15, 2025 at 9:26 PM
Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧬 Engineered nanobodies binding and stabilizing cancer-mutant p16INK4a—without blocking its CDK6 interaction or cell-cycle arrest function, in press at Structure from Endicott @nucancer.bsky.social and @lauraitzhaki.bsky.social groups!
📖 www.cell.com/structure/fu...
📖 www.cell.com/structure/fu...
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
Burbidge et al. characterize nanobodies against the tumor suppressor and CDK4/6 inhibitor
p16INK4a in vitro and in cells. They show the nanobodies restore mutant p16INK4a stability.
Nanobody binding t...
www.cell.com
August 15, 2025 at 7:43 AM
🧬 Engineered nanobodies binding and stabilizing cancer-mutant p16INK4a—without blocking its CDK6 interaction or cell-cycle arrest function, in press at Structure from Endicott @nucancer.bsky.social and @lauraitzhaki.bsky.social groups!
📖 www.cell.com/structure/fu...
📖 www.cell.com/structure/fu...
Reposted by Dr. Natalie Tatum
this is the thing. it's not nothing. in certain contexts it is really extraordinary, I am excited to be living to see what it does.
it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).
it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).
Yes, but tell me again how AI gets the number of B's in blueberry wrong.
A major health breakthrough and the start of a “second golden age of antibiotic discovery”, driven by AI.
August 14, 2025 at 3:36 PM
this is the thing. it's not nothing. in certain contexts it is really extraordinary, I am excited to be living to see what it does.
it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).
it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).
Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio
📖 www.sciencedirect.com/science/arti...
📖 www.sciencedirect.com/science/arti...
August 14, 2025 at 3:33 PM
Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio
📖 www.sciencedirect.com/science/arti...
📖 www.sciencedirect.com/science/arti...
Today was one of those Good Days in Academia where (a) an experiment gave me a result I was hoping for, which is Super Cool, and (b) an undergrad emailed asking for advice and I could give them resources and context to point them on the next step of their journey. Little important wins 🩷
July 2, 2025 at 8:53 PM
Today was one of those Good Days in Academia where (a) an experiment gave me a result I was hoping for, which is Super Cool, and (b) an undergrad emailed asking for advice and I could give them resources and context to point them on the next step of their journey. Little important wins 🩷
Reposted by Dr. Natalie Tatum
Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.
June 19, 2025 at 11:21 AM
Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.
I'm at #DurhamHPCDays today to present in the Computational Biosciences workshop. Always lovely to come back to Durham, and this time to see a shiny new Maths+CompSci building!
June 3, 2025 at 10:02 AM
I'm at #DurhamHPCDays today to present in the Computational Biosciences workshop. Always lovely to come back to Durham, and this time to see a shiny new Maths+CompSci building!
Reposted by Dr. Natalie Tatum
New Presidential executive order on proteins:
All amino acids now to be right w̶i̶n̶g̶ handed.
Leftist amino acids to be outlawed.
(Also, Z-DNA is deemed to be Communist, and is prohibited.)
Trans- and cis- peptide bonds to be banned.
Non-binary amino acid Glycine to be banned.
Proline is […]
All amino acids now to be right w̶i̶n̶g̶ handed.
Leftist amino acids to be outlawed.
(Also, Z-DNA is deemed to be Communist, and is prohibited.)
Trans- and cis- peptide bonds to be banned.
Non-binary amino acid Glycine to be banned.
Proline is […]
Original post on xtaldave.net
xtaldave.net
April 1, 2025 at 6:27 AM
New Presidential executive order on proteins:
All amino acids now to be right w̶i̶n̶g̶ handed.
Leftist amino acids to be outlawed.
(Also, Z-DNA is deemed to be Communist, and is prohibited.)
Trans- and cis- peptide bonds to be banned.
Non-binary amino acid Glycine to be banned.
Proline is […]
All amino acids now to be right w̶i̶n̶g̶ handed.
Leftist amino acids to be outlawed.
(Also, Z-DNA is deemed to be Communist, and is prohibited.)
Trans- and cis- peptide bonds to be banned.
Non-binary amino acid Glycine to be banned.
Proline is […]
@xtaldave.xtaldave.net.ap.brid.gy Your post to the ccp4bb is a thing of beauty.
a man in a black suit is sitting in a red chair
ALT: a man in a black suit is sitting in a red chair
media.tenor.com
April 1, 2025 at 5:26 PM
@xtaldave.xtaldave.net.ap.brid.gy Your post to the ccp4bb is a thing of beauty.
Latest preprint out in the wild! This is some older work which lingered on our to-do lists; we published the crystal structure of the human IRF4 DNA-binding domain (6TD4) in 2020!
Structural, biophysical and biological analysis and characterisation of IRF4 DNA-binding domain mutations associated with multiple myeloma https://www.biorxiv.org/content/10.1101/2025.03.12.642038v1
March 15, 2025 at 2:03 PM
Latest preprint out in the wild! This is some older work which lingered on our to-do lists; we published the crystal structure of the human IRF4 DNA-binding domain (6TD4) in 2020!
Reposted by Dr. Natalie Tatum
And thanks to the team at Newcastle for stepping up to the challenge!: @creechem.bsky.social, Rachael Pirie, @bieniekmat.bsky.social, @jthorton22.bsky.social, Ayaz Ahmad, Aaron Campbell, Kallie Friston, Natalie Roper, Roly Armstrong, Kate Harris, & @nataliejtatum.bsky.social
March 8, 2025 at 5:27 PM
And thanks to the team at Newcastle for stepping up to the challenge!: @creechem.bsky.social, Rachael Pirie, @bieniekmat.bsky.social, @jthorton22.bsky.social, Ayaz Ahmad, Aaron Campbell, Kallie Friston, Natalie Roper, Roly Armstrong, Kate Harris, & @nataliejtatum.bsky.social
Reposted by Dr. Natalie Tatum
My daughter messaged me after her chem class the other day and asked if i could do a cartoon about Trump and Musk as isomers. Dear followers, inspired by Amelia i present to you, unconstitutional arsomers.
*insert applause here*
#chemsky
*insert applause here*
#chemsky
February 14, 2025 at 5:01 PM
My daughter messaged me after her chem class the other day and asked if i could do a cartoon about Trump and Musk as isomers. Dear followers, inspired by Amelia i present to you, unconstitutional arsomers.
*insert applause here*
#chemsky
*insert applause here*
#chemsky
Reposted by Dr. Natalie Tatum
🌍👩🔬 Celebrating International Women in Science Day! Thank you to all the women in our drug discovery team, their dedication, innovation and inspiration. Together we are pushing boundaries to discover novel anticancer drugs! @nucancer.bsky.social @crhorizons.bsky.social @newcastleuni.bsky.social
February 11, 2025 at 12:32 PM
🌍👩🔬 Celebrating International Women in Science Day! Thank you to all the women in our drug discovery team, their dedication, innovation and inspiration. Together we are pushing boundaries to discover novel anticancer drugs! @nucancer.bsky.social @crhorizons.bsky.social @newcastleuni.bsky.social
Reposted by Dr. Natalie Tatum
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
What's Happening Inside the NIH and NSF
www.science.org
February 4, 2025 at 4:40 PM
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
Reposted by Dr. Natalie Tatum
Read about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials
www.linkedin.com/posts/cancer...
www.linkedin.com/posts/cancer...
Cancer Research Horizons on LinkedIn: #onmyhorizon #cancerresearch
2024 milestones worth celebrating 🧬🌟
Bravo to the incredible researchers at the Drug Discovery Unit at Newcastle University. They've unlocked a potential…
www.linkedin.com
December 27, 2024 at 6:50 PM
Read about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials
www.linkedin.com/posts/cancer...
www.linkedin.com/posts/cancer...
Reposted by Dr. Natalie Tatum
Our research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024:
Funds Raised: £6,440 (+£1,031 gift aid)
Online Donations: 283
Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz
Funds Raised: £6,440 (+£1,031 gift aid)
Online Donations: 283
Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz
December 19, 2024 at 2:36 PM
Our research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024:
Funds Raised: £6,440 (+£1,031 gift aid)
Online Donations: 283
Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz
Funds Raised: £6,440 (+£1,031 gift aid)
Online Donations: 283
Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz
Setting up some crystallisation plates today for a new year treat/Christmas miracle. First time setting up an in situ plate for some work with @diamondlightsource.bsky.social VMXi 💎
December 17, 2024 at 1:57 PM
Setting up some crystallisation plates today for a new year treat/Christmas miracle. First time setting up an in situ plate for some work with @diamondlightsource.bsky.social VMXi 💎
Reposted by Dr. Natalie Tatum
In early phase drug discovery, biology and assays are make-or-break. I can remember very few programs I worked on which were hampered by the inability to make molecules, but plenty that were hampered by the inability to capture disease biology complexity on a chip or in an enzyme readout.
December 15, 2024 at 10:51 PM
In early phase drug discovery, biology and assays are make-or-break. I can remember very few programs I worked on which were hampered by the inability to make molecules, but plenty that were hampered by the inability to capture disease biology complexity on a chip or in an enzyme readout.
Been flying the @newcastleuni.bsky.social and @nudrugdiscovery.bsky.social flags recently, talking to @mosmedcdt.bsky.social Cohort 6 about applying computational methods appropriately + short talk at the Durham BSI bit.ly/4d7nlbB on our cyclin D3 work! bit.ly/3D6SwHF🧬🧶#academicskycsky
December 13, 2024 at 9:30 AM
Been flying the @newcastleuni.bsky.social and @nudrugdiscovery.bsky.social flags recently, talking to @mosmedcdt.bsky.social Cohort 6 about applying computational methods appropriately + short talk at the Durham BSI bit.ly/4d7nlbB on our cyclin D3 work! bit.ly/3D6SwHF🧬🧶#academicskycsky
Reposted by Dr. Natalie Tatum
Thrilled to share the new collaboration between @diamondlightsource.bsky.social + @crhorizons.bsky.social + @newcastleuni.bsky.social to accelerate structure-based drug development via fragment screening! More here: bit.ly/4g7Et3f 🧬🧶 #chemsky #chembio We're already hard at work on exciting targets 💪
Cancer Research Horizons and Diamond Light Source establish drug discovery partnership
Cancer Research Horizons is partnering with Diamond Light Source, the UK’s national synchrotron, to build a world-leading fragment-based drug discovery programme.
bit.ly
December 13, 2024 at 8:25 AM
Thrilled to share the new collaboration between @diamondlightsource.bsky.social + @crhorizons.bsky.social + @newcastleuni.bsky.social to accelerate structure-based drug development via fragment screening! More here: bit.ly/4g7Et3f 🧬🧶 #chemsky #chembio We're already hard at work on exciting targets 💪
Reposted by Dr. Natalie Tatum
Per an email from Google DeepMind: Alphafold 3 is not licensed for academics to use for work that leads to a vaccine (pandemic preparations, anyone?). If structure prediction performance is comparable, people will leave AF3 for competitors with more permissive licenses
December 10, 2024 at 10:56 PM
Per an email from Google DeepMind: Alphafold 3 is not licensed for academics to use for work that leads to a vaccine (pandemic preparations, anyone?). If structure prediction performance is comparable, people will leave AF3 for competitors with more permissive licenses
Reposted by Dr. Natalie Tatum
In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c...
Thanks to the organisers for a well-run challenge!
@creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social
Thanks to the organisers for a well-run challenge!
@creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social
December 6, 2024 at 1:57 PM
In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c...
Thanks to the organisers for a well-run challenge!
@creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social
Thanks to the organisers for a well-run challenge!
@creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social
Reposted by Dr. Natalie Tatum
Well, there’s a story.
December 5, 2024 at 9:05 AM
Well, there’s a story.