📜History lover
🕊️ Aspiring to be better. Freethinker
📍 #NephJC executive editor
📍@KIreportsbsky.social
📍ERAkidney #ERA25 social media co-leader
#NephSky #MedSky
🔥 Remember, you can only vote for your favorites if you have subscribed to #NephJC newsletter
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www.nephjc.com/news/2025/11...
🔥 Remember, you can only vote for your favorites if you have subscribed to #NephJC newsletter
📬 Soon we'll send you the voting link. Check your email.
www.nephjc.com/news/2025/11...
🙏 Grateful to be in this with @brianrifkin.bsky.social #NephJC
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
🙏 Grateful to be in this with @brianrifkin.bsky.social #NephJC
Target emulated trial: potential benefits of finerenone in all sorts of outcomes, but we’re comparing 🔝methodology trials (FIGARO, FIDELIO) vs invetigator initiated trials
pubmed.ncbi.nlm.nih.gov/41173939/
Target emulated trial: potential benefits of finerenone in all sorts of outcomes, but we’re comparing 🔝methodology trials (FIGARO, FIDELIO) vs invetigator initiated trials
pubmed.ncbi.nlm.nih.gov/41173939/
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
✍️ By @nephroseeker.medsky.social
🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors
www.nephjc.com/news/2025/10...
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
👇👇 Here's a throwback for 2024
www.nephjc.com/news/2024/1/...
👇👇 Here's a throwback for 2024
www.nephjc.com/news/2024/1/...
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
Last #NephJC we discussed the ORIGIN 3 trial which investigated the use of Atacicept in IgAN #TenPostNephJC
Read the article 👇
www.nejm.org/doi/10....
Last #NephJC we discussed the ORIGIN 3 trial which investigated the use of Atacicept in IgAN #TenPostNephJC
Read the article 👇
www.nejm.org/doi/10....
PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....
PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....
#VisualAbstract by Sophia Ambruso
https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext
#VisualAbstract by Sophia Ambruso
https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext
Although sibeprenlimab targets APRIL alone while atacicept blocks both BAFF and APRIL, the two trials showed broadly similar clinical effects: meaningful reductions in proteinuria, strong improvements in key biomarkers, and high rates of hematuria resolution.
Although sibeprenlimab targets APRIL alone while atacicept blocks both BAFF and APRIL, the two trials showed broadly similar clinical effects: meaningful reductions in proteinuria, strong improvements in key biomarkers, and high rates of hematuria resolution.
Whether dual inhibition APRIL/BAFF offers a longer-term advantage over APRIL-selective therapy remains a key question that only eGFR slope data will answer. APRIL-selective therapy also prevents its action at other receptors (BCMA).
Do you think either has the advantage?
Whether dual inhibition APRIL/BAFF offers a longer-term advantage over APRIL-selective therapy remains a key question that only eGFR slope data will answer. APRIL-selective therapy also prevents its action at other receptors (BCMA).
Do you think either has the advantage?
Here we are, staring into nephro-void, where yesterday’s paradigm dissolves. IgAN therapy was a Sisyphian task- rolling the stone of CKD progression uphill, knowing it will tumble back down. A new era brings new hopes. Is ORIGIN 3 another IgAN success story?
pubmed.ncbi.nlm.nih....
Here we are, staring into nephro-void, where yesterday’s paradigm dissolves. IgAN therapy was a Sisyphian task- rolling the stone of CKD progression uphill, knowing it will tumble back down. A new era brings new hopes. Is ORIGIN 3 another IgAN success story?
pubmed.ncbi.nlm.nih....
The 4 hit model 🔨of IgAN pathophysiology gave us coherence where there was once only chaos: abnormal Gd‑IgA1 production, recognition by antiglycan antibodies, immune complex assembly & mesangial deposition
pubmed.ncbi.nlm.nih....
The 4 hit model 🔨of IgAN pathophysiology gave us coherence where there was once only chaos: abnormal Gd‑IgA1 production, recognition by antiglycan antibodies, immune complex assembly & mesangial deposition
pubmed.ncbi.nlm.nih....
🛑Remission is defined an eGFR decline of ~1 ml/min/1.73 m²/year, closer to physiological rate
📉Vs 2-3 ml per year with only conservative therapy; hopefully, B-cell therapies will further flatten the slope
By @brendonneuen.bsky.social &Co
pubmed.ncbi.nlm.nih....
🛑Remission is defined an eGFR decline of ~1 ml/min/1.73 m²/year, closer to physiological rate
📉Vs 2-3 ml per year with only conservative therapy; hopefully, B-cell therapies will further flatten the slope
By @brendonneuen.bsky.social &Co
pubmed.ncbi.nlm.nih....
We already discussed the @kdigo.org IgAN guidelines, with the feeling they will soon be outdated. Our topic tonight was only mentioned as future research direction
www.nephjc.com/news/...
We already discussed the @kdigo.org IgAN guidelines, with the feeling they will soon be outdated. Our topic tonight was only mentioned as future research direction
www.nephjc.com/news/...
Attacking the origins of IgAN with atacicept ⚔️
www.nephjc.com/news/2025/11/17/origin-3-the-visual-abstract
Attacking the origins of IgAN with atacicept ⚔️
www.nephjc.com/news/2025/11/17/origin-3-the-visual-abstract
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
someone check if I have missed anything
Read our blogs here www.nephjc.com/news/kidneyw...
#NephJC #KidneyWk
@nephroseeker.medsky.social @brendonneuen.bsky.social
someone check if I have missed anything
Read our blogs here www.nephjc.com/news/kidneyw...
#NephJC #KidneyWk
@nephroseeker.medsky.social @brendonneuen.bsky.social
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....