Cristina Popa
nephroseeker.medsky.social
Cristina Popa
@nephroseeker.medsky.social
🩺 Nephrologist = kidney philosopher
📜History lover
🕊️ Aspiring to be better. Freethinker
📍 #NephJC executive editor
📍@KIreportsbsky.social
📍ERAkidney #ERA25 social media co-leader
#NephSky #MedSky
Reposted by Cristina Popa
👇Here are the proposals for the #TopNephrology stories in 2025

🔥 Remember, you can only vote for your favorites if you have subscribed to #NephJC newsletter

📬 Soon we'll send you the voting link. Check your email.

www.nephjc.com/news/2025/11...
Which were the Top Nephrology Stories of 2024? — NephJC
Time to vote for the Top Stories of 2025
www.nephjc.com
November 26, 2025 at 3:45 PM
It began in 2021, wondering why anyone would pick me for #NSMC. I applied in '22 and was surprised to be accepted. I’ve grown thanks to many of you (@hswapnil.medsky.social @kidneyboy.bsky.social ), though I still feel like a newcomer 😊

🙏 Grateful to be in this with @brianrifkin.bsky.social #NephJC
November 26, 2025 at 3:16 AM
Probably #nephsky will never see a trial comparing spironolactone with finerenone

Target emulated trial: potential benefits of finerenone in all sorts of outcomes, but we’re comparing 🔝methodology trials (FIGARO, FIDELIO) vs invetigator initiated trials

pubmed.ncbi.nlm.nih.gov/41173939/
November 25, 2025 at 11:38 AM
Reposted by Cristina Popa
#NephJCshort on BICAR-ICU2 #Medsky #Nephsky

✍️ By @nephroseeker.medsky.social

🎭 Bicarbonate makes the picture look cleaner: better pH, more time. But beneath the smoother numbers, the patient hasn't changed. It's the same story, just told in softer colors

www.nephjc.com/news/2025/10...
Dialysis deferred, logic recycled: BICAR ICU2 — NephJC
NephJC short on BICAR-ICU2
www.nephjc.com
November 25, 2025 at 12:19 AM
Reposted by Cristina Popa
In older patients with frailty who were receiving antihypertensive drugs and had a systolic blood pressure below 130 mm Hg, reducing antihypertensive drugs did not lead to lower all-cause mortality over 4 years than usual care. Full RETREAT-FRAIL trial results and Research Summary: nej.md/45NUK9v
November 24, 2025 at 2:13 PM
Reposted by Cristina Popa
🧵 New #Skeetorial Drop! 🧵
1/ Hey #NephSky! 👋
We’re back with a fresh #Skeetorial from @kireports.bsky.social , this time diving into:
Dapagliflozin in Stage 4 CKD: no diabetes required? 🤔
Let’s unpack what this trial means for your next CKD patient. 💊💭
November 20, 2025 at 6:47 PM
Reposted by Cristina Popa
Every year, #NephJC celebrates successful, practice-changing trials. ✨ Which trials do you think are deserving for #TopNephrology 2025? #nephsky

👇👇 Here's a throwback for 2024
www.nephjc.com/news/2024/1/...
Top Stories in Nephrology 2024 — NephJC
Should we call 2024 the Renaissance of nephrology? It was probably the richest year in RCTs in the nephrology world, reflected in the higher number of Late-Breaking Clinical Trials sessions at every b...
www.nephjc.com
November 20, 2025 at 10:42 PM
Reposted by Cristina Popa
5/10
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
November 20, 2025 at 12:35 AM
Reposted by Cristina Popa
1/10
Last #NephJC we discussed the ORIGIN 3 trial which investigated the use of Atacicept in IgAN #TenPostNephJC
Read the article 👇
www.nejm.org/doi/10....
November 20, 2025 at 12:34 AM
Reposted by Cristina Popa
Up next: It might seem a little fishy, but was a great catch 🎣 #NephJC

PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....

November 19, 2025 at 2:58 AM
Reposted by Cristina Popa
November 19, 2025 at 12:00 AM
Reposted by Cristina Popa
T3g: #NephJC

Although sibeprenlimab targets APRIL alone while atacicept blocks both BAFF and APRIL, the two trials showed broadly similar clinical effects: meaningful reductions in proteinuria, strong improvements in key biomarkers, and high rates of hematuria resolution.
November 19, 2025 at 2:42 AM
Reposted by Cristina Popa
T3f: #NephJC

Whether dual inhibition APRIL/BAFF offers a longer-term advantage over APRIL-selective therapy remains a key question that only eGFR slope data will answer. APRIL-selective therapy also prevents its action at other receptors (BCMA).

Do you think either has the advantage?
November 19, 2025 at 2:41 AM
Reposted by Cristina Popa
#NephJC

Here we are, staring into nephro-void, where yesterday’s paradigm dissolves. IgAN therapy was a Sisyphian task- rolling the stone of CKD progression uphill, knowing it will tumble back down. A new era brings new hopes. Is ORIGIN 3 another IgAN success story?
pubmed.ncbi.nlm.nih....
November 19, 2025 at 2:00 AM
Reposted by Cristina Popa
T0e: #NephJC

The 4 hit model 🔨of IgAN pathophysiology gave us coherence where there was once only chaos: abnormal Gd‑IgA1 production, recognition by antiglycan antibodies, immune complex assembly & mesangial deposition

pubmed.ncbi.nlm.nih....
November 19, 2025 at 2:12 AM
Reposted by Cristina Popa
T0d: #NephJC

🛑Remission is defined an eGFR decline of ~1 ml/min/1.73 m²/year, closer to physiological rate

📉Vs 2-3 ml per year with only conservative therapy; hopefully, B-cell therapies will further flatten the slope

By @brendonneuen.bsky.social &Co

pubmed.ncbi.nlm.nih....
November 19, 2025 at 2:11 AM
Reposted by Cristina Popa
T0b: #NephJC
We already discussed the @kdigo.org IgAN guidelines, with the feeling they will soon be outdated. Our topic tonight was only mentioned as future research direction

www.nephjc.com/news/...
November 19, 2025 at 2:09 AM
Reposted by Cristina Popa
Check out the awesome visual abstract by @salinesolut.bsky.social
Attacking the origins of IgAN with atacicept ⚔️
www.nephjc.com/news/2025/11/17/origin-3-the-visual-abstract
ORIGIN-3: The Visual Abstract — NephJC
Atacicept, BAFF/APRIL inhibition in IgAN
www.nephjc.com
November 18, 2025 at 12:32 PM
Hi! I'm Cristina Popa, 🇷🇴 nephrologist #NephC

No COI

Mainly lurking tonight

👇 Pic from my city, called Iasi (borrowed)
November 19, 2025 at 2:03 AM
Reposted by Cristina Popa
Whoah

EBV not only causes multiple sclerosis, it also might be the root of SLE

www.science.org/doi/10.1126/...

An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?

#lupus #medsky #RheumSky

@christosargyrop.bsky.social
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 11:05 PM
Reposted by Cristina Popa
Reposted by Cristina Popa
Cui for a study of membranous with MIL62

#KidneyWk
November 8, 2025 at 5:21 PM
Reposted by Cristina Popa
Late breakers that included children:
✅Setanaxib in Alport (12+)

Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
November 8, 2025 at 8:27 PM
Reposted by Cristina Popa
The second sibeprenlimab paper in @nejm.org

(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)

www.nejm.org/doi/full/10....
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
www.nejm.org
November 8, 2025 at 5:03 PM