Nitin Kapadia
nitinkapadia.bsky.social
Nitin Kapadia
@nitinkapadia.bsky.social
EMBO and HFSP postdoctoral fellow in the Paul Nurse Lab @crick.ac.uk. Biophysicist studying biology from single molecules to the systems level. Alumnus of @reyes-lab.bsky.social @mcgill.ca 🇨🇦
Pinned
I'm very excited that my first postdoc paper is out now at @nature.com!
www.nature.com/articles/s41...

I developed new single cell CDK sensors to investigate how CDK orchestrates mitosis including investigating bistability/hysteresis, how activity is propagated, and the role of centrosomes.
Spatiotemporal orchestration of mitosis by cyclin-dependent kinase - Nature
Experiments in fission yeast show that cyclin-dependent kinase is first activated in the nucleus, from which the mitotic signal is propagated from CDK at the centrosome to the cytoplasm.
www.nature.com
Reposted by Nitin Kapadia
📢 Join us in sunny Lisbon 🇵🇹 2-5 June for the @embo.org workshop ☀️

“The rules of the game: biophysical & molecular principles in cellular evolution”

Apply by March 1st!
Please repost to help spread the word!

meetings.embo.org/event/26-cel...
#EMBORulesOfTheGame @gimmfoundation.bsky.social
The rules of the game: biophysical & molecular principles in cellular evolution
Cells are the fundamental units of life, shaped by evolution into a remarkable diversity of forms and functions. Much is known about the roles of genes and proteins, the regulation of molecular proce…
meetings.embo.org
December 18, 2025 at 3:48 PM
Reposted by Nitin Kapadia
📣 #Job alert!
Looking to establish your own independent research in cell biology, development or evo-devo?
The @cnrs.fr is recruiting 7 scientists in that area of research.
Here are updated unofficial guidelines. Reach out to members of the committee if you have questions
c3n-cn.fr/section-24-w...
December 18, 2025 at 8:52 AM
Reposted by Nitin Kapadia
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?

Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.

Sign up: meetings.embo.org/event/26-arc...

We look forward to seeing you in Cambridge, UK.

Please repost!
Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
meetings.embo.org
December 16, 2025 at 12:00 PM
Reposted by Nitin Kapadia
If anyone has any ideas that they would like to work on in choanoflagellates or Nematostella (or both) then please reach out!
Attention scientists from all over the world🙃
The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪
Get your international & interdisciplinary team. It's time to put your bold research idea into practice!
🔗https://bit.ly/48VsGCG
📅 15 Dec 2025–26 Mar 2026
#sts #LifeSciences
December 16, 2025 at 10:13 AM
Reposted by Nitin Kapadia
We're hiring an Assistant/Associate Professor of #Genomics & #Bioinformatics, #PhD, #MD, or both #Computational #Biology

Come work with us at the Institute for Genome Sciences
@medschool.umaryland.edu in #Baltimore!

Learn more/Apply: bit.ly/GenoBioinfo
December 11, 2025 at 4:16 PM
Reposted by Nitin Kapadia
New work published in @natcomms.nature.com has shone light on how a protein called geminin ensures DNA is only replicated once before cells divide, helping cells to maintain the integrity and accuracy of their DNA.

This work was a collaboration between the LMS and @imperialchemistry.bsky.social
Shining light on how the protein geminin ensures tight regulation of DNA replication
Research from the MRC Laboratory of Medical Science (LMS) and Imperial College London, published today in Nature Communications, has determined how a DNA replication inhibitor protein called geminin e...
lms.mrc.ac.uk
December 11, 2025 at 10:35 AM
Reposted by Nitin Kapadia
New work describes our efforts to achieve CRISPR editing of the mitochondrial genome.

www.biorxiv.org/lookup/conte...
Towards CRISPR-based editing of the mitochondrial genome in yeast
Mitochondria, which evolved from symbiotic bacteria, possess their own genomes (mtDNA) and support independent transcription and translation within the organelle. Given the essential role of mtDNA in ...
www.biorxiv.org
December 10, 2025 at 4:18 PM
Reposted by Nitin Kapadia
Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social
November 26, 2025 at 9:59 AM
Reposted by Nitin Kapadia
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!

GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.

Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.

👉 www.unige.ch/genexm/
December 10, 2025 at 8:43 PM
Reposted by Nitin Kapadia
Among other things, post-doc and doctorate fellowships for international candidates !
🇨🇦🇨🇦 Just announced: a massive new program from the Canadian govt, separate from the well-known CRCs and CERCs, to recruit foreign scientific talent

Canada was already a destination for scientists but whoa. Real impressive for a new govt to back political talking points with serious investment
$1.7 billion to attract international researchers to Canada
Details of the major federal initiative to draw new talent to the country's universities were announced today at UdeM.
nouvelles.umontreal.ca
December 10, 2025 at 2:22 PM
Reposted by Nitin Kapadia
Very happy to share our 'Evoscape' paper, now published in PNAS ! www.pnas.org/doi/10.1073/...
Generative epigenetic landscapes map the topology and topography of cell fates | PNAS
Epigenetic landscapes were proposed by Waddington as the central concept to describe cell fate dynamics in a locally low-dimensional space. In mode...
www.pnas.org
December 10, 2025 at 1:27 PM
Reposted by Nitin Kapadia
1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size!

www.biorxiv.org/content/10.6...
The fitness costs of reproductive specialization scale inversely with organismal size
The evolution of reproductive specialization represents a fundamental innovation in multicellular life, yet the conditions favoring its evolution remain poorly understood. Here, we develop a populatio...
www.biorxiv.org
December 9, 2025 at 7:44 PM
Reposted by Nitin Kapadia
🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥
www.biorxiv.org/content/10.6...
December 9, 2025 at 5:08 PM
Reposted by Nitin Kapadia
Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution https://www.biorxiv.org/content/10.64898/2025.12.06.692745v1
December 8, 2025 at 5:31 PM
Reposted by Nitin Kapadia
The Department of Genetics at the University of Cambridge invites expressions of interest from early career researchers who wish to be sponsored for external fellowships to establish an independent research group.

➡️For further details see the link below www.cam.ac.uk/jobs/group-l...
Group Leader Research Fellowship Sponsorship Scheme
The Department of Genetics at the University of Cambridge invites expressions of interest from early career researchers who wish to be sponsored for external fellowships to establish an independent
www.cam.ac.uk
December 8, 2025 at 1:40 PM
Reposted by Nitin Kapadia
2 recent preprints show the mitotic stopwatch monitors more than just mitotic delays - it protects against WGD, cell enlargement and other stresses that mildly activate p53. It may act to amplify p53 signals to suppress tumourigenesis

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.6...
The mitotic stopwatch limits the proliferation of whole genome doubled cells
Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...
www.biorxiv.org
December 8, 2025 at 10:21 AM
Reposted by Nitin Kapadia
🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
Reposted by Nitin Kapadia
TT in Experimental Biophysics

The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline

fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
DIAS Fellow in Experimental Biophysics
The Danish Institute for Advanced Study (DIAS) and the Department of Physics, Chemistry and Pharmacy (FKF) at the University of Southern Denmark (SDU) seek an excellent candidate to fill a tenure trac...
fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com
December 6, 2025 at 7:40 PM
Reposted by Nitin Kapadia
We’re hiring!

The Department of Physics
@sfuphysics.bsky.social
at Simon Fraser U (in beautiful and vibrant Vancouver) seeks applications for an Assistant or Associate Professor in Experimental Biophysics, encompassing all scales of life from molecules to ecosystems.
@sfuscience.bsky.social
December 5, 2025 at 5:54 PM
Reposted by Nitin Kapadia
Apply for #EMBOSynBio! 🥼🧪

The course offers hands-on experience with cutting-edge SynBio tools, supported by lectures covering the whole engineering cycle and its convergence toward a deeper understanding of biology.

30 Jun – 6 Jul 2026
EMBL Heidelberg
s.embl.org/syn26-01-bl
December 5, 2025 at 9:14 AM
Reposted by Nitin Kapadia
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.
www.bbc.com
December 5, 2025 at 6:35 AM
Reposted by Nitin Kapadia
I just published: ERC-Plus: jackpot science or missed chance to fix academia?

My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.

medium.com/p/erc-plus-j...
ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…
medium.com
December 3, 2025 at 11:42 AM
Reposted by Nitin Kapadia
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic

Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions

www.pnas.org/doi/10.1073/...
Reconstructing Waddington’s landscape from data | PNAS
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attemp...
www.pnas.org
December 4, 2025 at 6:29 AM
Reposted by Nitin Kapadia
New lab preprint!

We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry

A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook

www.biorxiv.org/cgi/content/...
Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry
Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let...
www.biorxiv.org
December 3, 2025 at 4:03 PM