Keith Robison
@omicsomics.bsky.social
Computational biologist & blogger
Reposted by Keith Robison
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
World first: Radboudumc pioneers new genetic test in clinical practice - New test is faster, more efficient, and provides more diagnoses for rare diseases
17 November 2025
www.radboudumc.nl
November 17, 2025 at 8:29 AM
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
A cadre of former colleagues is developing software tools for tracking designed genome edits, propagating annotations to the edited genomes & aligning in a graph-aware manner to assess the success of editing
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
Some news: Last April, I left Ginkgo Bioworks after 8+ years as a software engineer there. Since then, I’ve been working on starting a new company called GenHub with a couple other ex-Ginkgo people, Bob Van Hove and Chris Mitchell. (1/5)
November 13, 2025 at 3:57 AM
A cadre of former colleagues is developing software tools for tracking designed genome edits, propagating annotations to the edited genomes & aligning in a graph-aware manner to assess the success of editing
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
Another podcast host foolhardy enough to have me on! 🤣
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Ep 2: Evolution of Biotech with Keith Robison
YouTube video by Legible Bio
youtu.be
November 10, 2025 at 10:19 PM
Another podcast host foolhardy enough to have me on! 🤣
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Nineteen - musings on shrinking the number of amino acids in a proteome
🧬🖥️
omicsomics.blogspot.com/2025/11/nine...
🧬🖥️
omicsomics.blogspot.com/2025/11/nine...
Nineteen
If I had been more atop things, I would have written this just under a week ago, on the nineteenth anniversary of my starting to write in th...
omicsomics.blogspot.com
November 5, 2025 at 4:18 AM
Nineteen - musings on shrinking the number of amino acids in a proteome
🧬🖥️
omicsomics.blogspot.com/2025/11/nine...
🧬🖥️
omicsomics.blogspot.com/2025/11/nine...
GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons
Streamlit app within a docker container for carrying out genome QC and comparisons - meadm/GenomeCheck
github.com
October 30, 2025 at 4:23 PM
GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
Reposted by Keith Robison
Bacterial telomeres are common, just not so much in RefSeq 'complete' genomes. But they can be added by the new tool David Faurdal wrote. I am thrilled to see this out as a preprint here: www.biorxiv.org/content/10.1... @tilmweber.bsky.social @thombooth.bsky.social
October 15, 2025 at 10:04 AM
Bacterial telomeres are common, just not so much in RefSeq 'complete' genomes. But they can be added by the new tool David Faurdal wrote. I am thrilled to see this out as a preprint here: www.biorxiv.org/content/10.1... @tilmweber.bsky.social @thombooth.bsky.social
Reposted by Keith Robison
Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
The multifaceted roles of NAD+ in bacterial immunity
In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide
(NAD+) is a key player in diverse and widespread bacterial antiphage defense systems
and phage counterdefense. The au...
www.cell.com
October 17, 2025 at 5:55 PM
Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
Reposted by Keith Robison
Long-form complaint about the #ASHG25 event info system from @omicsomics.bsky.social omicsomics.blogspot.com/2025/10/ashg...
ASHG Posters: The Agony and The Ecstasy
ASHG is a huge meeting, probably the second largest I've ever attended after ASCO. ASBMB is similar in size perhaps, though I think a hair ...
omicsomics.blogspot.com
October 15, 2025 at 8:14 PM
Long-form complaint about the #ASHG25 event info system from @omicsomics.bsky.social omicsomics.blogspot.com/2025/10/ashg...
Reposted by Keith Robison
The link to download all abstracts is here. It's always a little well hidden. In previous years it was somewhere like a "Resources" page where no one would ever think to look. #ASHG25 www.ashg.org/wp-content/u...
October 15, 2025 at 8:13 PM
The link to download all abstracts is here. It's always a little well hidden. In previous years it was somewhere like a "Resources" page where no one would ever think to look. #ASHG25 www.ashg.org/wp-content/u...
October 15, 2025 at 7:07 PM
Reposted by Keith Robison
Ultra-sensitive DNA sequencing maps mutations that precede cancer. #DNAseq #Sequencing #GeneticVariants #CancerMutations #Genomics @nature.com 🧬 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
October 14, 2025 at 5:05 PM
Ultra-sensitive DNA sequencing maps mutations that precede cancer. #DNAseq #Sequencing #GeneticVariants #CancerMutations #Genomics @nature.com 🧬 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Keith Robison
From @plos.org #Computational #Biology | Ten quick tips for developing a reproducible #Shiny application | #Bioinformatics #Education #PLOSCBQT #OpenScience #OpenSource 🧬 🖥️ 🧪🔓
⬇️
journals.plos.org/ploscompbiol...
⬇️
journals.plos.org/ploscompbiol...
Ten quick tips for developing a reproducible Shiny application
journals.plos.org
October 14, 2025 at 12:12 PM
From @plos.org #Computational #Biology | Ten quick tips for developing a reproducible #Shiny application | #Bioinformatics #Education #PLOSCBQT #OpenScience #OpenSource 🧬 🖥️ 🧪🔓
⬇️
journals.plos.org/ploscompbiol...
⬇️
journals.plos.org/ploscompbiol...
The number of poster abstracts for #ashg2025 is bonkers
Great there is so much information flowing from labs, but going to be hectic trying to even visit the subset with most enticing titles!
Great there is so much information flowing from labs, but going to be hectic trying to even visit the subset with most enticing titles!
October 13, 2025 at 10:46 PM
The number of poster abstracts for #ashg2025 is bonkers
Great there is so much information flowing from labs, but going to be hectic trying to even visit the subset with most enticing titles!
Great there is so much information flowing from labs, but going to be hectic trying to even visit the subset with most enticing titles!
Reposted by Keith Robison
UPDATE: I saw it happen! At the Birds Canada research station at the tip of Long Point I watched an expert ever-so-gently and carefully put one of these tiny tags on a monarch. Let me walk you through the steps (1/4)
So cool to visit the Motus workshop at Birds Canada headquarters. The Motus community is studying the movement of birds, bats and insects. This tiny radio telemetry device will fit on a Monarch butterfly 😲 #invertebrates #birds 🌿 www.birdscanada.org/bird-science...
September 26, 2025 at 1:03 AM
UPDATE: I saw it happen! At the Birds Canada research station at the tip of Long Point I watched an expert ever-so-gently and carefully put one of these tiny tags on a monarch. Let me walk you through the steps (1/4)
Reposted by Keith Robison
Reposted by Keith Robison
Whole genome sequencing with AVITI and NovaSeq X Plus reveals comparable performance with contextual biases https://www.biorxiv.org/content/10.1101/2025.10.10.681584v1
October 11, 2025 at 2:34 AM
Whole genome sequencing with AVITI and NovaSeq X Plus reveals comparable performance with contextual biases https://www.biorxiv.org/content/10.1101/2025.10.10.681584v1
Reposted by Keith Robison
Journalist here
I’m interested in talking to a federal agency scientist who was fired, then rehired. I can keep you anonymous. I’m on Signal ginnyg.04
Reposts are appreciated!
I’m interested in talking to a federal agency scientist who was fired, then rehired. I can keep you anonymous. I’m on Signal ginnyg.04
Reposts are appreciated!
October 11, 2025 at 12:22 AM
Journalist here
I’m interested in talking to a federal agency scientist who was fired, then rehired. I can keep you anonymous. I’m on Signal ginnyg.04
Reposts are appreciated!
I’m interested in talking to a federal agency scientist who was fired, then rehired. I can keep you anonymous. I’m on Signal ginnyg.04
Reposts are appreciated!
Reposted by Keith Robison
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
October 11, 2025 at 2:10 AM
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
Reposted by Keith Robison
My spouse pulled data from the CDC’s MMWR team on a weekly basis for her company to include with public health reports. That entire team has just been RIFed by Trump.
No more public health reports.
www.cdc.gov/mmwr/index.h...
No more public health reports.
www.cdc.gov/mmwr/index.h...
Morbidity and Mortality Weekly Report
The MMWR series is the agency’s primary vehicle for ,,,
www.cdc.gov
October 11, 2025 at 2:57 AM
My spouse pulled data from the CDC’s MMWR team on a weekly basis for her company to include with public health reports. That entire team has just been RIFed by Trump.
No more public health reports.
www.cdc.gov/mmwr/index.h...
No more public health reports.
www.cdc.gov/mmwr/index.h...