Paresh Malhotra
@pareshmalhotra.bsky.social
Cognitive Neurologist; Head of #Neurology @ Imperial College London; NIHR RDN National Specialty Lead, #Dementia & #Neurodegeneration; Trustee @ Alzheimer’s Society; Looking after patients with, and carrying out research into, Dementia. Views my own.
Reposted by Paresh Malhotra
Agreed that negative trials present enormous learning opportunities. Learned long ago that the only "failed" studies are those that are poorly designed or conducted.
November 24, 2025 at 9:13 PM
Agreed that negative trials present enormous learning opportunities. Learned long ago that the only "failed" studies are those that are poorly designed or conducted.
Reposted by Paresh Malhotra
PhD Opportunity in Alzheimer’s Research
Seeking motivated applicants interested in advanced imaging or mathematical modelling (quantitative systems pharmacology) to investigate immune–nervous system interactions at The University of Queensland. Please reach out: [email protected]
Seeking motivated applicants interested in advanced imaging or mathematical modelling (quantitative systems pharmacology) to investigate immune–nervous system interactions at The University of Queensland. Please reach out: [email protected]
November 15, 2025 at 4:25 AM
PhD Opportunity in Alzheimer’s Research
Seeking motivated applicants interested in advanced imaging or mathematical modelling (quantitative systems pharmacology) to investigate immune–nervous system interactions at The University of Queensland. Please reach out: [email protected]
Seeking motivated applicants interested in advanced imaging or mathematical modelling (quantitative systems pharmacology) to investigate immune–nervous system interactions at The University of Queensland. Please reach out: [email protected]
Reposted by Paresh Malhotra
I was so lucky to have Jonny as my PhD supervisor. He was a one-of-a-kind scientist and person. He continues to be an inspiration to me and I will always be guided by the way he thought about science and life. He built an amazing network of wonderful people and we all miss you, Jonny.
Jonny Smallwood @themindwanders.bsky.social was a beloved friend and mentor. He was taken from us too soon. His was a beautiful mind who understood the beauty of minds. As ever before, his kind voice guides me and his work will continue. We miss you Jonny. www.cbs.mpg.de/news/obituar...
Obituary – Jonathan Smallwood
www.cbs.mpg.de
November 14, 2025 at 9:12 PM
I was so lucky to have Jonny as my PhD supervisor. He was a one-of-a-kind scientist and person. He continues to be an inspiration to me and I will always be guided by the way he thought about science and life. He built an amazing network of wonderful people and we all miss you, Jonny.
Reposted by Paresh Malhotra
Vacancy for a Professor of Old Age Psychiatry at University of Oxford. Lead dementia and mental health research shaping future care for older adults. Closing date: 5th January
www.dementiaresearcher.nihr.ac.uk/job/professo...
www.dementiaresearcher.nihr.ac.uk/job/professo...
Professor: Old Age Psychiatry - DEMENTIA RESEARCHER
Professor of Old Age Psychiatry at University of Oxford. Lead dementia and mental health research shaping future care for older adults.
www.dementiaresearcher.nihr.ac.uk
November 12, 2025 at 1:28 PM
Vacancy for a Professor of Old Age Psychiatry at University of Oxford. Lead dementia and mental health research shaping future care for older adults. Closing date: 5th January
www.dementiaresearcher.nihr.ac.uk/job/professo...
www.dementiaresearcher.nihr.ac.uk/job/professo...
Reposted by Paresh Malhotra
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration. Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/director...
www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute - DEMENTIA RESEARCHER
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.
www.dementiaresearcher.nihr.ac.uk
November 10, 2025 at 9:05 PM
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration. Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/director...
www.dementiaresearcher.nihr.ac.uk/job/director...
Reposted by Paresh Malhotra
A great piece about a man with a complicated legacy.
One of the many quotes:
E.O. Wilson... called him “the most unpleasant human being I had ever met”
One of the many quotes:
E.O. Wilson... called him “the most unpleasant human being I had ever met”
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 2:50 AM
A great piece about a man with a complicated legacy.
One of the many quotes:
E.O. Wilson... called him “the most unpleasant human being I had ever met”
One of the many quotes:
E.O. Wilson... called him “the most unpleasant human being I had ever met”
Reposted by Paresh Malhotra
Every year, ~120 people donate their brain and spinal cord tissue to advance #MS & #Parkinson's research. We spoke with Rory Türkmen Smith, Tissue Bank Engagement Manager, about facilitating these precious donations.
🧠 Read more: bit.ly/43ZdR0f
@imperialmed.bsky.social
🧠 Read more: bit.ly/43ZdR0f
@imperialmed.bsky.social
November 7, 2025 at 1:27 PM
Every year, ~120 people donate their brain and spinal cord tissue to advance #MS & #Parkinson's research. We spoke with Rory Türkmen Smith, Tissue Bank Engagement Manager, about facilitating these precious donations.
🧠 Read more: bit.ly/43ZdR0f
@imperialmed.bsky.social
🧠 Read more: bit.ly/43ZdR0f
@imperialmed.bsky.social
Reposted by Paresh Malhotra
Clinical Research Fellow Vacancy, Newcastle University, join Professor Camille Carroll on EJS ACT PD trial to test disease modifying therapies in Parkinsons. Closing date: 18th November
www.dementiaresearcher.nihr.ac.uk/job/clinical...
www.dementiaresearcher.nihr.ac.uk/job/clinical...
Clinical Research Fellow: Disease-modifying therapies for Parkinson’s
Clinical Research Fellow, Newcastle University, join Professor Camille Carroll on EJS ACT PD trial to test disease modifying therapies in Parkinsons.
www.dementiaresearcher.nihr.ac.uk
November 6, 2025 at 9:03 AM
Clinical Research Fellow Vacancy, Newcastle University, join Professor Camille Carroll on EJS ACT PD trial to test disease modifying therapies in Parkinsons. Closing date: 18th November
www.dementiaresearcher.nihr.ac.uk/job/clinical...
www.dementiaresearcher.nihr.ac.uk/job/clinical...
Reposted by Paresh Malhotra
Living in a deprived neighbourhood increases your #dementia risk and now @psychiatry-ucam.bsky.social researchers know why.
@audreylow.bsky.social and Prof John O'Brien found links to brain vessel damage and poorer management of lifestyle factors known to affect dementia risk: bit.ly/3JNMxv7
🧪
@audreylow.bsky.social and Prof John O'Brien found links to brain vessel damage and poorer management of lifestyle factors known to affect dementia risk: bit.ly/3JNMxv7
🧪
November 5, 2025 at 3:39 PM
Living in a deprived neighbourhood increases your #dementia risk and now @psychiatry-ucam.bsky.social researchers know why.
@audreylow.bsky.social and Prof John O'Brien found links to brain vessel damage and poorer management of lifestyle factors known to affect dementia risk: bit.ly/3JNMxv7
🧪
@audreylow.bsky.social and Prof John O'Brien found links to brain vessel damage and poorer management of lifestyle factors known to affect dementia risk: bit.ly/3JNMxv7
🧪
Coincidentally (but v aptly) finished #LollyWillowes last night. Happy Halloween!!
October 31, 2025 at 2:42 PM
Coincidentally (but v aptly) finished #LollyWillowes last night. Happy Halloween!!
Reposted by Paresh Malhotra
The #brain is often viewed as rather separate from the rest of body. One way it is separated somewhat is the BBB — the blood-brain-barrier.
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
The blood–brain barrier
Here, Audrey Chagnot and Axel Montagne discuss the structural and functional features
of the blood–brain barrier and the association of its disruption with various pathologies.
www.cell.com
October 30, 2025 at 4:54 PM
The #brain is often viewed as rather separate from the rest of body. One way it is separated somewhat is the BBB — the blood-brain-barrier.
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot
www.cell.com/current-biol...
Reposted by Paresh Malhotra
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
www.gov.uk/government/p...
The value of public R&D
www.gov.uk
October 30, 2025 at 1:28 PM
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
www.gov.uk/government/p...
Reposted by Paresh Malhotra
Are you a postdoc researcher interested in dementia and neurodegenerative diseases?
Join us in York on 25 November for a FREE policy workshop co-hosted by #denpruQM, NIHR Three Schools' Dementia Research Programme & @i-care-dtc.bsky.social.
Interested? Find out more & sign up:
tinyurl.com/4xz7ys27
Join us in York on 25 November for a FREE policy workshop co-hosted by #denpruQM, NIHR Three Schools' Dementia Research Programme & @i-care-dtc.bsky.social.
Interested? Find out more & sign up:
tinyurl.com/4xz7ys27
Policy workshop for early- and mid-career researchers
Supporting early and mid-career researchers focused on dementia & neurodegenerative conditions to bridge the gap between policy & research.
tinyurl.com
October 29, 2025 at 3:56 PM
Are you a postdoc researcher interested in dementia and neurodegenerative diseases?
Join us in York on 25 November for a FREE policy workshop co-hosted by #denpruQM, NIHR Three Schools' Dementia Research Programme & @i-care-dtc.bsky.social.
Interested? Find out more & sign up:
tinyurl.com/4xz7ys27
Join us in York on 25 November for a FREE policy workshop co-hosted by #denpruQM, NIHR Three Schools' Dementia Research Programme & @i-care-dtc.bsky.social.
Interested? Find out more & sign up:
tinyurl.com/4xz7ys27
Reposted by Paresh Malhotra
Following the launch of the Dementia Frontiers Fund, we are hosting two information webinars on the initiative and its application process.
📅 Nov 11, 0900 GMT
📅 Nov 13, 1700 GMT
Each session will include a live Q&A to address your questions.
Sign up: alzheimers.eventsair.com/dementia-fro...
📅 Nov 11, 0900 GMT
📅 Nov 13, 1700 GMT
Each session will include a live Q&A to address your questions.
Sign up: alzheimers.eventsair.com/dementia-fro...
October 28, 2025 at 3:44 PM
Following the launch of the Dementia Frontiers Fund, we are hosting two information webinars on the initiative and its application process.
📅 Nov 11, 0900 GMT
📅 Nov 13, 1700 GMT
Each session will include a live Q&A to address your questions.
Sign up: alzheimers.eventsair.com/dementia-fro...
📅 Nov 11, 0900 GMT
📅 Nov 13, 1700 GMT
Each session will include a live Q&A to address your questions.
Sign up: alzheimers.eventsair.com/dementia-fro...
Reposted by Paresh Malhotra
How does the brain fall asleep? 💤
In a fascinating new study, scientists led by Dr Nir Grossman have been able to pinpoint, for the first time, the exact moment the brain falls asleep, and precisely map the unfolding process in real time 👉 buff.ly/mcOumTw
In a fascinating new study, scientists led by Dr Nir Grossman have been able to pinpoint, for the first time, the exact moment the brain falls asleep, and precisely map the unfolding process in real time 👉 buff.ly/mcOumTw
October 28, 2025 at 10:05 AM
How does the brain fall asleep? 💤
In a fascinating new study, scientists led by Dr Nir Grossman have been able to pinpoint, for the first time, the exact moment the brain falls asleep, and precisely map the unfolding process in real time 👉 buff.ly/mcOumTw
In a fascinating new study, scientists led by Dr Nir Grossman have been able to pinpoint, for the first time, the exact moment the brain falls asleep, and precisely map the unfolding process in real time 👉 buff.ly/mcOumTw
Reposted by Paresh Malhotra
NIHR Clinical Future Leaders Fellowship with MRC, CRUK, BHF and @alzsocresearch.bsky.social offers 7-year funding for senior postdoctoral clinical academics.
www.dementiaresearcher.nihr.ac.uk/funding/clin...
www.dementiaresearcher.nihr.ac.uk/funding/clin...
Clinical Future Leaders Fellowship - DEMENTIA RESEARCHER
NIHR Clinical Future Leaders Fellowship with MRC, CRUK, BHF and Alzheimer’s Society offers 7-year funding for senior postdoctoral clinical academics.
www.dementiaresearcher.nihr.ac.uk
October 25, 2025 at 5:30 PM
NIHR Clinical Future Leaders Fellowship with MRC, CRUK, BHF and @alzsocresearch.bsky.social offers 7-year funding for senior postdoctoral clinical academics.
www.dementiaresearcher.nihr.ac.uk/funding/clin...
www.dementiaresearcher.nihr.ac.uk/funding/clin...
Reposted by Paresh Malhotra
1 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism.
Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH
Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH
October 14, 2025 at 9:31 AM
1 in 3 people is living with neurological condition, such as stroke, epilepsy, migraine, autism.
Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH
Despite the number of people with these conditions, those in low- and middle- income countries face the greatest challenges http://bit.ly/4oj81yH
Reposted by Paresh Malhotra
Apply to the Dementia Frontiers Fund (Worldwide oppertunity) from @alzheimersresearchuk.org and Gates Ventures to pursue bold #dementia research with staged support and multi year awards.
www.dementiaresearcher.nihr.ac.uk/funding/deme...
www.dementiaresearcher.nihr.ac.uk/funding/deme...
Dementia Frontiers Fund - DEMENTIA RESEARCHER
Apply to the Dementia Frontiers Fund from Alzheimer's Research UK and Gates Ventures to pursue bold dementia research with staged support and multi year awards.
www.dementiaresearcher.nihr.ac.uk
October 23, 2025 at 5:02 PM
Apply to the Dementia Frontiers Fund (Worldwide oppertunity) from @alzheimersresearchuk.org and Gates Ventures to pursue bold #dementia research with staged support and multi year awards.
www.dementiaresearcher.nihr.ac.uk/funding/deme...
www.dementiaresearcher.nihr.ac.uk/funding/deme...
Reposted by Paresh Malhotra
Congratulations to @hdemnitzking.bsky.social, @claudiacooper.bsky.social & team on your NIHR/ESRC APPLE-Tree publication 🎉
Harriet & Claudia are joining @ilcuk.bsky.social at the House of Lords today to launch the findings & share #denpruQM work on public health policy for dementia risk reduction.
Harriet & Claudia are joining @ilcuk.bsky.social at the House of Lords today to launch the findings & share #denpruQM work on public health policy for dementia risk reduction.
🎉 Exciting news!
A huge congratulations to the entire APPLE-Tree team on the publication of our latest paper—an important step forward in dementia prevention research. @denpru-qm.bsky.social
Read the full paper here: www.sciencedirect.com/science/arti...
A huge congratulations to the entire APPLE-Tree team on the publication of our latest paper—an important step forward in dementia prevention research. @denpru-qm.bsky.social
Read the full paper here: www.sciencedirect.com/science/arti...
Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial
Trials of high-intensity, multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aimed …
www.sciencedirect.com
October 21, 2025 at 9:02 AM
Congratulations to @hdemnitzking.bsky.social, @claudiacooper.bsky.social & team on your NIHR/ESRC APPLE-Tree publication 🎉
Harriet & Claudia are joining @ilcuk.bsky.social at the House of Lords today to launch the findings & share #denpruQM work on public health policy for dementia risk reduction.
Harriet & Claudia are joining @ilcuk.bsky.social at the House of Lords today to launch the findings & share #denpruQM work on public health policy for dementia risk reduction.
Reposted by Paresh Malhotra
New post just out:
"On the edge"
On my unexpected week in hospital and five things I learnt about the state of the NHS.
(Free to read)
open.substack.com/pub/samf/p/o...
"On the edge"
On my unexpected week in hospital and five things I learnt about the state of the NHS.
(Free to read)
open.substack.com/pub/samf/p/o...
On the edge
My week in the NHS
open.substack.com
October 19, 2025 at 8:14 AM
New post just out:
"On the edge"
On my unexpected week in hospital and five things I learnt about the state of the NHS.
(Free to read)
open.substack.com/pub/samf/p/o...
"On the edge"
On my unexpected week in hospital and five things I learnt about the state of the NHS.
(Free to read)
open.substack.com/pub/samf/p/o...
Reposted by Paresh Malhotra
We’re excited to announce that recruitment for the first multi-arm, multi-stage (MAMS) platform for Parkinson’s in the UK – EJS ACT-PD – is open. This project will continuously test new therapies that could impact Parkinson's progression.
Read more: buff.ly/W7eqbec
Read more: buff.ly/W7eqbec
October 16, 2025 at 1:02 PM
We’re excited to announce that recruitment for the first multi-arm, multi-stage (MAMS) platform for Parkinson’s in the UK – EJS ACT-PD – is open. This project will continuously test new therapies that could impact Parkinson's progression.
Read more: buff.ly/W7eqbec
Read more: buff.ly/W7eqbec
www.bmj.com/content/391/... well worth reading this if you can.
John Goldsmith: refugee from Nazi Germany who became a pioneer of kidney dialysis
John Goldsmith overcame a tumultuous childhood and adolescence, first as a refugee from Nazi Germany and later as an interned “enemy alien,” to become an early pioneer in kidney dialysis, setting up t...
www.bmj.com
October 15, 2025 at 7:04 PM
www.bmj.com/content/391/... well worth reading this if you can.
Reposted by Paresh Malhotra
Research Assistant or Associate in Computational Genomics at Imperial College London, with Dr Cynthia Sandor analysing single cell omics in Parkinsons. Closing date: 29th October
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Assistant: Single Cell Genomics -
Research Assistant or Associate in Computational Genomics at Imperial College London, with Dr Cynthia Sandor analysing single cell omics in Parkinsons
www.dementiaresearcher.nihr.ac.uk
October 12, 2025 at 9:38 PM
Research Assistant or Associate in Computational Genomics at Imperial College London, with Dr Cynthia Sandor analysing single cell omics in Parkinsons. Closing date: 29th October
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by Paresh Malhotra
We must find an effective treatment for #ALS #MND
@ukmndri.bsky.social
BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...
@ukmndri.bsky.social
BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...
Lewis Moody: Former England captain reveals motor neurone disease diagnosis
Former England captain Lewis Moody reveals he has been diagnosed with motor neurone disease in an exclusive BBC interview.
www.bbc.com
October 6, 2025 at 7:32 AM
We must find an effective treatment for #ALS #MND
@ukmndri.bsky.social
BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...
@ukmndri.bsky.social
BBC News - Former England captain Moody reveals MND diagnosis
www.bbc.com/sport/rugby-...
Reposted by Paresh Malhotra
In this passage from Our Brains, Our Selves, winner of the Royal Society Trivedi Science Book Prize, neuroscientist Masud Husain recounts how novelist Marcel Proust became convinced, wrongly, that he'd had a stroke
Read an extract from Our Brains, Our Selves by Masud Husain
In this passage from Our Brains, Our Selves, winner of the Royal Society Trivedi Science Book Prize, neuroscientist Masud Husain recounts how novelist Marcel Proust became convinced, wrongly, that he'd had a stroke
www.newscientist.com
October 5, 2025 at 8:03 AM
In this passage from Our Brains, Our Selves, winner of the Royal Society Trivedi Science Book Prize, neuroscientist Masud Husain recounts how novelist Marcel Proust became convinced, wrongly, that he'd had a stroke