Parker Singleton
@parkersingleton.bsky.social
Senior Scientist at Penn Lifespan Informatics and Neuroimaging Center (PennLINC) studying psychedelics and the brain.
sypres.io
sypres.io
Pinned
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Come join an amazing team where you're guaranteed to set yourself up for future success!
#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs.
Website: www.pennlinc.io
Job: bit.ly/4ojvCir
Website: www.pennlinc.io
Job: bit.ly/4ojvCir
neuroimaging | Satterthwaite Lab | UPenn
www.satterthwaitelab.com
Homepage for Satterthwaite lab
neuroimaging | neurodevelopment | adolescence | psychiatry | machine learning | network science
www.pennlinc.io
November 24, 2025 at 10:13 PM
Come join an amazing team where you're guaranteed to set yourself up for future success!
Reposted by Parker Singleton
💊 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.
November 21, 2025 at 4:38 PM
💊 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.
Reposted by Parker Singleton
🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 12, 2025 at 9:53 PM
🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Parker Singleton
After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:
Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications
The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...
www.biorxiv.org
November 11, 2025 at 10:03 PM
After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:
Reposted by Parker Singleton
Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA
10.1093/brain/awaf391
10.1093/brain/awaf391
October 27, 2025 at 3:33 AM
Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA
10.1093/brain/awaf391
10.1093/brain/awaf391
I thought about busting the PS out of the attic recently just for Spyro and Crash Bandicoot
October 20, 2025 at 7:44 PM
I thought about busting the PS out of the attic recently just for Spyro and Crash Bandicoot
Hot off the press!
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 7:42 PM
Hot off the press!
Reposted by Parker Singleton
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
nature.com
October 15, 2025 at 8:18 PM
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.
October 14, 2025 at 3:32 PM
If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.
Reposted by Parker Singleton
I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.
October 6, 2025 at 10:00 PM
I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.
Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.
Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...
Funded by National Institute of Mental Health (NIMH)
Funded by National Institute of Mental Health (NIMH)
September 24, 2025 at 12:58 PM
Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.
Reposted by Parker Singleton
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
September 7, 2025 at 2:59 PM
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
my linkedin feed has become filled with psychedelic memes and I'm connected with an OG acid kingpin.
August 28, 2025 at 1:18 PM
my linkedin feed has become filled with psychedelic memes and I'm connected with an OG acid kingpin.
I'm near certain sLFOs are big for psychedelics.
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Systemic physiological "noise" in fMRI has clinical relevance
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...
www.medrxiv.org
August 26, 2025 at 5:14 PM
I'm near certain sLFOs are big for psychedelics.
Reposted by Parker Singleton
Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊
August 15, 2025 at 9:08 AM
Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity"
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity
We investigate the spatiotemporal organization of resting-state brain activity in individuals with and without major depressive disorder (MDD), identifying stable and recurring whole-brain functional ...
www.researchsquare.com
August 21, 2025 at 1:26 PM
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity"
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Reposted by Parker Singleton
✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky
#neuroskyence #devpsych #PsychSciSky
Timing and plasticity are critical to progress in research on stress and neurodevelopment
@ariellekeller.bsky.social
@jamapediatrics.com
@utdallas.bsky.social
jamanetwork.com/journals/jam...
@ariellekeller.bsky.social
@jamapediatrics.com
@utdallas.bsky.social
jamanetwork.com/journals/jam...
Neurodevelopmental Timing Links Stress and Psychopathology
This Viewpoint discusses the importance of contextualizing stressful experiences and the neurodevelopmental trajectory to predict the risk of psychopathology.
jamanetwork.com
August 19, 2025 at 5:56 PM
✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky
#neuroskyence #devpsych #PsychSciSky
Reposted by Parker Singleton
Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant?
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
On the left is a rabbit. On the right is an elephant. But guess what: They’re the *same image*, rotated 90°!
In @currentbiology.bsky.social, @chazfirestone.bsky.social & I show how these images—known as “visual anagrams”—can help solve a longstanding problem in cognitive science. bit.ly/45BVnCZ
In @currentbiology.bsky.social, @chazfirestone.bsky.social & I show how these images—known as “visual anagrams”—can help solve a longstanding problem in cognitive science. bit.ly/45BVnCZ
August 19, 2025 at 4:51 PM
Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant?
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
Thanks Parker!
August 18, 2025 at 6:42 PM
Thanks Parker!
Reposted by Parker Singleton
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 2:37 PM
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
Analiese Lahey, @pimcuijpers.bsky.social, @mathiasharrer.bsky.social, @mntj21.bsky.social, Sandeep Nayak, Eric Strain, @vandyatvandy.bsky.social, Bob Dworkin, @jcobbscott.bsky.social. @ted-satterthwaite.bsky.social, @pennlinc.bsky.social
August 18, 2025 at 1:17 PM
Analiese Lahey, @pimcuijpers.bsky.social, @mathiasharrer.bsky.social, @mntj21.bsky.social, Sandeep Nayak, Eric Strain, @vandyatvandy.bsky.social, Bob Dworkin, @jcobbscott.bsky.social. @ted-satterthwaite.bsky.social, @pennlinc.bsky.social
All of this and more can be easily accessed through sypres.io
Team effort with co-first author (!!!) @bsevchik.bsky.social and the rest of the SYPRES and Metapsy team who made this happen!
Team effort with co-first author (!!!) @bsevchik.bsky.social and the rest of the SYPRES and Metapsy team who made this happen!
SYPRES
The official website for the sypres initiative.
sypres.io
August 18, 2025 at 1:17 PM
All of this and more can be easily accessed through sypres.io
Team effort with co-first author (!!!) @bsevchik.bsky.social and the rest of the SYPRES and Metapsy team who made this happen!
Team effort with co-first author (!!!) @bsevchik.bsky.social and the rest of the SYPRES and Metapsy team who made this happen!
In partnership with metapsy.org we built an interactive dashboard for exploring the data. Users can:
• Filter studies by characteristics
• Test different analysis parameters
• Test moderators
• Download figures and reports
Dashboard: metapsy.org/sypres/psilo...
• Filter studies by characteristics
• Test different analysis parameters
• Test moderators
• Download figures and reports
Dashboard: metapsy.org/sypres/psilo...
August 18, 2025 at 1:17 PM
In partnership with metapsy.org we built an interactive dashboard for exploring the data. Users can:
• Filter studies by characteristics
• Test different analysis parameters
• Test moderators
• Download figures and reports
Dashboard: metapsy.org/sypres/psilo...
• Filter studies by characteristics
• Test different analysis parameters
• Test moderators
• Download figures and reports
Dashboard: metapsy.org/sypres/psilo...
Our database includes 200+ effect sizes, encompassing all depression outcomes and timepoints reported by arm in each of the 12 RCTs included. This database can be downloaded from our website (sypres.io) or imported directly into R environments using the metapsyData package from metapsy.org
August 18, 2025 at 1:17 PM
Our database includes 200+ effect sizes, encompassing all depression outcomes and timepoints reported by arm in each of the 12 RCTs included. This database can be downloaded from our website (sypres.io) or imported directly into R environments using the metapsyData package from metapsy.org
Here, psilocybin showed a greater reduction in depression scores compared to control conditions, with a pooled Hedges’ g = -0.91 (k = 9; p = 0.0013, I2 = 58.1%, n = 501). But important caveats—small studies, blinding challenges, risk of bias, and design heterogeneity, which we discuss in the paper.
August 18, 2025 at 1:17 PM
Here, psilocybin showed a greater reduction in depression scores compared to control conditions, with a pooled Hedges’ g = -0.91 (k = 9; p = 0.0013, I2 = 58.1%, n = 501). But important caveats—small studies, blinding challenges, risk of bias, and design heterogeneity, which we discuss in the paper.