D. Parker Kelley, PhD
@sequencemyneuro.bsky.social
Data Science Fellow in Trauma and PTSD @ UCSF & SFVAHCS
Mitochondrial psychobiology, psychoneuroimmunology, stress, PTSD, and psychedelics
This must be the place
Mitochondrial psychobiology, psychoneuroimmunology, stress, PTSD, and psychedelics
This must be the place
Reposted by D. Parker Kelley, PhD
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
January 22, 2026 at 5:35 PM
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms
January 23, 2026 at 4:29 PM
Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms
Reposted by D. Parker Kelley, PhD
Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)
December 27, 2025 at 11:13 PM
Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)
I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social
Thanks so much for having me on!
Check er out:
youtu.be/-e49-DwCZ9A?...
Thanks so much for having me on!
Check er out:
youtu.be/-e49-DwCZ9A?...
Could Stress Be The Hidden Driver of Mental Illness?
YouTube video by Metabolic Mind
youtu.be
December 10, 2025 at 8:10 PM
I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social
Thanks so much for having me on!
Check er out:
youtu.be/-e49-DwCZ9A?...
Thanks so much for having me on!
Check er out:
youtu.be/-e49-DwCZ9A?...
Congrats @carmensandi10.bsky.social !!
Warm congratulations to @carmensandi10.bsky.social for winning the Mika Salpeter award. Incredibly well-deserved as I know of few other stellar neuroscientists who have advanced the careers of women in the field
Congratulations to the 2025 SfN award & prize recipients!
Their dedication to advancing the understanding of the brain paves the way for future discoveries.
SfN looks forward to celebrating their achievements at #SfN25.
Learn about the recipients.
🔗 vist.ly/4cni8
#neurosky
Their dedication to advancing the understanding of the brain paves the way for future discoveries.
SfN looks forward to celebrating their achievements at #SfN25.
Learn about the recipients.
🔗 vist.ly/4cni8
#neurosky
November 6, 2025 at 4:53 PM
Congrats @carmensandi10.bsky.social !!
Reposted by D. Parker Kelley, PhD
Metabolism is an energetic circuitry that transcends cellular and organellar boundaries
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism
Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to disease...
www.nature.com
October 30, 2025 at 3:52 PM
Metabolism is an energetic circuitry that transcends cellular and organellar boundaries
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Wait so midazolam is an antidepressant? Wut?
New 6-month depression RCT in n=65, serial Ketamine infusions as adjunctive care vs active placebo midazolam.
Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.
🧪 #psychiary #PsychSciSky
jamanetwork.com/journals/jam...
Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.
🧪 #psychiary #PsychSciSky
jamanetwork.com/journals/jam...
Serial Ketamine Infusions for Depression
This randomized clinical trial evaluates outcomes following adjunctive ketamine infusions vs midazolam for depression.
jamanetwork.com
October 23, 2025 at 1:32 PM
Wait so midazolam is an antidepressant? Wut?
Reposted by D. Parker Kelley, PhD
Hot off the press!
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 7:42 PM
Hot off the press!
Reposted by D. Parker Kelley, PhD
The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria.
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
October 17, 2025 at 2:42 AM
The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria.
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 3:59 PM
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Reposted by D. Parker Kelley, PhD
Pα+ Psychedelic Bulletin #207
- Lykos Rebrands to Resilient
- Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision
- AbbVie-Gilgamesh Deal Viewed as Validation
- Psilocybin Rescheduling Petition Heads to HHS
- Much, much more...
psychedelicalpha.com/news/p%ce%b1...
- Lykos Rebrands to Resilient
- Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision
- AbbVie-Gilgamesh Deal Viewed as Validation
- Psilocybin Rescheduling Petition Heads to HHS
- Much, much more...
psychedelicalpha.com/news/p%ce%b1...
Pα+ Psychedelic Bulletin #207: Lykos Rebrands to Resilient; Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision; AbbVie-Gilgamesh Deal Viewed as Validation - Psychedelic Alpha
Lykos Therapeutics Rebrands to Resilient Pharmaceuticals • Pharma Pushes Back on Norway’s Off-Label Ketamine Decision • AbbVie–Gilgamesh Deal Viewed as Validation for Short-Acting Psychedelics •
psychedelicalpha.com
August 28, 2025 at 5:08 PM
Pα+ Psychedelic Bulletin #207
- Lykos Rebrands to Resilient
- Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision
- AbbVie-Gilgamesh Deal Viewed as Validation
- Psilocybin Rescheduling Petition Heads to HHS
- Much, much more...
psychedelicalpha.com/news/p%ce%b1...
- Lykos Rebrands to Resilient
- Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision
- AbbVie-Gilgamesh Deal Viewed as Validation
- Psilocybin Rescheduling Petition Heads to HHS
- Much, much more...
psychedelicalpha.com/news/p%ce%b1...
Reposted by D. Parker Kelley, PhD
I'm near certain sLFOs are big for psychedelics.
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Systemic physiological "noise" in fMRI has clinical relevance
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...
www.medrxiv.org
August 26, 2025 at 5:14 PM
I'm near certain sLFOs are big for psychedelics.
Reposted by D. Parker Kelley, PhD
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 2:37 PM
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
Reposted by D. Parker Kelley, PhD
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.
You all have my sympathies. Unfair doesn’t even begin to describe it.
You all have my sympathies. Unfair doesn’t even begin to describe it.
August 18, 2025 at 4:14 AM
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.
You all have my sympathies. Unfair doesn’t even begin to describe it.
You all have my sympathies. Unfair doesn’t even begin to describe it.
Reposted by D. Parker Kelley, PhD
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 1:17 PM
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 6:27 PM
Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.
Reposted by D. Parker Kelley, PhD
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2)
Reporting by @jasteralaina.bsky.social.
The entire Dispatch is now free to read.
psychedelicalpha.com/news/dispatc...
Reporting by @jasteralaina.bsky.social.
The entire Dispatch is now free to read.
psychedelicalpha.com/news/dispatc...
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) - Psychedelic Alpha
In this second Dispatch from the inaugural Neurobiology of Psychedelics Gordon Research Conference, Dr. Alaina Jaster recaps Days 2 through 4, highlighting cutting-edge research on neuroplasticity…
psychedelicalpha.com
July 29, 2025 at 4:21 PM
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2)
Reporting by @jasteralaina.bsky.social.
The entire Dispatch is now free to read.
psychedelicalpha.com/news/dispatc...
Reporting by @jasteralaina.bsky.social.
The entire Dispatch is now free to read.
psychedelicalpha.com/news/dispatc...
Reposted by D. Parker Kelley, PhD
Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture.
Now we’re expanding further to provide services! Check it out!
Now we’re expanding further to provide services! Check it out!
Psychedelic Brain Science is officially an LLC!
To celebrate we’re launching Psychedelic Brain Science Consulting where a variety of services will be offered including workshops, one-on-one coaching, general consulting, independent analysis, and more!
For details visit our website!
To celebrate we’re launching Psychedelic Brain Science Consulting where a variety of services will be offered including workshops, one-on-one coaching, general consulting, independent analysis, and more!
For details visit our website!
Psychedelics | Your Brain On Science
Your Brain on Science is a psychedelic science communication platform dedicated to making psychedelic science accessible, understandable, and relatable for all through blog posts and podcast episodes.
www.psychedelicbrainscience.com
July 30, 2025 at 3:29 PM
Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture.
Now we’re expanding further to provide services! Check it out!
Now we’re expanding further to provide services! Check it out!
Reposted by D. Parker Kelley, PhD
I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!
Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health
Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...
www.nature.com
July 30, 2025 at 10:25 AM
I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!
Reposted by D. Parker Kelley, PhD
Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social
psychedelicalpha.com/news/dispatc...
psychedelicalpha.com/news/dispatc...
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Plasticity, Psychotherapy, and Perception (Part 1) - Psychedelic Alpha
Here, we share Dr. Alaina Jaster’s observations from the inaugural Neurobiology of Psychedelics Gordon Research Conference, where leading scientists gathered to explore various realms of psychedelic…
psychedelicalpha.com
July 23, 2025 at 2:26 PM
Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social
psychedelicalpha.com/news/dispatc...
psychedelicalpha.com/news/dispatc...
Reposted by D. Parker Kelley, PhD
Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶
Per usual, I took no pics - but luckily Missy had it covered for me 😂
Per usual, I took no pics - but luckily Missy had it covered for me 😂
July 18, 2025 at 11:25 PM
Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶
Per usual, I took no pics - but luckily Missy had it covered for me 😂
Per usual, I took no pics - but luckily Missy had it covered for me 😂
Reposted by D. Parker Kelley, PhD
Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to
@mayoonthebrain.bsky.social for bringing me ❤️
@mayoonthebrain.bsky.social for bringing me ❤️
July 18, 2025 at 6:09 PM
Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to
@mayoonthebrain.bsky.social for bringing me ❤️
@mayoonthebrain.bsky.social for bringing me ❤️
Reposted by D. Parker Kelley, PhD
Bring out the dancing lobsters 🦞🕺
#GRCPsychedelics
@sequencemyneuro.bsky.social
@fredbarrettphd.bsky.social
@tanner-anderson.bsky.social
#GRCPsychedelics
@sequencemyneuro.bsky.social
@fredbarrettphd.bsky.social
@tanner-anderson.bsky.social
July 18, 2025 at 12:29 AM
Bring out the dancing lobsters 🦞🕺
#GRCPsychedelics
@sequencemyneuro.bsky.social
@fredbarrettphd.bsky.social
@tanner-anderson.bsky.social
#GRCPsychedelics
@sequencemyneuro.bsky.social
@fredbarrettphd.bsky.social
@tanner-anderson.bsky.social
Reposted by D. Parker Kelley, PhD
Everyone approves of the dinner to end the #GRCPsychedelics 🦞
@deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart
@deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart
July 17, 2025 at 11:22 PM
Everyone approves of the dinner to end the #GRCPsychedelics 🦞
@deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart
@deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart
Obviously the mitochondria is the best organelle.
1 can leave cell, but stays
2 own genome
3 regulates nuclear gene expression
4 can kill whole cell
5 makes energy, distributes it to orchestrate cellular processes
6 controls whole organisms behavior
7 makes (sex, growth, stress, etc) steroids
1 can leave cell, but stays
2 own genome
3 regulates nuclear gene expression
4 can kill whole cell
5 makes energy, distributes it to orchestrate cellular processes
6 controls whole organisms behavior
7 makes (sex, growth, stress, etc) steroids
July 17, 2025 at 7:46 PM
Obviously the mitochondria is the best organelle.
1 can leave cell, but stays
2 own genome
3 regulates nuclear gene expression
4 can kill whole cell
5 makes energy, distributes it to orchestrate cellular processes
6 controls whole organisms behavior
7 makes (sex, growth, stress, etc) steroids
1 can leave cell, but stays
2 own genome
3 regulates nuclear gene expression
4 can kill whole cell
5 makes energy, distributes it to orchestrate cellular processes
6 controls whole organisms behavior
7 makes (sex, growth, stress, etc) steroids