🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔

In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...

Great work

Without resistance there can be no transformation of anything into anything else. Like a beaming photon in outer space.

But with too much resistance, energy cannot flow, damage accumulates, and we die. Like electrons trying to flow in a defective mitochondrion.

Excellent framework to understand the processes favoring health vs disease based on the Energy Resistance Principle. Makes me wonder whether the shape of this inverted-U curve, or linked parameters, are trait-like across individuals. Congrats @martinpicardenergy.bsky.social & @msahsorin.bsky.social

We don’t pass down our mitochondria, but we may pass down other things that contribute to the health of our little ones

One of my most exciting & frame-shifting papers to date.

The Energy Resistance Principle shows how resistance to energy shapes the dynamics of life and health.

A new lens to understand & optimize energy across the lifespan, inspiring tools that sense & tune the body’s energetic architecture.

GDF15 is one of the most fascinating hormones. Discovered separately in different fields, linked to energy and aging, and the best predictor of morbidity and mortality in humans.

GDF15 is also induced by mental stress: linkinghub.elsevier.com/retrieve/pii...

We'd love to hear your thoughts, ideas, and questions.

Please join us for a X space discussion on Oct 21. Maybe we need to use a different platform in the future...
twitter.com/i/spaces/1dR...

Too much resistance, your energy cannot flow easily, you feel tired, become inflamed, age faster, and get sick more easily. When éR is too high, we die.

ERP's key idea is that we live in a narrow zone of energy resistance (éR). For energy to transform into metabolites, cells, organs, and thoughts, it needs to run through éR. Too little resistance, you would burst into flames.

☯︎ Why is exercise good for us?
☯︎ How does ketosis work as a treatment for mental illness?
☯︎ Why do we age well or not so well?
☯︎ Where does fatigue and the need to sleep come from?
☯︎ Why is the brain warmer than other tissues?
☯︎ How can we measure energy resistance (éR)?

The ERP is a quantitative framework that can be used to understand some profound things that we know matter for our health:

We are grateful for the dozens of colleagues, friends, and lab members who have contributed to sharpening the ideas, concepts, and definitions in the ERP.

The ERP bridges physics and biology, providing a first-principles understanding of the central force behind health and disease dynamics.

This morning I felt a little sadness when I remembered that many of the colleagues I wished to share something dear to my heart with, had departed from X.

@msahsorin.bsky.social and I would love to know what people think of the Energy Resistance Principle (ERP)

authors.elsevier.com/a/1luVK5WXUl...